Medicine and Health Sciences Commons^™

The Benefits Of Dogs For Children With Autism Spectrum Disorder, Emma Raugh

Senior Honors Theses

Autism Spectrum Disorder (ASD) is a condition that primarily affects neurological development, causing decreased social aptness, diminished executive function, and abnormal sensory processing, among many other characteristic symptoms. Additional problems that often accompany ASD include anxiety disorders, depression, and attention deficit hyperactivity disorder (ADHD). Canine assisted animal therapy is one non-pharmacologic therapy option that has been researched for children with ASD to improve their social, psychological, mental, and other difficulties. Studies thus far have shown positive results in children with ASD who have dogs as pets or access to therapy dogs, including improved social functioning, decreased anxiety, overall improved behavior, …

Prevalence Of Canine Vector-Borne Blood Parasites In The Plain Regions Of Cambodia, Koemseang Nhuong, Samut Sum, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

Canine vector-borne blood parasites (CVBP) cause various diseases in dogs. The aim of this study was to survey canine blood parasites in the plain regions of Cambodia. The study was conducted from November 2014 to September 2015. A total of 455 blood samples were collected from rural and urban areas in the plain regions of Cambodia. Six infected dogs were found (1.32%), with the following parasites: Dirofilaria immitis (2/6), Brugia pahangi (1/6), Babesia vogeli (1/6) and two co-infections of Ehrlichia canis with Anaplasma platys (1/6) and Babesia vogeli with Anaplasma platys (1/6). However, the rate of detection of blood parasitic …

Canine Hypoadrenocorticism: A Retrospective Study Of 32 Cases From 2011 To 2018., Cinthia Peres Camilo, Mauro Jose Lahm Cardoso, Paula Nassar De Marchi, Rafael Fagnani

Turkish Journal of Veterinary & Animal Sciences

Primary hypoadrenocorticism is characterized by insufficient adrenocortical hormonal secretion of glucocorticoids and mineralocorticoids, which causes unspecific signs and laboratory alterations such as hyponatremia and hyperkalemia, resulting in a low relation between these two electrolytes. The aim of this work was to carry out a retrospective study with data obtained from the medical records of 32 dogs with a proven diagnosis of hypoadrenocorticism between the years 2011 and 2018. The parameters weight, sex, reproductive condition, breed, and age were analyzed, as well as the results of laboratory tests of dogs with confirmed hypoadrenocorticism. There was no breed or sex predisposition. There …

Clinical And Hemostasis Predictors Of Mammary Gland Tumors In Bitches, Dmytro Bilyi, Mykhailo Rublenko, Liudmyla Kovalova, Dmytro Sliusarenko, Liudmyla Haluzina, Oleksandr Stotskyi, Sergey Maslikov

Turkish Journal of Veterinary & Animal Sciences

This study presents the results of the study of clinical and hemostasis predictors of mammary gland tumors in bitches, which allow to determine the risk groups for this disease. The highest incidence rates were found in German and Eastern European Shepherds (22.1%), Dachshunds (12.8%) and Yorkshire terriers (9.5%) when kept in private households: 97.1%, 96.3% and 97.3%, respectively. Significantly increases the likelihood of mammary gland cancer in excess body weight - by 30%-100%, in the case of mixed feeding - up to 39.3%, the use of hormonal contraceptives - by 50%-60%. Adverse prognosis correlates with an increase in the size, …

Possible Transmission Flow Of Sars-Cov-2 Based On Ace2 Features, Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M Tambuwala, Gajendra Kumar Azad, Samendra P Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M Brufsky

All publications

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the …

Central Nervous System Pathology In Preclinical Mps Iiib Dogs Reveals Progressive Changes In Clinically Relevant Brain Regions, Martin T Egeland, Marta M Tarczyluk-Wells, Melissa M Asmar, Evan G Adintori, Roger Lawrence, Elizabeth M Snella, Jackie K Jens, Brett E Crawford, Jill C M Wait, Emma Mccullagh, Jason Pinkstaff, Jonathan D Cooper, N Matthew Ellinwood

