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Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Graduate School of Medicine - Papers (Archive)
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological (M) and supraphysiological (MZ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry before and during insulin administration. mTG was determined in vastus lateralis muscles obtained by percutaneous biopsy. Percentage of body fat (mean 29 ± 1%, …