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The Need For Standardized Assessment Of Muscle Quality In Skeletal Muscle Function Deficit And Other Aging-Related Muscle Dysfunctions: A Symposium Report, Rosaly Correa de Araujo, Michael O. Harris-Love, Iva Miljkovic, Maren Fragala, Brian Anthony, Todd Manini 2017 George Washington University

The Need For Standardized Assessment Of Muscle Quality In Skeletal Muscle Function Deficit And Other Aging-Related Muscle Dysfunctions: A Symposium Report, Rosaly Correa De Araujo, Michael O. Harris-Love, Iva Miljkovic, Maren Fragala, Brian Anthony, Todd Manini

Exercise and Nutrition Sciences Faculty Publications

A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other ...


Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott 2016 Chapman University

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 ...


Stack And Bend, Ngoc “Knock” Ho 2016 Jagged Vertical Dance Fitness

Stack And Bend, Ngoc “Knock” Ho

The STEAM Journal

An excerpt on body contortion.


Transforming Body, Angelina Prendergast 2016 Claremont Colleges

Transforming Body, Angelina Prendergast

The STEAM Journal

This is a reflection about the use of balls for body therapy.


Get Up, Stand Up: A Brief History Of Sedentarism And Why Movement Is Good Medicine, Tony Federico 2016 Selected Works

Get Up, Stand Up: A Brief History Of Sedentarism And Why Movement Is Good Medicine, Tony Federico

Tony Federico

Chairs first emerged as a way for high-status individuals to designate their social standing, and their use was almost exclusively the domain of the affluent class until the Industrial Revolution made affordable, mass-produced seating possible. Prior to this point, the vast majority of people sat on improvised objects such as beds, tree stumps, or benches, or simply squatted on their haunches. Social aspirations, continued technological innovations (e.g. the automobile), and a shift towards sedentary work drove the adoption of the chair until its use became ubiquitous at home, at work, at school, and at play (e.g. computer and ...


The Physiological Responses To Cycling Stress., Moriah Larsen 2016 Northern Arizona University

The Physiological Responses To Cycling Stress., Moriah Larsen

Skyline - The Big Sky Undergraduate Journal

Background: As the intensity of exercise increases, the risk of incidences for exertional heat illness (EHI) continues to climb. The National Athletic Trainers Association (NATA) has set an official position statement; stating a “gold standard” for obtaining core body temperature is via rectal thermometry. It has been reported that other field-expedient methods of obtaining core body temperature (oral, axillary, tympanic, temporal) are invalid or unreliable sources after intense exercise in hot temperature regions. Purpose: To determine if a relationship exists between rectal temperature measurements and tympanic temperature measurements during intensive long bouts of exercise. Design: Controlled Laboratory Study. Setting: Human ...


Hip Flexor Extensibility And Its Correlation To Hip Hyperextension And Lower Back Pain In Dancers, Tessa Richards 2016 University of Montana, Missoula

Hip Flexor Extensibility And Its Correlation To Hip Hyperextension And Lower Back Pain In Dancers, Tessa Richards

Skyline - The Big Sky Undergraduate Journal

The goal of this research was to measure the correlation between hip flexor extensibility, arabesque height, and lower back pain; specifically, whether a tight iliopsoas group restricts range of motion and correlates with lower back pain in dancers. Through a series of non-invasive measurements, the rectus femoris and iliopsoas group were tested for range of motion and general extensibility. The measurements were as follows: Patrick’s Test, Thomas’s Test, Modified Thomas Test, and prone hip hyperextension. Each subject also completed a pre-screening form to assess degree of lower back pain. The outcomes of the measurements were analyzed to find ...


The Role Of Osteocyte Estrogen Receptor Beta (Erβ) In Regulating The Skeletal Response To Mechanical Loading, Julia P. Townsend, Russell P. Main 2016 Purdue University

The Role Of Osteocyte Estrogen Receptor Beta (Erβ) In Regulating The Skeletal Response To Mechanical Loading, Julia P. Townsend, Russell P. Main

The Summer Undergraduate Research Fellowship (SURF) Symposium

Estrogen’s biological functions are mediated by estrogen binding to estrogen receptors (ER). Understanding what role both ERα and ERβ have in bone maintenance and formation can contribute to possible treatment of osteoporosis. This study examined osteocyte specific deletion of ERβ in mice. The cross of ERβ-floxed mice with DMP1-8kb-Cre mice provided both experimental knockout mice as well as littermate control mice. At 24 weeks of age the left tibiae of all mice were mechanically loaded five days per week for two weeks to induce bone formation. Analysis of cortical bone was conducted using microcomputed tomography (microCT) to measure load-induced ...