2020-Current year OA Pubs

Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha-N-acetylglucosaminidase activity, leading to increased levels of nondegraded heparan sulfate (HS). A mouse model has been useful to evaluate novel treatments for MPS IIIB, but has limitations. In this study, we evaluated the naturally occurring canine model of MPS IIIB for the onset and progression of biochemical and neuropathological changes during the preclinical stages (onset approximately 24-30 months of age) of canine MPS IIIB disease. Even by 1 month of age, MPS IIIB dogs had elevated HS levels in brain …

Transcriptomes From German Shepherd Dogs Reveal Differences In Immune Activity Between Atopic Dermatitis Affected And Control Skin, K Tengvall, K Bergvall, M Olsson, B Ardesjö-Lundgren, F H G Farias, M Kierczak, Å Hedhammar, K Lindblad-Toh, G Andersson

2020-Current year OA Pubs

Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease with both genetic and environmental risk factors described. We performed mRNA sequencing of non-lesional axillary skin biopsies from nine German shepherd dogs. Obtained RNA sequences were mapped to the dog genome (CanFam3.1) and a high-quality skin transcriptome was generated with 23,510 expressed gene transcripts. Differentially expressed genes (DEGs) were defined by comparing three controls to five treated CAD cases. Using a leave-one-out analysis, we identified seven DEGs: five known to encode proteins with functions related to an activated immune system (CD209, CLEC4G, LOC102156842 (lipopolysaccharide-binding protein-like), LOC480601 (regakine-1-like), LOC479668 …

Development And Management Of Canine Adverse Food Reactions And Its Connections To The Grain-Free Dog Food Movement, Savannah Dunn

Senior Honors Theses

Canine Adverse Food Reactions include immunologically-mediated food allergies as well as non-immunological food intolerances. Although popular belief holds grains are responsible for AFR, the majority are aggravated by the common protein sources found in commercial dog foods. Elimination diets, a time-intensive method in which suspected allergens are removed from the dog’s diet, are the most effective form of diagnosis, though alternative techniques including patch testing and serum antibody tests have been explored. Presently, avoidance of allergens is the recommended management approach. The erroneous association of grains with AFR has led to the rise of grain-free dog food. However, these nontraditional …

Functionalized Scaffold And Barrier Membrane With Anti-Bmp-2 Monoclonal Antibodies For Alveolar Ridge Preservation In A Canine Model, Seiko Min, Taewan Kim, Oksu Kim, Carames Goncalo, Tadahiko Utsunomiya, Takashi Matsumoto, Kayo Kuyama, Nikola Angelov

Journal Articles

INTRODUCTION: The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model.

MATERIALS AND METHODS: The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM). The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group). Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses. Outcomes were compared …

Behavioural Risks In Female Dogs With Minimal Lifetime Exposure To Gonadal Hormones, Melissa J. Starling, Anne Fawcett, Bethany Wilson, James Serpell, Paul Mcgreevy

Physiology Collection

Spaying of female dogs is a widespread practice, performed primarily for population control. While the consequences of early spaying for health are still being debated, the consequences for behaviour are believed to be negligible. The current study focused on the reported behaviour of 8981 female dogs spayed before 520 weeks (ten years) of life for reasons other than behavioural management, and calculated their percentage lifetime exposure to gonadal hormones (PLGH) as a proportion of their age at the time of being reported to the online Canine Behavioral Assessment and Research Questionnaire (C-BARQ). We found that 23 behaviours differed between entire …

A Retrospective Study Of The Effect Of Single Dose Intra-Articular Hyaluronic Acid Injection On Postoperative Recovery In Dogs Undergoing Stifle Surgery, Jiradet Trairatthanom, Sasithorn Trairatthanom, Naris Thengchaisri

The Thai Journal of Veterinary Medicine

Hyarulonicacid (HA) is an abundant molecule found in synovial fluid and plays an important role as a lubricant and shock absorber for the joints. Nonetheless, the effects of synovial fluid replacement with HA after canine stifle surgery remains elusive. A retrospective study was conducted on 54 small breed dogs with either medial patellar luxation (MPL) or cranial cruciate ligament ruptures (CCLR). Dogs were classified as HA (21 with MPL-HA and 16 with CCLR-HA) or control (10 with MPL-C and 7 with CCLR-C) groups. The weight bearing score, lameness score, and pain scores were compared between HA and control groups on …

