Medicine and Health Sciences Commons^™

Premorbid Personality And The Risk Of Parkinson's Disease, Kelly L. Sullivan, James A. Mortimer, Wei Wang, Theresa A. Zesiewicz, James H. Brownlee Jr., Amy R. Borenstein

Kelly L. Sullivan

Background: Previous studies support the hypothesis that premorbid personality characteristics may be associated with the risk of Parkinson’s disease (PD). However, most of these relied upon subjective reports of premorbid personality earlier in life, which may be subject to recall bias. The objective of the current study was to evaluate the association of PD with risk-taking, routinization, smoking and alcohol consumption in early-adult life as indicators of premorbid personality.
Methods: In-person interviews were conducted with 89 PD patients and 99 controls from a university-based medical center. Associations between indicators of early-adult personality and risk of PD were examined using logistic …

His Name Is Alton, Susan Sanders

Susan F Sanders PhD, RN

No abstract provided.

Making Better Decisions During Triage, Susan Sanders, Ptlene Minick

Susan F Sanders PhD, RN

No abstract provided.

Tsu Faculty Publication Database, David Owerbach

David Owerbach

THE TSU faculty publication database is for the years 2012-2014. The database was constructed by the Office of Research and was last updated on November 20, 2014.

Bovine Serum Albumin (Bsa) And Cleaved-Bsa Conjugated Ultrasmallgd2o3nanoparticles: Synthesis, Characterization, And Application To Mri Contrast Agents, Md Wasi Ahmad, Cho Rong Kim, Jong Su Baeck, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae, Gang Ho Lee

Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)

No abstract provided.

Brief Treatment Of Co-Occurring Post-Traumatic Stress And Depressive Symptoms By Use Of Accelerated Resolution Therapy®, Kevin E. Kip, Kelly L. Sullivan, Cecile A. Lengacher, Laney Rosenzweig, Diego F. Hernandez, Rejendra P. Kadel, Frank A. Kozel, Amy Shuman, Sue Ann Girling, Marian J. Hardwick, David M. Diamond

Kelly L. Sullivan

This uncontrolled prospective cohort study evaluated the use of accelerated resolution therapy (ART) for treatment of comorbid symptoms of post-traumatic stress disorder (PTSD) and major depressive disorder. Twenty-eight adult subjects, mean age of 41 years (79% female, 36% Hispanic), received a mean of 3.7 ± 1.1 ART treatment sessions (range 1-5). ART is a new exposure-based psychotherapy that makes use of eye movements. Subjects completed a range of self-report psychological measures before and after treatment with ART including the 17-item PCL-C checklist (symptoms of PTSD) and 20-item Center for Epidemiologic Studies Depression Scale (CES-D). For the PCL-C, the pre-ART mean …

Patent Landscape Of Helminth Vaccines And Related Technologies, Jon R. Cavicchi, Stanley P. Kowalski, John Schroeder, Rayna Burke, Jillian Michaud-King

Law Faculty Scholarship

Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths. These technologies include methods of formulating vaccines, methods of producing of subunits, the composition of complete vaccines, and other technologies that have the potential to aid in a global response to this pathogen. The purpose of this patent landscape study was to search, identify, and categorize patent documents that are relevant to the development of vaccines that can efficiently promote the development of protective immunity against helminths. The search strategy used keywords which the team felt would be general …

Epidemiology News, Georgia Southern University

Epidemiology News (2012-2018)

• JPHCOPH Student Publications

Community Health News, Georgia Southern University

Community Health Department News (2011-2018)

• JPHCOPH Student Publications

Sustained Medication Reduction Following Unilateral Vim Thalamic Stimulation For Essential Tremor, Andrew S. Resnick, Michael S. Okun, Teresita Malapira, Donald A. Smith, Fernando L. Vale, Kelly L. Sullivan, Amber M. Miller, Israt Jahan, Theresa A. Zesiewicz

Kelly L. Sullivan

Background: Deep brain stimulation (DBS) is an increasingly utilized therapeutic modality for the management of medication refractory essential tremor (ET). The aim of this study was to determine whether DBS allowed for anti-tremor medication reduction within the year after the procedure was performed.
Methods: We conducted a retrospective chart review and telephone interviews on 34 consecutive patients who had been diagnosed with ET, and who had undergone unilateral DBS surgery.
Results: Of the 34 patients in our cohort, 31 patients (91%) completely stopped all anti-tremor medications either before surgery (21 patients, 62%) or in the year following DBS surgery (10 …

