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East Tennessee State University

2018

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Articles 1 - 30 of 112

Full-Text Articles in Medicine and Health Sciences

Outcomes And Experiences Of An Rn To Bsn Online Cohort: An Academic-Practice Partnership, Donna Copenhaver Dr., Marilyn Dubree Msn, Rn, Chris Wilson Msn, Rn-Bc, Martha Buckner Phd, Cathy R. Taylor Drph, Kathy Jordan Msn, Rn Dec 2018

Outcomes And Experiences Of An Rn To Bsn Online Cohort: An Academic-Practice Partnership, Donna Copenhaver Dr., Marilyn Dubree Msn, Rn, Chris Wilson Msn, Rn-Bc, Martha Buckner Phd, Cathy R. Taylor Drph, Kathy Jordan Msn, Rn

International Journal of Health Sciences Education

Abstract

This article describes the result of an academic-practice partnership between a School of Nursing (SON) and a University Medical Center (UMC) for the purpose of promoting BSN education in response to the Institute of Medicine’s recommendation that 80% of RNs hold a baccalaureate degree or higher by 2020. The mutually beneficial partnership worked together to offer a pilot online RN-BSN nursing program, increase the number of BSNs in the workforce, and to collect information from RN-BSN students returning to school about their challenges, recommendations for future programs, and why they were interested in returning to school. The BSN graduates …


As A Pediatrician, I Don’T Know The Second, Third, Or Fourth Thing To Do: A Qualitative Study Of Pediatric Residents’ Training And Experiences In Behavioral Health, Rachel Petts Phd, Jeffrey D. Shahidullah Phd, Paul W. Kettlewell Phd, Kathryn A. Dehart Md, Kris Rooney Md, Ilene G. Ladd Ms, Tyler Bogaczyk Bs, Sharon L. Larson Phd Dec 2018

As A Pediatrician, I Don’T Know The Second, Third, Or Fourth Thing To Do: A Qualitative Study Of Pediatric Residents’ Training And Experiences In Behavioral Health, Rachel Petts Phd, Jeffrey D. Shahidullah Phd, Paul W. Kettlewell Phd, Kathryn A. Dehart Md, Kris Rooney Md, Ilene G. Ladd Ms, Tyler Bogaczyk Bs, Sharon L. Larson Phd

International Journal of Health Sciences Education

Despite a mandated 1-month rotation in developmental-behavioral pediatrics (DBP), pediatric residents report inadequate training in behavioral health care. As a first step in much needed curriculum development in this area, this study sought to assess learner experiences regarding the management of behavioral health problems during residency. Four focus groups were conducted for residents in years 1-3 of training in 2 residency programs in a northeastern state. Transcripts were analyzed and coded by researchers through qualitative classical content analysis. The exploratory analysis revealed 9 key themes: time requirements, rapport building, resources and referrals for behavioral health, psychiatric medications, diagnosis vs. treatment, …


Patient Deception In Health Care: Physical Therapy Education, Beliefs, And Attitudes, Drew A. Curtis, Han-Hung Huang, Kendra L. Nicks Dec 2018

Patient Deception In Health Care: Physical Therapy Education, Beliefs, And Attitudes, Drew A. Curtis, Han-Hung Huang, Kendra L. Nicks

International Journal of Health Sciences Education

A good professional-patient relationship is important to clinical practice, which may be compromised by deception. Deception research in physical therapy is scant. The current study investigated how the topic of patient deception is addressed in Doctor of Physical Therapy (DPT) educational curriculum, explore DPT students’ beliefs about deception and attitudes toward patient deception, and examine the effects of a pedagogical intervention on DPT students’ beliefs about deception and attitudes toward patient deception. The first objective was pursued by a descriptive survey sent to 217 DPT programs in the US. The second and third objectives were achieved by one-group pretest-posttest design …


The Effect Of Competency-Based Education On Medical And Nursing Students' Academic Performance, Technical Skill Development, And Overall Satisfaction And Preparedness For Future Practice: An Integrative Literature Review, Haris Saud, Ruth Chen Dec 2018

The Effect Of Competency-Based Education On Medical And Nursing Students' Academic Performance, Technical Skill Development, And Overall Satisfaction And Preparedness For Future Practice: An Integrative Literature Review, Haris Saud, Ruth Chen

International Journal of Health Sciences Education

Purpose: This article provides an integrative review of competency-based education (CBE) in medical and nursing programs and examines the effect of CBE on students’ academic performance, technical skill development, and overall satisfaction and preparedness for future practice.