The Meaning And Motivation Of Children Participating In Animal-Assisted Therapy: A Pilot Study, Beth Laskowski, Melissa Y. Winkle, Whitney Lucas Molitor

People and Animals: The International Journal of Research and Practice

Background: Despite claims that animal-assisted therapy is beneficial, there is limited empirical evidence supporting this. Current literature supports the physical, emotional, and psychological benefits an animal can provide, but few studies have explored the outcomes of incorporating an animal into skilled treatment facilitated by a healthcare professional. This study seeks to explore the effects of animal-assisted therapy in outpatient pediatric occupational therapy practice.

Purpose: The purpose of this research is to explore the meaningfulness and motivation animal-assisted therapy interventions provide for pediatric clients when compared with traditional occupational therapy treatment.

Methods: Researchers utilized a within-participants repeated-measures design for this study. …

The Use Of B-Scan Coupling With A-Scan Ultrasonography To Characterize Ocular Biometry In Canine Absolute Glaucoma, Napasorn Ngamrojanavanit, Natthaporn Tanthasathien, Nirachon Srisamai, Suchaya Taotongnuntasin, Panrawee Phoomvuthisarn, Nalinee Tuntivanich

The Thai Journal of Veterinary Medicine

This study was to investigate intraocular structures of canine absolute glaucomatous eyes using real time B-scan ultrasonography in accordance with the amplitude mode. Ten normal eyes and twenty absolute glaucomatous eyes were included in this study. Ocular biometry via closed-eye technique was performed usingthe Ultrascan®Imaging System (Alcon Surgical Laboratory,Fort Worth, USA), with a 10 MHz mechanical sector probe. Changes of intraocular structures were descriptively analyzed. Ocular biometry was measured, statistically analyzed and compared between both groups. While mean lens thickness was comparable betweennormotensive and glaucomatous eyes, mean lens equatorial length was higher in the latter group. Increased hyperechogenicity of lens …

An Exploration Of Attitudes Toward Dogs Among College Students In Bangalore, India, Shelly Volsche, Miriam Mohan, Peter B. Gray, Madhavi Rangaswamy

Anthropology Faculty Research

Conversations in the field of anthrozoology include treatment and distinction of food animals, animals as workers versus pests, and most recently, emerging pet trends including the practice of pet parenting. This paper explores attitudes toward pet dogs in the shared social space of urban India. The data include 375 pen-and-paper surveys from students at CHRIST (Deemed to be University) in Bangalore, India. Reflecting upon Serpell’s biaxial concept of dogs as a relationship of affect and utility, the paper considers the growing trend of pet dog keeping in urban spaces and the increased use of affiliative words to describe these relationships. …

Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists, Anne Fawcett, Vanessa Barrs, Magdoline Awad, Georgina Child, Laurencie Brunel, Erin Mooney, Fernando Martinez-Taboada, Beth Mcdonald, Paul Mcgreevy

Paul McGreevy, PhD

This article, written by veterinarians whose caseloads include brachycephalic dogs, argues that there is now widespread evidence documenting a link between extreme brachycephalic phenotypes and chronic disease, which compromises canine welfare. This paper is divided into nine sections exploring the breadth of the impact of brachycephaly on the incidence of disease, as indicated by pet insurance claims data from an Australian pet insurance provider, the stabilization of respiratory distress associated with brachycephalic obstructive airway syndrome (BOAS), challenges associated with sedation and the anaesthesia of patients with BOAS; effects of brachycephaly on the brain and associated neurological conditions, dermatological conditions associated …

“I Do Have A Softer Side”: A Phenomenological Investigation Of The Prisoner-Dog Relationship In The Canine Partners For Life Training Program, Kathleen Kocherzat

