Medicine and Health Sciences Commons^™

Modified Maxillary Palatal Ramp Prosthesis To Guide Mandibular Deviation Following Segmental Mandibulectomy For Squamous Cell Carcinoma, Manu Rathee, Sujata Chahal, Maqbul Alam, Prachi Jain

Journal of Dentistry Indonesia

Benign or malignant tumor is one of the frequent causes of resection of the mandible. The extent and location of the tumor decides the mode of treatment of the neoplastic lesion. Surgical removal of oral neoplasm leads to an extensive resection of the mandible along with the associated structures. Objective: This case report describes the use of palatal ramp prosthesis to guide the mandible during movements and restore a stable occlusal relationship with an additional acrylic buccal pad to achieve partial esthetics. Case Report: A 30-years-old female patient reported with the inability to chew food following the mandibular resection of …

A Case Of Longitudinal Melanonychia In A Child: Benign Or Malignant?, Heffi Anindya Putri, Ennesta Asri, Qaira Anum

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Longitudinal melanonychia (LM) describes a longitudinal brown-to-black band of discoloration affecting a finger, thumb, or toenail. Discoloration of the nails can be a sign of benign or malignant nail disorders. Although nail melanoma rarely occurs in children, health practitioners should be aware of melanonychia. Dermoscopy and histopathology are helpful in the diagnosis.

Case Illustration: A case of LM in a thirteen-year-old girl was reported with a complaint of brownish-black discoloration, sometimes painful, on her right thumb since 1 year ago. She had no history of trauma, nail damage, or bleeding tendency. Dermatological examination found a homogeneous brownish-black …

Risk Factors For Hiv-Positive Status In Condyloma Acuminata, Izazi Hari Purwoko, Putri Laksmi Karim, Suroso Adi Nugroho, Theresia Toruan, Fitriani .

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Condyloma acuminata (CA) is a sexually transmitted infection (STI) caused by human papillomavirus (HPV), especially types 6 and 11. The number of HPV infections increases in immunosuppressed conditions, such as human immunodeficiency virus (HIV) infection. Risk factors in CA patients such as gender, sexual partner, sexual orientation, and sexual intercourse can increase HIV status.

Methods: This is a descriptive-analytic study with a cohort retrospective design. The subjects are all CA patients who visited the polyclinic STI Dr. Mohammad Hoesin, General Hospital, Palembang, Indonesia, between 2016-2020. The number of CA patients included in the study were 115 patients …

Correlation Between Serum 25 Hydroxy-Vitamin D Levels And The Worst Pain Intensity In Postherpetic Neuralgia, Wizar Putri Mellaratna, Nelva K. Jusuf, Ariyati Yosi

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Postherpetic neuralgia (PHN) is persistent pain in the affected dermatome that occurs more than three months after the eruption of the herpes zoster has disappeared. Vitamin D has a role in Schwann cell regeneration and stimulates the release of nerve growth factors.

Methods: Blood sampling was performed to test serum 25(OH)D levels. Patients filled out their worst pain intensity using the Zoster Brief Pain Inventory questionnaire. The score was reported in Likert score (0-10), 0 indicating no pain and 10 indicating the most severe pain. Spearman correlation test was used, and p 0.05) and PHN durations (p …

Effectiveness Of Garlic Extract (Allium Sativum) To Reduce Level Of Malondialdehyde Serum And Improve Quality Of Life In Patients With Chronic Hemodialysis: A Randomized Double-Blind Placebo-Controlled Trial, Amelia Istiqomah, Zulkhair Ali, Irsan Saleh

Jurnal Penyakit Dalam Indonesia

Introduction. Study reported that malondialdehyde (MDA) levels as an in vivo marker of oxidative stress were increased in patients undergoing hemodialysis. Antioxidants allicin compounds contained in garlic (Allium sativum) are known to have antioxidant activity by inducing antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and inhibiting prooxidant enzymes (nitric oxide synthase, xanthine, NADPH oxidase, and cyclooxygenase). This study aimed to investigate the effectiveness of Allium sativum to reduce level of MDA serum and improve quality of life in patients with chronic hemodialysis. Methods. This study was a crossover randomized double-blind placebo-controlled trial. The subjects were 40 chronic kidney …

Value Of Heart Rate Variability, Neutrophil-Lymphocyte Ratio And Quality Of Life Of Patients With Depressive Symptoms In Acute Myocardial Infarction, Hamzah Shatri, Mizanul Adli, Muhadi Muhadi, Murdani Abdullah, Cosphiadi Irawan, Rudi Putranto, Sukamto Koesnoe, Ika Prasetya Wijaya

Jurnal Penyakit Dalam Indonesia

Introduction. Major depression criteria can be found in more than 20% of coronary heart patients and more than 30% acute coronary syndrome patients have significant depressive symptoms. Several studies have shown that reduction of hearth rate variability (HRV) and enhancement of neutrophil lymphocyte ratio (NLR) can cause enhancement of morbidity and mortality in myocardial infarction patients. On the other hand, depression can cause reduction of HRV, enhancement of NLR and reduction of quality of life. This study aimed to determine differences in HRV, NLR and quality of life between acute myocardial infarction (AMI) patients with depressive symptoms and AMI patients …

Kecubung Intoxication: A Case Report On A 16-Year-Old Male At Kuningan District, Monica Djaja Saputera, Jessica Djaja Saputera

Jurnal Penyakit Dalam Indonesia

Kecubung (angel’s trumpet) is a plant with hallucinogen effect which contain a tropane alkaloid, which are widely grown in Indonesia and is widely abused by several groups of adolescents aged 18 years in East Nusa Tenggara. Kecubung intoxication is a common case in Indonesia, but rarely reported and hard to make a definitive diagnosis due to lack of the toxicology screening assessment. Besides, an antidote of this case also not available in this country. We present a case of 16-years old male who visited the emergency room with fluctuating level of consciousness accompanied by anxiety, anger, and a visual hallucination. …

Second-Line Therapy Tyrosine Kinase Inhibitor For Chronic Phase Chronic Myeloid Leukemia Resistant To Imatinib, Chici Pratiwi, Wulyo Rajabto

Jurnal Penyakit Dalam Indonesia

Since the era of tyrosine kinase inhibitor (TKI) therapy, there has been an increase in the median survival of chronic myeloid leukemia. Nevertheless, nowadays there were several cases of chronic myeloid leukemia that are resistant to the first-line TKIs, so that several second-line TKIs were introduced. Assessment of the therapeutic response was performed using a complete peripheral blood examination, bone marrow aspiration cytogenetic examination, and quantitative BCR-ABL examination. The treatment failure criteria were applied based on the ELN criteria. In selecting the second line TKI should be based on the results of mutation analysis and consider the safety profile of …

Effect Of Advance Care Planning On Heart Failure Patients: An Evidence Based Case Report, Hamzah Shatri, Nandika Nurfitria, Dika Sinulingga, Vinandia Irvianita, Edward Faisal, Rudi Putranto, Diah Martina

Jurnal Penyakit Dalam Indonesia

Despite the advances in medical therapy, heart failure remains a disease that requires attention due to the course of the illness; it can lead to unpredictable, progressive, and fatal conditions. Existing therapy aims to improve the condition and prevent disease progression, with a balanced secondary therapy for various conditions that can trigger acute decompensated heart failure. Advances in technology and therapy may increase the prevalence of patients with heart failure, including prolonging the refractory phase of the disease. There are recommendations for advance care planning to support patient therapy and improve the quality of life of patients with heart failure. …

The Application Of Echo-Guided Injection Of Steroid And Botulinum Toxin Type A For Ankle Contracture In Traumatic Trans-Metatarsal Amputation: A Casereport, Ching Yu Wang, Simon F Tang, Yu Ting Hsieh

Rehabilitation Practice and Science

In this report we share 21 year-old young man with traumatic transmetatarsal amputation treated with multiple operations after few weeks of surgery. Foot equinovarus deformity was noted which leads to walking disability and affects daily activities. Patient was referred to us from orthopedic doctor because he hesitated to have another operation for Achilles tendon lengthening. During the physical examination, equinovarus foot with hip contracture were observed which may be caused by muscle imbalance or nerve injury. Nerve conduction velocity and electromyography tests (NCV/EMG) was arranged for differentiating between neurogenic contraction and myogenic contracture. Peroneal nerve injury was ruled outafter the …

