Medicine and Health Sciences Commons^™

Simian Virus 40 Host Range/Helper Function Mutations Cause Multiple Defects In Viral Late Gene Expression., Terryl Stacy, Michele Chamberlain, Charles N. Cole

Dartmouth Scholarship

Simian virus 40 (SV40) deletion mutants dlA2459 and dlA2475 express T antigens that lack the normal carboxy terminus. These mutants are called host range/helper function (hr/hf) mutants because they form plaques at 37 degrees C on BSC-1 and Vero monkey kidney cell lines but not on CV-1p monkey kidney cells. Wild-type SV40 can provide a helper function to permit growth of human adenoviruses in monkey kidney cells; the hr/hf mutants cannot. Progeny yields of hr/hf mutants are also cold sensitive in all cell lines tested. Patterns of viral macromolecular synthesis in three cell lines (Vero, BSC-1, and CV-1) at three …

Correspondence - Resolution 89-3-F, Amos Gott, Howard Bailey, Charles Kupchella, Kevin Charles

Student Government Association

Correspondence regarding Resolution 89-3-F requesting AIDS, HIV and sexually transmitted disease education.

Ua12/2/1 College Heights Herald, Vol. 65, No. 19, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Hernes, Thomas. Officials Seek Gift for Recreation Center – Preston Health & Activities Center
• Lawson, Jamie. Graduate Ron Jerrell Tells 400 His Story of AIDS
• Summers, Kaye & Allison Tutt. Hilltopper Athletic Foundation Raises Support, $660,000
• Summers, Kaye & Allison Tutt. Students, School Lend Services to Athletics
• Eugene Evans to Outline Goals at Open Forum
• Potter Lot Closed Until Tomorrow
• University Logo to be Unveiled Today
• Kinslow, Gina. Central Women Get Tucked In – Minton Hall, Barnes-Campbell Hall
• Green, Travis. Associated Student Government Wants AIDS …

Resolution 89-3-F - Class On Sexually Transmitted Diseases, Wku Student Government Association

Student Government Association

Resolution requesting AIDS, HIV and sexually transmitted disease education.

Maternal-Neonatal Serum Vitamin A Concentrations., Girish S. Shirali, D G. Oelberg, K P. Mehta

Manuscripts, Articles, Book Chapters and Other Papers

Prevention of neonatal vitamin A deficiency is related to the adequacy of maternal vitamin A stores. In this study we investigated maternal and cord serum vitamin A and retinol-binding protein (RBP) values in an Indian population including, for the first time, clinically vitamin A-deficient mothers. Twenty-eight maternal-neonatal pairs were selected from maternal cohorts of high socioeconomic status without clinical evidence of vitamin A deficiency (group I) and low socioeconomic status with conjunctival xerosis and Bitot's spots (group II). Maternal education, caloric and vitamin A intakes, weight, height, hemoglobin, and birth weight were significantly lower in group II. Serum vitamin A …

In Vitro Evaluation Of Cancer Patient Immune Responses Following Infusion Of Radiolabeled Murine Monoclonal Antibody, Kelly A. King

Loma Linda University Electronic Theses, Dissertations & Projects

Several monoclonal antibody (MAb) types derived from mice have been developed specifically for the use of targeting human tumors. The specificity of these murine MAb’s for their respective tumor antigens is very high making them potentially good immunotherapeutic agents for cancer treatment and diagnosis. A limiting factor in using these murine MAb’s in patients is the development of human anti-mouse antibody (HAMA). The presence of HAMA may reduce the effectiveness of MAb for tumor targeting. If patient sensitization could be quickly detected following the initial infusion of MAb, then future infusion could be altered or terminated to prevent further sensitization. …

Enhancement Of Intratumor Antibody Distribution With A Bifunctional Antibody Delivery System And With Hyperthermia, Karen Lynn King

Loma Linda University Electronic Theses, Dissertations & Projects

The intratumor distribution of a new monoclonal antibody-hapten-based delivery system was examined. From two marine antibodies, Hybritech, Inc. has developed a bifunctional antibody (BPA) with specificities against CEA (ZCE-025 or GEM 231) and against one of two derivatives of [¹¹¹In]-benzyl-EDTA (CHA 255), EOTUBE or BLEDTA IV, to form ZCE/CHA or CEM/CHA. BFA accumulates in CEA-expressing tissue and clears from non-antigenic tissues prior to administration of an [¹¹¹In]-hapten.

Using five groups of nude mice bearing human colon tumor xenografts (T380), we evaluated different carriers of [¹¹¹In]-EOTUBE to prelocalized ZCE/CHA. We administered all antibodies and haptens …

Autonomic Nervous System And Cholesterol Transport, Yuan-Line Hung

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of autonomic nervous system on cholesterol transport is of clinical interest because the relationship between lipoprotein metabolism and atherogenesis is expressed in coronary artery disease.

Generally speaking, beta blockers increase serum VLDL level but decrease both HDL and HDL₂ cholesterol levels without affecting the LDL in humans. We are unaware of reports concerning the effects of metoprolol on lipoprotein metabolism nor comparison of the effects of metoprolol and propranolol in the unhandled rat model. In part I we employed the unhandled rats to compared the effects of these 2 drugs administered with the drinking water in order …

Factors Determining Peripheral Vascular Disease Clients' Intent To Adhere To Prescribed Behaviors, Gretchen Grahn Hitchcock

Nursing Theses & Dissertations

Motivation of clients with Peripheral Vascular Disease (PVD) to adhere to Recommended risk-reducing behaviors (RRB’s) was explored. The sample (n =30) was comprised of clients in a vascular physician group’s practice with a medical diagnosis of PVD. A nonexperimental, descriptive design was utilized to investigate how much variation in adherence to RRB’s by PVD clients could be accounted for by the client’s perceived effectiveness of a RRB and the client’s perceived difficulty in adhering to a RRB. A self-administered three part instrument, a demographic data form, and a self-administered qualitative data form were utilized to collect the data. Regression analysis …

Can Coal Miners Escape Black Lung--An Analysis Of The Coal Miner Job Transfer Program And Its Implications For Occupational Medical Removal Protection Programs, Emily A. Spieler

West Virginia Law Review

No abstract provided.

The Federal Black Lung Program: Its Evolution And Current Issues, Allen R. Prunty, Mark E. Solomons

West Virginia Law Review

No abstract provided.

More People May Be 20th Century's Greatest Feat, Chester Smolski

Smolski Texts

"This century may well go down in history as humanity's most productive period of accomplishment."

Breeding Phomopsis-Resistant Lupins, John Sylvester Gladstones

Journal of the Department of Agriculture, Western Australia, Series 4

The release of Gungurru and Yorrel lupins marks the coming of age of the narrow-leafed lupin as a crop plantt. These are the first cultivars of the species th have substantial resistance to Phomopsis stem blight, which will make the stubbles much safer for grazing stock.

This article describes the new lupins, their background, and how they were bred. It also acknowledges the contributions of colleagues who helped in important ways.

Leaf Diseases Of Wheat And Time Of Sowing, J M. Wilson

Journal of the Department of Agriculture, Western Australia, Series 4

Leaf diseases of wheat can be avoided by delaying the planting of a crop, but this often leads to reduced yield because the benefits of early sowing usually outweigh anylosses caused by leaf disease.

However, it is only in exceptional circumstances that farmers need to consider leaf disease when making decisions about planting date, as this article shows. Most examples are taken from department of Agriculture trials in its northern advisory region, but the principals apply to other agricultural areas.

What Is The Health Impact Of Day Care Attendance On Infants And Preschoolers?, Ruth L. Berkelman, Mary Guinan, Phen B. Thacker

Public Health Faculty Publications

The impact of various child care arrangements on the health of infants and preschool children is not known in any systematic way, yet by 1990 more than 10 million of these children may be receiving their care in day care facilities (1). Concerns over the health of these children and health practices within day care facilities have already led some States to place regulation of day care facilities under the jurisdiction of the department of health (2,3), and others are presently considering such legislation. In addition, the American Academy of Pediatrics has recently published "Health in Day Care," a manual …

Herpes Simplex Virus Type 2 Antibodies: High Prevalence In Monogamous Women In Costa Rica, Mark W. Oberle, Luis Rosero-Bixby, Francis K. Lee, Maria Sanchez-Braverman, A J. Nahmias, Mary Guinan

Public Health Faculty Publications

We studied the prevalence of antibody to Herpes simplex virus types I and 2 (HSV-I and HSV-2) in 766 randomly selected Costa Rican women 25-59 years of age in a national household survey in 1984-1985. Overall, 97.1% were seropositive for HSV-l and 39.4% for HSV -2. Only 1.1% of HSV -2 seropositive women gave a history of symptomatic genital herpes. HSV-2 virus antibody increased with age and with the number of lifetime sexual partners. HSV -2 seroprevalence among women who reported only 1 lifetime sexual partner was almost twice as high as the prevalence among women who denied sexual experience …

Economic Impact Of Growing Phomopsis-Resistant Lupins, J M. Warren, Jeremy Allen, Wallace Cowling

Journal of the Department of Agriculture, Western Australia, Series 4

The planting of Phomopsis-resistant lupins will increase net farm income. They will also alter the traditional blend of pastures and cropping, depending on grain and wool prices. In mixed farming areas of Western Australia's southern wheatbelt, they will allow more land to be sown to lupins rather than cereals on farms in which the lack of sheep feed over summer severely restricts wool production.

The benefits of Phompsis-resistant lupins arise from a reduction in sheep deaths due to lupinosis, a longer safe grazing period (free from lupinosis) on lupin stubbles, a decrease in the need for supplementary sheep feed over …

Evaluation Of The Crack Approach For The Control Of Drench Resistance In Sheep Worms, J R. Edwards, Helen Chapman, Jon Dunsmore

Journal of the Department of Agriculture, Western Australia, Series 4

The Department of Agriculture launched the CRACK approach to worm control in September 1985 in response to finding that anthelmintic (drench) resistant worms were present on 68 per cent of a random selection of Western Australian sheep farms.

The high cost of internal parasites in terms of lost production and drench costs, together with the high prevalence of resistant worms of farms, confirmed that changes were needed to existing parasite control measures in sheep.l

Farmers' Estimations Of Sheep Weights To Calculate Drench Dose, R B. Besier, Diane Hopkins

Journal of the Department of Agriculture, Western Australia, Series 4

Undersosing with drenches is a mojor cause of anthelmintic (drench) resistance in worm parasites of sheep.

When farmers use a drench at less than the recommended dose rate, some worms may survive, and their ability to resist treatment with the chemical involved is passed to their offspring. Over a period of time, matings between worms with different degrees of resistance can produce individuals able to resist the drench at the recommended dose rate or even higher.

Farmers must use adequate dose rates so that worms do not have a chance to survive treatment.

Case Report Of Human Infection With Capillaria Philippinensis, Ching-Yu Chen, Wei-Chuan Hsieh, Tsang-Lie Chen

Harold W. Manter Laboratory: Library Materials

In July 1988, a case of human infection with Capillaria philippinensis, so-called the intestinal capillariasis, was discovered at the National Taiwan University Hospital (NTUH). This is the first case reported in Taiwan.

Capillaria philippinesis is a parasite of fish-eating birds In nature it has a fish-bird life cycle. When human populations disrupt the natural cycle by eating raw fish infected with the larvae of C. philippinensis, they may acquire the disease.