Effect Of Exercise Position On Percent Changes In Serratus Anterior Muscle Thickness, 2019 University of Dayton
Effect Of Exercise Position On Percent Changes In Serratus Anterior Muscle Thickness, Joseph M. Day
Objective: A reliable method for measuring SA thickness with ultrasound imaging has been reported, yet the ability to detect differences in levels of contractility has yet to be established. The purpose of this study was to determine if there are differences in the percent change in thickness of the SA during four different exercise positions performed by healthy individuals.
Design: Observational study
Participants: Twenty-eight healthy participants, mean age 26 (SD 4, 57% female, 100% right handed)
Methods: Volunteers were positioned in a standardized sitting posture and anatomical landmarks were marked for ultrasound probe positioning. Two resting and two ...
How The Foot Modulates Its Mechanics During Uphill And Downhill Walking, 2019 Department of Biomechanics
How The Foot Modulates Its Mechanics During Uphill And Downhill Walking, Jeffrey M. Patterson, Kota Z. Takahashi
Student Research and Creative Activity Fair
The foot's biomechanical role in walking on sloped surfaces is currently unclear. While previous biomechanics studies have examined the hip, knee, and ankle, the foot is oversimplified as a rigid-body segment. This oversimplification overshadows its complex structure and function. In this project, we use an innovative multi-segment foot model to explore how the foot adapts its mechanics to incline and decline walking. Preliminary results have revealed that the foot is capable of adapting its mechanical work profile to both incline and decline walking. Specifically, the foot can increase its positive work output (i.e., increased energy generation) during inclined ...
Elbow Ulnar Collateral Ligament Reconstruction Using The Novel Docking Plus Technique In 324 Athletes, 2019 Cayuga Medical Associates
Elbow Ulnar Collateral Ligament Reconstruction Using The Novel Docking Plus Technique In 324 Athletes, Benjamin F. Donohue, Marc G. Lubitz, Timothy E. Kremchek
Open Access Articles
BACKGROUND: This retrospective case series examined 324 athletes who received elbow ulnar collateral ligament (UCL) reconstruction by a single surgeon in a private practice over a 9-year period. The novel Docking Plus technique for elbow UCL reconstruction in 324 athletes provided good or excellent Conway score results in 88% of patients. The preponderance of previous studies examining UCL reconstruction outcomes were performed by surgeons at one of only three institutions (Andrews Institute, Hospital for Special Surgery, Kerlan Jobe Orthopedic Clinic).
METHODS: Patients undergoing UCL reconstruction from November 2005 to December 2014 were identified and contacted with a mailed survey and ...
Session 4 - Musculoskeletal Anatomy, 2019 Thomas Jefferson University
Session 4 - Musculoskeletal Anatomy, Skmc Surface Anatomy
- Be able to appropriately identify the location to assess upper and lower extremity pulses
- Be able to identify the contents of the femoral canal
- Be able to identify the safe location for an inter gluteal injection
- Be able to identify the contents of the tarsal tunnel
Correction To: Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction Induced Injury, 2018 Edith Cowan University
Correction To: Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction Induced Injury, Andrew N. Billin, Samuel E. Honeycutt, Alan V. Mcdougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
ECU Publications Post 2013
Following publication of the original article , the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
The Relationship Between Feeding Type And Temporomandibular Joint Morphology In Superfamily Musteloidea, 2018 Grand Valley State University
The Relationship Between Feeding Type And Temporomandibular Joint Morphology In Superfamily Musteloidea, Travis L. Garvin
Many studies have focused on the soft tissue analysis of carnivores and have demonstrated a relationship between feeding biomechanics and feeding types. Herbivores and omnivores rely heavily on anteroposterior and helical movement of the mandible and teeth for the breakdown of fibrous foods resulting in a flat mandibular fossa while the function of the carnivore TMJ is different, as they need a much stable joint for ripping and tearing of the flesh. I aim to look at whether the bony morphology of the temporomandibular joint (TMJ) can be directly related to feeding type, specifically in the superfamily Musteloidea. I sampled ...
