Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
The Effect Of Vasoconstrictors On Oxygen Consumption In Resting And Contracting Skeletal Muscle Of The Autologous Pump-Perfused Rat Hindlimb, Andrew Hoy, Peter L. Mclennan, Gregory E. Peoples
The Effect Of Vasoconstrictors On Oxygen Consumption In Resting And Contracting Skeletal Muscle Of The Autologous Pump-Perfused Rat Hindlimb, Andrew Hoy, Peter L. Mclennan, Gregory E. Peoples
Graduate School of Medicine - Papers (Archive)
No abstract provided.
Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Skeletal Muscle Triglyceride Levels Are Inversely Related To Insulin Action, D A. Pan, S Lillioja, A D. Kriketos, M R. Milner, L A. Baur, C Bogardus, A B. Jenkins, L H. Storlien
Graduate School of Medicine - Papers (Archive)
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological (M) and supraphysiological (MZ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry before and during insulin administration. mTG was determined in vastus lateralis muscles obtained by percutaneous biopsy. Percentage of body fat (mean 29 ± 1%, …
Skeletal Muscle Membrane Lipid Composition Is Related To Adiposity And Insulin Action, David A. Pan, Stephen Lillioja, Michael R. Milner, Adamandia D. Kriketos, Louise A. Baur, Clifton Bogardus, Leonard H. Storlien
Skeletal Muscle Membrane Lipid Composition Is Related To Adiposity And Insulin Action, David A. Pan, Stephen Lillioja, Michael R. Milner, Adamandia D. Kriketos, Louise A. Baur, Clifton Bogardus, Leonard H. Storlien
Graduate School of Medicine - Papers (Archive)
The cellular basis of insulin resistance is still unknown, however, relationships have been demonstrated between insulin action in muscle and the fatty acid profile of the major membrane structural lipid (phospholipid). The present study aimed to further investigate the hypothesis that insulin action and adiposity are associated with changes in the structural lipid composition of the cell. In 52 adult male Pima Indians, insulin action (euglycemic clamp), percentage body fat (pFAT; underwater weighing), and muscle phospholipid fatty acid composition (percutaneous biopsy of vastus lateralis) were determined. Insulin action (high-dose clamp; MZ) correlated with composite measures of membrane unsaturation (% C20-22 …
Skeletal Muscle Capillary Density And Fiber Type Are Possible Determinants Of In Vivo Insulin Resistance In Man., Stephen Lillioja, A Young, Carol L. Culter, John L. Ivy, W Abbott, J K. Zawadzki, H Yki-Jarvinen, L Christin, Timothy W. Secomb, Clitton Bogardus
Skeletal Muscle Capillary Density And Fiber Type Are Possible Determinants Of In Vivo Insulin Resistance In Man., Stephen Lillioja, A Young, Carol L. Culter, John L. Ivy, W Abbott, J K. Zawadzki, H Yki-Jarvinen, L Christin, Timothy W. Secomb, Clitton Bogardus
Graduate School of Medicine - Papers (Archive)
We have compared the capillary density and muscle fiber type of musculus vastus lateralis with in vivo insulin action determined by the euglycemic clamp (M value) in 23 Caucasians and 41 Pima Indian nondiabetic men. M value was significantly correlated with capillary density (r = 0.63; P less than or equal to 0.0001), percent type I fibers (r = 0.29; P less than 0.02), and percent type 2B fibers (r = -0.38; P less than 0.003). Fasting plasma glucose and insulin concentrations were significantly negatively correlated with capillary density (r = -0.46, P less than or equal to 0.0001; r …