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Calcitonin Gene-related Peptide; Substance P; Osteoblast Growth and Differentiation; Cellular Alkaline Phosphatase Levels; Osteoblast Mineralization
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Full-Text Articles in Musculoskeletal System
Effects Of Neurotrophic Factors On Osteoblast Growth And Differentiation, Colleen M. Moran
Effects Of Neurotrophic Factors On Osteoblast Growth And Differentiation, Colleen M. Moran
Loma Linda University Electronic Theses, Dissertations & Projects
Recent evidence suggests that bone metabolism may be influenced by the innervation of skeletal tissues. Innervation of skeletal tissues might directly influence bone volume by the release or secretion of osteogenic growth factors in the form of neuropeptides. These neuropeptides could act locally on osteoblasts to increase bone formation and/or mineralization. Since calcitonin gene-related peptide (CGRP) and Substance P (SP) are the most abundant neuropeptides present in sensory nerves in bone, the current studies were intended to test the hypothesis that these two neuropeptides may have direct effects on osteoblast growth, differentiation, and mineralization. Replicate cultures of murine calvarial osteoblasts …