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1996

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Full-Text Articles in Medicine and Health Sciences

Magnetic Resonance Imaging Of Ocular And Orbital Disease In 5 Dogs And A Cat, R Morgan, R Ring, Daniel Ward, William Adams Dec 2013

Magnetic Resonance Imaging Of Ocular And Orbital Disease In 5 Dogs And A Cat, R Morgan, R Ring, Daniel Ward, William Adams

Daniel A. Ward

Magnetic resonance (MR) images were acquired in 5 dogs and one cat with ocular and orbital disease. MR images were obtained in the dorsal or oblique dorsal, and oblique sagittal planes. Pathological changes identified in MR images included inflammatory lesions, cystic structures, and neoplasms. All abnormalities were readily apparent in T1-weighted images. MR findings in affected animals were often similar in signal intensity, location, and growth pattern to those found in humans with comparable diseases. Although no MR changes were considered pathognomonic for a given disease, MR imaging provided detailed information on the homogeneity, extent and invasiveness of the lesions.


Long-Term And High-Dose Trials Of Enzyme Replacement Therapy In The Canine Model Of Mucopolysaccharidosis I., E Kakkis, Michael Mcentee, A Schmidtchen, E Neufeld, Daniel Ward, Rebecca Gompf, Stephen Kania, C Bedolla, S Chien, R Shill Dec 2013

Long-Term And High-Dose Trials Of Enzyme Replacement Therapy In The Canine Model Of Mucopolysaccharidosis I., E Kakkis, Michael Mcentee, A Schmidtchen, E Neufeld, Daniel Ward, Rebecca Gompf, Stephen Kania, C Bedolla, S Chien, R Shill

Daniel A. Ward

Enzyme replacement is a potential therapy for mucopolysaccharidosis I (MPS I), a lysosomal storage disorder caused by alpha-L-iduronidase deficiency. Previous work showed improvement in the tissues of MPS I dogs treated intravenously for 3 months with recombinant human alpha-L-iduronidase (25,000 units or approximately 0.1 mg/kg/week). We have now treated an MPS I-affected dog for 13 months to assess the clinical effects of enzyme replacement. The treated dog gained more weight, was more active, and had less joint stiffness than the untreated littermate. Biochemical and histologic studies demonstrated uptake of alpha-L-iduronidase and decreased lysosomal storage in the ...


T9-T10 Intervertebral Disc Herniation In Three Dogs, B Wilkens, R Slecer, William Adams, William Thomas May 2013

T9-T10 Intervertebral Disc Herniation In Three Dogs, B Wilkens, R Slecer, William Adams, William Thomas

William B. Thomas, MS, DACVIM (Neurology)

Herniation of the T9-T10 intervertebral disc was diagnosed in three Dachshunds with acute paraplegia. The clinical diagnosis and surgical management of T9-T10 disc herniation are similar to that in the more common sites of disc herniation.


Treatment Of Blastomycosis With Itraconazole In 112 Dogs, Alfred Legendre, Barton Rohrbach, Robert Toal, M Rinaldi, L Grace, J Jones Dec 2010

Treatment Of Blastomycosis With Itraconazole In 112 Dogs, Alfred Legendre, Barton Rohrbach, Robert Toal, M Rinaldi, L Grace, J Jones

Alfred M Legendre DVM, MS, DACVIM

70 dogs with blastomycosis received 10 mg/kg of body weight of itraconazole, daily (group 1), and a second group of 42 dogs received 5 mg/kg of itraconazole, daily (group 2). The proportion of dogs cured with a 60-day course of itraconazole was similar for both groups (53.6% in group 1 vs. 54.3% in group 2) and for a control group treated with amphotericin B (57%); the recurrence rate was also similar, 20%, 21.4%, and 20%, respectively. Dogs treated with itraconazole had similar mortality rates (25.7% at 5 mg/kg; 25% at 10 mg/kg ...


