Medicine and Health Sciences Commons^™

Genetic Counselling And Testing For Inherited Gene Mutations In Newly Diagnosed Patients With Breast Cancer: A Review Of The Existing Literature And A Proposed Research Agenda, Bettina Meiser, Kathy Tucker, Michael Friedlander, Kristine Barlow-Stewart, Elizabeth Lobb, Christobel Saunders, Gillian Mitchell

Research outputs pre 2011

Many women newly diagnosed with breast cancer and with a strong family history of breast cancer are referred to a family cancer service for genetic counselling and for consideration of genetic testing for germline mutations in cancer predisposition genes following completion of their cancer treatment. However, there is growing evidence that mutation status may influence treatment recommendations, and that there may be benefits in having 'treatment-focused genetic counselling and testing' available shortly after cancer diagnosis. This article reviews the literature that could inform the development of treatment-focused genetic counselling and testing, including: the rationale for genetic testing to aid with …

A Luteinizing Hormone Receptor Intronic Variant Is Significantly Associated With Decreased Risk Of Alzheimer's Disease In Males Carrying An Apolipoprotein E Epsilon 4 Allele, Ryan J. Haasl, M Reza Ahmadi, Sivan Vadakkadath Meethal, Carey E. Gleason, Sterling C. Johnson, Sanjay Asthana, Richard L. Bowen, Craig S. Atwood

Research outputs pre 2011

Genetic and biochemical studies support the apolipoprotein E (APOE) ε4 allele as a major risk factor for late-onset Alzheimer's disease (AD), though ~50% of AD patients do not carry the allele. APOE transports cholesterol for luteinizing hormone (LH)-regulated steroidogenesis, and both LH and neurosteroids have been implicated in the etiology of AD. Since polymorphisms of LH beta-subunit (LHB) and its receptor (LHCGR) have not been tested for their association with AD, we scored AD and age-matched control samples for APOE genotype and 14 polymorphisms of LHB and LHCGR. Thirteen gene-gene interactions between the …

The Potential Role Of Life-Writing Therapy In Facilitating 'Recovery' For Those With Mental Illness, Philip Max Neilsen, Ffion Murphy

Research outputs pre 2011

This article addresses the experience of designing and conducting life-writing workshops for a group of clients with severe mental illness; the aim of this pilot study was to begin to determine whether such writing about the self can aid in individual ‘recovery’, as that term is understood by contemporary health professionals. A considerable amount has been written about the potential of creative writing in mental health therapy; the authors of this article provide a brief summary of that literature, then of the concept of ‘recovery’ in a psychology and arts therapy context. There follows a first-hand account by one of …

Regional Differences In Lumbar Spinal Posture And The Influence Of Low Back Pain, Tim Mitchell, Peter O'Sullivan, Angus Burnett, Leon Straker, Anne Smith

Research outputs pre 2011

Background: Spinal posture is commonly a focus in the assessment and clinical management of low back pain (LBP) patients. However, the link between spinal posture and LBP is not fully understood. Recent evidence suggests that considering regional, rather than total lumbar spine posture is important. The purpose of this study was to determine; if there are regional differences in habitual lumbar spine posture and movement, and if these findings are influenced by LBP. Methods: One hundred and seventy female undergraduate nursing students, with and without LBP, participated in this cross-sectional study. Lower lumbar (LLx), Upper lumbar (ULx) and total lumbar …

Promoting Healthy Weight In The Preschool Years: A Portfolio And Planning Guide To Address Barriers In Primary Care, Margaret Miller, Renee Campbell-Pope, Lydia Hearn

Research outputs pre 2011

The rapidly rising incidence of overweight and obesity in Australia, particularly among young children has led to an urgent need for effective prevention. Recent figures indicate that 15% of preschool children in Australia are overweight, and a further 6% are obese1,2, with rates rising steadily especially among children from lower socioeconomic groups.

Family, childcare, primary health care, early childhood education and the community are influential environments for young children3-7 with the potential to engage in an integrated approach to promote healthy weight and development of healthy eating and active lifestyle habits during the pre-school years5,8,9.

In 2006, the Child Health …

Falls, Depression And Antidepressants In Later Life: A Large Primary Care Appraisal, Ngaire Kerse, Leon Flicker, Jon J. Pfaff, Brian Draper, Nicola T. Lautenschlager, Moira Sim, John Snowdon, Osvaldo P Almeida

Research outputs pre 2011

Background: Depression and falls are common and co-exist for older people. Safe management of each of these conditions is important to quality of life.

Methods: A cross-sectional survey was used to examine medication use associated with injurious and non-injurious falls in 21,900 community-dwelling adults, aged 60 years or over from 383 Australian general practices recruited for the DEPS-GP Project. Falls and injury from falls, medication use, depressive symptoms (Primary Health Questionnaire (PHQ-9)), clinical morbidity, suicidal ideation and intent, health status (SF-12 Health Survey), demographic and lifestyle information was reported in a standardised survey.

