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Targeting Calcium Homeostasis For The Treatment Of Multiple Myeloma, Osama M. Elzamzamy
Targeting Calcium Homeostasis For The Treatment Of Multiple Myeloma, Osama M. Elzamzamy
Graduate Theses, Dissertations, and Problem Reports
Multiple myeloma (MM) is a hematological malignancy characterized by the neoplastic proliferation of the plasma cells. MM is a relatively rare cancer that accounts for about 1.8% of all cancers and is the second most common hematologic malignancies, and despite the advancement from untreatable to treatable malignancy, it is yet incurable. Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora of physiological and pathological processes, hence cytoplasmic Ca2+ is tightly regulated with strict spatial and temporal control to initiate, maintain, and terminate appropriate signaling pathways and phenotypes including cellular proliferation, cell cycle …