Medicine and Health Sciences Commons^™

Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley

Dartmouth Scholarship

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited the Cdx-Hox pathway, a genetic program important for blood development, to enhance the differentiation of ESCs along the hematopoietic lineage. Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4 , we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice. Clonal analysis of retroviral integration sites …

A Hybrid Model For Reducing Ecological Bias, Ruth Salway, Jon Wakefield

UW Biostatistics Working Paper Series

A major drawback of epidemiological ecological studies, in which the association between area-level summaries of risk and exposure are used to make inference about individual risk, is the difficulty in characterising within-area variability in exposure and confounder variables. To avoid ecological bias, samples of individual exposure/confounder data within each area are required. Unfortunately these may be difficult or expensive to obtain, particularly if large samples are required. In this paper we propose a new approach suitable for use with small samples. We combine a Bayesian non-parametric Dirichlet process prior with an estimating functions approach, and show that this model gives …

A Huntington's Christmas Story: Ten Years Of Wondering, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Health-Exposure Modelling And The Ecological Fallacy, Jon Wakefield, Gavin Shaddick

UW Biostatistics Working Paper Series

Recently there has been increased interest in modelling the association between aggregate disease counts and environmental exposures measured, for example via air pollution monitors, at point locations. This paper has two aims: first we develop a model for such data in order to avoid ecological bias; second we illustrate that modelling the exposure surface and estimating exposures may lead to bias in estimation of health effects. Design issues are also briefly considered, in particular the loss of information in moving from individual to ecological data, and the at-risk populations to consider in relation to the pollution monitor locations. The approach …

Disaster And Emergency Communications Prior To Computers/Internet: A Review, John W. Farnham

Faculty Publications and Other Works -- Nursing

When communications are needed the most desperately and most urgently, the difficulty of effecting the desired communications increases exponentially. Recent natural disasters in different parts of the world have provided eloquent testament to this. The history of disaster or emergency communications can provide us with a foundation for understanding the problems encountered today, and can offer us insight into how we might improve the systems and processes for communications. The first applications of communication technology that allowed messages to be sent more rapidly than the fastest form of transportation were mainly military in origin. This review takes us from the …

Dump Truck Driver Dies After Unintentional Release Of Asphalt, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On June 6, 2005 a 55-year-old male dump truck driver (Driver 1) died when he was buried waist deep in 400-degree Fahrenheit asphalt. Driver 1 stopped along the highway to help another dump truck driver (Driver 2), (both were independent truck drivers), who had experienced brake problems. As the two men were examining the pneumatic brake system at the rear of the disabled dump truck, the tailgate opened unexpectedly, spilling hot asphalt onto the decedent who was under the rear of the truck.

To prevent similar incidents, the following recommendations have been made:

Recommendation No. 1: Tailgate chains should always …

Ada News - 12/12/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Analysis Of Indentation Loading Of Cortical Bone Using Acoustic Emission Techniques, Ashkan Safari, Ger Reilly, Brendan Mccormack

Conference Papers

In this study, we recorded the number of Acoustic emission (AE) hits and related AE energy during indentation fracture of cortical bone using a PAC PCI-2 card and pico sensor. A threshold value of 43dB was used to filter premature trigger due to background noise. Registered AE hits had more than one count (threshold crossing). Amplifier gain was set at 40dB with a (0.1-1) MHz band pass filter. 8mm cubes of cortical bones were indented in the longitudinal direction at constant crosshead speed of 1 mm min-1 using a large 2D, 50˚ wedge indenter. We hypothesised that signals occurring as …

Issn Roundtable: Faqs About The Issn, Jose Antonio, Marc Gann, Douglas Kalman, Frank Katch, Susan Kleiner, Richard Kreider, Darryn Willoughby

Department of Health and Human Performance Faculty Articles

: MISSION STATEMENT OF THE ISSN : The mission of the International Society of Sports Nutrition is to be recognized as the leading professional organization in the study and application of sports nutrition. The ISSN is dedicated to promoting and supporting the study, practice, education, research and development of sports nutrition and the sports nutrition profession. All information disseminated by the ISSN is unbiased and scientifically supported.

Orally Delivered, Plant-Produced Tat Protein Primes Mice For A Challenge Dna Vaccine Expressing Tat, A V. Karasev, S Foulke, C Wellens, I Zwierzynski, R Baldwin, H Koprowski, M S. Reitz Jr

Department of Microbiology and Immunology Faculty Papers

Oral Presentation.

