Medicine and Health Sciences Commons^™

Hospitalized Adult Patient Characteristics Associated With Participation In A Volunteer-Assisted Mobility Program: A Feasibility Study, Gordana Dermody, Tamara Odom-Maryon, Jennifer Zimmerman, Courtney Glass

Research outputs 2014 to 2021

BACKGROUND:

Physical inactivity during hospitalization commonly results in functional decline. Structured multidisciplinary programs/approaches may be useful to promote mobility in hospitalized adults.

PURPOSE:

The purpose was to determine whether a volunteer-assisted mobility program was feasible to improve the ambulation of hospitalized patients, and examine the characteristics of patients associated with willingness to participate in the program.

METHODS:

A prospective descriptive correlation study was conducted in 2 acute care units. A volunteer-staffed program was implemented with the aim of improving the ambulation of hospitalized patients.

RESULTS:

Hospitalized patients (N = 490) were approached, with 39.2% (n = 192) agreeing to ambulate …

Excisional Treatment Comparison For In Situ Endocervical Adenocarcinoma (Excise): A Phase 2 Pilot Randomized Controlled Trial To Compare Histopathological Margin Status, Specimen Size And Fragmentation After Loop Electrosurgical Excision Procedure And Cold Knife Cone Biopsy, Paul A. Cohen, Yee Leung, Lyndal Anderson, Rachael Van Der Griend, Paola Chivers, Sanela Bilic, Sophie Bittinger, Alison Brand, Max K. Bulsara, Jim Codde, Lois Eva, Louise Farrell, Dianne Harker, Unine Herbst, Stephanie Jeffares, Diane Loh, Orla Mcnally, Ganendra Raj Mohan, Tarryn Nicholson, Aime Powell, Stuart G. Salfinger, Bryony Simcock, Colin Stewart, Julie Silvers, Martin R. Stockler, Peter Sykes, Pennie Stoyles, Adeline Tan, Ai Ling Tan, C. David H. Wrede

Research outputs 2014 to 2021

Objective:

Adenocarcinoma in situ (AIS) of the cervix is a precursor to cervical adenocarcinoma. When AIS is detected by cervical screening an excision biopsy is mandatory to exclude invasion. We aimed to compare margins status, specimen size and fragmentation after loop electrosurgical excision procedure (LEEP) and ‘cold knife cone biopsy’ (CKC).

Methods:

The EXCISE Trial was an investigator-initiated, multicenter, open-label, parallel-group, phase 2, randomized study. Patients were enrolled at seven hospitals in Australia and New Zealand. We randomly assigned women aged ≥ 18 to ≤ 45 years with screen detected AIS to LEEP or CKC. Co-primary endpoints were margin status, …

The Aboriginal Gap In Online Active Vaccine Safety Surveillance, Patrick Cashman, Sally-Anne Munnoch, Katrina Clark, Natalie Allan, Stephen Clarke, Kristine Macartney, David Durrheim

Australian Indigenous HealthBulletin

Objectives: To investigate if Aboriginal people are equally included in new forms of vaccine safety post-marketing surveillance that support safety signal detection and confidence in the vaccine program by comparing the use of Vaxtracker active adverse events following immunisation (AEFI) surveillance between Aboriginal and non-Aboriginal parents of vaccinated children.

Methods: In 2016, automated AEFI surveillance was conducted to monitor seasonal influenza vaccine in children aged 18 months to less than 5 years and for DTPa vaccine after the inclusion of a new dose at 18 months of age. To explore reasons for non-response, Aboriginal Immunisation Officers contacted the …

Pd-L1 Expression On Circulating Tumor Cells May Be Predictive Of Response To Pembrolizumab In Advanced Melanoma: Results From A Pilot Study, Muhammad K. Khattak, Anna L. Reid, James Freeman, Michelle Pereira, Ashleigh Mcevoy, Johnny Lo, Markus Frank, Tarek Meniawy, Ali Didan, Isaac Spencer, Benhur Amanuel, Michael Millward, Mel Ziman, Elin Gray

Research outputs 2014 to 2021

BACKGROUND: PD-1 inhibitors are routinely used for the treatment of advanced melanoma. This study sought to determine whether PD-L1 expression on circulating tumor cells (CTCs) can serve as a predictive biomarker of clinical benefit and response to treatment with the PD-1 inhibitor pembrolizumab.