Explaining And Improving Breast Cancer Information Acquisition Among African-American Women In The Deep South, Charkarra Anderson-Lewis, Levi Ross, Jarrett Johnson, Janice Hastrup, Lee Green, Connie L. Kohler

Levi Ross

Objectives: A major challenge facing contemporary cancer educators is how to optimize the dissemination of breast cancer prevention and control information to African American women in the Deep South who are believed to be cancer free. The purpose of this research was to provide insight into the breast cancer information-acquisition experiences of African American women in Alabama and Mississippi and to make recommendations on ways to better reach members of this high-risk, underserved population.

Methods: Focus group methodology was used in a repeated, cross-sectional research design with 64 African American women, 35 years old or older who lived …

Chimeric Protein A/G Conjugate For Detection Of Anti–Toxoplasma Gondii Immunoglobulin G In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade

John J Schaefer

Serological testing for toxoplasmosis diagnosis remains the method of choice in human medicine due to the accessibility of the requisite sample, the difficulty in predicting the parasite’s location in the host for direct detection, and the availability of established commercial methods. In veterinary medicine, although the first 2 conditions are unchanged, there is a need for commercially produced test methods that are validated for Toxoplasma gondii detection across the range of animal species that can serve as intermediate hosts. The development of such a serological method for animals would allow the diagnosis of toxoplasmosis in individual animals and a higher …

Are Podcasts Effective At Educating African American Men About Diabetes, Jarrett Johnson, Levi Ross, Walter Iwanenko, Judith Schiffert, Arup Sen

Levi Ross

Education is a critical component of the National Blueprint to eliminate racial disparities in diabetes. Research indicates that traditional methods of diabetes education has had limited effectiveness with minority populations and suggests that different educational approaches be explored. The purpose of the research was to explore the effectiveness of an emergent technology (podcast) for use in educating inner-city, African American men about diabetes prevention. Thirty African American men participated in self-administered, pretest-posttest surveys in August 2009. Surveys collected information on demographic characteristics, perceptions of diabetes, and diabetes knowledge. Paired samples t test was computed to evaluate pretest-posttest changes in overall …

Quantitative Tremor Analysis In Welders: Comparison With Idiopathic Parkinson's Disease And Essential Tremor, Juan Sanchez-Ramos, Dacy Reimer, Theresa A. Zesiewicz, Kelly L. Sullivan, Paul A. Nausieda

Kelly L. Sullivan

Background: Workers chronically exposed to manganese in welding fumes may develop an extra-pyramidal syndrome with postural and action tremors.
Objectives: To determine the utility of tremor analysis in distinguishing tremors among workers exposed to welding fumes, patients with Idiopathic Parkinson’s Disease (IPD) and Essential Tremor (ET).
Methods: Retrospective study of recorded tremor in subjects from academic Movement Disorders Clinics and Welders. Quantitative tremor analysis was performed and associated with clinical status.
Results: Postural tremor intensity was increased in Welders and ET and was associated with visibly greater amplitude of tremor with arms extended. Mean center frequencies (Cf) of welders and …

Creating Community-Academic Partnerships For Cancer Disparities Research And Health Promotion, John S. Luque, Cathy D. Meade, Janelle M. Menard, Dinorah Martinez Tyson, Clement K. Gwede

John S. Luque

To effectively attenuate cancer disparities in multiethnic, medically underserved populations, interventions must be developed collaboratively through solid community-academic partnerships and driven by community-based participatory research (CBPR). The Tampa Bay Community Cancer Network (TBCCN) has been created to identify and implement interventions to address local cancer disparities in partnership with community-based nonprofit organizations, faith-based groups, community health centers, local media, and adult literacy and education organizations. TBCCN activities and research efforts are geared toward addressing critical information and access issues related to cancer control and prevention in diverse communities in the Tampa Bay area. Such efforts include cross-cultural health promotion, screening, …

Modification Of A Commercial Toxoplasma Gondii Immunoglobulin G Enzyme-Linked Immunosorbent Assay For Use In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade

John J Schaefer

A challenge faced by veterinary diagnosticians in serologic analysis for exposure to pathogens is the need for a protein conjugate capable of antibody attachment in many animal species. The advent of protein conjugates that are less specific in nature allows diagnosis across many species with little or no modification of technique. Toxoplasma gondii is an organism of veterinary interest that has been demonstrated to infect a plethora of warm-blooded animals. However, the serologic tests available for simultaneous diagnosis in this broad range are limited in number. The current study examined the use of an immunoglobulin G enzyme-linked immunosorbent assay (ELISA) …

Skin Blood Flow Response To 2-Hour Repositioning In The Long-Term Care Residents: A Pilot Study, Vivian K. Wong

Faculty Publications

PURPOSE: The purpose of this noninvasive pilot study was to examine the changes in transcutaneous oxygen (tcO2), skin temperature, and hyperemic response in the heels, sacrum, and trochanters in a 2-hour loading-unloading condition in nursing home residents who are positioned in supine and lateral positions. DESIGN: A 1-group, prospective, repeated-measures design was used. SUBJECTS AND SETTING: Nine subjects (5 males, 4 females) with a mean age of 85.3 ± 10.86 years (mean ± SD) who required help in turning and positioning at a skilled nursing facility participated in the study. METHODS: Oxygen and temperature sensors were placed on the heels, …

Changes In Temperature Of Heel Skin Under Pressure In Hip Surgery Patients, Vivian K. Wong, N. A. Stotts, H. W. Hopf, G. A. Dowling, E. S. Froelicher

Vivian K. Wong

OBJECTIVE: The aim of the study was to examine the effect of external pressure of the bed surface on heel skin temperature in adults in the first 3 days after hip surgery.

DESIGN: A quasi-experimental study in a prospective, within-subjects, repeated-measures design.

SETTING: This study was performed at 2 acute-care hospitals.

PARTICIPANTS: Eighteen subjects (9 men and 9 women) with a mean age of 58.3 (±16.1) years were recruited after hip surgery at the 2 hospitals.

METHODS: Temperature sensors were placed on the plantar surface of each foot, close to the heels. Measures were taken when the heels were (1) …

Skin Blood Flow Response To 2-Hour Repositioning In The Long-Term Care Residents: A Pilot Study, Vivian K. Wong

Vivian K. Wong

PURPOSE: The purpose of this noninvasive pilot study was to examine the changes in transcutaneous oxygen (tcO2), skin temperature, and hyperemic response in the heels, sacrum, and trochanters in a 2-hour loading-unloading condition in nursing home residents who are positioned in supine and lateral positions.

DESIGN: A 1-group, prospective, repeated-measures design was used.

SUBJECTS AND SETTING: Nine subjects (5 males, 4 females) with a mean age of 85.3 ± 10.86 years (mean ± SD) who required help in turning and positioning at a skilled nursing facility participated in the study.

METHODS: Oxygen and temperature sensors were placed on the heels, …

Changes In Temperature Of Heel Skin Under Pressure In Hip Surgery Patients, Vivian K. Wong, N. A. Stotts, H. W. Hopf, G. A. Dowling, E. S. Froelicher

Faculty Publications

OBJECTIVE: The aim of the study was to examine the effect of external pressure of the bed surface on heel skin temperature in adults in the first 3 days after hip surgery. DESIGN: A quasi-experimental study in a prospective, within-subjects, repeated-measures design. SETTING: This study was performed at 2 acute-care hospitals. PARTICIPANTS: Eighteen subjects (9 men and 9 women) with a mean age of 58.3 (±16.1) years were recruited after hip surgery at the 2 hospitals. METHODS: Temperature sensors were placed on the plantar surface of each foot, close to the heels. Measures were taken when the heels were (1) …

Efficacy Of A Doxycycline Treatment Regimen Initiated During Three Different Phases Of Experimental Ehrlichiosis, Jennifer C. Mcclure, Michelle L. Crothers, John J. Schaefer, Patrick D. Stanley, Glen R. Needham, S A. Ewing, Roger W. Stich

John J Schaefer

Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences outcomes of these treatments. The purpose of this study was to evaluate the efficacy of a 28-day doxycycline regimen for clearance of experimental E. canis infections from dogs treated during three phases of the disease. Ten dogs were inoculated with blood from E. canis carriers and treated with doxycycline during acute, subclinical, or chronic phases of CME. Daily …

Overview Of The Essential Tremor, Theresa A. Zesiewicz, Abinaya Chari, Israt Jahan, Amber M. Miller, Kelly L. Sullivan

Kelly L. Sullivan

Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper.

