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Full-Text Articles in Musculoskeletal System
Optimizing Biomechanical Models: Estimation Of Muscle Tendon Parameters And Ankle Foot Orthosis Stiffness, Sepehr Ramezani
Optimizing Biomechanical Models: Estimation Of Muscle Tendon Parameters And Ankle Foot Orthosis Stiffness, Sepehr Ramezani
Electronic Theses and Dissertations, 2020-
The complexity of the human musculoskeletal system presents challenges in accurately identifying its characteristics, particularly due to the presence of redundant actuators on a single joint. Non-invasive measures are necessary to overcome these challenges. Optimization algorithms have emerged as a crucial tool to advance subject-specific musculoskeletal modeling allows a more realistic representation of biomechanical behaviors, enhancing our understanding of human movement and enabling better clinical decision-making. Furthermore, optimization algorithms play a vital role in customizing rehabilitation and assistive devices, such as orthoses and prostheses. The current ankle-foot orthosis (AFO) stiffness measurement methods require bulky, complex designs, and often permanent modification …
Investigating The Role Of The Skeletal Muscle In Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah
Investigating The Role Of The Skeletal Muscle In Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah
Electronic Theses and Dissertations, 2020-
Neuromuscular junction (NMJ) dysfunction has been identified as one of the earliest events in Amyotrophic Lateral Sclerosis (ALS) pathology. However, which tissue type induces NMJ disruption; be it the motoneurons (hMN), Schwann cells or skeletal muscle (hSKM) remains unresolved. While mechanisms by which ALS hMN contribute to NMJ dysfunction are well-described in literature, limited information exist on how the other tissue types in the tripartite synapse (hSKM and Schwann cells) induce and/or contribute to ALS NMJ disruption. A fair understanding of the role of each tissue type in NMJ dysfunction would help shape the trajectory of future ALS research and …