Cerebrospinal Fluid Acid-Base Status During Normocapnia And Acute Hypercapnia In Equine Neonates, Dennis Geiser, Frank Andrews, Barton Rohrbach, M Provenza Oct 2010

Cerebrospinal Fluid Acid-Base Status During Normocapnia And Acute Hypercapnia In Equine Neonates, Dennis Geiser, Frank Andrews, Barton Rohrbach, M Provenza

Dennis R. Geiser DVM, DAVBP

Cerebrospinal fluid (CSF) and arterial and venous blood samples were collected every 15 min during 45 min of normocapnia and 90 min of hypercapnia in 10 isoflurane-anaesthetized foals. CSF samples were collected by subarachnoid catheter placed in the atlanto-occipital space. Comparison of blood and CSF gases during normocapnia indicated that CSF was significantly more acidic than blood. The lower pH was attributable to higher CO2 and lower bicarbonate concentrations than those in blood. During hypercapnia, CSF CO2 increased and pH decreased parallel to changes in blood, but changes were not as great as similar changes in venous blood, indicating that ...


Prediction Of Stress Appraisals From Mastery, Extraversion, Neuroticism, And General Appraisal Tendencies, S. H. Hemenover, Richard A. Dienstbier Dec 1996

Prediction Of Stress Appraisals From Mastery, Extraversion, Neuroticism, And General Appraisal Tendencies, S. H. Hemenover, Richard A. Dienstbier

Faculty Publications, Department of Psychology

Several personality dimensions (mastery, extraversion, and neuroticism) and a new General Appraisal Measure were used to predict stress appraisals made by college students in specific situations. Using multiple-regression techniques, mastery and general appraisal tendencies predicted appraisals for an intellectual task. Path analysis supported a structural model with general appraisal tendencies as a mediator between mastery and specific appraisal. In the second study mastery, extraversion, neuroticism, and general appraisal tendencies predicted appraisals for an academic stressor. Path analysis again supported the mediational nature of general appraisal tendencies from personality variables to specific appraisal. We discuss a potential causal mechanism between personality ...


Mill Owner Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center Dec 1996

Mill Owner Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 51-year-old mill owner (the victim) was killed while pulling a 16-foot log from the woods. He had reached the top of a 10-12-degree slope, turned slightly to the left and stopped, when the tractor he was driving turned over. It landed on the victim and then rolled again. The victim's partner, who was with him, ran to a nearby house where he had seen two men working outdoors earlier. He asked them to call 911 and then returned with a backhoe with which to lift the tractor. While he was doing this, emergency medical services (EMS) personnel arrived ...


Method For Obtaining Antifungal And Herbicidal Compounds That Target The First Committed Step In Shingolipid Long-Chain Base Biosynthesis, Robert C. Dickson, Robert L. Lester Dec 1996

Method For Obtaining Antifungal And Herbicidal Compounds That Target The First Committed Step In Shingolipid Long-Chain Base Biosynthesis, Robert C. Dickson, Robert L. Lester

Molecular and Cellular Biochemistry Faculty Patents

The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of the long-base component of the sphingolipids. The present specification describes the isolation of the LCB1 and LCB2 genes. The invention further relates to methods of using these genes to either inhibit SPT activity or to inhibit synthesis of the enzyme. Furthermore, the invention relates to methods for constructing strains of S. cerevisiae or other organisms that can be used to select and to test for compounds that either inhibit SPT activity ...


Farmer Killed When Caught In Hay Baler, Kentucky Injury Prevention And Research Center Dec 1996

Farmer Killed When Caught In Hay Baler, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 48-year-old part-time farmer was using a roll baler to bale hay on his farm around noon on a Saturday. Although there were no eyewitnesses to the event, it is believed that hay became clogged in the tines of the baler and he got off the tractor to try and force the hay in with his foot. His shoe or his pant leg became entangled in the tines of the baler and he was pulled into the machine.

In order to prevent similar incidents, FACE investigators recommend that

  • machinery always be turned off before the operator dismounts or attempts to ...


