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Full-Text Articles in Medicine and Health Sciences
Should Methionine Be Added To Every Paracetamol Tablet?, Alison L. Jones, P C. Hayes, A T. Proudfoot, J A. Vale, L F. Prescott
Should Methionine Be Added To Every Paracetamol Tablet?, Alison L. Jones, P C. Hayes, A T. Proudfoot, J A. Vale, L F. Prescott
Graduate School of Medicine - Papers (Archive)
Paracetamol is commonly used for self poisoning, and the costs of treating the resulting liver failure in the few who develop it are high. The morbidity could be avoided by adding methionine to paracetamol tablets, but this would mean that the millions of people who take paracetamol responsibly would have to take methionine unnecessarily. Alison Jones and colleagues and Edward Krenzelok debate the issue.
Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Graduate School of Medicine - Papers (Archive)
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological (M) and supraphysiological (MZ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry before and during insulin administration. mTG was determined in vastus lateralis muscles obtained by percutaneous biopsy. Percentage of body fat (mean 29 ± 1%, …