Electronic Theses and Dissertations

This qualitative study investigated the relationship between incarcerated dog handlers and the service dogs they trained. Six men at a large northeastern prison were interviewed during the summer of 2017; all were current or former dog trainers in the Canine Partners for Life (CPL) training program. The men were serving prison sentences ranging anywhere from several years to life without parole. The interviews focused on their lived experience, rasing and training puppies for a period up to eighteen months. The qualitative data consisted of approximately thirteen hours of transcribed interviews, which were then interpreted using the phenomenological psychological method developed …

Effect Of Dexmedetomidine Combined With Pethidine On Minimum Alveolar Concentration Of Isoflurane In Dogs, Kanjana Vinyunantakul, Sumit Durongphongtorn, Marissak Kalpravidh

The Thai Journal of Veterinary Medicine

The effect of dexmedetomidine alone and when combined with pethidine on a minimum alveolar concentration (MAC) of isoflurane was determined in 24 client-owned adult male dogs before castration. Dogs were assigned to Group 1 (n = 12; dexmedetomidine, 5 µg/kg IM) or Group 2 (n = 12; dexmedetomidine, 5 µg/kgand pethidine, 5 mg/kg IM) . Sedation and response to noxious stimulation (digit clamping) were evaluated at 15 minutes after drug injection. Then, anaesthesia was induced via a face mask with isoflurane in oxygen and maintained via an endotracheal tube with an end tidal concentration of isoflurane (E´ISO%) of 1%, at …

Discovery Of Selective Toxoplasma Gondii Dihydrofolate Reductase Inhibitors For The Treatment Of Toxoplasmosis, Allen T Hopper, Adam Brockman, Andy Wise, Julie Gould, Jennifer Barks, Joshua B Radke, L. David Sibley, Yongmao Zou, Stephen Thomas

2010-2019 OA Pubs

A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR). We previously reported on the identification of meta-biphenyl analog 2, designed by in silico modeling of key differences in the binding pocket between TgDHFR and hDHFR. Compound 2 improves TgDHFR selectivity 6.6-fold and potency 16-fold relative to 1. Here, we report on the optimization and structure-activity relationships of this arylpiperazine series leading to the discovery of 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine 3. Compound 3 has a TgDHFR IC

Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists, Anne Fawcett, Vanessa Barrs, Magdoline Awad, Georgina Child, Laurencie Brunel, Erin Mooney, Fernando Martinez-Taboada, Beth Mcdonald, Paul Mcgreevy

Professional Veterinary Ethics Collection

This article, written by veterinarians whose caseloads include brachycephalic dogs, argues that there is now widespread evidence documenting a link between extreme brachycephalic phenotypes and chronic disease, which compromises canine welfare. This paper is divided into nine sections exploring the breadth of the impact of brachycephaly on the incidence of disease, as indicated by pet insurance claims data from an Australian pet insurance provider, the stabilization of respiratory distress associated with brachycephalic obstructive airway syndrome (BOAS), challenges associated with sedation and the anaesthesia of patients with BOAS; effects of brachycephaly on the brain and associated neurological conditions, dermatological conditions associated …

Risk And Protective Factors Associated With Gastrointestinal Parasites Of Dogs From An Urban Area Of Córdoba, Argentina, Carlos Eugenio Motta, Maria Romina Rivero, Carlos Daniel De Angelo, Ana María Sbaffo, Karina Ivana Tiranti

Turkish Journal of Veterinary & Animal Sciences

Prevalence of gastrointestinal (GI) parasites and the effect of associated factors were evaluated in household dogs from an urban area of Córdoba, Argentina. A total of 493 fecal samples were collected during 2010 and 2013 and processed with Willis` salt, Sheathers sugar flotation, and formol-ether concentration techniques. Overall prevalence of GI parasites was 45.23% (95% CI 40.83-49.62), and Ancylostoma caninum (30.83%) was the most frequent parasite, followed by Trichuris vulpis (9.94%), Cystoisospora spp. (7.71%), Toxocara canis (6.90%), and Giardia spp. (5.88%). Independent variables were presence of at least one parasite element, named "all parasites", and each GI parasite more frequently …

Greyhounds And Racing Industry Participants: A Look At The New South Wales Greyhound Racing Community, Justine Groizard