METHODS: Blood samples were collected from patients with metastatic melanoma receiving pembrolizumab, prior to treatment and 6-12 weeks after initiation of therapy. Multiparametric flow cytometry was used to identify CTCs and evaluate the expression of PD-L1.

RESULTS: CTCs were detected in 25 of 40 patients (63%). Patients with detectable PD-L1

CONCLUSION: Our results reveal the potential of …

Medical Decision Making Using Knowledge Of Patient Identification As Aboriginal Or Torres Strait Islander: What Do Medical Students Think?, Winnifred Knight, Michael J. Platow, Diana M. Grace, Oliver Tye, Jess Styles

Australian Indigenous HealthBulletin

Objective

Best-practices guidelines require Australian health practitioners to ask all patients “are you [is the person] of Aboriginal and/or Torres Strait Islander origin?”. The present study investigated medical student attitudes regarding medical decisions made after asking this standard status question.

Methods

A hypothetical interaction between a doctor and an Aboriginal patient was presented in a pen-and-paper questionnaire in which: (1) the doctor considered (or did not consider) the patient’s Indigenous status relevant to make a medical diagnosis, and (2) the doctor registered (or did not register) the patient for the Closing the Gap PBS co-payment. Participants were first- and second-year …

An Exploration Of Interventions For Healing Intergeneration Trauma To Develop Successful Healing Programs For Aboriginal Australians: A Literature Review, Alison J. Simpson, William Abur, James A. Charles

Australian Indigenous HealthBulletin

Introduction

Health outcomes and life expectancy of Indigenous people throughout the world are far poorer than non-Indigenous populations. Emerging evidence from research shows that many social issues which impact on Indigenous peoples globally is linked to trauma over generations. This review explores literature about Indigenous people from around the world to seek interventions which have been successful in healing intergenerational trauma.

Method

To identify interventions that have been successful in healing intergenerational trauma amongst Indigenous populations globally, a systematic search strategy was conducted using keywords and synonyms related to the topic. Peer reviewed academic literature was sourced from four …

Serum Midkine, Estimated Glomerular Filtration Rate And Chronic Kidney Disease-Related Events In Elderly Women: Perth Longitudinal Study Of Aging Women, Jeffrey Wang, Joshua R. Lewis, Elizabeth Byrnes, Germaine Wong, Warren D. Raymond, Kun Zhu, Graham R. Robertson, Wai H. Lim, Qi Cao, Richard L. Prince, Vincent W. Lee

Research outputs 2014 to 2021

© 2020, The Author(s). Midkine (MDK), a heparin-binding growth factor cytokine, is involved in the pathogenesis of kidney diseases by augmenting leukocyte trafficking and activation. Animal models and small case control studies have implicated MDK as a pathological biomarker in chronic kidney diseases (CKD), however this is yet to be confirmed in prospective human studies. In a prospective study of 499 elderly, predominantly Caucasian women aged over 70 years the association between serum MDK collected in 1998, and renal function change and the risk of CKD-related hospitalisations and deaths at 5 and 14.5 years, respectively, was examined. Baseline serum MDK …

Association Between Remnant Lipoprotein Cholesterol Levels And Non-Alcoholic Fatty Liver Disease In Adolescents, Justin Chin, Trevor A. Mori, Leon A. Adams, Lawrence J. Beilin, Rae-Chi Huang, John K. Olynyk, Oyekoya T. Ayonrinde

Research outputs 2014 to 2021

Background & Aims: Remnant lipoprotein cholesterol (RLP-C) is an atherogenic lipid profile associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). With increased rates of CVD seen in adults with NAFLD, RLP-C has the potential to identify individuals with NAFLD who are at increased risk of CVD. This study examined in adolescents sex-different associations among RLP-C, NAFLD, and cardiometabolic risk factors, and whether RLP-C is associated with NAFLD beyond traditional cardiometabolic risk factors. Methods: Adolescents in the Raine Study had anthropometry, clinical, biochemistry and arterial stiffness measurements recorded at 17 years of age. Fatty liver, subcutaneous and visceral …