Farmer Killed When Crushed By Tractor, Kentucky Injury Prevention And Research Center Dec 1996

Farmer Killed When Crushed By Tractor, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 70-year-old farmer (the victim) was killed while mowing his pasture. He had completed mowing around the top of a ridge, and was beginning to mow the sloping sections, when the power take-off (PTO) shaft connecting the rotary mower (bushhog) to the tractor came off. When he attempted to re-attach the shaft, the tractor began to roll down the steep slope; he lost control as it descended into the hollow. Apparently he attempted to jump from the left side of the tractor and his right foot became wedged between the high/low shift lever; as a result his body went ...


Welder Dies After 30-Foot Fall From Steel Structure, Kentucky Injury Prevention And Research Center Dec 1996

Welder Dies After 30-Foot Fall From Steel Structure, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

A 31-year-old welder working at a construction site died after falling 30 feet. The victim, along with two co-workers, was on an I-beam structure preparing to weld handrails when the incident occurred. The victim informed his two co-workers that he was going to talk with another person on the crew and left the area. He was wearing a hard hat, full-body safety harness with two shock-absorbing lanyards, and steel-toed shoes. He went down one level and crossed a roped-off area, stepping onto a steel-grate floor. The unsecured flooring moved, and the victim fell 30 feet to the dirt floor below ...


Logger Killed By Falling Snag [96ky089], Kentucky Injury Prevention And Research Center Dec 1996

Logger Killed By Falling Snag [96ky089], Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 54-year-old logger (the victim) was killed after being struck on the head by a falling snag (dead standing tree). The victim was cutting the last tree to make up a load (3 trees) for the skidder. The driver was about 10-15 feet away, waiting for the last tree. He did not witness the incident. When the victim felled the tree, a nearby dead tree broke at a point approximately 12 feet up. The dead tree fell directly on the victim, striking him on the crown of the head. He was not wearing any type of head protection at the ...


Retired Farmer Thrown From And Run Over By Tractor, Kentucky Injury Prevention And Research Center Dec 1996

Retired Farmer Thrown From And Run Over By Tractor, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 67-year-old retired farmer (the victim) was killed while mowing a field of the family farm. He had made several passes around the field using a rotary mower recently equipped with new blades by his son. At one end of the field was an approximate 20-foot hill of 15-degree slope. The top of this hill was a plateau across which the tractor could be driven in order to ascend at the end which was less steep. The victim had come close to rolling the tractor over in the past, and so it was never his practice to mow across the ...


Beck, Barbara (Fa 301), Manuscripts & Folklife Archives Dec 1996

Beck, Barbara (Fa 301), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid only for Folklife Archives Project 301. Paper titled "Images of Nurses in the Print Media: 'RN Magazine,' January 1995-June 1995" written by Barbara Beck for a Western Kentucky University Folk Studies class.


Gross And Histological Features Of A Myofascial Trigger Point In The Upper Trapezius, Kathryn E. Levee Dec 1996

Gross And Histological Features Of A Myofascial Trigger Point In The Upper Trapezius, Kathryn E. Levee

Electronic Theses and Dissertations

The purpose of this study was to precisely locate, in living humans, a myofascial trigger point associated with the upper portion of the trapezius muscle (TrP1) that refers pain to the head and neck and to determine if this point is associated with anatomical structures. This study is descriptive and utilizes data from measurements of the location of TrP1 in relation to anatomical landmarks, of pressure sensitivity overlying the trigger point and electromyography recordings in localizing the trigger point. Information obtained from living humans was used to determine anatomical correlation to structures in cadavers. Results indicated there is little variability ...


Keynote Address: Science And Not-Science In Nurse Education, Stephen Kermode Dec 1996

Keynote Address: Science And Not-Science In Nurse Education, Stephen Kermode

School of Health and Human Sciences

Science is under threat from a number of sources. In nurse education a range of discourses have been attempting to marginalise science and to replace it with epistemologies which are deemed to be more appropriate. This paper examines the 'not-science' discourses of postmodernism and feminism and evaluates their importance to nursing through their relationship to, and effect on science.