Background: In recent decades, CBE has increasingly been discussed in medical and nursing education programs. The impact of the CBE curriculum on learning outcomes including academic performance, technical skill development, overall satisfaction, and preparedness for future practice has not been fully elucidated.

Method: A review of the literature was conducted, and multiple databases were searched for studies that analyzed the impact of CBE …


The Influence Of Maternal Body Mass Index And Physical Activity On Select Cardiovascular Risk Factors Of Preadolescent Hispanic Children, Basil A. Alhassan, Ying Liu, Deborah Slawson, Jonathan M. Peterson, Jo-Ann Marrs, William A. Clark, Arsham Alamian Dec 2018

The Influence Of Maternal Body Mass Index And Physical Activity On Select Cardiovascular Risk Factors Of Preadolescent Hispanic Children, Basil A. Alhassan, Ying Liu, Deborah Slawson, Jonathan M. Peterson, Jo-Ann Marrs, William A. Clark, Arsham Alamian

ETSU Faculty Works

Background. Maternal obesity and physical inactivity have been identified as correlates of overweight and obesity and physical inactivity in older preadolescents; however, no study has explored this relationship in Hispanic preadolescents. Furthermore, the relation between maternal physical activity (PA) and blood pressure (BP) in Hispanic preadolescents has not been examined. Purpose. This study aimed to assess the associations between Hispanic mothers’ PA and body mass index (BMI) and their preadolescents’ PA, screen time, BP, and BMI. Methods. Data of 118 mother-child (aged 2–10 years) dyads enrolled in a crosssectional study of metabolic syndrome in Hispanic preadolescents at a community health …


Assessing The Validity And Reliability Of A Freehand Tool Method For Analysis Of Ultrasound Cross-Sectional Area Images, Donald J. Marsh, Dylan Suarez, Luis Rodriguez-Castellano, Kyle Rochau, Ai Ishida, Caleb D. Bazyler Dec 2018

Assessing The Validity And Reliability Of A Freehand Tool Method For Analysis Of Ultrasound Cross-Sectional Area Images, Donald J. Marsh, Dylan Suarez, Luis Rodriguez-Castellano, Kyle Rochau, Ai Ishida, Caleb D. Bazyler

ETSU Faculty Works

No abstract provided.


The Role Of Cyp2a5 In Cadmium-Induced Liver Injury, Julia Salamat Dec 2018

The Role Of Cyp2a5 In Cadmium-Induced Liver Injury, Julia Salamat

Electronic Theses and Dissertations

Cadmium is present in food and groundwater. Tobacco smoking and occupational exposure are also major sources for cadmium. Cadmium is primarily accumulated in liver, a major organ metabolizing exogenous chemicals. Chemical metabolism may cause detoxification, but it can also cause bio-activation resulting in liver damage. Cytochrome P450s (CYP) are major liver metabolism enzymes, and cadmium chloride (CdCl2) can induce CYP2A5 in mice. We examined the effect of CYP2A5 on CdCl2-induced liver injury using CYP2A5-knockout (cyp2a5-/-) mice. The cyp2a5-/- mice and their control WT mice were injected CdCl2 intraperitoneally at 5 mg/kg body weight, respectively, to induce liver injury. …


Dreadd Targeting Projections From The Nucleus Accumbens To The Ventral Pallidum With Nicotine Self-Administration, Amanda Smith Dec 2018

Dreadd Targeting Projections From The Nucleus Accumbens To The Ventral Pallidum With Nicotine Self-Administration, Amanda Smith

Electronic Theses and Dissertations

Projections from the Nucleus Accumbens (NAc) to the Ventral Pallidum (VP) play a critical role in motivation and reward. Rewards and reward-associated cues are thought to alter this pathway by suppressing GABA release to the VP, however, the role of the NAc to VP pathway has never been investigated with regard to nicotine self-administration. We hypothesized that increasing GABAergic signaling from the NAc to the VP would decrease the reinforcing effects of nicotine. To increase GABA release, CRE dependent DREADD was expressed in the NAc of male rats. Administration of low dose clozapine activated the DREADD receptor and showed a …


The Study Of Alcoholic Liver Diseases, Seun Emmanuel Owoseni Dec 2018

The Study Of Alcoholic Liver Diseases, Seun Emmanuel Owoseni

Electronic Theses and Dissertations

Excessive alcohol consumption is the primary contributing factor in the development of alcoholic liver diseases (ALD). Nicotine contained in tobacco is a major addictive alkaloid, which enhances the effects of ALDs. The major enzyme involved in nicotine metabolism is cytochrome P450 2A5 (CYP2A5) which is produced in the liver. Alcohol can stimulate the CYP2A5 enzyme. We utilized cyp2a5-/- knockout mice in this research to examine the effects of CYP2A5.