A Race For A Better Understanding Of Covid-19 Vaccine Non-Adopters, Zhaohui Su, Jun Wen, Jaffar Abbas, Dean Mcdonnell, Ali Cheshmehzangi, Xiaoshan Li, Junaid Ahmad, Sabina Šegalo, Daniel Maestro, Yuyang Cai

Research outputs 2014 to 2021

In this paper, we aim to underscore the need for a more nuanced understanding of vaccine non-adopters. As the availability of vaccines does not translate into their adoption-a phenomenon that may be more pronounced amid "Operation Warp Speed"-it is important for public health professionals to thoroughly understand their "customers" (i.e., end users of COVID-19 vaccines) to ensure satisfactory vaccination rates and to safeguard society at large.

Biological System Energy Algorithm Reflected In Sub-System Joint Work Distribution Movement Strategies: Influence Of Strength And Eccentric Loading, Jeffrey M. Mcbride, Sophia Nimphius

Research outputs 2014 to 2021

© 2020, The Author(s). To better understand and define energy algorithms during physical activity as it relates to strength and movement strategy of the hip, knee and ankle, a model of increasing eccentric load was implemented in the current investigation utilizing a countermovement jump and a series of drop jumps from different heights (15, 30, 45, 60, 75 cm). Twenty-one participants were grouped by sex (men, n = 9; women, n = 12) and muscle strength (higher strength, n = 7; moderate strength, n = 7; lower strength, n = 7) as determined by a maximal squat test. Force plates …

Prospective Reporting Of Injury In Community-Level Cricket: A Systematic Review To Identify Research Priorities, Geordie Mcleod, Siobhán O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

© 2020 Sports Medicine Australia Objectives: Cricket is a popular sport enjoyed worldwide. Injuries in cricket are not well understood at community level but are important to understand for prevention to ensure the game continues to be enjoyed safely. This systematic review was designed to assess the quality of data collection and reporting, and to summarise the injury data, in studies of community cricket players. Design: Systematic review. Methods: Nine databases were searched to November 2018 using the terms “cricket*” and “injur*”. A nine-item critical appraisal and three-item likelihood-of-bias evaluation was conducted on included studies. Data completeness was evaluated against …

Medication Use Among Older Australians Seeking Alcohol And Other Drug Treatment, Stephen Bright, John Milroy, Katherine Walsh, Emily Blatchford

Research outputs 2014 to 2021

Objective:

To describe the use of medications that interact with alcohol or for which alcohol reduces the medication's efficacy in older adults consuming alcohol at hazardous levels.

Method:

Retrospective file audit of patients discharged from Australia's only older adult-specific alcohol and other drug treatment service.

Results:

Seventy-two patients aged between 58 years and 87 years (M = 65.88; SD = 5.67) drinking alcohol at hazardous or harmful levels were taking between 1 and 12 pharmaceutical drugs (M = 4.03; SD = 2.42). The majority (92%) of patients were taking at least one medication that placed them at high risk of …

Association Between Circulating Osteocalcin And Cardiometabolic Risk Factors Following A 4-Week Leafy Green Vitamin K-Rich Diet, Alexander Tacey, Marc Sim, Cassandra Smith, Mary N. Woessner, Elizabeth Byrnes, Joshua R. Lewis, Tara Brennan-Speranza, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Itamar Levinger

Research outputs 2014 to 2021

Background:

Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. Materials and

Methods:

Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction …

Development, Psychometrics And Feasibility Of The School Participation Questionnaire: A Teacher Measure Of Participation Related Constructs, Donald Maciver, Vaibhav Tyagi, Jessica M. Kramer, Janet Richmond, Liliya Todorova, Dulce Romero-Ayuso, Hiromi Nakamura-Thomas, Margo Van Hartingsveldt, Lorna Johnston, Anne O'Hare, Kirsty Forsyth

Research outputs 2014 to 2021

© 2020 Background: We report development of the SPQ (School Participation Questionnaire) a teacher-completed measure of participation related constructs for schools. The SPQ was developed to support participation-related assessment, interventions, and research in the inclusive school context. Methods: Several iterative steps were undertaken. An international panel of experts reviewed content validity. A 66-item pilot questionnaire was administered in schools. Mokken and Rasch model analysis were applied. Internal consistency was assessed using Cronbach's alpha. Analyses were conducted on associations with teacher and child demographic variables. Feedback was sourced from users. Participants were teachers of 101 children (5−12 years old) with a …