Tibiotalar Arthrodesis: Development Of A Novel Jig And Alignment Guide, 2018 The University of Western Ontario
Tibiotalar Arthrodesis: Development Of A Novel Jig And Alignment Guide, Adam Mathew Ropchan
Electronic Thesis and Dissertation Repository
Tibiotalar arthrodesis is a surgical procedure, used for the treatment of end-stage ankle arthrosis and instability. There are dozens of described procedures in the literature, all with varying rates of success. Two of the most common reasons for reoperation in tibiotalar arthrodesis are nonunion and infection; few studies have established any associations between patient/surgical factors and reoperation for nonunion and infection.
The first part of this thesis focuses on determining the rate of reoperation to the ipsilateral lower limb and if any patient/surgical factors are associated with reoperation for nonunion and infection. The second part of this thesis ...
Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction-Induced Injury, 2018 Edith Cowan University
Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction-Induced Injury, Andrew N Billin, Samuel E Honeycutt, Alan V Mcdougal, Jaclyn P Kerr, Zhe Chen, Johannes M Freudenberg, Deepak K Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S Geske, Frank Fang, Bert Yao, Richard V Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C Hinken, Alan J Russell
ECU Publications Post 2013
BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF.
METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects ...
The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, 2018 Chapman University
The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch
Mathematics, Physics, and Computer Science Faculty Articles and Research
Osteoporosis is the most common metabolic bone disease and goes largely undiagnosed throughout the world, due to the inaccessibility of DXA machines. Multivariate analyses of serum bone turnover markers were evaluated in 226 Orange County, California, residents with the intent to determine if serum osteocalcin and serum pyridinoline cross-links could be used to detect the onset of osteoporosis as effectively as a DXA scan. Descriptive analyses of the demographic and lab characteristics of the participants were performed through frequency, means and standard deviation estimations. We implemented logistic regression modeling to find the best classification algorithm for osteoporosis. All calculations and ...
The Effects Of Tracheal Occlusion On Wnt Signaling In A Rabbit Model Of Congenital Diaphragmatic Hernia, 2018 The University of Western Ontario
The Effects Of Tracheal Occlusion On Wnt Signaling In A Rabbit Model Of Congenital Diaphragmatic Hernia, Martina M. Mudri
Electronic Thesis and Dissertation Repository
Purpose: Tracheal occlusion (TO) reverses pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH), but its effect on epithelial-mesenchymal transition (EMT) in lung development remains poorly understood. The purpose of this study was to a) confirm the CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/- TO on EMT pathways.
Methods: CDH was created at 23 days, TO at 28 days and lung collection at 31 days gestation in fetal rabbits. Lung body weight ratio (LBWR), mean terminal bronchiole density (MTBD), and expression of mRNA and micro-RNA was determined.
Results: Fifteen CDH, 15 ...
Comparative Analysis Of Body Composition And Reference Values Of Visceral Adipose Tissues In Various American Collegiate Sports, 2018 California Polytechnic State University, San Luis Obispo
Comparative Analysis Of Body Composition And Reference Values Of Visceral Adipose Tissues In Various American Collegiate Sports, Eshan M. Dandekar
Master's Theses and Project Reports
Background: Currently, body composition (BC) assessment is usually performed to diagnose disease states and accurately estimate certain types of tissues. In athletes, performing BC assessments helps gauge training and nutrition programs to see if they are adequately meeting the athlete’s needs to improve performance. Annual Dual Energy X-ray Absorptiometry (DXA) scans before the start of an athlete’s season can help identify an athlete’s preparedness or health before training begins.
Objective: To assess the preseason BC of four collegiate sports: Men’s basketball, men’s baseball, women’s volleyball, and women’s soccer, for Fat Mass (FM), bone ...