Basement Membrane And Repair Of Injury To Peripheral Nerve: Defining A Potential Role For Macrophages, Matrix Metalloproteinases, And Tissue Inhibitor Of Metalloproteinases-1, Monique La Fleur, Johnnie L. Underwood, Daniel A. Rappolee, Zena Werb Dec 1996

Basement Membrane And Repair Of Injury To Peripheral Nerve: Defining A Potential Role For Macrophages, Matrix Metalloproteinases, And Tissue Inhibitor Of Metalloproteinases-1, Monique La Fleur, Johnnie L. Underwood, Daniel A. Rappolee, Zena Werb

Department of Obstetrics and Gynecology Research Publications

Injury to a peripheral nerve is followed by a remodeling process consisting of axonal degenera- tion and regeneration. It is not known how Schwann cell–derived basement membrane is pre- served after injury or what role matrix metalloproteinases (MMPs) and their inhibitors play in axonal degeneration and regeneration. We showed that the MMPs gelatinase B (MMP-9), stromelysin-1 (MMP-3), and the tissue inhibitor of MMPs (TIMP)-1 were induced in crush and distal segments of mouse sciatic nerve after injury. TIMP-1 inhibitor activity was present in excess of proteinase activity in extracts of injured nerve. TIMP-1 protected basement mem- brane type ...


Update - December 1996, Loma Linda University Center For Christian Bioethics Dec 1996

Update - December 1996, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Bioehtics Endowment Honors Jack and Margaret Provonsha
-- Partial Birth Abortion: Ethical Issues
-- Partial Birth Abortion: Mandates, Methods, and Morality
-- Partial Birth Abortion Dialogue


Training Examiners For A National Epidemiological Survey Of Oral Mucosal Lesions, Rosnah Binti Zain, Razak I. A., Ikeda N., Axéll T., Downer M. C. Dec 1996

Training Examiners For A National Epidemiological Survey Of Oral Mucosal Lesions, Rosnah Binti Zain, Razak I. A., Ikeda N., Axéll T., Downer M. C.

Prof. Dr. Rosnah Binti Zain

Ensuring the validity and reliability of data collected in epidemiological surveys is an important consideration. The purpose of the present report is to describe a training and calibration programme for 16 examiners taking part in a national survey of oral mucosal lesions and to present an evaluation of the results. The programme included the distribution of a pictorial manual to participants and a series of lectures followed by three diagnostic sessions, two using slides and the last involving patients. At the final session, the trainees classified 88 per cent of 16 patients correctly in comparison with the definitive diagnoses of ...


Using Information Technology Strategically In Home Care, Jerry A. Benson, Jeffrey E. Michelman, Doreen Radjenovic Dec 1996

Using Information Technology Strategically In Home Care, Jerry A. Benson, Jeffrey E. Michelman, Doreen Radjenovic

Accounting and Finance Faculty Publications

As home healthcare agencies examine new and innovative ways to deliver quality care more efficiently, the historical role of information technology as a way to automate clerical tasks will be significantly broadened to facilitate the true value of technology to home care providers. More importantly, a reduction in time spent on paperwork will allow agency caregivers to spend more time with clients. This article looks beyond the boundaries of desktop computing and examines the costs and benefits of network computing to develop strategic advantages for home healthcare agencies.


Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996 Dec 1996

Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996

Jefferson Medical College Alumni Bulletin

Jefferson Alumni Bulletin – Volume XLVI, Number 1, December 1996

Rational Drug Design, Page 4

Technology Transfer, Page 7

Clinical Trials, Page 9

World-Class Athletes and Drugs, Page 12

The Makings of the Complete Physician, Page 14

Major Alliance Links Jefferson with Mercy Health, Page 17

“Gene Repair” Corrects Mutation Leading to Disease, Page 19

Genetic Discoveries Lead to New Lung Cancer Tests, Page 20

Alumni Can Participate in JeffHOPE, Page 24

Student AMA Organizes Bone Marrow Drive, Page 25


Competitive Orientations And Motives Of Adult Sport And Exercise Participants, Diane L. Gill, Lavon Williams, Deborah A. Dowd, Christina M. Beaudoin, Jeffrey J. Martin Dec 1996

Competitive Orientations And Motives Of Adult Sport And Exercise Participants, Diane L. Gill, Lavon Williams, Deborah A. Dowd, Christina M. Beaudoin, Jeffrey J. Martin

Kinesiology, Health and Sport Studies

Participants in four different adult sport and exercise programs (running club, exercise classes, cardiac rehabilitation program, senior games) completed measures of competitive orientation and participation motivation. Our samples were older and more diverse than samples of previous research, and their competitive orientations and motives were similarly diverse. Multivariate analyses revealed gender and sample differences. Males were higher than females on competitiveness and win orientation, and runners were less win-oriented than other groups, but overall, all groups were similar to previous college-age samples in competitive orientation. Groups varied on specific motives, with females rating fitness, flexibility, affiliation, and appearance higher than ...


An Analysis Of Occupational Health In Pork Production, Terrance M. Hurley, James B. Kliebenstein, Peter Orazem Dec 1996

An Analysis Of Occupational Health In Pork Production, Terrance M. Hurley, James B. Kliebenstein, Peter Orazem

Economic Staff Paper Series

The rapid expansion of large-scale pork production has been accompanied by increasing . concerns regarding potential detrimental consequences of environmental hazards on the health of producers. This study makes use of health indicators obtained from attendees at the WorldPork Expo between 1991-and 1995 to evaluate the impact of pork production generally and of confinement production, specifically, on producer health., The analysis expands existing studies - because the larger number of participants allows for detailed analysis, both non farmers and non pork farmers are used as controls,.both objective as well as self-reported health measures ^e • considered, and personal characteristics such as height ...


Canine Hypoadrenocorticism (Canine Addison's Disease): History, Contemporary Diagnosis By Practicing Veterinarians, And Epidemiology, William James Kelch Dec 1996

Canine Hypoadrenocorticism (Canine Addison's Disease): History, Contemporary Diagnosis By Practicing Veterinarians, And Epidemiology, William James Kelch

Doctoral Dissertations

This study of canine hypoadrenocorticism (canine Addison's disease; adrenal insufficiency) used several techniques to determine the incidence and prevalence of the disease and to identify factors associated with its occurrence. These techniques were historical; statistical, including meta-analysis and logistic regression; and epidemiologic, including both case series and case control data. Data were gathered by: extracting the details of cases reported in the veterinary literature, a rudimentary meta-anaylsis; using data obtained by Ciba Animal Health in the clinical trial of the drug microcrystalline desoxycorticosterone pivalate (DOCP); using data obtained from the Veterinary Medical Data Base (VMDB), a data repository of ...


Predictors Of Depression Among Workers At The Time Of A Plant Closing, Nancy R. Vosler, Deborah Page-Adams Dec 1996

Predictors Of Depression Among Workers At The Time Of A Plant Closing, Nancy R. Vosler, Deborah Page-Adams

The Journal of Sociology & Social Welfare

Using an ecological theoretical perspective, this study of white male UAW workers stressed by a plant closing explored predictors of depression at multiple systems levels. The five best predictors of workers' depression were family strengths, age, economic strain, health, and social support. Additional bivariate predictors included self-esteem and having an alcohol problem at the individual level, marital status and family satisfaction at the family system level, and household income, home ownership, and key relationships at the social-environmental level. Implications for collaboration between direct-service and policy-practice social workers are discussed.


Moral Theory And Moral Life, Michael Pritchard Dec 1996

Moral Theory And Moral Life, Michael Pritchard

Center for the Study of Ethics in Society Papers

This paper was originally presented as The Distinguished Scholar Award Lecture, January 25, 1996.