Reduction Of Circulating Endothelial Cells In Peripheral Blood Of Als Patients, Svitlana Garbuzova-Davis, Robert L. Woods Iii, Michael K. Louis, Theresa A. Zesiewicz, Nicole Kuzmin-Nichols, Kelly L. Sullivan, Amber M. Miller, Diana G. Hernandez-Ontiveros, Paul R. Sanberg

Kelly L. Sullivan

Background: Amyotrophic Lateral Sclerosis (ALS) treatment is complicated by the various mechanisms underlying motor neuron degeneration. Recent studies showed that the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are compromised in an animal model of ALS due to endothelial cell degeneration. A later study demonstrated a loss of endothelium integrity in the spinal cords of ALS patients. Since circulating endothelial cells (CECs) in the peripheral blood are associated with endothelium damage, being detached dysfunctional endothelial cells, we hypothesized that CEC levels may reflect endothelium condition in ALS patients.
Methodology/Principal Findings: CEC levels were estimated in whole blood smears from …

Ssrn As An Initial Revolution In Academic Knowledge Aggregation And Dissemination, David Bray, Sascha Vitzthum, Benn Konsynski

Sascha Vitzthum

Within this paper we consider our results of using the Social Science Research Network (SSRN) over a period of 18 months to distribute our working papers to the research community. Our experiences have been quite positive, with SSRN serving as a platform both to inform our colleagues about our research as well as inform us about related research (through email and telephoned conversations of colleagues who discovered our paper on SSRN). We then discuss potential future directions for SSRN to consider, and how SSRN might well represent an initial revolution in 21st century academic knowledge aggregation and dissemination. Our paper …

Applicability Of A Video Intervention To Increase Informed Decision Making For Prostate Specific Antigen (Psa) Testing Among African-American Men With Different Levels Of Health Literacy, Levi Ross, Alicestine D. Ashford, Sherese J. Bleechington, Tyra Dark, Deborah C. Erwin

Levi Ross

Purpose: To evaluate the applicability of an evidence-based video intervention to promote informed decision making for prostate cancer (CaP) screening among African-American men with different levels of health literacy.

Methods: Forty nine African-American men participated in interviewer-administered, pretest-posttest interviews between January and March 2008. Health literacy status was assessed with the Test of Functional Health Literacy in Adults (TOFHLA). Repeated measures analysis of covariance (ANCOVA), McNemar or binomial distributions were computed to assess pretest/posttest differences in knowledge. Descriptive statistics were produced to describe participants’ perceptions of the information presented in the video.

Results: Results indicated that men with functional health …

Sleep Disorders In Parkinson's Disease, Israt Jahan, Robert A. Hauser, Kelly L. Sullivan, Amber M. Miller, Theresa A. Zesiewicz

Kelly L. Sullivan

Sleep disorders occur commonly in Parkinson’s disease (PD), and reduce quality of life. Sleep-related problems in PD include insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder, sleep apnea, parasomnias, excessive daytime sleepiness, and sleep attacks. This article reviews sleep disorders and their treatment in PD.

Funeral Program, 2009, John P. Mcgovern Museum Of Health And Medical Science

Museum Publications (1998-2009)

Funeral program for Louise Geerts.

Disparities In The Receipt Of Cardiac Revascularization Procedures Between Blacks And Whites: An Analysis Of Secular Trends, C. Perry, Levi Ross, Ivette Lopez, Angela Thornton, Gebre-Egzib Kiros

Levi Ross

Introduction: Mortality rates for coronary heart disease (CHD) have declined markedly since the early 1970s. However, CHD remains the number one cause of death in the United States. The decline in mortality has been attributed to declines in CHD risk factors (tobacco use, hypertension) and the increase in protective behaviors (exercise, weight control). Medical interventions may have also contributed to the decline in mortality. Despite these declines in mortality, racial disparities persist between Blacks and Whites. The purpose of this study was to examine the differences in receipt of cardiac catheterization, percutaneous transluminal coronary angioplasty, and coronary artery bypass …

Microarray Analysis Demonstrates A Role For Slug In Epidermal Homeostatsis, Kim M. Newkirk

Kim M Newkirk

No abstract provided.

The Acute Cutaneous Inflammatory Response Is Attenuated In Slug Knockout Mice. Newkirk K, Duncan F, Brannick E, Chandler H, Parent A, Kusewitt D., Kim M. Newkirk

Kim M Newkirk

No abstract provided.