Prognostic Value Of Hla-I Homozygosity In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Leslie Calapre, Johnny Lo, Suzana Correia, Samantha Bowyer, Abha Chopra, Mark Watson, Muhammad A. Khattak, Michael Millward, Elin Solomonovna Gray

Research outputs 2014 to 2021

Background We aimed to assess the impact of genomic human leukocyte antigen (HLA)-I/II homozygosity on the survival benefit of patients with unresectable locally advanced, metastatic non-small lung cancer treated by single-agent programmed cell death protein-1/programmed death ligand 1 (PD1/PDL1) inhibitors.

Methods We collected blood from 170 patients with advanced lung cancer treated with immunotherapy at two major oncology centers in Western Australia. Genomic DNA was extracted from white blood cells and used for HLA-I/II high-resolution typing. HLA-I/II homozygosity was tested for association with survival outcomes. Univariable and multivariable Cox regression models were constructed to determine whether HLA homozygosity was an …

A Survey Identifying Leadership And Research Activities Among Nurse Practitioners, Mary Ryder, Elisabeth Jacob, Joyce Hendricks

Research outputs 2014 to 2021

Background:

Nurse Practitioners are identified as the ideal conduit to transform healthcare delivery internationally. Healthcare transformation requires the application of leadership and research skills. Current literature has limited information on NPs as leaders or researchers in the nursing profession.

Objectives:

Determine if Nurse Practitioners identify themselves as leaders in nursing. Identify the leadership and research activities and influencing characteristics of Nurse Practitioners in Ireland and Australia. Establish similarities in leadership and research activities between Nurse Practitioners in Ireland and Australia. To identify if there is a relationship between leadership and research activities.

Design:

A quantitative electronic survey.

Methods:

A …

Perceptual Oscillations In Gender Classification Of Faces, Contingent On Stimulus History, Jason Bell, David C. Burr, Kate Crookes, Maria Concetta Morrone

Research outputs 2014 to 2021

Perception is a proactive ‘‘predictive’’ process, in which the brain takes advantage of past experience to make informed guesses about the world to test against sensory data. Here we demonstrate that in the judgment of the gender of faces, beta rhythms play an important role in communicating perceptual experience. Observers classified in forced choice as male or female, a sequence of face stimuli, which were physically constructed to be male or female or androgynous (equal morph). Classification of the androgynous stimuli oscillated rhythmically between male and female, following a complex waveform comprising 13.5 and 17 Hz. Parsing the trials based …

Association Between Telomere Length In Peripheral Blood Leukocytes And Risk Of Ischemic Stroke In A Han Chinese Population: A Linear And Non‑Linear Mendelian Randomization Analysis, Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

Background: Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studies in previous years. This study aims to investigate whether the leukocyte telomere length is associated with an increased IS risk or not, based on the Mendelian randomization (MR) approach. Methods: Based on the NHGRI-EBI GWAS Catalog database, the Chinese online genetic database as well as the previous published studies, twelve single nucleotide polymorphisms (SNPs) with minor allele frequency ≥ 0.05 were selected and the leukocyte telomere length was measured in …

Cochrane Corner Summary Of Review Titled: “Peer Support For People With Schizophrenia Or Other Serious Mental Illness”, Beverley Ewens, Amanda Barnard-Towell, Sheila Mortimer-Jones, Vivien Kemp, Amanda Cole

Research outputs 2014 to 2021

Serious mental illnesses affect how people feel, think, and behave, and frequently contribute to disability in psychosocial and occupational functioning and quality of life (American Psychiatric Association 2015; Harvey & Strassnig, 2012; Mohamed et al., 2008). Psychosocial interventions designed to support people with schizophrenia and their families have shown to improve the person’s rehabilitation, reintegration into the community, and recovery (The National Collaborating Centre for Mental Health, 2009; Pharoah et al., 2012). Peer workers are defined as individuals with lived experience of mental illness (Aguey-Zinsou et al., 2018), with peer support principles based on shared responsibility and mutual respect (Mead …

Cardiovascular Health In China: Low Level Vs High Diversity, Wei Wang

Research outputs 2014 to 2021

No abstract provided.