Model Checking For Roc Regression Analysis, Tianxi Cai, Yingye Zheng

Harvard University Biostatistics Working Paper Series

The Receiver Operating Characteristic (ROC) curve is a prominent tool for characterizing the accuracy of continuous diagnostic test. To account for factors that might invluence the test accuracy, various ROC regression methods have been proposed. However, as in any regression analysis, when the assumed models do not fit the data well, these methods may render invalid and misleading results. To date practical model checking techniques suitable for validating existing ROC regression models are not yet available. In this paper, we develop cumulative residual based procedures to graphically and numerically assess the goodness-of-fit for some commonly used ROC regression models, and …

Ua12/2/1 College Heights Herald, Vol. 81, No. 23 [25], Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. Articles in this issue:

• Leslie, Joey. More Students Tested During AIDS Day
• Hupman, Samantha. J-term More Popular than Anticipated
• Fontana, Alex. Student Government Association Proposes New Bicycles for Police
• Bosken, Nina. Students Dodge, Duck, Dive for Charity and Prizes – Special Olympics
• Richardson, Kelly. Kentucky Community Technical College System Requests Funding – KCTCS
• Taking the Next Step – Cultural Diversity
• Eoff, Allison. Pass on Adderall
• Gabler, R. XXX Ads Disappointing
• Williams, Suzanne. A Woman’s Heart
• Hupman, Samantha. Two Fights Reported on Hill
• Paul, Corey. Kwanzaa to Be Celebrated Today …

Redesigning Practice To Improve Care Delivery (Boston), Laura A. Dummit, Lisa Sprague

National Health Policy Forum

This site visit focused on how the practice of medicine is changing or can be changed to improve care delivery across the spectrum of patient populations. Regarded as a “medical Mecca,” Boston is home to the academic health centers and teaching hospitals where many of the nation’s physicians are trained. As a center of innovation, Boston prides itself on its high bar with respect to standards of care. Panels addressed the used of clinical information technology (IT) in the physician’s office, in the hospital, and community-wide. Participants observed how IT is being used to further the mission of community health …

A Thanksgiving Visit: A Time To Reflect On Hd, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

History-Adjusted Marginal Structural Models To Estimate Time-Varying Effect Modification , Maya L. Petersen, Steven G. Deeks, Jeffrey N. Martin, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Much of epidemiology and clinical medicine is focused on the estimation of treatments or interventions administered over time. In such settings of longitudinal treatment, time-dependent confounding is often an important source of bias. Marginal structural models are a powerful tool for estimating the causal effect of a treatment using observational data, particularly when time-dependent confounding is present. Recent statistical work presented a generalization of marginal structural models, called history-adjusted marginal structural models. Unlike standard marginal structural models, history-adjusted marginal structural models can be used to estimate modification of treatment effects by time-varying covariates. Estimation of time-dependent causal effect modification is …

Aflatoxin Contamination Of Commercial Maize Products During An Outbreak Of Acute Aflatoxicosis In Eastern And Central Kenya, Karen E. Gieseker, Lauren Lewis, Mary Onsongo, Henry Njapau, Helen Schurz Rogers, George Luber, Stephanie Kieszak, Jack Nyamongo, Lorraine Backer, Abdikher Mohamud Dahiye, Ambrose Misore, Kevin Decock, Carol Rubin, Kenya Aflatoxicosis Investigation Group

Public Health Faculty Publications

n April 2004, one of the largest aflatoxicosis outbreaks occurred in rural Kenya, resulting in 317 cases and 125 deaths. Aflatoxin-contaminated homegrown maize was the source of the outbreak, but the extent of regional contamination and status of maize in commercial markets (market maize) were unknown. We conducted a cross-sectional survey to assess the extent of market maize contamination and evaluate the relationship between market maize aflatoxin and the aflatoxicosis outbreak. We surveyed 65 markets and 243 maize vendors and collected 350 maize products in the most affected districts. Fifty-five percent of maize products had aflatoxin levels greater than the …

Weight Gain In High-Risk Pregnant Women: Comparison By Primary Diagnosis And Type Of Care, Jennifer Herrera-Perdigon, Ellen Hopkins, Martha Marcalle, Dorothy Brooten, Joanne M. Youngblut, Maria Lourdes Lizardo