The cyp2a5-/- mice and wild-type (WT) mice were fed liquid ethanol diet with or without nicotine to induce ALD. Nicotine enhancing effects on ALD were observed in WT mice but not …


Comparisons Between Movement Onset Identification Methods Used In Isometric Mid-Thigh Pull Test, Junshi Liu Dec 2018

Comparisons Between Movement Onset Identification Methods Used In Isometric Mid-Thigh Pull Test, Junshi Liu

Electronic Theses and Dissertations

This dissertation aimed to explore the usefulness of using force derivatives for onset detection in the isometric mid-thigh pull test. First, we examined applications of three differential calculus principles, first and second derivative, and curvature using visual detection as a reference under different baseline conditions. Second, we compared the best derivative method to a threshold-based method using visual detection as a reference. Results of our first investigation showed trivial differences between many differential calculus methods and visual detection. However, statistical differences exceeding a trivial effect was observed when instantaneous force and rate of force develop were examined. Through the first …


The Ecology Of Fecal Indicators, Dennis A. Gilfillan Dec 2018

The Ecology Of Fecal Indicators, Dennis A. Gilfillan

Electronic Theses and Dissertations

Animal and human wastes introduce pathogens into rivers and streams, creating human health and economic burdens. While direct monitoring for pathogens is possible, it is impractical due to the sporadic distribution of pathogens, cost to identify, and health risks to laboratory workers. To overcome these issues, fecal indicator organisms are used to estimate the presence of pathogens. Although fecal indicators generally protect public health, they fall short in their utility because of difficulties in public health risk characterization, inconsistent correlations with pathogens, weak source identification, and their potential to persist in environments with no point sources of fecal pollution. This …


Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey Dec 2018

Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey

Electronic Theses and Dissertations

Pseudomonas aeruginosa is a Gram-negative bacillus able to colonize a wide variety of environments. In the human host, P. aeruginosa can establish an acute infection or persist and create a chronic infection. P. aeruginosa is able to establish a niche and persist in human hosts by using a wide array of virulence factors used for: movement, killing host cells, and evading immune cells and antibiotics. Understanding virulence factors and their regulation has proved to be an important means of combating the morbidity and mortality of P. aeruginosa as well as the ever-increasing threat of drug resistance. By targeting virulence factors …


Stigma For Caring For Those With Mental Health Issues In The Student Nurse Community: A Survey, Matthew Boyd Dec 2018

Stigma For Caring For Those With Mental Health Issues In The Student Nurse Community: A Survey, Matthew Boyd

Undergraduate Honors Theses

People living with a mental health issue is elevated both nationally and internationally, and the likelihood of a person interacting with someone who has a mental health issue is high. It is even higher for those who work in the health care profession, so understanding their attitudes on this matter is important. As a review of current literature reveals, there is not only stigma in the health care system, but there is also stigma among health care professionals and students. One of the groups of students that has not been researched to a great extent is nursing students and the …


Effects Of Weightlifting Training On Isometric Mid-Thigh Pull Rate Of Force Development, Dylan G. Suarez, Kristina Ushakova, Satoshi Mizuguchi, Guy Hornsby, Michael H. Stone Dec 2018

Effects Of Weightlifting Training On Isometric Mid-Thigh Pull Rate Of Force Development, Dylan G. Suarez, Kristina Ushakova, Satoshi Mizuguchi, Guy Hornsby, Michael H. Stone