Jnk Regulates Muscle Remodeling Via Myostatin/Smad Inhibition, 2018 Harvard Medical School
Jnk Regulates Muscle Remodeling Via Myostatin/Smad Inhibition, Sarah J. Lessard, Tara L. Macdonald, Prerana Pathak, Myoung Souk Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, Laurie J. Goodyear
Open Access Articles
Skeletal muscle has a remarkable plasticity to adapt and remodel in response to environmental cues, such as physical exercise. Endurance exercise stimulates improvements in muscle oxidative capacity, while resistance exercise induces muscle growth. Here we show that the c-Jun N-terminal kinase (JNK) is a molecular switch that when active, stimulates muscle fibers to grow, resulting in increased muscle mass. Conversely, when muscle JNK activation is suppressed, an alternative remodeling program is initiated, resulting in smaller, more oxidative muscle fibers, and enhanced aerobic fitness. When muscle is exposed to mechanical stress, JNK initiates muscle growth via phosphorylation of the transcription factor ...
Unfolded Protein Response Pathways In Skeletal Muscle Homeostasis., 2018 University of Louisville
Unfolded Protein Response Pathways In Skeletal Muscle Homeostasis., Kyle R. Bohnert
Electronic Theses and Dissertations
Skeletal muscle mass, contractile properties, and metabolic function are regulated through the coordinated activation of multiple intracellular signaling pathways and genetic reprogramming. The endoplasmic reticulum (ER) plays a pivotal role in protein folding and calcium homeostasis in many cell types, including skeletal muscle. Disruption of calcium levels or accumulation of misfolded proteins in the ER lumen leads to stress, which results in the activation of a signaling network called the unfolded protein response (UPR). Further, recent studies have suggested that in certain conditions, UPR pathways can be activated independent of ER stress. However, the role of ER stress and the ...
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, 2018 Marquette University
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, Alex Thomas
Master's Theses (2009 -)
The purpose of this study was to validate a 3D musculoskeletal model in OpenSim and assess OpenSim’s ability to determine muscle-length variation during ambulation. An 18 camera motion capture system was used to analyze 20 healthy individuals between the ages of 18 and 35. Following data collection, the data was processed through OpenSim and Visual3D. The kinematic output processed through the OpenSim model was then compared to the kinematic output of the validated Visual3D model to validate the OpenSim model. Muscle fiber length data obtained from the same experimental data was compared to control data to assess OpenSim’s ...
Glucosamine From Hydrolysis Of 3d Printing Chitosan For Osteoarthritis Treatment, 2018 Kamnoetvidya Science Academy
Glucosamine From Hydrolysis Of 3d Printing Chitosan For Osteoarthritis Treatment, Ruj Dansriboon, Laphon Premcharoen
The International Student Science Fair 2018
This project aims to introduce a new way for osteoarthritis treatment which is expected to increase in the future. Glucosamine is the main subject for a treatment, which can be derived by hydrolyzing chitosan. This project also includes extraction of chitosan from shrimp waste to make a worthy use of food waste from industry. In this project, 3D printer is applied to print chitosan gel since 3D printing is adjustable to form various shapes of the gel.
The research process begins with the extraction of chitosan from shrimp shells. For the next step, the percent of deacetylation of chitosan was ...
Transcriptional Profiling Reveals Extraordinary Diversity Among Skeletal Muscle Tissues, 2018 Washington University in St. Louis
Transcriptional Profiling Reveals Extraordinary Diversity Among Skeletal Muscle Tissues, Erin E. Terry, Xiping Zhang, Christy Hoffmann, Laura D. Hughes, Scott A. Lewis, Jiajia Li, Matthew J. Wallace, Lance A. Riley, Collin M. Douglas, Miguel A. Gutierrez-Monreal, Nicholas F. Lahens, Ming C. Gong, Francisco H. Andrade, Karyn A. Esser, Michael E. Hughes
Physiology Faculty Publications
Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others. Even monogenic muscular dystrophies selectively affect certain muscle groups. These observations suggest that factors intrinsic to muscle tissues influence their resistance to disease. Nevertheless, most studies have not addressed transcriptional diversity among skeletal muscles. Here we use RNAseq to profile mRNA expression in skeletal, smooth, and cardiac muscle tissues from mice and rats. Our data set, MuscleDB, reveals extensive transcriptional diversity, with greater than 50% of transcripts differentially expressed among skeletal muscle tissues. We detect ...