Nicole Wertheim College of Nursing and Health Sciences

Reasonable weight gain in pregnancy is essential for the health of the woman and fetus. The purpose of this secondary analysis was to examine patterns of prenatal weight gain in women with diabetes and hypertension using data from a randomized controlled trial examining physician-only (n = 29) versus APN and physician-delivered (n = 38) prenatal care. Data collection included gestational age at enrollment, delivery, diagnosis (diabetes, hypertension), prepregnancy body mass index (BMI), weight every 4 weeks during pregnancy, and total weight gain during pregnancy. Based on prepregnancy BMI, 21% of the sample was normal weight, 16% overweight, and 63% obese. …

Family Health Portrait, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Applications Of Pooled Dna Samples To The Assessment Of Population Affinities: Short Tandem Repeats, M. H. Crawford, P. Banerjee, D. A. Demarchi, M. Zlojutro, J. Mccomb, G. Livshits, M. Henneberg, M.J. Mosher, M. S. Schanfield, J. A. Knowles

Anthropology Faculty and Staff Publications

Pooled DNA samples have been used in association studies of Mendelian disease genes. This method involves combining equal quantities of DNA from patients and control subjects into separate pools and comparing the pools for distributions of genetic markers. In this study identical quantities of DNA from 300 individuals representing 6 populations were pooled and amplified for 296 loci using the touchdown polymerase chain reaction (PCR) method. The purpose of this study is to test the efficacy of pooled DNA markers in the reconstruction of the genetic structure of human populations. The populations sampled included Chuvash, Buryats, Kizhi, Native Americans, South …

Genotype-By-Sex Interaction In The Regulation Of High-Density Lipoprotein: Theframingham Heart Study, M.J. Mosher, L. J. Martin, L. A. Cupples, Q. Yang, T. D. Dyer, J. T. Williams, K. E. North

Anthropology Faculty and Staff Publications

Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL levels and the prevalence of CVD. However, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. We examined the evidence for genotypeby- sex effects on HDL in a longitudinal sample of 1,562 participants from 330 families in the Framingham Heart Study at three times points corresponding approximately to 1971-1974, 1980-1983, and 1988-1991. Using a variance component method, we conducted a genome scan of HDL at each time point in …

“Texts Memorized, Texts Performed: A Reconsideration Of The Role Of Paritta In Sri Lankan Monastic Education.”, Jeffrey Samuels

Philosophy & Religion Faculty Publications

During the past twenty years there has been a growing interest in monastic education within the larger field of Buddhist studies. Within the last ten years in particular, a number of monographs and articles examining the training and education of monks in Korea (Buswell [1992]), Tibet/India (Dreyfus [2003]), Thailand/Laos (Collins [1990], McDaniel [2002, 2003]), and Sri Lanka (Blackburn [1999a, 1999b, 2001] Samuels [2002]), have been published. Many of those works have paid particular attention to the texts used in monastic training, as well as to how the information contained in those very texts is imparted to and embodied by monks …

The Health Status Of Southern Children: A Neglected Regional Disparity, Jeffrey Goldhagen, Radley Remo, Thomas Bryant, Peter Wludyka, Amy B. Dailey, David Wood, Graham Watts, William Livingood

Health Sciences Faculty Publications

Purpose: Great variations exist in child health outcomes among states in the United States, with southern states consistently ranked among the lowest in the country. Investigation of the geographical distribution of children’s health status and the regional factors contributing to these outcomes has been neglected. We attempted to identify the degree to which region of residence may be linked to health outcomes for children with the specific aim of determining whether living in the southern region of the United States is adversely associated with children’s health status.

Methods: A child health index (CHI) that ranked each state in the United …

Placental Expression Of Angiopoietin-1, Angiopoietin-2 And Tie-2 During Placental Development In An Ovine Model Of Placental Insufficiency-Fetal Growth Restriction., Amy S Erickson Hagen, Ryan J Orbus, Randall B Wilkening, Timothy Regnault, Russell V Anthony

Paediatrics Publications

Fetal growth restriction (FGR) is associated with increased perinatal morbidity and mortality, and often results from functional placental insufficiency. Placentation requires extensive vasculogenesis and subsequent angiogenesis, in both maternal and fetal tissues. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for binding to a common receptor, Tunica interna endothelial cell kinase-2 (Tie-2). Our objective was to examine Ang-1, Ang-2 and Tie-2 expression in ovine placental tissue obtained from normal and FGR pregnancies throughout gestation. Fetal cotyledon and maternal caruncle tissue concentrations of Ang-1, Ang-2 and Tie-2 mRNA were assessed by real-time reverse transcriptase-polymerase …

