Musculoskeletal System Commons^™

Evaluating Sex Related Differences In The Osteocyte Lacunar Canalicular Network Across The Lifespan: A Confocal Laser Scanning Microscopy Approach, Gina Tubo

Williams Honors College, Honors Research Projects

Bone is a dynamic tissue with the ability to remodel itself. This capability is facilitated via communication mechanisms through the osteocyte-lacunar-canalicular (LCN) network. Osteocytes are bone cells housed in small, hollow spaces called lacunae. Lacunae are linked by canals called canaliculi. A diminished network can lead to the inability to form bone following breakdown. A decrease in osteocyte-LCN density has been shown to correlate with aging (Ashique et al. 2017). This decline leads to the development of osteoporosis. Osteoporosis preferentially affects women. Prior studies have shown that women older than 50 are four times more likely to be osteoporotic when …

Short-Term Estrogen-Depletion-Related Changes In Anatomic Variation Of Time-Dependent Material Properties, And Evidence Of Secondary Remodeling Of Ovine Compact Bone, Ryan Allen, Kathleen De Guzman

Biomedical Engineering

Recognized as the most common type of bone disease in humans, osteoporosis poses a major health threat to roughly 28 million Americans [1]. In women, the leading cause of osteoporosis is known to be a drop in estrogen during the time of menopause. Thus, it becomes essential to acquire a better understanding of postmenopausal osteoporosis, as many individuals desire a longer lifetime and an improved quality of life for the elderly. To further current knowledge of postmenopausal osteoporosis and help develop methods of overcoming it, it is important to find an appropriate animal model.

In this study, pretreated ovine compact …