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The Role Of Nogo-A During Development Of The Chick Central Nervous System, Shelly A. Caltharp
The Role Of Nogo-A During Development Of The Chick Central Nervous System, Shelly A. Caltharp
Loma Linda University Electronic Theses, Dissertations & Projects
Nogo-A is a potent inhibitor of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during embryonic development. To examine its potential role we isolated and analyzed the Nogo-A sequence in the chick, we localized its mRNA expression pattern and cell-specific distribution during key phases of cortical development, and studied regulation of its expression during phases that showed promise of function based on expression patterns.
Our results revealed five previously undescribed Nogo-A specific …