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A Comparative Effectiveness Meta-Analysis Of Drugs For The Prophylaxis Of Migraine Headache, Jeffrey L. Jackson, Elizabeth Cogbill, Rafael Santana-Davila, Christina Eldredge, William Collier, Andrew Gradall, Neha Sehgal, Jessica Kuester
A Comparative Effectiveness Meta-Analysis Of Drugs For The Prophylaxis Of Migraine Headache, Jeffrey L. Jackson, Elizabeth Cogbill, Rafael Santana-Davila, Christina Eldredge, William Collier, Andrew Gradall, Neha Sehgal, Jessica Kuester
School of Information Faculty Publications
OBJECTIVE: To compare the effectiveness and side effects of migraine prophylactic medications.
DESIGN: We performed a network meta-analysis. Data were extracted independently in duplicate and quality was assessed using both the JADAD and Cochrane Risk of Bias instruments. Data were pooled and network meta-analysis performed using random effects models.
DATA SOURCES: PUBMED, EMBASE, Cochrane Trial Registry, bibliography of retrieved articles through 18 May 2014.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included randomized controlled trials of adults with migraine headaches of at least 4 weeks in duration.
RESULTS: Placebo controlled trials included alpha blockers (n = 9), angiotensin converting enzyme inhibitors …