Nervous System Commons^™

Dentate Gyrus Neurogenesis Across Different Ages In Male Rats: An Immunohistochemical Approach, Ayman Ghallab, Ayman Mohammed Ghallab

Dentistry

Abstract Dentate gyrus is a fundamental sub-region of the hippocampus which is directly engaged in higher memory and cognitive functions. This study was performed to describe the histological and immunohistochemical changes in dentate gyrus in experimental animals during postnatal development. Forty four male albino rats were classified into four equal groups: new born group aged one day, adult group aged 3–6 months, early senile group aged 18–20 months and late senile group aged 30–31 months. Specimens of hippocampus were processed and prepared for routine hematoxylin and eosin stains and immunohistochemical expressions of calretinin, glial fibrillary acidic protein and Ki67 (Kiel …