Medicine and Health Sciences Commons^™

A Comparative Effectiveness Meta-Analysis Of Drugs For The Prophylaxis Of Migraine Headache, Jeffrey L. Jackson, Elizabeth Cogbill, Rafael Santana-Davila, Christina Eldredge, William Collier, Andrew Gradall, Neha Sehgal, Jessica Kuester

School of Information Faculty Publications

OBJECTIVE: To compare the effectiveness and side effects of migraine prophylactic medications.

DESIGN: We performed a network meta-analysis. Data were extracted independently in duplicate and quality was assessed using both the JADAD and Cochrane Risk of Bias instruments. Data were pooled and network meta-analysis performed using random effects models.

DATA SOURCES: PUBMED, EMBASE, Cochrane Trial Registry, bibliography of retrieved articles through 18 May 2014.

ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included randomized controlled trials of adults with migraine headaches of at least 4 weeks in duration.

RESULTS: Placebo controlled trials included alpha blockers (n = 9), angiotensin converting enzyme inhibitors …

A Novel Algorithm For Analyzing Drug-Drug Interactions From Medline Literature, Yin Lu, Dan Shen, Maxwell Pietsch, Chetan Nagar, Zayd Fadli, Hong Huang, Yi-Cheng Tu, Feng Chen

School of Information Faculty Publications

Drug-drug interaction (DDI) is becoming a serious clinical safety issue as the use of multiple medications becomes more common. Searching the MEDLINE database for journal articles related to DDI produces over 330,000 results. It is impossible to read and summarize these references manually. As the volume of biomedical reference in the MEDLINE database continues to expand at a rapid pace, automatic identification of DDIs from literature is becoming increasingly important. In this article, we present a random-sampling-based statistical algorithm to identify possible DDIs and the underlying mechanism from the substances field of MEDLINE records. The substances terms are essentially carriers …