Animal Studies Journal

Subsequent to the exposure of live baiting and animal cruelty within the NSW greyhound racing industry in 2015, a public debate emerged about animal welfare, oppression and exploitation. It resulted in a community outcry, an inquiry into live baiting and animal welfare within the industry and a proposed ban of greyhound racing in the state of NSW. Whilst the proposed ban of greyhound racing was celebrated amongst animal activists, it was met with a mixture of sadness, shock and animosity from people from within the industry. Many of the people within the greyhound racing community felt stigmatised and discriminated against, …

The New World Of Pet Prosthetics, Anna Brooks

Capstones

When an abandoned dog was found in Brooklyn with his paw gnawed off, the animal shelter had two options: amputate the leg, or put the dog down. But neither seemed like a solution. So they decided to do something different, and fit the dog for a prosthetic leg. Prosthetics for people have been around for millennia, and now these devices are moving into the animal kingdom. This story explores the new world of animal prosthetics, and how these devices have changed the lives of animals like Mr. Stubbs — the first alligator with a prosthetic tail — and saved the …

Oxidative Stress And Antioxidant In Canine Cutaneous Mast Cell Tumors, Arayaporn Macotpet, Ekkachai Pattarapanwichien, Fanan Suksawat, Patcharee Boonsiri

The Thai Journal of Veterinary Medicine

Oxidative stress can result from either the excessive production of reactive oxygen species (ROS) or an impaired antioxidant system, or both. It causes damage to lipids, proteins and DNA. Therefore, oxidative stress may be involved in carcinogenesis, and is associated with many types of cancer in dogs. The objective of this study was to compare the levels of malondialdehyde, protein hydroperoxides, glutathione, retinol and alpha-tocopherol between dogs with mast cell tumors and clinically healthy controls. Blood samples were obtained from eighteen clinically healthy dogs and fourteen dogs with spontaneous mast cell tumors. Malondialdehyde and protein hydroperoxides levels were measured by …

Comparison Of Isolation Techniques For Bone Marrow Derived Canine Mesenchymal Stem Cells (Mscs) And The Compatibility Of Mscs Loaded Onto Polycarpolactone Hydroxyapatite, Chalika Wangdee, Sasithorn Panasophonkul, Napaphat Thadavirul, Kumpanart Soontornvipart, Prasit Pavasant, Pitt Supaphol, Mongkol Techakumphu, Theerawat Tharasanit

The Thai Journal of Veterinary Medicine

Bone marrow was collected from 7 dogs and submitted to 3 different MSC isolation techniques (direct plating, red blood cell lysis and gradient density). The number of cells, expression of MSC markers and in vitro the osteogenic differentiation obtained from each technique were examined. In order to study in vivo the osteogenic capability of derived MSCs, non-union ulna lesions (n=3) were firstly induced by transplantation of a composite of polycarprolactone/ hydroxyapatite (PCL/HAp) scaffold experimentally on to a critical-size ulna bone defect. The MSCs were injected into the lesions. The non-union sites were examined by radiography, angiography and histology at 2, …

Proteomics Of Human Liver Membrane Transporters: A Focus On Fetuses And Newborn Infants., Bianca D. Van Groen, Evita Van De Steeg, Miriam G. Mooij, Marola M H Van Lipzig, Barbara A E De Koning, Robert M. Verdijk, Heleen M. Wortelboer, R Gaedigk, Chengpeng Bi, J Steven Leeder, Ron H N Van Schaik, Joost Van Rosmalen, Dick Tibboel, Wouter H. Vaes, Saskia N. De Wildt

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples.

METHODS: Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3, NTCP, OCT1, OATP1B1, OATP1B3, OATP2B1 and ATP1A1 were quantified with LC-MS/MS in isolated crude membrane fractions of snap-frozen post-mortem fetal and pediatric, and surgical adult liver samples. mRNA expression was quantified using RNA sequencing, and genetic variants with TaqMan assays. We explored relationships between protein expression and age …

Novel Methods To Diagnose Pulmonary Hypertension In Dogs Assessed By Thoracic Radiography, Kawinthip Chanroon, Thanat Tuntipas, Promsin Sukpanich, Pawit Punyarit, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

The objective of this retrospective study was to distinguish between dogs with pulmonary hypertension (PH) and non-PH by using parameters obtained from thoracic radiographs. Data of 72 dogs of small breeds aged more than 1 year old and weighing less than 10 kg were retrieved. Echocardiography was used as a gold standard to diagnose PH and separate the dogs into two groups: PH (n=15) and non-PH (n=57). Seven formulae were created from measurements on right lateral and ventrodorsal radiographic views. Five formulae from the ventrodorsal view provided an outcome that could differentiate PH and non-PH dogs. Two formulae are recommended …

Development Of An Insoluble Hyaluronic Acid Membrane As An Effective Material For The Prevention Of Post-Thoracotomy Pleural Adhesions In Dogs, Akiko Uemura, Takashi Tanaka, Pinkarn Chantawong, Pitipat Kitpipatkun, Ryou Tanaka

The Thai Journal of Veterinary Medicine

A novel membrane was previously found to be effective in preventing post-thoracotomy pleural adhesions in dogs. The aim of the present study was to verify the animals’ clinical condition, the biological fate of the residual membrane, the presence or absence of pleural adhesions, and any inflammatory reactions over a 10-week observation period following membrane implantation. The animals used were two male beagles. The experimental membrane, an insoluble hyaluronic acid membrane containing glycerin, was implanted under general anesthesia above the visceral pleura in the left pleural cavity of each dog after exposure to air for 30 min. A drainage tube was …

Suture Attachment Sites On Stifle Joint Of Small And Large Dog Breeds For Cranial Cruciate Ligament Rupture Repair, Chaiyakorn Thitiyanaporn

The Thai Journal of Veterinary Medicine

Cranial cruciate ligament rupture is one of the most common problems in dogs. Previous studies have arrived at no absolute conclusion regarding suture attachment sites using the extracapsular technique to repair cranial cruciate ligaments in dogs. Therefore, the objective of this study was to identify and compare suture attachment sites on the femur and tibia between small and large dog breeds at different stifle angles. Twenty-seven cadaveric hind limbs of small dogs and 16 cadaveric limbs of large dogs were collected, and lateral photographs were taken at different stifle angles (including 40, 60, 80, 100, 120, 140, and 160 degrees). …

Efficacy Of Postoperative Oral Tepoxalin After Decompressive Surgery In Dogs With Degenerative Lumbosacral Stenosis, Niyada Thitaram, Herman A.W. Hazewinkel, Björn P. Meij

The Thai Journal of Veterinary Medicine

Twenty-three client-owned dogs with degenerative lumbosacral stenosis (DLS) treated by decompressive surgery were included in this study. The dogs were assigned to postoperative medication protocols of tepoxalin (10 mg/kg, SID) for 2 weeks (8 dogs, group 1), of tepoxalin (10 mg/kg, SID) for 6 weeks (7 dogs, group 2), and of carprofen (2 mg/kg, BID) for 2 weeks (8 dogs, group 3). Gait function after decompressive surgery of the dogs was evaluated by force plate analysis (FPA) and questionnaires filled out by their owners. FPA was performed before surgery, and at 4 days, 6 weeks, and 6 months after surgery. …

Evaluation Of Symptomatic Improvements Observed By Switching To Alacepril From Other Ace-Inhibitors In Dogs With Mitral Valve Regurgitation, Akiko Uemura, Lina Hamabe, Kazumi Shimada, Miki Shimizu, Ryou Tanaka

The Thai Journal of Veterinary Medicine

Alacepril is an ACE-inhibitor (ACE-I), which has unique properties including peripheral sympathoinhibitory effect and negative chronotropic effect, and it is suspected to have a superior cough suppressive effect in comparison to other ACE-Is. The purpose of the study was to evaluate whether switching to alacepril from other ACE-Is will alleviate the clinical symptoms of congestive heart failure (CHF) caused by mitral valve regurgitation (MR). The prospective clinical study included 73 client-owned dogs with MR that had been treated with ACE-Is other than alacepril for over a period of one month. The ACE-Is were replaced by alacepril and observed for four …