Noncontact Anterior Cruciate Ligament Injuries In Collegiate Female Soccer Players: The Effects Of A 4-Week Prevention Program On Landing Kinematics, Tess Marcordes
Honors Program Projects
BACKGROUND: Noncontact anterior cruciate ligament (ACL) injuries are highly prevalent in soccer as quick changes in direction, stop-start motions, as well as jumping and landing often paired with shooting or passing a ball are occurring continuously throughout a practice or match. Exaggeration of these movements with extreme joint motions increases the likelihood of ACL injury. An ACL injury can be detrimental to an athlete’s career as 25% of athletes do not return to their pre-injury level of play (Padua, DiStefano, Beutler, de la Motte, DiStefano, & Marshall, 2015). Myer, Ford, McLean, & Hewitt (2006), Garcia (2011), and Pollard, Sigward, Ota, Langford ...
Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, 2018 Duquesne University
Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, Sifat Maria
Electronic Theses and Dissertations
Objective: The purpose of this study was to assess if a novel combination of melatonin and three other natural bone-aiding micronutrients: strontium citrate, vitamins D3 and K2 (MSDK) could improve bone health by modulating the activity of osteoblasts and osteoclasts in favor of balanced bone remodeling and by improving the overall health-related quality of life in postmenopausal osteopenic women.
Methods: The Melatonin-micronutrients Osteopenia Treatment Study (MOTS) is a translational research study that used both clinical and in vitro approaches to assess the efficacy of MSDK on bone health in women and to identify potential mechanisms for its effects ...
Functional Anatomy Of Palmar Musculature, 2018 The University of Western Ontario
Functional Anatomy Of Palmar Musculature, Colin W. Moore
Electronic Thesis and Dissertation Repository
The palmaris longus (PL) and palmaris brevis (PB) are upper limb muscles considered atavistic remnants of those found in animal species. Despite their use in surgical grafting and tendon transfer procedures, the functional role of the PL and PB have not been investigated comprehensively in vivo. Using a multi-modal experimental approach consisting of indwelling fine wire electromyography (EMG), ultrasonography and immunohistochemical muscle staining techniques, the function of the PL and PB in the hand was evaluated both in in vivo and in situ.
The purpose of Study 1 was to determine whether the PL provides synergistic contributions to thenar contractions ...
Human Body Composition And Immunity: Visceral Adipose Tissue Produces Il-15 And Muscle Strength Inversely Correlates With Nk Cell Function In Elderly Humans, Ahmad Al-Attar, Steven R. Presnell, Jody L. Clasey, Douglas E. Long, R. Grace Walton, Morgan Sexton, Marlene E. Starr, Philip A. Kern, Charlotte A. Peterson, Charles T. Lutz
Pathology and Laboratory Medicine Faculty Publications
Natural killer (NK) lymphocyte-mediated cytotoxicity and cytokine secretion control infections and cancers, but these crucial activities decline with age. NK cell development, homeostasis, and function require IL-15 and its chaperone, IL-15 receptor alpha (IL-15Rα). Macrophages and dendritic cells (DC) are major sources of these proteins. We had previously postulated that additional IL-15 and IL-15Rα is made by skeletal muscle and adipose tissue. These sources may be important in aging, when IL-15-producing immune cells decline. NK cells circulate through adipose tissue, where they may be exposed to local IL-15. The objectives of this work were to determine (1) if human muscle ...