ETSU Faculty Works

PURPOSE: To examine the influence of three distinct training phases on isometric mid-thigh pull (IMTP) measures in well-trained weightlifters. METHODS: Pre- and post-block IMTP data from 11 collegiate weightlifters was used for analysis. The mean of the best two attempts from each athlete for measures of PF and RFD from 0-50ms, 0-100ms, 0-150ms, 0-200ms, and 0-250ms were used for comparison. In total, results from five timepoints for each of the 11 athletes were examined in order to compare the effects of the three training phases. RESULTS: A repeated measures ANOVA revealed no statistically significant (p ≥ 0.05) effects of training …


The Role Of Non-Neuronal Acetylcholine In Urogenital Chlamydial Infection, Jessica R. Lockhart Dec 2018

The Role Of Non-Neuronal Acetylcholine In Urogenital Chlamydial Infection, Jessica R. Lockhart

Electronic Theses and Dissertations

Chlamydia trachomatiscauses a bacterial sexually transmitted infection, Chlamydia, that is often chronic and casues reproductive complications in women. We hypothesized that Chlamydia infection increases local acetylcholine (ACh) production, which regulates the host’s inflammatory response to the infection. Female mice infected with C. muridarumwere sacrificed at days 3, 9, 15, and 21 post-infection, genital tract tissues harvested, and immunohistochemistry performed to enumerate ACh-producing cells. Infection increased the number of ACh-producing cells in cervical tissue at days 3,15, and 21 post-infection (pi), uterine tissue at day 3 and 9 pi, and ovarian tissue day 3, 15, and 21 pi. These …


The Effect Of Altering Body Posture And Barbell Position On The Between-Session Reliability Of Force-Time Curve Characteristics In The Isometric Mid-Thigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Michael H. Stone, Nikola Medic, Guy Gregory Haff Nov 2018

The Effect Of Altering Body Posture And Barbell Position On The Between-Session Reliability Of Force-Time Curve Characteristics In The Isometric Mid-Thigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Michael H. Stone, Nikola Medic, Guy Gregory Haff

ETSU Faculty Works

Seventeen strength and power athletes (n = 11 males, 6 females; height: 177.5 ± 7.0 cm, 165.8 ± 11.4 cm; body mass: 90.0 ± 14.1 kg, 66.4 ± 13.9 kg; age: 30.6 ± 10.4 years, 30.8 ± 8.7 years), who regularly performed weightlifting movements during their resistance training programs, were recruited to examine the effect of altering body posture and barbell position on the between-session reliability of force-time characteristics generated in the isometric mid-thigh pull (IMTP). After participants were familiarised with the testing protocol, they undertook two testing sessions which were separated by seven days. In each session, the participants …


Personal Commitment Statements In Evaluating Continuing Education: Evolutionary Practice, Juan Bornman, Brenda Louw Nov 2018

Personal Commitment Statements In Evaluating Continuing Education: Evolutionary Practice, Juan Bornman, Brenda Louw

ETSU Faculty Works

The use of a Commitment-to-Change (CTC) statement to evaluate Continuing Education was investigated through a case study design. A CE event on communication disorders within the ICF-CY framework was evaluated by a Personal Commitment form and a follow-up survey. Results of a thematic analysis of statements and follow-up survey illustrate the important potential of this evolutionary approach.


Young Adults With Cleft Lip And Palate: Personal Perspectives Of Transition Of Care, Courtney Buchanan, Bethany Johnson, A. Jade Morgan, Jessica Morgan, Carissa Padgett, Brenda Louw Nov 2018

Young Adults With Cleft Lip And Palate: Personal Perspectives Of Transition Of Care, Courtney Buchanan, Bethany Johnson, A. Jade Morgan, Jessica Morgan, Carissa Padgett, Brenda Louw

ETSU Faculty Works

Children with cleft lip/palate receive team care which typically ends at eighteen. Young adults then need to transition into an adult-centered model of care. A paucity of literature exists regarding their perspective on transition of care experience. This research explores the experiences of young adults with CLP regarding their transition of care process, within the person-centered ICF framework.


Clinician-Research Collaboration: Determining Research Interests And Needs Of Clinicians In The Tri-Cities, Tn, Kara Detty, Lauren Fabrize, Mary Trifiro, Jessica Weiner, Brenda Louw Nov 2018

Clinician-Research Collaboration: Determining Research Interests And Needs Of Clinicians In The Tri-Cities, Tn, Kara Detty, Lauren Fabrize, Mary Trifiro, Jessica Weiner, Brenda Louw

ETSU Faculty Works

This research explores the disconnect between researchers and practicing clinicians on research collaboration, which is attributed to various barriers, therefore creating a researcher-clinician gap. Survey research was conducted and practicing clinicians in the Tri-Cities region of Tennessee acted as respondents. Results may contribute to establishing practicing clinician-research collaboration in this context.