Fatigue-Related Feedback From Calf Muscles Impairs Knee Extensor Voluntary Activation, Harrison T. Finn, David S. Kennedy, Simon Green, Janet L. Taylor

Research outputs 2014 to 2021

INTRODUCTION:

Fatigue-related group III/IV muscle afferent firing from agonist, antagonist or distal muscles impairs the ability to drive the elbow flexors maximally, that is, reduces voluntary activation. In the lower limb, the effect of feedback from distal muscles on the proximal knee extensors is unknown. Here, we test whether maintained group III/IV afferent feedback from the plantarflexor muscles reduces voluntary activation of the knee extensors.

METHODS:

On 2 d, voluntary activation of the knee extensors during maximal voluntary contractions (MVCs) was assessed in 12 participants before and after a 3-min fatiguing task of the plantarflexors. On 1 d, an inflatable …

Postgraduate Nurse Education And The Implications For Nurse And Patient Outcomes: A Systematic Review, Ma'en Zaid Abu-Qamar, Caroline Vafeas, Beverley Ewens, Manonita Ghosh, Deborah Sundin

Research outputs 2014 to 2021

© 2020 Elsevier Ltd Objectives: To synthesise the current evidence of the implications of postgraduate nursing qualifications on patient and nurse outcomes. Design: A systematic review. Data sources: Primary research findings. Review methods: A systematic search following PRISMA guidelines and the Joanna Briggs Institute's framework was conducted. A structured and comprehensive search of three electronic databases CINAHL, MEDLINE, PsychINFO, search engine Google Scholar, and a manual-search of reference lists was undertaken. The search was limited to articles in English between 2000 and 2019. The combined search yielded 3710 records. Search records were exported to EndNote X8 and duplicates were removed. …

Effects Of An 8-Week Resistance Training Intervention On Plantar Flexor Muscle Quality And Functional Capacity In Older Women: A Randomised Controlled Trial, Pedro Lopez, Brendan James Crosby, Bruna Patrícia Robetti, Douglas Jean Preussler Turella, Thaís Andréia Schepa Weber, Morgana Lima De Oliveira, Anderson Rech

Research outputs 2014 to 2021

© 2020 The present study examined 8 weeks of resistance training and its effects on muscle quality measures, plantar flexor muscle strength, muscle thickness and functional capacity in older women. Moreover, we tested if changes in muscle quality were associated with functional capacity. Twenty-four older women (66.3 ± 5.8 years; 69.0 ± 3.0 kg; 25.3 ± 1.4 kg·m−2) were recruited to the study. After completion of the baseline assessment, participants were randomly assigned to either the resistance training (RET, n = 12) or an active control group (CTR, n = 12). Muscle quality was evaluated through muscle echo intensity (MQEI) …

Associations Between Social And Intellectual Activities With Cognitive Trajectories In Chinese Middle-Aged And Older Adults: A Nationally Representative Cohort Study, Haibin Li, Changwei Li, Anxin Wang, Yanling Qi, Wei Feng, Chengbei Hou, Lixin Tao, Xiangtong Liu, Xia Li, Wei Wang, Deqiang Zheng, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: Associations between the frequency of social and intellectual activities and cognitive trajectories are understudied in Chinese middle-aged and older adults. We aimed to examine this association in a nationally representative longitudinal study. METHODS: The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative sample of Chinese middle-aged and older participants. The frequency of social and intellectual activities was measured at baseline. Interview-based cognitive assessments of orientation and attention, episodic memory, and visuospatial skills and the calculation of combined global scores were assessed every 2 years from 2011 to 2016. Cognitive aging trajectories over time were analyzed using …

Otud4 Enhances Tgfβ Signalling Through Regulation Of The Tgfβ Receptor Complex, Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn

Research outputs 2014 to 2021

© 2020, The Author(s). Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in the general regulation of this pathway. Here we identify the deubiquitinating enzyme OTUD4 as a transcriptional target of the TGFβ pathway that functions through a positive feedback loop to enhance overall TGFβ activity. Interestingly we demonstrate that OTUD4 functions through both catalytically dependent and independent mechanisms to regulate TGFβ activity. Specifically, we find that OTUD4 enhances TGFβ signalling by promoting the membrane presence of TGFβ receptor …

