Medicine and Health Sciences Commons^™

Comparison Heart Rate Variability And One-Year Survival In Acute Coronary Syndrome [Poster], Patricia Harris

Patricia Harris

Altruism And Innovation In Health Care, Anupam Bapu Jena, Stéphane Mechoulan, Tomas J. Philipson

Stéphane Mechoulan

The joint presence of technological change and consumption externalities is central to health care industries around the world, because medical innovation drives the expansion of the health care sector and altruism seems to motivate many public subsidies. Although traditional economic analysis has proposed well-known remedies to deal with consumption externalities and inefficient technological change in isolation, it lacks clear principles for addressing them jointly. We argue that standard remedies to each of the two problems are inadequate. Focusing on U.S. health care, we provide illustrative calculations of the dynamic inefficiency in the level of research and development (R&D) spending when …

Ganaxolone Suppression Of Behavioral And Electrographic Seizures In The Mouse Amygdala Kindling Model, Doodipala S. Reddy, Michael A. Rogawski

Michael A. Rogawski

Ganaxolone (3alpha-hydroxy-3alpha-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABA-A receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25—20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested. The ED50 for suppression of behavioral seizures was 6.6 mg/kg. The seizure suppression produced by ganaxolone was comparable to that of clonazepam (ED50, 0.1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, …

Características Dos Acidentes De Trânsito Com Vítimas De Atropelamento No Município De Maringá-Pr, 2005-2008 / Characteristics Of Traffic Accidents From 2005 To 2008 With Run Over Victims In Maringá, Pr, Brazil., Everton Fernando Alves

Everton Fernando Alves

Trata-se de um estudo retrospectivo descritivo, que teve por objetivo conhecer as características dos acidentes de trânsito por atropelamento no município de Maringá entre 2005 e 2008. Para o estudo foram consideradas as vítimas de acidentes de trânsito por atro-pelamentos ocorridos em Maringá, no período de 2005 a 2008, através dos dados do Registro Geral de Ocorrência – RGO do 5º Grupamento de Bombeiros (GB). Foram identificadas 1841 vítimas. Do total de víti-mas, foi estudado o número de ocorrências registradas (1486), distribu-ídos em 399 no ano de 2005, 376 em 2006, 361 em 2007 e 350 no ano de 2008. …

Review Of Understanding Healthcare Information By Lyn Robinson, Sharon Leslie

Sharon Leslie

This is a review of Understanding Healthcare Information by Lyn Robinson

Psychiatrists And Neuroscientists Of Indian Origin In Canada: Glimpses, Amresh Shrivastava, D. Natarajan

Amresh Srivastava

Psychiatrists of Indian origin are popular in Canada, being firmly rooted in the Canadian mental health system, and they have been making considerable contributions internationally. The Indian Psychiatric Society has long been collaborating with and inviting contributions from overseas Indian psychiatrists, particularly those in academics, and this collaboration has fructified well. There are several different challenges these psychiatrists have had to face in their own specialty work, with having to adjust to a new culture, new ways of living, and new ways of work. Our colleagues of Indian origin have demonstrated excellence in almost all fields of mental health and …

Review: Intimate Partner Violence In Sri Lanka, Achini C. Jayatilleke, Krishna C. Poudel, Junko Yasuoka, Achala U. Jayatilleke, Masamine Jimba

Krishna C. Poudel

Statutes Undermine The Progress Made: The Criminalisation Of Positive Women, Aziza Ahmed, Beri Hull, Alice Welbourn, Emma Bell, Heidi Nass

Aziza Ahmed

Criminalisation laws have a specific and nuanced impact on women living with HIV. An understanding of the consequences of such laws will help positive women and other advocates to combat negative uses of such laws, and to frame and advocate for effective alternatives for HIV prevention. This article helps tease out some of the ways that criminalisation can negatively impact the lives of positive women in particular: the explicit sex discrimination in the laws, the gender bias in courtrooms, the impact on marginalised women, and the increase in stigma and discrimination through criminalisation laws.

