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Effects Of Coordinated Reset Deep Brain Stimulation Of Subthalamic Nucleus On Parkinsonian Gait In The Non-Human Primate Model, Kanon Nakajima
Effects Of Coordinated Reset Deep Brain Stimulation Of Subthalamic Nucleus On Parkinsonian Gait In The Non-Human Primate Model, Kanon Nakajima
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Parkinson’s Disease (PD) is a neurodegenerative disorder that affects over 10 million people worldwide. Deep Brain Stimulation (DBS) has been a successful treatment for advanced PD, however, can be accompanied with current spread related side effects. Coordinated Reset (CR) DBS is a novel therapeutic approach that could reduce the risk of side-effects by using lower current. Previous research has shown therapeutic effects of CR DBS on PD motor symptoms including akinesia, bradykinesia, rigidity, and tremor that sustained after stimulation cessation (i.e., carryover effect), however its effect on gait dysfunction is unknown even though it can be one of the most …