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Examining Permeability And Contractility Of Skeletal Muscle In Castrated Male Mice, Evan Scott 2020 Ursinus College

Examining Permeability And Contractility Of Skeletal Muscle In Castrated Male Mice, Evan Scott

Health and Exercise Physiology Honors Papers

A common method of treating skeletal muscle injury is temperature therapy. Temperature affects one of the initial aspects of skeletal muscle healing, the increasing of vascular permeability. Previous data accumulated from the Ursinus College Skeletal Muscle Lab suggests that vascular permeability following temperature therapy is different between the anatomically intact male and female mice. However, there have not been any studies to date that are able determine the cause of these permeability differences following temperature treatment. In addition, it is currently unclear how increased vascular permeability affects skeletal muscle healing. A possible cause for these differences is the increased presence ...


Beyond The Brain: ?-Synuclein And Its Implications In Bone And Fat Metabolism, C A. Figueroa, P Bajgain, C J. Rosen 2020 Maine Medical Center

Beyond The Brain: ?-Synuclein And Its Implications In Bone And Fat Metabolism, C A. Figueroa, P Bajgain, C J. Rosen

Costas T. Lambrew Research Retreat 2020

Introduction: Pathological form of α-synuclein is the major component of the Lewy body in the brain of Parkinson’s disease (PD) patients. Research efforts have been directed towards understanding the root and progression of the neurodegeneration and its association to symptoms. Physiological α-synuclein is ubiquitously present in the human body, however, its role outside the central nervous system has been poorly studied. PD seriously impairs life quality; symptoms comprehend from locomotor dysfunction including resting tremors, rigidity and bradykinesia to non-motor features such as autonomic dysfunction, cognitive/neurobehavioral abnormalities, sleep and sensory disorders. Additionally, PD patients often experiment weight loss, impaired ...


Role Of Zfp467in Mediating The Anti-Adipogenic And Pro-Osteogenic Effects Of Pth: An In-Vitroanalysis, H Liu, I Leon Calle, P T. Le, R Baron, C J. Rosen 2020 Maine Medical Center

Role Of Zfp467in Mediating The Anti-Adipogenic And Pro-Osteogenic Effects Of Pth: An In-Vitroanalysis, H Liu, I Leon Calle, P T. Le, R Baron, C J. Rosen

Costas T. Lambrew Research Retreat 2020

Parathyroid hormone (PTH) analogs are the main anabolic pharmacological agent for osteoporosis. PTH is an endogenous hormone. Its amino acids 1-34 bind the parathyroid hormone receptor (PTH1r), a G-coupled protein receptor expressed in kidney, fat, and bone. PTH increases trabecular bone mass by promoting the differentiation of the mesenchymal stem cell (MSC) into the osteogenic lineage. The Zinc Finger Protein 467 (Zfp467) is a potential downstream target of PTH1r and an important mediator of the MSC into the adipogenic lineage. Taken together, we ask whether Zfp467 knockout cells will show greater osteogenic potential and increased sensitivity to PTH treatment. We ...


Bnip3 Mediated Mitophagy Is Essential For Osteoblast Differentiation, Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, Anyonya R. Guntur 2020 Maine Medical Center

Bnip3 Mediated Mitophagy Is Essential For Osteoblast Differentiation, Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, Anyonya R. Guntur

Costas T. Lambrew Research Retreat 2020

Osteoblasts generate bone by secreting collagen and mineralizing it in response to various signaling cues. We have previously identified bioenergetic pathways that are active during osteoblastogenesis. We showed that a majority of ATP generated by differentiated osteoblasts is through glycolysis in contrast to undifferentiated cells that are oxidative phosphorylation dependent. To identify mechanisms involved in this shift we hypothesized that increased mitochondrial turnover through mitophagy reprograms metabolism towards glycolysis. Mitophagy is a specialized autophagy process that targets dysfunctional mitochondria to lysosomes for recycling. Utilizing a mitophagy reporter mouse line (MitoQC) we first identified active basal mitophagy in skeletal cells in ...


Loss Of Spry1 In Vascular Smooth Muscle Cells Promotes Hypercholesterolemiainduced Vsmc Phenotypic Transitions And Regulates Atherogenesis, Xuehui Yang, Shivangi Pande, Robert Friesel 2020 Maine Medical Center

Loss Of Spry1 In Vascular Smooth Muscle Cells Promotes Hypercholesterolemiainduced Vsmc Phenotypic Transitions And Regulates Atherogenesis, Xuehui Yang, Shivangi Pande, Robert Friesel

Costas T. Lambrew Research Retreat 2020

Atherosclerosis is an inflammatory disease characterized by arterial wall thickening and plaque accumulation, and is a major cause of death worldwide. Vascular smooth muscle cells (VSMC), which have the unique ability to transition from mature contractile cells to myofibroblasts and macrophagelike foam cells, and adopt a proinflammatory state contribute to atherogenic microenvironment (1). We aimed to investigate how Spry1, a regulator of receptor tyrosine kinase signaling, affects hypercholesterolemia induced plaque formation in mice by manipulating Spry1 expression specifically in VSMC.


The Role Of Smooth Muscle Cell Notch2 In Atherosclerotic Plaque Burden And Composition, Jess Davis-Knowlton, Jackie Turner, Anne Harrington, Lucy Liaw 2020 Maine Medical Center

The Role Of Smooth Muscle Cell Notch2 In Atherosclerotic Plaque Burden And Composition, Jess Davis-Knowlton, Jackie Turner, Anne Harrington, Lucy Liaw

Costas T. Lambrew Research Retreat 2020

Background: Vascular occlusive diseases, such as atherosclerosis, underlie ischemic heart disease and stroke, the leading causes of death worldwide. We are interested in vascular smooth muscle cells (SMC) in the pathogenesis of disease, as they contribute to plaque formation and may determine susceptibility to rupture upon switching from a quiescent/contractile phenotype to a proliferative/migratory one. Notch signaling is implicated in vascular disease progression, and we previously identified a Notch receptor-specific regulatory role in SMC proliferation and contractile phenotype. We thus hypothesize that Notch signaling within vascular SMC can regulate plaque morphology.

Methods: To study this in vivo, we ...


Reliability And Criterion Validity Of Ultrasonic Measurements Of The Supraspinatus And Infraspinatus Cross-Sectional Area, Dirk Kokmeyer, Lori-Thein Brody, Shane Koppenhaver, Charles Thigpen 2020 Maine Medical Center

Reliability And Criterion Validity Of Ultrasonic Measurements Of The Supraspinatus And Infraspinatus Cross-Sectional Area, Dirk Kokmeyer, Lori-Thein Brody, Shane Koppenhaver, Charles Thigpen

Costas T. Lambrew Research Retreat 2020

Purpose/Background: Diagnostic ultrasound (US) offers a cost-effective and accessible means of evaluating the cross-sectional area (CSA) of muscles as compared to the gold standard of Magnetic Resonance Imaging (MRI). Muscle CSA is directly related to the amount of force a muscle can produce. Rotator cuff CSA is especially important when considering the strength and function of the shoulder joint. The present study aims to test the validity, same-day and between day intra-rater reliability of US CSA measures of the supraspinatus (SS) and infraspinatus (IS) muscles of the shoulder compared to MRI. Number of Subjects: Thirty-two, right-hand dominant subjects were ...


Functional Study Of Cthrc1 On Skeletal Muscle Regeneration And Skeletal Muscle Stem Cells, Yong-Ri Jin, Qiaozeng Wang, Igor Prudovsky, Volkhard Lindner 2020 Maine Medical Center

Functional Study Of Cthrc1 On Skeletal Muscle Regeneration And Skeletal Muscle Stem Cells, Yong-Ri Jin, Qiaozeng Wang, Igor Prudovsky, Volkhard Lindner

Costas T. Lambrew Research Retreat 2020

Purpose/Background: CTHRC1 is a secreted protein highly induced in tissues undergoing repair and remodeling. Osteogenic differentiation of osteoblasts in vitro revealed that endogenously expressed CTHRC1 promotes bone formation by affecting both proliferation and differentiation. Our recent study demonstrated that CTHRC1 also inhibits osteoclastogenic differentiation, thereby playing a key role in balancing bone formation with bone resorption in vivo. However, its function on skeletal muscle stem cell and skeletal muscle regeneration is still remains unknown.

Methods/Approach: In vitro culture of skeletal muscle stem cell isolated from wildtype and Cthrc1 mutant mice. Western blotting, Immuno-histological staining, Flow cytometry analysis, and ...


A Closer Look At Muscle Breakdown: An Overview Of The Causes, Complications, And Diagnostics Of Rhabdomyolysis, Jamie Holchin 2020 Liberty University

A Closer Look At Muscle Breakdown: An Overview Of The Causes, Complications, And Diagnostics Of Rhabdomyolysis, Jamie Holchin

Senior Honors Theses

Rhabdomyolysis is the rapid breakdown of myocytes in skeletal muscle. This condition can be triggered by a variety of things including crush injury, drugs, prolonged exercise, and venom. Although the causes can vary, the general pathophysiology of rhabdomyolysis is similar. Increased intracellular calcium ion levels instigate the breakdown of cellular and certain organelle membranes of muscle cells. Reactive oxygen species form, ATP is depleted, and the sarcoplasmic reticulum, which regulates muscle contraction, is also damaged. Necrosis ensues, leading to toxic intracellular components spreading throughout the body. Rhabdomyolysis can then lead to several complications including acute renal injury and heart arrhythmias ...


Comparison Of Pre- And Post-Operative Shoulder Muscle Emg Profiles In Reverse Total Shoulder Arthroplasty Patients, Emily Lau, Sreten Franovic, Noah Kuhlmann, Eric C. Makhni MD, Stephanie Muh MD 2020 Henry Ford Health System

Comparison Of Pre- And Post-Operative Shoulder Muscle Emg Profiles In Reverse Total Shoulder Arthroplasty Patients, Emily Lau, Sreten Franovic, Noah Kuhlmann, Eric C. Makhni Md, Stephanie Muh Md

Medical Student Research Symposium

Background: Deltoid muscle function is central in reverse total shoulder arthroplasty (RTSA) function; however, there is limited information available regarding changes in deltoid activity before and after surgery. Few tests exist to evaluate specific muscle metrics pre and post operatively. Surface Electromyographic (EMG) is non-invasive and allows for observation of motions with multifaceted analysis of movement with minimal patient demand. Understanding the changes in shoulder muscle activation, namely in the deltoid, in patients pre and post-RTSA can further advance understanding of the procedure and rehabilitation efforts.

Methods: Nine individuals were recruited for this study: all patients underwent RTSA by a ...


Application Of Laser Technology In The Non-Surgical Management Of Periprosthetic Joint Infection (Pji); Novel Insights From Peri-Implantitis, Kareem Giovanni Elhage, Mohamed Awad, Ahmad Hasan, Brendan Farley, Khaled Saleh 2020 Wayne State University

Application Of Laser Technology In The Non-Surgical Management Of Periprosthetic Joint Infection (Pji); Novel Insights From Peri-Implantitis, Kareem Giovanni Elhage, Mohamed Awad, Ahmad Hasan, Brendan Farley, Khaled Saleh

Medical Student Research Symposium

Introduction: The management of periprosthetic joint infection (PJI) is challenging, and its socio-economic impact is significant. Moreover, the incidence of MRSA and other resistant organisms are on the rise. Recently, laser technology has been incorporated into treatment protocols of dental peri-implantitis. This review explores the possibility of using laser technology to manage peri-implantitis.

Methods: This article will provide a detailed, comprehensive, and perspective review of the existing evidence of laser technology in management of dental peri-implantitis.

Results: Dental literature investigated the efficacy of several types of lasers. It was shown that diode lasers improved periodontal probing depth (PPD) and bleeding ...


Syllabus For Clinical Exercise Physiology (Kine 4700), Phillip Drouet 2020 California State University, San Bernardino

Syllabus For Clinical Exercise Physiology (Kine 4700), Phillip Drouet

Q2S Enhancing Pedagogy

The syllabus has newly developed learning objectives that will prepare students entering the field of clinical exercise physiology. This course will cover the etiology and pathophysiology of many chronic diseases that plague the population. Assessments of chronic diseases include but are not limited to understanding symptomology will also be covered. Due to the limitations in time the most prevalent chronic disease will be covered and students will have to present on a disease that was not presented in class. The practical application portion of this course will take place during a lab section. Here students will have the opportunity to ...


Validity Of The Body Scan Scanner® And Structure Sensor To Measure Limb Volume In Healthy Adults, Mary Insana Fisher, Michaela Claire Viola, Noah James Brueckner, Madison Elizabeth Wolfe, Rachel Lynn Kremer 2020 University of Dayton

Validity Of The Body Scan Scanner® And Structure Sensor To Measure Limb Volume In Healthy Adults, Mary Insana Fisher, Michaela Claire Viola, Noah James Brueckner, Madison Elizabeth Wolfe, Rachel Lynn Kremer

Physical Therapy Faculty Publications

Purpose/Hypothesis: Secondary lymphedema is a chronic condition that can develop in approximately 30 percent of women treated for breast cancer. It is important to measure limb volume changes for early detection of lymphedema, when it is possible to reverse the swelling (stage 1). Common clinical measures carry concerns of infection control (water displacement), are time consuming (truncated cone calculation using circumferential measures), or expensive (perometry). Use of a portable 3D scanner addresses these concerns, but the validity is unknown. The purpose of this phase I study is to investigate the validity of the Body Scan Scanner to measure limb ...


Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer 2020 Arcadia University

Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer

Capstone Showcase

ABSTRACT

Introduction: Anterior Cruciate Ligament (ACL) injuries are an upsetting setback for many athletes that require a long and costly recovery process. The injury rates are four times greater in women than men. Preventative measures that help to prevent ACL injuries are limited to stretching and strengthening. Therefore, this review aims to investigate if oral contraceptive [I] usage provides a possible new avenue for prevention of ACL injury [O] in young female athletes (ages 18-30) [P] compared to those that do not take oral contraceptives [C].

Methods: A literature review was performed though PubMed, Google Scholar, SCOPUS Database, and ClinicalKey ...


Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng 2020 The University of Akron

Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng

Williams Honors College, Honors Research Projects

This proposed project will be developing an artificial reverse shoulder arthroplasty joint that focuses on improvements to the Zimmer Biomet Comprehensive Reverse System by freating a unique feature, or features, to the humeral component that focuses on the prevention of dislocation by not limiting the range of motion of men from ages 45 to 65 years.

The development of the this project will utilize the Food and Drug Administration (FDA) medical device design process. This project will involve a total of four Biomedical Engineering students from the University of Akron. Two students, Michael and Bailei, are in the Honors college ...


Analyzing The Effects Of Opioids On Cortical Pore Networks In Rabbit Tibiae And Femora, Kassidy Wilson 2020 The University of Akron

Analyzing The Effects Of Opioids On Cortical Pore Networks In Rabbit Tibiae And Femora, Kassidy Wilson

Williams Honors College, Honors Research Projects

The following project was approved by the Institutional Animal Care and Use Committee (IACUC) (Protocol number #18-11-12 ARC). This study was completed as a subset of Dr. Andronowski's overarching lab project. Femora and tibiae were procured from New Zealand White rabbits to study the prolonged effects of opioid use in bone remodeling. This specific project analyzed the effects of opioids on the pore networks and the pore orientation.