Short-Term Progression Of Functional Capabilities And Pain Levels Following Autologous Chondrocyte Implantation, Dalton Main 2016 University of Arkansas, Fayetteville

Short-Term Progression Of Functional Capabilities And Pain Levels Following Autologous Chondrocyte Implantation, Dalton Main

Health, Human Performance and Recreation Undergraduate Honors Theses

Purpose: The purpose of this study was to evaluate patient-centered outcomes of functional capability and pain levels following Autologous Chondrocyte Implantation (ACI) surgery, as well as compare results from previous studies. Research was also conducted to find possible predictors of short-term success following ACI surgery. Methods: 10 patients (43 ± 6 years) were asked to complete a survey packet pre-operatively, and at three, six, and 12 months post-surgery as part of their standard medical files. These surveys included the International Knee Documentation Committee (IKDC), Visual Analog Scale (VAS) for pain, Depression Self-assessment (DSA), and a Global Rating of Change (GROC) for ...


Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg 2016 Cedarville University

Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg

The Research and Scholarship Symposium

Individuals with intellectual and developmental disabilities (IDD) are commonly prescribed antiepileptic drugs (AEDs) to manage seizures, manage behavior, and stabilize mood. Though research has been done on the effects of antiepileptic medications in patients with epilepsy, little study has been done on the persons with intellectual and developmental disabilities population. After surveying IDD patients with a history and current use of AEDs on osteoprotective behaviors, we were unable to use SPSS due to incomplete surveys and low sample sizes. However, we were still able to analyze for common themes, and we found that the most prevalent use of AEDs was ...


Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge 2016 Cedarville University

Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge

The Research and Scholarship Symposium

Introduction: Anterior cruciate ligament injuries occur over 200,000 times annually in the United States alone (Brophy, et al. 2009). This injury strains the healthcare system and affects the players, teams, parents, and the organization they are a part of. There have been, however, clinically researched risk factors that predispose athletes to ACL injury (Gignac, et al. 2015; Laible, et al. 2014). As a result, there is a clinical need for an effective screening tool to identify those athletes at risk for ACL injury. The Functional Movement Screen has been shown to be an effective screening tool for detecting athletes ...


Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon 2016 The University of Western Ontario

Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon

Electronic Thesis and Dissertation Repository

The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.

Although this generic ...


Musculoskeletal Disorders In The Nursing Profession: A Case Study, Kaitlin A. Kee-Dayton 2016 Embry-Riddle Aeronautical University - Daytona Beach

Musculoskeletal Disorders In The Nursing Profession: A Case Study, Kaitlin A. Kee-Dayton

Human Factors and Applied Psychology Student Conference

Musculoskeletal Disorders in the Nursing Profession: A Case Study

Kaitlin Kee-Dayton

Beth Blickensderfer, Ph.D.

Embry-Riddle Aeronautical University

Daytona Beach, FL

This ergonomics assessment focused on a female Licensed Practical Nurse (LPN) and her life inside and outside of her job. In particular, this case study assessed how working as a nurse may affect the human body in terms of Musculoskeletal Disorders (MSDs). The researcher first conducted an in-depth interview with the nurse about her workplace layout, typical daily work schedule, work habits, physical challenges, MSD injuries she has sustained, and the workplace environment/organizational culture. Next, the researcher conducted ...


Using Mixed Methods To Measure The Perception Of Community Capacity In An Academic–Community Partnership For A Walking Intervention, Charkarra Anderson-Lewis, Diana Castellanos, Arnecca Byrd, Karen Zynda, Alicia Sample, Vickie Reed, Mary Beard, Latessa Minor, Kathleen Yadrick 2016 University of Southern Mississippi

Using Mixed Methods To Measure The Perception Of Community Capacity In An Academic–Community Partnership For A Walking Intervention, Charkarra Anderson-Lewis, Diana Castellanos, Arnecca Byrd, Karen Zynda, Alicia Sample, Vickie Reed, Mary Beard, Latessa Minor, Kathleen Yadrick

Diana Cuy Castellanos

H.U.B. City Steps is a 5-year community-based participatory research walking intervention designed to help lower blood pressure in a majority African American population in southern Mississippi via community collaboration and capacity building, increased walking, culturally tailored health education sessions, and motivational interviewing. Building community capacity for physical activity is a key component of this intervention. Qualitative and quantitative methods have been used to assess how project stakeholders perceive the community capacity-building efforts of the project. This article illustrates the baseline results of this mixed methods approach from the perspective of three groups of stakeholders: project researchers and staff ...


Intravascular Atp And The Regulation Of Blood Flow And Oxygen Delivery In Humans, Anne Crecelius, Brett Kirby, Frank Dinenno 2016 University of Dayton

Intravascular Atp And The Regulation Of Blood Flow And Oxygen Delivery In Humans, Anne Crecelius, Brett Kirby, Frank Dinenno

Anne R. Crecelius

Regulation of vascular tone is a complex response that integrates multiple signals which allow for blood flow and oxygen supply to appropriately match oxygen demand. Here, we discuss the potential role of intravascular ATP as a primary factor in these responses and propose that deficient ATP release may contribute to impairments in vascular control exhibited in aged and diseased populations.


Vascular Regulation Via Kir Channels And Na+ /K+-Atpase, Anne Crecelius, Frank Dinenno 2016 University of Dayton

Vascular Regulation Via Kir Channels And Na+ /K+-Atpase, Anne Crecelius, Frank Dinenno

Anne R. Crecelius

Despite the longstanding knowledge that blood flow increases in proportion to metabolic activity of skeletal muscle, the underlying mechanisms that govern this response have only recently been identified.1 Given the role of endothelial cells in mediating exercise hyperemia,2 interest has been focused on endothelium-derived vasodilation occurring via the synthesis of nitric oxide (NO) and vasodilating prostaglandins (PGs; i.e. prostacyclin) or endothelium- derived hyperpolarization. A number of studies performed in humans have established a minimal-to-modest role for NO and PGs during mild- and moderate- intensity exercise. In animal preparations, prevention of hyperpolarization attenuates contraction-induced hyperemia; however, performing similar ...


Kir Channel Activation Contributes To Onset And Steady-State Exercise Hyperemia In Humans, Anne Crecelius, Gary Luckasen, Dennis Larson, Frank Dinenno 2016 University of Dayton

Kir Channel Activation Contributes To Onset And Steady-State Exercise Hyperemia In Humans, Anne Crecelius, Gary Luckasen, Dennis Larson, Frank Dinenno

Anne R. Crecelius

We tested the hypothesis that activation of inwardly rectifying potassium (KIR) channels and Na+-K+-ATPase, two pathways that lead to hyperpolarization of vascular cells, contributes to both the onset and steady-state hyperemic response to exercise. We also determined whether after inhibiting these pathways nitric oxide (NO) and prostaglandins (PGs) are involved in the hyperemic response. Forearm blood flow (FBF; Doppler ultrasound) was determined during rhythmic handgrip exercise at 10% maximal voluntary contraction for 5 min in the following conditions: control [saline; trial 1 (T1)]; with combined inhibition of KIR channels and Na+-K+-ATPase alone [via barium chloride (BaCl2 ...


Central And Peripheral Weight Gain Affect Trunk Kinematics And Lower-Extremity Muscle Activation Differently During Sit-To-Stand, Michelle Christine Walaszek 2016 University of Kentucky

Central And Peripheral Weight Gain Affect Trunk Kinematics And Lower-Extremity Muscle Activation Differently During Sit-To-Stand, Michelle Christine Walaszek

Theses and Dissertations--Kinesiology and Health Promotion

Background: Obesity-induced alterations in biomechanics and muscle recruitment during activities of daily living, such as sit-to-stand (STS) are often attributed to increases in adipose tissue (AT) mass. Central or peripheral distribution of AT may differently affect biomechanics and muscle recruitment.

Methods: Fifteen healthy, normal weight (BMI 22.4 ± 1.9 kg/m2, 24.1 ± 4.2 years) subjects volunteered. External loads equivalent to a 5 kg/m2 BMI increase were applied in three conditions: unloaded (UN), centrally loaded (CL), and peripherally loaded (PL). Subjects completed three successful STS movements in a backless chair under each load condition in ...


Temporal Neuromuscular Alterations Of The Quadriceps After Unilateral Anterior Cruciate Ligament Reconstruction, Conrad M. Gabler 2016 University of Kentucky

Temporal Neuromuscular Alterations Of The Quadriceps After Unilateral Anterior Cruciate Ligament Reconstruction, Conrad M. Gabler

Theses and Dissertations--Rehabilitation Sciences

Objective: The primary aim of this research was to examine the temporal pattern of neuromuscular quadriceps deficits in both the involved and uninvolved limbs of patients assigned to the control group after anterior cruciate ligament reconstruction (ACLr), by assessing quadriceps strength, voluntary activation, and corticomotor excitability prior to surgery (baseline), three months after ACLr, and six months after ACLr. A secondary aim of this research was to determine whether quadriceps strength, voluntary activation, and/or corticomotor excitability assessed in patients prior to ACLr and/or at three months after surgery, is predictive of lower extremity postural control and/or self-reported ...


Effects On Muscle Tissue Remodeling And Lipid Metabolism In Muscle Tissue From Adult Patients With Polymyositis Or Dermatomyositis Treated With Immunosuppressive Agents., Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova, Ingrid E Lundberg 2016 George Washington University

Effects On Muscle Tissue Remodeling And Lipid Metabolism In Muscle Tissue From Adult Patients With Polymyositis Or Dermatomyositis Treated With Immunosuppressive Agents., Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova, Ingrid E Lundberg

Integrative Systems Biology Faculty Publications

BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are autoimmune muscle diseases, conventionally treated with high doses of glucocorticoids in combination with immunosuppressive drugs. Treatment is often dissatisfying, with persisting muscle impairment. We aimed to investigate molecular mechanisms that might contribute to the persisting muscle impairment despite immunosuppressive treatment in adult patients with PM or DM using gene expression profiling of repeated muscle biopsies.

METHODS: Paired skeletal muscle biopsies from six newly diagnosed adult patients with DM or PM taken before and after conventional immunosuppressive treatment were examined by gene expression microarray analysis. Selected genes that displayed changes in expression were analyzed ...


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