Resistance Training Volume Load With And Without Exercise Displacement, W. Guy Hornsby, Jeremy A. Gentles, Paul Comfort, Timothy J. Suchomel, Satoshi Mizuguchi, Michael H. Stone Nov 2018

Resistance Training Volume Load With And Without Exercise Displacement, W. Guy Hornsby, Jeremy A. Gentles, Paul Comfort, Timothy J. Suchomel, Satoshi Mizuguchi, Michael H. Stone

ETSU Faculty Works

Monitoring the resistance training volume load (VL) (sets × reps × load) is essential to managing resistance training and the recovery–adaptation process. Subjects: Eight trained weightlifters, seven of which were at national level, participated in the study. Methods: VL was measured both with (VLwD) and without (VL) the inclusion of barbell displacement, across twenty weeks of training, in order to allow for comparisons to be made of these VL calculating methods. This consisted of recording the load, repetition count, and barbell displacement for every set executed. Comparisons were made between VL and VLwD for individual blocks of training, select training …


Preliminary Scale Of Reference Values For Evaluating Reactive Strength Index-Modified In Male And Female Ncaa Division I Athletes, Christopher J. Sole, Timothy J. Suchomel, Michael H. Stone Oct 2018

Preliminary Scale Of Reference Values For Evaluating Reactive Strength Index-Modified In Male And Female Ncaa Division I Athletes, Christopher J. Sole, Timothy J. Suchomel, Michael H. Stone

ETSU Faculty Works

The purpose of this analysis was to construct a preliminary scale of reference values for reactive strength index-modified (RSImod). Countermovement jump data from 151 National Collegiate Athletic Association (NCAA) Division I collegiate athletes (male n = 76; female n = 75) were analyzed. Using percentiles, scales for both male and female samples were constructed. For further analysis, athletes were separated into four performance groups based on RSImod and comparisons of jump height (JH), and time to takeoff (TTT) were performed. RSImod values ranged from 0.208 to 0.704 and 0.135 to 0.553 in males and females, respectively. Males had greater RSImod …


Psychology, Medical Family Therapy, Social Work, Psychiatric Nursing, Counseling, And Others: Effective Collaborators, Or Sibling Disciplines At-War?, Tai Mendenhall, Angela Lamson, Jodi Polaha Oct 2018

Psychology, Medical Family Therapy, Social Work, Psychiatric Nursing, Counseling, And Others: Effective Collaborators, Or Sibling Disciplines At-War?, Tai Mendenhall, Angela Lamson, Jodi Polaha

ETSU Faculty Works

At the conclusion of this session, the participant will be able to: Articulate ways that we all – across a myriad of guildmemberships, license-types, and field/practice orientations – can do better work when we work together


Almost Everything We Need To Better Serve Children Of The Opioid Crisis We Learned In The 80s And 90s, Kimberly A. Horn, Robert P. Pack, Robert Trestman, Gerard Lawson Oct 2018

Almost Everything We Need To Better Serve Children Of The Opioid Crisis We Learned In The 80s And 90s, Kimberly A. Horn, Robert P. Pack, Robert Trestman, Gerard Lawson

ETSU Faculty Works

Opioid use disorder impedes dependent parents' abilities to care for their children. In turn, children may languish in unpredictability and persistent chaos. Societal responses to these children are often guided by a belief that unless the drug dependent parent receives treatment, there is little help for the child. While a preponderance of the drug dependence research is adult-centric, a significant body of research demonstrates the importance of not only addressing the immediate well being of the children of drug dependent caregivers but preventing the continuing cycle of drug dependence. The present commentary demonstrates through a brief review of the US …


Views On Healthcare: The Hispanic Migrant Worker Study In Rural Appalachia, Vickie Hughes, Kim Priode, Teresa Carnevale Oct 2018

Views On Healthcare: The Hispanic Migrant Worker Study In Rural Appalachia, Vickie Hughes, Kim Priode, Teresa Carnevale

ETSU Faculty Works

Purpose: The purpose of this qualitative study was to highlight the lived experiences of Hispanic migrant workers seeking healthcare at a community care clinic in rural Appalachia with participation from student nurses learning about qualitative research methods.