Inter-Rater Reliability And Intra-Rater Reliability Of Synchronous Ultrasound Imaging And Electromyography Measure Of The Lumbopelvic-Hip Muscle Complex, Courtney Caputo 2020 University of Central Florida

Inter-Rater Reliability And Intra-Rater Reliability Of Synchronous Ultrasound Imaging And Electromyography Measure Of The Lumbopelvic-Hip Muscle Complex, Courtney Caputo

Honors Undergraduate Theses

Objective: The purpose of this study was to determine inter-rater and intra-rater reliability of synchronous ultrasound imaging and electromyography measures of lumbopelvic-hip muscle activity performed by a novice and an experienced investigator in healthy individuals. Electromyography (EMG) has served as the gold standard for quantification of onset of muscle activation; however, ultrasound imaging can visualize muscle activity when collected simultaneously. Methods: A novice and experienced investigator collected a series of 3 ultrasound images at rest and 3 M-mode clips during contraction of each muscle while EMG electrodes collected muscle activity. Muscles collected included: external oblique, erector spinae, rectus abdominis, gluteus ...


Deformable Multisurface Segmentation Of The Spine For Orthopedic Surgery Planning And Simulation, Rabia Haq, Jérôme Schmid, Roderick Borgie, Joshua Cates, Michel Audette 2020 Old Dominion University

Deformable Multisurface Segmentation Of The Spine For Orthopedic Surgery Planning And Simulation, Rabia Haq, Jérôme Schmid, Roderick Borgie, Joshua Cates, Michel Audette

Computational Modeling and Simulation Engineering Faculty Publications

Purpose: We describe a shape-aware multisurface simplex deformable model for the segmentation of healthy as well as pathological lumbar spine in medical image data.

Approach: This model provides an accurate and robust segmentation scheme for the identification of intervertebral disc pathologies to enable the minimally supervised planning and patient-specific simulation of spine surgery, in a manner that combines multisurface and shape statistics-based variants of the deformable simplex model. Statistical shape variation within the dataset has been captured by application of principal component analysis and incorporated during the segmentation process to refine results. In the case where shape statistics hinder detection ...


The Effects Of Intrinsic Foot Muscle Strengthening On Foot Posture, Balance, And Agility In Ice Hockey Players, Rebecca Eve Veltrie 2020 West Virginia University

The Effects Of Intrinsic Foot Muscle Strengthening On Foot Posture, Balance, And Agility In Ice Hockey Players, Rebecca Eve Veltrie

Graduate Theses, Dissertations, and Problem Reports

Context: Research has shown that intrinsic foot muscle strengthening over a 4-week period is beneficial for improvements in dynamic postural control, function, stability and foot posture. Ice hockey is a sport that requires immense levels of balance, stability and performance on the lateral aspect of the skate. With research lacking on the impact of intrinsic foot muscle strengthening on ice hockey athletes’ balance, foot posture and performance, implementation of such a program may be beneficial for ice hockey players. Objective: The purpose of this study was to explore the effects of foot intrinsic muscle strengthening versus a traditional extrinsic muscle ...


Effects Of A Strength Training Intervention And Quality Of Life: Case Study On A Sedentary Adult Female, Lucas Frazier 2020 The University of Akron

Effects Of A Strength Training Intervention And Quality Of Life: Case Study On A Sedentary Adult Female, Lucas Frazier

Williams Honors College, Honors Research Projects

The purpose of the project is to evaluate physiological and quality of life changes in a

sedentary, senior-aged (55 or older) female using a six-week strength training

intervention. This case study will instruct how to perform a push-pull-legs split

routine by going to the gym three times per week. Prior to the six week intervention,

both quantitative and qualitative variables will be collected to assess baseline data,

including the subject’s resting heart rate, resting blood pressure, grip strength, one-

repetition maximum on seven whole body exercises (dumbbell bicep curl, tricep

pushdown, barbell bench press, wide-grip lat pull-down, seated dumbbell ...


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