Findings: Respondents were 71.8 years (sd 7.7) …

Participation In Sports, Arts And Racing And Its Relationship To Message Literacy And Health Behaviours, Christina Mills, Michael Rosenberg, Sarah French, Jenna Mitchell, Lisa Wood

Research outputs pre 2011

The purpose of this study was to assess health message awareness and health behaviours by participation/non participation in sport, arts and racing (SAR) in Western Australia. In this study a 'participant' was defined as someone who was (1) a member of a SAR organisation, group or club; and/or (2) having attended a SAR event as a spectator or audience member in the last 12 months. A 'non participant' was someone who did not participate in any SAR events as a member and/or spectator and/or audience member in the last 12 months.

Research Criteria For The Diagnosis Of Alzheimer's Disease: Genetic Risk Factors, Blood Biomarkers And Olfactory Dysfunction, Jonathan Foster, Hamid Sohrabi, Giuseppe Verdile, Ralph Martins

Research outputs pre 2011

No abstract provided.

Review Of The Social And Emotional Wellbeing Of Indigenous Australian Peoples, Darren Garvey

Research outputs pre 2011

The first case of diabetes among Indigenous people was recorded in Adelaide in 1923. Records prior to this time showed that Indigenous people were fit, lean, and did not suffer from any form of metabolic condition, which were largely believed to be a characteristic of European populations. The earliest detailed studies investigating the development of diabetes in Indigenous populations were not undertaken, however, until the early 1960s. These and subsequent studies found a significant correlation between the development of a ‘westernised’ lifestyle and the levels of type 2 diabetes in the Indigenous population.

Since that time, type 2 diabetes has …

A Review Of The Evaluation Of Healthway Sponsorships, Michael Rosenberg, Christina Mills, Joanna Granich, Renee Ferguson, Sarah French, Lisa Wood

Research outputs pre 2011

This study reviewed the methods used by Healthway to assess sponsorship implementation/value and to explore complimentary or alternative evaluation measures...

Interview questions related to sponsorship activities, procedures, requirements and evaluation. Suggestions for practical and alternative ways of assessing sponsorship implementation and conducting evaluations were also asked. In addition, the perceived value of sponsorship investments to Healthway and satisfaction with the existing evaluation framework were also sought...

The Relationship Between Isometric And Dynamic Strength In College Football Players, Michael R. Mcguigan, Jason Winchester

Research outputs pre 2011

Previous research has demonstrated the importance of both dynamic and isometric maximal strength and rate of force development (RFD) in athletic populations. The purpose of this study was to examine the relationships between measures of isometric force (PF), RFD, jump performance and strength in collegiate football athletes. The subjects in this study were twenty-two men [(mean ± SD):age 18.4 ± 0.7 years; height 1.88 ± 0.07 m; mass 107.6 ± 22.9 kg] who were Division I college football players. They were tested for PF using the isometric mid thigh pull exercise. Explosive strength was measured as RFD from the isometric …

Association Of Alleles Carried At Tnfa -850 And Bat1 -22 With Alzheimer's Disease, Anastazija Gnjec, Katarzyna D'Costa, Simon Laws, Ross Hedley, Kelvin Balakrishnan, Kevin Taddei, Georgia Martins, Athena Paton, Giuseppe Verdile, Samuel Gandy, Anthony Broe, William Brooks, Hayley Bennett, Olivier Piguet, Patricia Price, Judith Miklossy, Joachim Hallmayer, Patrick Mcgeer, Ralph Martins

Research outputs pre 2011

Background: Inflammatory changes are a prominent feature of brains affected by Alzheimer's disease (AD). Activated glial cells release inflammatory cytokines which modulate the neurodegenerative process. These cytokines are encoded by genes representing several interleukins and TNFA, which are associated with AD. The gene coding for HLA-B associated transcript 1 (BAT1) lies adjacent to TNFA in the central major histocompatibility complex (MHC). BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with AD pathology. In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and …

Organisational Survey: Impact Of Healthway Funding On Currently Funded And Previously Funded Sar Organisations, Michael Rosenberg, Sarah French, Jenna Mitchell, Christina Mills, Lisa Wood

Research outputs pre 2011

Since 1992, organisations in receipt of Healthway funding have demonstrated consistently high levels of commitment to sponsorship requirements. In part, the high levels of commitment observed may reflect a trend towards organisations with similar values to Healthway applying for funding. Organisations with different values to Healthway may receive funding once and decide that the sponsorship does riot match the needs of their organisation. This may result in difficulties fo.r Healthway to access hard to reach organisations, or to establish longer-term partnerships with Sports, Arts or Racing (SAR) organisations that target high priority groups. To better understand how Healthway's requirements of …

Pax7 Is Requisite For Maintenance Of A Subpopulation Of Superior Collicular Neurons And Shows A Diverging Expression Pattern To Pax3 During Superioir Collicular Development, Jennifer Thompson, Andreas Zembrzycki, Ahmed Mansouri, Melanie Ziman

Research outputs pre 2011

Pax7 encodes a transcription factor well-established as an important determinant of mesencephalic identity and superior collicular development. Pax7 mutant mice, however, present with no obvious morphological impairments to the superior colliculus. This finding is paradoxical and has been attributed to functional redundancy afforded by its paralogue Pax3. Here we utilise Pax7 mutant mice to investigate the precise role of this important developmental regulator during superior collicular development and neuronal specification/differentiation. We also assess its spatiotemporal relationship with Pax3 during embryonic development. Analysis of the superior colliculus of Pax7 mutant and wildtype mice at a variety of developmental timepoints revealed that …