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Multi-Block Data Integration Analysis For Identifying And Validating Targeted N-Glycans As Biomarkers For Type Ii Diabetes Mellitus, Eric Adua, Ebenezer Afrifa-Yamoah, Emmanuel Peprah-Yamoah, Enoch Odame Anto, Emmanuel Acheampong, Kwaafo Akoto Awuah-Mensah, Wei Wang
Multi-Block Data Integration Analysis For Identifying And Validating Targeted N-Glycans As Biomarkers For Type Ii Diabetes Mellitus, Eric Adua, Ebenezer Afrifa-Yamoah, Emmanuel Peprah-Yamoah, Enoch Odame Anto, Emmanuel Acheampong, Kwaafo Akoto Awuah-Mensah, Wei Wang
Research outputs 2022 to 2026
Plasma N-glycan profiles have been shown to be defective in type II diabetes Mellitus (T2DM) and holds a promise to discovering biomarkers. The study comprised 232 T2DM patients and 219 healthy individuals. N-glycans were analysed by high-performance liquid chromatography. The multivariate integrative framework, DIABLO was employed for the statistical analysis. N-glycan groups (GPs 34, 32, 26, 31, 36 and 30) were significantly expressed in T2DM in component 1 and GPs 38 and 20 were related to T2DM in component 2. Four clusters were observed based on the correlation of the expressive signatures of the 39 N-glycans across T2DM and controls. …