Assessment Of The Effects Of Edentulousness On Temporomandibular Components By Using Cone Beam Computed Tomography, Büşra Arıkan, Numan Dedeoğlu, Şuayip Burak Duman

Journal of Dentistry Indonesia

Objective: The aim of this study is to evaluate the effects of edentulousness on the temporomandibular joint using cone beam computed tomography (CBCT). Methods: In this study, CBCT images were evaluated in a total of 48 patients (24 dentulous, 24 edentulous). Ninety-six temporomandibular joint CBCT images were examined. Eminence inclination, condyle head widths and joint space were measured and statistically compared between the edentulous and dentulous groups. Results: The articular eminence inclination value the mediolateral width of the condyle and the anteroposterior width of the condyle were found significantly higher in the dentulous group than in the edentulous group. …

Effect Of Preflaring On Accuracy Of Endodontic Length Determination By Four Electronic Apex Locators, Arash Izadi, Maliheh Bayandari, Ezatolah Kazeminejad

Journal of Dentistry Indonesia

Objective: Root canal anatomy significantly impacts the working length determination. This study aimed to investigate the effect of the preflaring technique on the accuracy of four electronic apex locators. Methods: Forty-five single-canal central maxillary teeth were selected. The working length was measured before and after the coronal preparation by four types of electronic apex locators in the range of ±0.5 and ±1 mm matched for the apical constriction. The actual working length was calculated under a microscope. Data were analyzed using ICC and paired t-tests in SPSS16. A p < 0.05 was considered significant. Results: The accuracies of Root ZX, DTE, Denjoy, and Coxo apex …

Comparison Of Ultrasonography And Cone Beam Computed Tomography In The Differential Diagnosis Of Periapical Lesions: A Prospective Radiopathological Study, Gozde Serindere, Ceren Aktuna Belgin, Mert Bulte, Didar Gursoy, Fariz Salimov

Journal of Dentistry Indonesia

Objective: The aim of this study is to evaluate the correlation between ultrasonography (USG) and cone beam computed tomography (CBCT) and the accuracy between histopathological diagnosis and preliminary diagnosis in the diagnosis of periapical lesion. Methods: 20 patients with periapical lesion in the jaw, were included in the study. The presence of expansion or perforation and dimensions of the lesion were performed with CBCT. In the examination of the lesion with USG, shape, echogenicity, vascularization of the lesion and the presence of buccal expansion and perforation, were determined. Subsequently, a biopsy was taken from the lesion for histopathological examination and …

Endodontic Management Of An Unusual Mandibular First Molar With Six Canals: A Case Report And Systematic Review, Sarah Ahmad, Syed Mukhtar -Un- Nisar Andrabi, Ashok Kumar, Surendra Kumar Mishra, Rajendra Kumar Tewari

Journal of Dentistry Indonesia

The permanent mandibular first molar is frequently involved in conventional root canal treatment due to its function and position in the oral cavity. Additional root canals mandate accurate diagnosis and conservative management to prevent any procedural errors. The first independent middle mesial canal incidence was verified in mandibular molars in 1974, with a global incidence of 10.8–27.0%. Reporting of the middle distal canal in the endodontic literature is scarce, with an incidence of 0.2–3%. The present case report describes the endodontic management of an unusual permanent mandibular first molar with three canals in the mesial and distal roots, diagnosed with …

Medical Ethics Principles Underscore Advocating For Human Papillomavirus Vaccine, C Mary Healy, Lara S Savas, Ross Shegog, Rebecca Lunstroth, Sally W Vernon

Journal Articles

Studies have consistently shown that vaccination rates against human papillomavirus (HPV) lag far behind other adolescent vaccinations recommended at the same age, resulting in exposing adolescents to unnecessary future risk of infection, and genital and head and neck cancers. Studies also have demonstrated that a major barrier to vaccination is lack of a strong provider recommendation. Factors that providers offer for failing to give a strong recommendation range from perception that the child is not at risk or the need to explain that the vaccine is not mandated (lack of equity and justice) or respect for parental autonomy. We look …

A Pilot Intervention Combining Assessment And Feedback With Communication Training And Behavioral Nudges To Increase Hpv Vaccine Uptake., Andrea Bradley-Ewing, Brian R. Lee, Jason N. Doctor, Georgann Meredith, Kathy Goggin, Angela Myers

Manuscripts, Articles, Book Chapters and Other Papers

Human papillomavirus (HPV) causes >40,000 cancer diagnoses each year, yet vaccination rates remain low because widespread implementation of strategies to increase vaccinations has not occurred. Behavioral nudges have demonstrated efficacy in improving uptake of desired behaviors in health care settings but have not been tested for increasing HPV vaccinations. We assessed the impact of an intervention combining behavioral nudges with other proven strategies (i.e., assessment and feedback, provider communication training) on HPV vaccination rates and parental satisfaction in four Midwestern pediatric, outpatient practices. Practices were randomly assigned to receive either assessment and feedback or assessment and feedback combined with vaccine …

Effect Of Playstation® Vr Sessions On Health-Related Quality Of Life And Motor Function In Stroke Patients Undergoing Inpatient Rehabilitation, Chien-Min Chen, Yi-Ching Huang, Kuan-Yu Kung, Yun-Chien Li, I-Lin Yen, Shih-Che Lin, Chu-Hsu Lin, Chia-Hung Lin

Rehabilitation Practice and Science

Background: Virtual Reality (VR) systems have been introduced for rehabilitation of stroke patients. Existing evidence regarding the effects of fully-immersive commercial games on health-related quality of life (HRQOL) and motor function in stroke patients is limited. Objective: To evaluate the efficacy of seven supplemental PlayStation® VR sessions on the HRQOL and motor function of stroke patients undergoing inpatient rehabilitation during a 16-day study period within the first year after stroke. Methods: A randomized, single-blind clinical trial with parallel groups (VR plus conventional therapy vs. conventional therapy) was carried out. For the assessment of outcome measures, the Stroke Impact Scale (SIS) …

Insulin Autoimmune Syndrome In A Patient With Hemorrhagic Stroke: A Rare Casereport And Literature Reviewarticle, Kuan-Yu Kung, Chu-Hsu Lin, Yen-Liang Ke

Rehabilitation Practice and Science

Introduction: Insulin Autoimmune Syndrome (IAS), also known as Hirata's disease, is a rare cause of hyperinsulinemia hypoglycemia, with an overall incidence of one over one billion. Only three hundred and eightycases of IAS were reported world-wide during 1970 to 2009. Such disease was easily underestimated and misdiagnosed. Thus, we sincerely introduce a case newly diagnosed as IAS possibly induced by Angiotensin-Converting Enzyme inhibitor (ACEI) after cerebral vascular accident (CVA).The literature of insulin autoimmune syndrome was also reviewarticleed. Case presentation: This 34-year-old male with past history of hypertension and hyperlipidemia hadsudden onset of mental drowsiness and weakness on left side limbs …

Hypertonic Dextrose Injections For Osteoarthritis, Tai-Yung Yi, Ta-Wei Wu, Kuen-Huei Lin

Rehabilitation Practice and Science

Among the elderly, an increase in the prevalence of certain diseases, such as osteoarthritis, has been observed. Patients with osteoarthritis not only experience discomfort and pain but also have limited range of motion in the joints, which lowers their quality of life. At present, non-drug, drug, and surgical treatment options are available for patients with osteoarthritis; these approaches mainly focus on relieving symptoms and reducing the impact of joint disability. Initially, non-drug therapies, such as those focusing on changing the habits of patients, are usually administered. If the disease remains uncontrolled following non-drug therapy, drugs are administered and/or surgery is …

Diagnosis And Treatment Of Stroke-Related Sarcopenia: A Narrative Reviewarticle, Szu-Han Chen, Tieh-Cheng Fu

Rehabilitation Practice and Science

Stroke patients have a high prevalence of sarcopenia due to the presence of several risk factors, including immobilization, impaired feeding, sympathetic activation, inflammation, and denervation. The occurrence of sarcopenia further exacerbates the disability caused by the stroke. Thus, appropriate diagnosis and intervention for sarcopenia is an important health issue for the stroke population. The article discusses the dilemma in diagnostic tests and potential treatment for stroke-related sarcopenia based on the currently available literature evidence.

Effectiveness And Predictors Of Home-Based Postacute Stroke Care, Yuan-Ting Lo, Wen-Chih Lin, Lin-Fu Lee, Willy Chou

Rehabilitation Practice and Science

Introduction: Stroke is the leading cause of disability in adults. In 2014, Taiwan's National Health Insurance Administration started to provide inpatient postacute care, and the results indicated that this model improves the overall functional status of patients with stroke. In 2017, home-based postacute stroke care was initiated; however, no study has evaluated its effectiveness. Therefore, we explored the functional recovery of patients with stroke after 6 weeks of postacute care at home and the factors that influenced their functional improvement. Method: We recruited patients with stroke who received a score of 3 or 4 on the modified Rankin Scale between …

Effects Of Supervised Exercise Training On Health-Related Physical Fitness In Community Dwellers Aged Over 50 Years, Chun-Yi Lee, Tieh-Cheng Fu, Jong-Shyan Wang, Chih-Chin Hsu

Rehabilitation Practice and Science

Effects of supervised aerobic exercise training on physical fitness in aging community residents were highlighted in the study. 76 community-dwellers aged ＞ 50 years who completed an 8-week cohort study were included. All participants were instructed to walk ≥ 8000 steps per day (stp/d) and wore a smart watch to record the every-day step amount. The average number of everyday step amount in a week was used as the mean walking steps per day in a week. Among them, 39 participants were randomized to the supervised exercise training (SET) and 37 were allocated to the home exercise training (HET) groups. …

Age-Related Sonoanatomical Change Of The Knee In Children, Shu-Mei Yang, Chia-Wei Lin, Wen-Shiang Chen

Rehabilitation Practice and Science

Ultrasound has been thoroughly studied and become a well-established tool for assessment of adult patients' musculoskeletal system both in research and clinical practice. However, the use of musculoskeletal ultrasound in pediatric populations is still limited. The age-dependent variability of normal sonoanatomy dueto bone maturation and ossification in children is the main limitation to establishing its validity as an imaging tool. Also, standardized definitions of gray-scale and power Doppler ultrasonography findings in different age groups of children is still lacking. Nonetheless, ultrasound is a readily accessible imaging modality that is well tolerated by children. It also allows physicians to perform a …

The Use Of Ultrasonography In Suspected Tibia Plateau Fracture With Lipohemarthrosis: A Casereport, Wei-Nung Hsu, Pon-An Chen, Sen-Wei Tsai

Rehabilitation Practice and Science

Knee pain is a common complaint in rehabilitation outpatient clinics. Plain radiography is typically used to detect knee pain and trauma. However, a slight depression plateau fracture could be easily overlooked on plain radiography. This is a casereport of a 57-year-old woman with left knee pain who visited the outpatient clinic for help. Ultrasonography showed fat-fluid level, but plain radiography did not reveal any fracture. Magnetic resonance examination confirmed the depression fracture of the tibial plateau and the lipohemarthrosis. Lipohemarthrosis is a highly sensitive predictor of intra-articular surface fractures. Ultrasound is a convenient and reliable tool to detect lipohemarthrosisof the …

Application Of Ultrasonography In The Diagnosis And Treatment (5% Dextrose Hydrodissection) For Entrapment Of Spinal Accessory Nerve: A Casereport, Tien-Lee Hsieh, Wei-Ting Wu, Chun-Ping Wang, Liang-Chun Chien, Lin-Fen Hsieh

Rehabilitation Practice and Science

The anatomical structure of the neck area is exceedingly complex; thus, cervical nerve damage during surgical procedures is not uncommon. A 25-year-old woman underwent excisional biopsy for neck lymphadenopathy. The patient reported left upper back pain and left shoulder weakness 1 day after the surgery. Physical examination revealed weakness of the left upper trapezius muscle and winging of the left scapula. A nerve conduction study indicated decreased compound muscle action potential amplitude on stimulation of the left spinal accessory nerve (SAN); electromyography also revealed denervation changes with the presence of voluntary motor unit action potentials in the left upper trapezius …

A Casereport Of Speech Therapy Combined With Repetitive Transcranial Magnetic Stimulation In Patients With Global Aphasia, Shih-Chen Lai, Yan-Ting Lin, Long-Wei Dai

Rehabilitation Practice and Science

For patients with stroke-induced aphasia, speech therapy is the most common speech rehabilitation program. In recent years, increasing empirical discussions have been conducted on the application of repetitive transcranial magnetic stimulation in treating stroke-related comorbidities; however, such discussions are lacking in Chinese. The present casereport investigated a patient with global aphasia who received frequent sessions of conventional speech therapy (2.5 hours per week) in conjunction with repetitive transcranial magnetic stimulation (5 sessions per week). The total intervention period was 6 months. The Concise Chinese Aphasia Test was used to conduct a pretest and posttest before and after the intervention. This …

Compartment Syndrome With Severe Neurovascular Complications After Trans-Radial Approach Of Percutaneous Coronary Intervention: A Casereport And Literature Reviewarticle, Pei-Yi Chen, Hong-Yi Lin

Rehabilitation Practice and Science

The gold standard for the acute coronary syndrome is percutaneous coronary intervention. Access site practice has shifted from transfemoral to transradialaccess (TRA), with the latter being more popular in Europe and Asia due to higher success rates, fewer site-related vascular complications, mortality, and shorter hospital stay. Significant complications following TRA of percutaneous coronary intervention have been reported, including spasm, occlusion, perforation, pseudoaneurysm formation, arteriovenous fistula, and rarely, compartment syndrome and complex regional pain syndrome (CRPS). Here, we report the case of a 66-y-old male who had persistent right-hand painful swelling, clawed hand, and sensory disturbance for 2 months following TRA …

Ability Of The Australian General Public To Identify Common Emergency Medical Situations: Results Of An Online Survey Of A Nationally Representative Sample, Brennen W. Mills, Michella G. Hill, Alecka K. Miles, Erin C. Smith, Eben Afrifa-Yamoah, David N. Reid, Shane L. Rogers, Moira G. B. Sim

Research outputs 2022 to 2026

Objective: To investigate the Australian general public's ability to identify common medical emergencies as requiring an emergency response. Methods: An online survey asked participants to identify likely medical treatment pathways they would take for 17 hypothetical medical scenarios (eight emergency and nine non-emergency). The number and type of emergency scenarios participants correctly suggested warranted an emergency medical response was examined. Participants included Australian residents (aged > 18 years; n = 5264) who had never worked as an Australian registered medical doctor, nurse or paramedic. Results: Most emergencies were predominately correctly classified as requiring emergency responses (e.g. Severe chest pain, 95 % …

Facial Dermatosis Papulosa Nigra, A Risk For The Development Of Pterygium And Myopia: A Descriptive Cross-Sectional Study In Ghana, Du Bois Asante, Korantema M. Tsegah, Ebenezer Afrifa-Yamoah, Samuel Kyei, Dunyah J. Dzidzor, Reindolf Anokye

Research outputs 2022 to 2026

Background: Dermatosis papulosa nigra (DPN) affects sun-exposed areas such as the face, neck, and trunk. The prevalence of pterygium and myopia in DPN patients in Ghana has not been studied. In this study, we examined the risk and protective factors for pterygium and myopia in DPN patients. Materials and Methods: The study involved 100 participants with facial DPN. A standard ophthalmic exam was performed using a portable slit lamp and a 3.5 X magnified loop. Participants completed a closed-ended questionnaire. Logistic regression was used to summarize the level of association between DPN, myopia, and pterygium, as well as demographic factors …

Small Extracellular Vesicle-Mediated Itgb6 Sirna Delivery Downregulates The Αvβ6 Integrin And Inhibits Adhesion And Migration Of Recipient Prostate Cancer Cells, Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri, Lucia R Languino

Department of Cancer Biology Faculty Papers

The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding the β6 integrin subunit) are significantly increased in metastatic castrate-resistant androgen receptor-negative prostate tumors compared to androgen receptor-positive prostate tumors. In addition, the αVβ6 integrin protein levels are significantly elevated in androgen receptor-negative PrCa patient derived xenografts (PDXs) compared to androgen receptor-positive PDXs. In vitro, the androgen receptor-negative PrCa cells express high levels of the αVβ6 integrin compared to androgen receptor-positive PrCa cells. Additionally, …