Large Plasmids Of Avian Escherichia Coli Isolates, Dawn M. Doetkott, Lisa K. Nolan, Catherine W. Giddings, David L. Berryhill Dec 1996

Large Plasmids Of Avian Escherichia Coli Isolates, Dawn M. Doetkott, Lisa K. Nolan, Catherine W. Giddings, David L. Berryhill

Lisa K. Nolan

The plasmid DNA of 30 Escherichia coli isolates from chickens was extracted and examined using techniques designed to isolate large plasmids. This plasmid DNA was examined for the presence of certain known virulence-related genes including cvaC, tra7 and some aerobactin-related sequences. Seventeen of the 30 isolates contained from one to four plasmids greater than 50 kb in size. Eleven of these 17 strains possessed plasmids greater than 100 kb in size. Therefore, E. coli isolates of chickens frequently contain large plasmids, and many of these plasmids are likely to contain virulence related sequences.


Experience With Larangeal Mask Airway In Pakistani Patients, F A. Khan, M A. Afzal, R S. Kamal Dec 1996

Experience With Larangeal Mask Airway In Pakistani Patients, F A. Khan, M A. Afzal, R S. Kamal

Department of Anaesthesia

One hundred and thirty seven adult patients undergoing peripheral surgery were studied regarding ease of larangeal mask airway (LMA) insertion, airway maintenance during surgery and complication encountered during insertion, maintenance and in the postoperative period. In a majority (84%) of patients, the airway was positioned correctly at the first attempt, 3% patients had mild laryngospasm at insertion and in 85% a good airway was obtained. No airway related problems were encountered intraoperatively. Two percent patients had laryngospasm on removal of LMA. Postoperatively, the complaint of sore throat and uvular trauma was seen in 4% cases.


Prevalence Of Antimicrobial Resistance Among 723 Outpatient Clinical Isolates Of Moraxella Catarrhalis In The United States In 1994 And 1995: Results Of A 30-Center National Surveillance Study, Gary V. Doern, Angela B. Brueggemann, G Pierce, Tricia Hogan, H. Preston Holley Jr., Alan Rauch Dec 1996

Prevalence Of Antimicrobial Resistance Among 723 Outpatient Clinical Isolates Of Moraxella Catarrhalis In The United States In 1994 And 1995: Results Of A 30-Center National Surveillance Study, Gary V. Doern, Angela B. Brueggemann, G Pierce, Tricia Hogan, H. Preston Holley Jr., Alan Rauch

Open Access Articles

Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. The overall rate of beta-lactamase production was 95.3%. When the National Committee for Clinical Laboratory Standards MIC interpretive breakpoints for Haemophilus influenzae were applied, percentages of strains found to be susceptible to selected oral antimicrobial agents were as follows: azithromycin, clarithromycin, and erythromycin, 100%; tetracycline and chloramphenicol, 100%; amoxicillin-clavulanate, 100%; cefixime, 99.3%; cefpodoxime, 99.0%; cefaclor, 99.4%; loracarbef, 99.0 ...


Pain Levels And Rating Of Perceived Exertion Of People With Herniated Lumbar Disc While Walking In Two Environments, Brenda L. Cunningham-Boerger Dec 1996

Pain Levels And Rating Of Perceived Exertion Of People With Herniated Lumbar Disc While Walking In Two Environments, Brenda L. Cunningham-Boerger

Master's Theses

The purpose of the study was to investigate if walking in water is an effective substitute for walking on land as an aerobic exercise for people with herniated lumbar disc. The study involved the dependent variables o f perceived pain levels (PPL) and ratings o f perceived exertion (RPE). Independent variables were walking condition and work intensity. Land walking was performed on a treadmill; water walking was performed in an indoor pool 4.5 ft deep and 90*F. Work was set at four different intensities, based on the formula for predicting maximum heart rate (MHR), 220 minus age. The ...