Risk Prediction Of Late-Onset Alzheimer’S Disease Implies An Oligogenic Architecture, Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E. Marioni, Margaret J. Wright, Alison M. Goate, Edoardo Marcora, Kuan-Lin Huang, Tenielle Porter, Simon M. Laws, Perminder S. Sachdev, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yeng, Naomi R. Wray Robertson, Allan F. Mcrae, Peter M. Visscher, Steven Collins, Christine Thai, Brett Trounson, Kate Lennon, Qiao Xin Li, Fernanda Yevenes Ugarte, Irene Volitakis, Michael Vovos, Australian Imaging Biomarkers And Lifestyle

Research outputs 2014 to 2021

© 2020, The Author(s). Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 family history proxy cases. We show that the discriminative ability of GRS in LOAD prediction is maximised when selecting a small number of SNPs. Both simulation results and direct estimation indicate that the number of causal common SNPs for LOAD may be less than 100, suggesting …

Age And Apoe Genotype Affect The Relationship Between Objectively Measured Physical Activity And Power In The Alpha Band, A Marker Of Brain Disease, Jaisalmer De Frutos-Lucas, Pablo Cuesta, Federico Ramírez-Toraño, Alberto Nebreda, Esther Cuadrado-Soto, África Peral-Suárez, David Lopez-Sanz, Ricardo Bruña, Silvia Marcos-De Pedro, María Luisa Delgado-Losada, Ana María López-Sobaler, Inmaculada Concepción Rodríguez-Rojo, Ana Barabash, Juan Manuel Serrano Rodriguez, Simon M. Laws, Alberto Marcos Dolado, Ramón López-Higes, Belinda M. Brown, Fernando Maestú

Research outputs 2014 to 2021

BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer's disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using …

Arthropathy In Hereditary Haemochromatosis Segregates With Elevated Erythrocyte Mean Corpuscular Volume, A. Rehman, G. J. Carroll, L. W. Powell, L. E. Ramm, G. A. Ramm, John K. Olynyk

Research outputs 2014 to 2021

© 2020 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation. Objective: To evaluate the relationship between erythrocyte parameters and the presence or absence of arthritis in HFE C282Y homozygous hereditary haemochromatosis (HH) subjects compared to control groups of non-HH subjects with arthritis. Method: Erythrocyte and arthritis parameters [mean corpuscular volume (MCV) and mean cell haemoglobin (MCH)] were obtained from consecutive HH subjects (n = 119) who were referred for initial evaluation and management. For comparison, MCV and MCH values were collected from randomly selected non-HH subjects with rheumatoid arthritis (n = 100) and osteoarthritis (n = 100), consisting of …

A Pilot Evaluation Of Simulation-Based Interprofessional Education For Occupational Therapy, Speech Pathology And Dietetic Students: Improvements In Attitudes And Confidence, Brennen Mills, Sara Hansen, Charn Nang, Helen Mcdonald, Philippa Lyons-Wall, Jacqui Hunt, Therese O’Sullivan

Research outputs 2014 to 2021

Many higher education institutions struggle to provide interprofessional practice opportunities for their pre-licensure students due to demanding workloads, difficulties with timetabling, and problems with sourcing suitable placements that provide appropriate practice opportunities. A series of complex unfolding video-based simulation scenarios involving a patient who had experienced a stroke was utilized as a case study for a three-hour interprofessional practice workshop. 69 occupational therapy (OT), speech pathology (SP) and dietetics (DT) students participated in a mixed-methods study comparing interprofessional attitudes before and after the workshop. Attitudes toward interprofessional practice improved pre- vs. post-workshop and overall. Students were highly satisfied with the …

Voluntary Exercise In Mesothelioma: Effects On Tumour Growth And Treatment Response In A Murine Model, Scott A. Fisher, Carolyn J. Peddle-Mcintyre, Kimberley Burton, Robert U. Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak

Research outputs 2014 to 2021

OBJECTIVE: There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen-induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced …