Medicine and Health Sciences Commons^™

A Novel Elvitegravir Nanoformulation For Drug Delivery Across The Blood-Brain Barrier To Suppress Hiv-1 In Macrophages And Microglia, Yuqing Gong

Theses and Dissertations (ETD)

Over the last two decades, the use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection. However, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The appearance and persistence of HAND are partially due to the entry of HIV-1-infected monocytes into the brain. Within the central nervous system (CNS), HIV-1-infected macrophages and microglia serve as the major viral reservoirs and provide active viral replication even when systemic viral suppression has been achieved by ART. Efficient viral suppression of CNS macrophages and microglia is important for an effective HIV-1 treatment in the brain. The primary …

Us Guided Management Of Undifferentiated Dyspneic Patient In The Ed, Kaleigh Miller

Longitudinal Scholar's Project

Intro: Undifferentiated dyspnea can be a complicated presentation muddled by patient comorbidities and similar symptomology shared among etiologies. Some studies have shown increased mortality and length of stay in the hospital when incorrectly initially diagnosed in the ED. US has been shown more effective at differentiating these causes and improves diagnostic accuracy. This study will implement US exam upon initial exam of patient and chart time to diagnosis/treatment, length of stay in ED, length of stay in hospital admissions versus discharge rates, and 30 day mortality. ADHF and COPD/asthma patient differentiation will be the focus.

Methods: Prospective cohort study of …

How One Library’S Location Change Impacted Health Information Requests: Comparing Zip Codes And Health Disparities To Inform Library Services: Data Files, David Petersen, Martha Earl, Cameron Watson, Kelsey Grabeel

Faculty Publications

No abstract provided.

A Dynamic Ankle Orthosis For Alleviating Mechanical Foot And Ankle Pain, Preserving Joint Motion, And Restoring Patient Function, Chloe Ly Chung

Theses and Dissertations (ETD)

Over two million Americans visit the doctor each year for foot and ankle pain stemming from a degenerative condition or injury. Standard of care ankle-foot orthoses have been shown to effectively manage pain symptoms of the lower limb, but they can also significantly hinder joint motion and limit function. The Dynamic Ankle Orthosis (DAO) was created with the intent to alleviate pain using an offloading mechanism without interfering with natural joint motion. This dissertation presents the development, benchtop validation, functional assessment, and clinical evaluation of this novel treatment option for patients suffering from acute and chronic foot and ankle pain.A …

Tobacco/Hiv-1-Induced Myeloid Cell-Derived Extracellular Vesicles In Hiv-1 Pathogenesis, Sanjana Haque

Theses and Dissertations (ETD)

Introduction. Smoking, which is highly prevalent in people living with HIV/AIDS, has been shown to exacerbate HIV-1 replication, in part via cytochrome P450 (CYP)-induced oxidative stress. CYP enzymes metabolize cigarette smoke condensate (CSC), causing oxidative stress and cytotoxicity. Our previous studies have demonstrated that CSC and specific CSC constituents, benzo(a)pyrene and nicotine, potentially induce CYPs, resulting in higher oxidative stress and subsequent exacerbation of HIV-1 replication in monocytes and macrophages. However, the exact mechanism behind tobacco-induced, oxidative stress-mediated enhancement of HIV-1 replication is still poorly understood. Extracellular vesicles (EVs) have recently gained attention for their unique nature as intercellular messengers …