Expert Testimony In Capital Sentencing: Juror Responses, John H. Montgomery, J. Richard Ciccone, Stephen P. Garvey, Theodore Eisenberg

Cornell Law Faculty Publications

The U.S. Supreme Court, in Furman v. Georgia (1972), held that the death penalty is constitutional only when applied on an individualized basis. The resultant changes in the laws in death penalty states fostered the involvement of psychiatric and psychologic expert witnesses at the sentencing phase of the trial, to testify on two major issues: (1) the mitigating factor of a defendant’s abnormal mental state and (2) the aggravating factor of a defendant’s potential for future violence. This study was an exploration of the responses of capital jurors to psychiatric/psychologic expert testimony during capital sentencing. The Capital Jury Project is …

What Is Comprehensive Sexuality Education Really All About? Perceptions Of Students Enrolled In An Undergraduate Human Sexuality Course, Eva Goldfarb

Department of Public Health Scholarship and Creative Works

The purpose of this study was to use qualitative evaluation techniques to explore the perceptions of students enrolled in undergraduate human sexuality classes regarding their expectations for the course as well as outcomes. One hundred forty-eight students were surveyed at the beginning and again at the end of the semester-long course. While pregnancy and STI prevention were considered important components of their courses, other outcomes associated with positive, healthy sexuality were given greater emphasis. Results suggest that while primary and secondary level sexuality education have been increasingly focused on abstinence-only education with a focus on pregnancy and STI reduction, this …

Ethics Of Critical Care, Bernard E. Rollin

Experimentation Collection

No abstract provided.

Representation Of Lexical Form: Evidence From Studies Of Sublexical Ambiguity, Conor T. Mclennan, Paul A. Luce, Jan Charles Luce

Psychology Faculty Publications

The authors examined the role of intermediate, sublexical representations in spoken word perception. In particular, they tested whether flaps, which are neutralized allophones of intervocalic /t/s and /d/s, map onto their underlying phonemic counterparts. In 2 shadowing tasks, the authors found that flaps primed their carefully articulated counterparts, and vice versa. Because none of the flapped stimuli were lexically ambiguous (e.g., between rater and raider), these results provide evidence that such priming is sublexically mediated. Therefore, the current study provides further insights into when underlying form-based representations are activated during spoken word processing. In particular, the authors argue that phonological …

The Caenorhabditis Elegans Heterochronic Regulator Lin-14 Is A Novel Transcription Factor That Controls The Developmental Timing Of Transcription From The Insulin/Insulin-Like Growth Factor Gene Ins-33 By Direct Dna Binding, Marta Hristova, Darcy Birse, Yang Hong, Victor Ambros

Dartmouth Scholarship

A temporal gradient of the novel nuclear protein LIN-14 specifies the timing and sequence of stage-specific developmental events in Caenorhabditis elegans. The profound effects of lin-14 mutations on worm development suggest that LIN-14 directly or indirectly regulates stage-specific gene expression. We show that LIN-14 can associate with chromatin in vivo and has in vitro DNA binding activity. A bacterially expressed C-terminal domain of LIN-14 was used to select DNA sequences that contain a putative consensus binding site from a pool of randomized double-stranded oligonucleotides. To identify candidates for genes directly regulated by lin-14, we employed DNA microarray hybridization to compare …

Rehab Exercise Prescription Sequencing For Shoulder External Rotators, Jason Brumitt, Erik Meira

Faculty Publications - College of Physical Therapy

Overhead athletes are susceptible to shoulder injuries. One component of a complete rehabilitation program is a systematic exercise prescription for the shoulder's external rotators. An overhead athlete should be progressed from basic rehab exercise positions to dynamic, sport-specific positions prior to returning to sport.

Velo-Cardio-Facial Syndrome, Robert J. Shprintzen, Anne Marie Higgins, Kevin M. Antshel, Wanda Fremont, Nancy Roizen, Wendy R. Kates

Communication Disorders Faculty Publications

Purpose of review: Velo-cardio-facial syndrome has emerged from obscurity to become one of the most researched disorders this past decade. It is one of the most common genetic syndromes in humans, the most common contiguous gene syndrome in humans, the most common syndrome of cleft palate, and the most common syndrome of conotruncal heart malformations. Velo-cardio-facial syndrome has an expansive phenotype, a factor reflected in the wide range of studies that cover both clinical features and molecular genetics. In this review, we cover multiple areas of research during the past year, including psychiatric disorders, neuroimaging, and the delineation of clinical …