When The 5 Rights Go Wrong: Medication Errors From The Nursing Perspective, Jackie H. Jones, Linda A. Treiber

Linda A. Treiber

Maternal Depressive Symptoms Not Associated With Reduced Height In Young Children In A Us Prospective Cohort Study, Karen A. Ertel, Karestan C. Koenen, Janet W. Rich-Edwards, Matthew W. Gillman

Karen A. Ertel

Background: Shorter stature is associated with greater all cause and heart disease mortality, but taller stature with increased risk of cancer mortality. Though childhood environment is important in determining height, limited data address how maternal depression affects linear growth in children. We examined the relationships between antenatal and postpartum depressive symptoms and child height and linear growth from birth to age 3 years in a U.S. sample. Methods: Subjects were 872 mother-child pairs in Project Viva, a prospective pre-birth cohort study. The study population is relatively advantaged with high levels of income and education and low risk of food insecurity. …

Shooting Pains: Addressing Illness-Related Pain Through Video Autobiography, Broderick Fox

Broderick Fox

This paper examines autobiographical videos and emergent uses of social software sites such as YouTube to explore the possibilities of first-person media as a pain management tool. Beyond the therapeutic possibilities, the paper also explores the potential of such personal media acts as a means of breaking down taboos around pain and illness – offering up models for managing, discussing, and even ‘performing’ pain in the public sphere.

Obat Kanker Paru Paru

beni wae

Strength And Coordination Training Are Both Effective In Reducing The Postural Tremor Amplitude Of Older Adults, Justin W.L. Keogh, Steve Morrison, Rod Barrett

Justin Keogh

The current study investigated the effect of 2 different types of unilateral resistance training on the postural tremor output of 19 neurologically healthy men age 70–80 yr. The strength- (n = 7) and coordination-training (n = 7) groups trained twice a week for 6 wk, performing dumbbell biceps curls, wrist flexions, and wrist extensions, while the control group (n = 5) maintained their normal activities. Changes in index-finger tremor (RMS amplitude, peak, and proportional power) and upper limb muscle coactivation were assessed during 4 postural conditions that were performed separately with the trained and untrained limbs. The 2 training groups …

Tumor Resistance Explained By Hormesis, Edward J. Calabrese Ph.D., Marc A. Nascarella Ph.D.

Edward Calabrese

Enhanced drug (GDC 0449) resistance in a mouse model for human medulloblastoma is shown in the present paper to act via an hormetic response. This has significant implications, imposing constraints on the quantitative features of the dose response of the chemotherapeutic agent, affecting optimal study design, mechanism assessment strategy, potential for tumor rebound, patient relapse and disease outcome.

Post-Quake Food Security In Haiti, John Mazzeo

John Mazzeo, Ph.D.

No abstract provided.

Initiatives In Biological Research In Indian Psychiatry, Amresh Shrivastava

Amresh Srivastava

Biological psychiatry is an exploratory science for mental health. These biological changes provide some explicit insight into the complex area of 'brain-mind and behavior'. One major achievement of research in biological field is the finding to explain how biological factors cause changes in behavior. In India, we have a clear history of initiatives in research from a biological perspective, which goes back to 1958. In the last 61 years, this field has seen significant evolution, precision and effective utilization of contemporary technological advances. It is a matter of great pride to see that in spite of difficult times in terms …

Sleep Disorders And Chronic Constipation Relation To Other Co-Morbidities, S.L. Szeinbach, Rosa Rodriguez-Monguio, R.W. Baran, P.B. Williams

Rosa Rodriguez-Monguio

Sleep disorders are common complaints and frequently associated with a number of disease states. Although the link between sleep disorders, respiratory diseases, and other co-morbid conditions experienced by patients has been investigated, the link between sleep disorders and chronic constipation is relatively unexplored. Given the widespread occurrence of sleep disorders, it is important to evaluate how sleep disorders relate to respiratory diseases and other comorbid disease states in participants with chronic constipation. Thus, the purpose of this study was to identify co-morbid conditions that were significant predictors for chronic constipation participants with and without sleep disorders. Of the 311 participants …

Implementation Issues For Mobile-Wireless Infrastructure And Mobile Health Care Computing Devices For A Hospital Ward Setting, Liza Heslop, Stephen Weeding, Linda Dawson, Julie Fisher, Andrew Howard

Associate Professor Linda Dawson

mWard is a project whose purpose is to enhance existing clinical and administrative decision support and to consider mobile computers, connected via wireless network, for bringing clinical information to the point of care. The mWard project allowed a limited number of users to test and evaluate a selected range of mobile-wireless infrastructure and mobile health care computing devices at the neuroscience ward at Southern Health’s Monash Medical Centre, Victoria, Australia. Before the project commenced, the ward had two PC’s which were used as terminals by all ward-based staff and numerous multidisciplinary staff who visited the ward each day. The first …

Scholar-Baller: Student Athlete Socialization, Motivation, And Academic Performance In American Society, Keith Harrison

Dr. C. Keith Harrison

No abstract provided.

Ovarian Function And Cigarette Smoking In The Biocycle Study, Brian W. Whitcomb, Sara D. Bodach, Sunni L. Mumford, Neil J. Perkins, Maurizio Trevisan, Jean Wactawski-Wende, Aiyi Liu, Enrique F. Schisterman

Brian W. Whitcomb

Cigarette smoking has been implicated in reproductive outcomes including delayed conception, but mechanisms underlying these associations remain unclear. One potential mechanism is the effect of cigarette smoking on reproductive hormones; however, studies evaluating associations between smoking and hormone levels are complicated by variability of hormones and timing of specimen collection. We evaluated smoking among women participating in the BioCycle Study, a longitudinal study of menstrual cycle function in healthy, premenopausal, regularly menstruating women (n = 259). Fertility monitors were used to help guide timing of specimen collection. Serum levels of oestradiol, progesterone, follicle-stimulating hormone (FSH), luteinising hormone (LH) and total …

Review Of Writing And Publishing: The Librarian’S Handbook. Edited By Carol Smallwood., Sharon Leslie

Sharon Leslie

This is a book review of Writing and Publishing: The Librarian’s Handbook, edited by Carol Smallwood

Smoking During Pregnancy And Risk Of Abnormal Glucose Tolerance: A Prospective Cohort Study, Amy E. Haskins, Elizabeth R. Bertone-Johnson, Penelope Pekow, Elana Carbone, Renée T. Fortner, Lisa Chasan-Taber

Lisa Chasan-Taber

Background Disturbances in glucose metabolism during pregnancy are associated with negative sequalae for both mother and infant. The association between smoking and abnormal glucose tolerance (AGT) remains controversial. Therefore, the aim of this study was to examine the relationship between smoking prior to and during pregnancy and risk of AGT. Methods We utilized data from a prospective cohort of 1,006 Hispanic (predominantly Puerto Rican) prenatal care patients in Western Massachusetts. Women reported pre- and early pregnancy smoking at recruitment (mean = 15 weeks) and mid pregnancy smoking at a second interview (mean = 28 weeks). AGT was defined as > 135 …

Effects Of A Single Exercise Bout On Insulin Sensitivity In Black And White Individuals, Rebecca E. Hasson, Kirsten Granados, Stuart R. Chipkin, Patty S. Freedson, Barry Braun

Stuart R. Chipkin

Background: Previous research suggests non-Hispanic blacks (blacks) are more insulin resistant than non-Hispanic whites (whites). Physical activity can play an important role in reducing insulin resistance. However, it is unknown whether racial differences exist in response to exercise. Therefore, the purpose of this study was to compare metabolic responses to a single bout of exercise in blacks and age-, sex-, and body mass index-matched whites. Methods: Whole-body insulin sensitivity, glucose storage, glucose oxidation, and respiratory exchange ratio (RER) were assessed during a hyperinsulinemic-euglycemic clamp in normoglycemic blacks (n = 11) and whites (n = 10). Outcome measures were evaluated in …

Neurosteroids On The Epilepsy Chessboard — Keeping Seizures In Check, Michael A. Rogawski

Michael A. Rogawski

No abstract provided.

Treatment Of Batch In The Detection, Calibration, And Quantification Of Immunoassays In Large-Scale Epidemiologic Studies, Brian W. Whitcomb, Neil J. Perkins, Paul S. Albert, Enrique F. Schisterman

Brian W. Whitcomb

Many laboratory assays measure biomarkers via a 2-stage process. Direct measurement yields relative measures that are subsequently transformed to the unit of interest by using a calibration experiment. The calibration experiment is performed within the main experiment and uses a validation set for which true values are known and relative values are measured by assays to estimate the relation between relative and absolute values. Immunoassays, polymerase chain reaction, and chromatographic approaches are among assays performed in this manner. METHODS: For studies with multiple batches, data from more than a single calibration experiment are available. Conventionally, calibration of assays based on …

Use Of 15n Natural Abundance And N Species Concentrations To Assess N-Cycling In Constructed And Natural Coastalwetlands, C. Marjorie Aelion, Melissa R. Engle, Hongbo Ma

C. Marjorie Aelion

Natural abundance of N stable isotopes used in combination with concentrations may be useful indicators of N-cycling in wetlands. Concentrations and 15N signatures of NO −3 , NH + 4 , and sediment organic nitrogen (SON) were measured in two impacted coastal golf course retention ponds and two natural marshes. Limited NO − 3 was detected in natural site surface water or pore water, but both isotopic signature and concentrations of NO − 3 in surface water of impacted sites indicated anthropogenic inputs. In natural sites, NH + 4 concentrations were greatest in deeper pore water and least in surface …

Treatment Of Early And Late Kainic-Acid Induced Status Epilepticus With The Non-Competitive Ampa Receptor Antagonist Gyki 52466, Brita Fritsch, Jeffrey J. Stott, J. Joelle Donofrio, Michael A. Rogawski

Michael A. Rogawski

Purpose: Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA-A receptors are internalized progressively with continued seizure activity. Ionotropic glutamate receptors, including AMPA receptors, are externalized, so that AMPA receptor antagonists, which are broad-spectrum anticonvulsants, could be more effective treatments for satus epilepticus. We assessed the ability of the non-competitive AMPA receptor antagonist GYKI 52466 to protect against kainic acid-induced status epilepticus in mice. Methods: Groups of animals treated with kainic acid received GYKI 52466 (50 mg/kg followed in 15 min by 50 mg/kg) or diazepam (25 mg/kg followed in 20 min by 12.5 mg/kg) …

Enhancement Of The Cervical Cancer Screening Program In Malaysia: A Qualitative Study, Tin Tin Su

Tin Tin Su

Introduction: Cervical cancer has long been known as a preventable disease. Yet it still is a prime women's health issue globally. In Malaysia, the current cervical cancer screening program, introduced in the 1960s, has been found to be unsuccessful in terms of Pap smear coverage. The aim of this study is to determine providers perceptives on the program and the feasibility of practicing an organized cervical screening program in Malaysia. Methods: 11 key informant interviews were conducted with policy makers and health care providers from the Ministry of Health in Malaysia from October 2009 to May 2010. Interviewees' perceptions were …

A Critical Race Analysis Of The Hiring Process For Head Coaches In Ncaa College Football, Keith Harrison

Dr. C. Keith Harrison

In this article, we respond to Singer’s (2005) challenge to sport management scholars to consider race-based epistemologies in conducting certain kinds of research in the field, as we use critical race theory (CRT) as a framework to analyze the Black Coaches & Administrators (BCA) Hiring Report Card (HRC) (Harrison & Yee, 2009). The BCA HRC was created as a result of the access discrimination that has historically taken place in college sport (Brooks & Althouse, 2000; Cunningham & Sagas, 2005), which has consequently contributed to the underrepresentation of racial minorities in the head coach position in college football. The HRC …

Developing Constructs For Psychopathology Research: Research Domain Criteria, Charles A. Sanislow, Daniel S. Pine, Kevin J. Quinn, Michael J. Kozak, Marjorie A. Garvey, Robert K. Heinssen, Philip S. Wang, Bruce N. Cuthbert

Charles A. Sanislow, Ph.D.

There exists a divide between findings from integrative neuroscience and clinical research focused on mechanisms of psychopathology. Specifically, a clear correspondence does not emerge between clusters of complex clinical symptoms and dysregulated neurobiological systems, with many apparent redundancies. For instance, many mental disorders involve multiple disruptions in putative mechanistic factors (e.g., excessive fear, deficient impulse control), and different disrupted mechanisms appear to play major roles in many disorders. The Research Domain Criteria (RDoC) framework is a heuristic to facilitate the incorporation of behavioral neuroscience in the study of psychopathology. Such integration might be achieved by shifting the central research focus …