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University of Rhode Island

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Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment

Fundamentals Of The Medical Laboratory Mls 360, Michael Cerbo Feb 2020

Fundamentals Of The Medical Laboratory Mls 360, Michael Cerbo

Library Impact Statements

No abstract provided.


Acute Promyelocytic Leukemia: A Case Study Correlating Cytogenetic Abnormality With Prognosis, Alyssa Lamond, Theresa Tellier-Castellone May 2019

Acute Promyelocytic Leukemia: A Case Study Correlating Cytogenetic Abnormality With Prognosis, Alyssa Lamond, Theresa Tellier-Castellone

Senior Honors Projects

Advancements in medical technology today have positively impacted the diagnosis, treatment, and prognosis of cancers. Particularly acute promyelocytic leukemia (APL) has completely improved from having the poorest prognosis to one of the best. Acute promyelocytic leukemia is a malignant disease of hematopoietic tissue classified by WHO as leukemia with >20% blasts from the myeloid lineage, specifically promyelocytes. Determined in 1976, FAB classified AML subtypes M1-M7, with APL being M3. Specific characteristics classify the subtype of AML, with each resulting from a different genetic abnormality. The focus of APL diagnosis, treatment, and prognosis occurs around the known PML-RARα fusion gene. Flow …


Tamsulosin Use After Shock Wave Lithotripsy: A Systematic Review, Katherine Harte Apr 2019

Tamsulosin Use After Shock Wave Lithotripsy: A Systematic Review, Katherine Harte

Senior Honors Projects

Urolithiasis, or the formation of stones in the urinary tract, is a potentially painful process that impacts many people across the world. However, the results of clinical trials disagree on the proper treatment and management of kidney stones. One way to help those who have kidney stones is to perform extracorporeal shock wave lithotripsy (SWL), a medical procedure in which shock waves are directed towards kidney stones to prevent them from migrating and causing pain. Following SWL, patients are sometimes given additional medications, such as alpha blockers (e.g., tamsulosin), to aid in the passage of the stones. However, the benefits …


Is Ca-125 The Leading Biomarker In Determining Early-Onset Ovarian Cancer Diagnosis In 2016?, Alexa Clark Apr 2016

Is Ca-125 The Leading Biomarker In Determining Early-Onset Ovarian Cancer Diagnosis In 2016?, Alexa Clark

Senior Honors Projects

Epithelial ovarian cancer is the most lethal gynecologic malignancy with very ineffective efforts at early detection and therapeutic methodologies to reduce mortality. The origin and pathogenicity of ovarian cancer is vastly unclear, which is why diagnosing the disease early on is difficult. CA-125 is a used as therapeutic tumor marker for ovarian cancer, but it is not diagnostic or specific. The role of CA-125 in the early detection of ovarian cancer is extremely controversial and has not been widely accepted for screening in women who do not show any symptoms. In order to enhance the sensitivity for early disease detection …


Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham May 2014

Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham

Senior Honors Projects

A noted characteristic found in several neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and bovine spongiform encephalopathy, is the accumulation of amyloid plaques in the brain. Amyloid plaques contain deposits of fibrillar aggregates of misfolded proteins that disrupt normal functionality in neurons. Certain variants of these misfolded proteins are self-replicating; these self-replicating amyloids are termed prions (for infectious protein). We are interested in how protein misfolding contributes to amyloid formation and how molecular chaperone proteins can change the formation of amyloid deposits. Chaperone proteins function by catalyzing the proper folding of other proteins, the refolding of misfolded proteins, …


Forensic Nursing: Death Investigation, Lauren Palazzo May 2006

Forensic Nursing: Death Investigation, Lauren Palazzo

Senior Honors Projects

Forensic Nursing is a fairly new exciting nursing specialty. Television shows such as CSI portray forensic nurses and investigators in a less than realistic manner. Forensic nursing and investigation are exciting fields to specialize in, but the role of the forensic nurse and investigator are often misunderstood. For my project I wrote a research paper on forensic nursing, joined the international association of Forensic nurses, attended the international conference in washington dc and set in on a few meetings with a board, including lawyers, represenatives from the rape crisis center, clinical managers from W&I ED, nurses, NP’s, etc. in discussing …