Design/method: A phenomenological qualitative study was approved by the institutional IRB. Senior BSN nursing students, community care clinic staff and interpreters, and nurse educators participated in structured interviews during healthcare visits from Hispanic migrant workers at a local community care clinic in rural Appalachia. An audit trail provided the process to highlight common themes on health from the lived experiences of the Hispanic …


Disseminating Your Ideas: A Conversation With The Editors Of Families, Systems, & Health, Jodi Polaha, Nadiya Sunderji, L. Mauksch, C. Fogarty Oct 2018

Disseminating Your Ideas: A Conversation With The Editors Of Families, Systems, & Health, Jodi Polaha, Nadiya Sunderji, L. Mauksch, C. Fogarty

ETSU Faculty Works

No abstract provided.


New Faculty Mentoring In Respiratory Care Programs, Kristen L. Mchenry, Jim Lampley, Randy L. Byington, Donald W. Good, Stephanie R. Tweed Oct 2018

New Faculty Mentoring In Respiratory Care Programs, Kristen L. Mchenry, Jim Lampley, Randy L. Byington, Donald W. Good, Stephanie R. Tweed

ETSU Faculty Works

Introduction: The purpose of this study was to identify mentoring practices of new faculty members in Commission on Accreditation for Respiratory Care (CoARC) accredited respiratory care programs in the U.S. and to identify the perceptions of program directors regarding the observed impact of program mentoring practices. Methods: The method for the study was quantitative non-experimental survey research. The survey instrument was an electronic questionnaire titled Respiratory Care Faculty (RCF) Mentoring Survey. The 25-item survey was divided into three dimensions: mentoring practices, mentor/mentee relationship, and perceptions of the impact of new faculty mentoring. Of the 410 possible program director …


Champion Teams As A Mechanism For Developing Team Care Capacity, Robert M. Tolliver, Gayatri Jaishankar, Jodi Polaha Oct 2018

Champion Teams As A Mechanism For Developing Team Care Capacity, Robert M. Tolliver, Gayatri Jaishankar, Jodi Polaha

ETSU Faculty Works

"Practice transformation" toward team care as a singular undertaking can be daunting. In this presentation, we describe the development of a mechanism for small, iterative and sustainable practice changes toward team care known as "Champion Teams." Champion Teams are based on the Institute of Medicine's "learning health care system" approach in which practitioners develop an internal mechanism for and culture around digesting and implementing new evidence based practices on an ongoing basis. In addition to presenting the Champion Team concept as a strategy for implementing new team care initiatives, interprofessional providers will present two case examples from each adult and …


Maxent Estimation Of Aquatic Escherichia Coli Stream Impairment, Dennis Gilfillan, Timothy A. Joyner, Phillip Scheuerman Sep 2018

Maxent Estimation Of Aquatic Escherichia Coli Stream Impairment, Dennis Gilfillan, Timothy A. Joyner, Phillip Scheuerman

ETSU Faculty Works

Background.The leading cause of surface water impairment in United States’ rivers and streams is pathogen contamination. Although use of fecal indicators has reduced human health risk, current approaches to identify and reduce exposure can be improved. One important knowledge gap within exposure assessment is characterization of complex fate and transport processes of fecal pollution. Novel modeling processes can inform watershed decision-making to improve exposure assessment.


Maxent Estimation Of Aquatic Escherichia Coli Stream Impairment, Dennis Gilfillan, Timothy Andrew Joyner, Phillip R. Scheuerman Sep 2018

Maxent Estimation Of Aquatic Escherichia Coli Stream Impairment, Dennis Gilfillan, Timothy Andrew Joyner, Phillip R. Scheuerman

ETSU Faculty Works

Background: The leading cause of surface water impairment in United States’ rivers and streams is pathogen contamination. Although use of fecal indicators has reduced human health risk, current approaches to identify and reduce exposure can be improved. One important knowledge gap within exposure assessment is characterization of complex fate and transport processes of fecal pollution. Novel modeling processes can inform watershed decision-making to improve exposure assessment.

Methods: We used the ecological model, Maxent, and the fecal indicator bacterium Escherichia coli to identify environmental factors associated with surface water impairment. Samples were collected August, November, February, and May for 8 …


Hcv-Associated Exosomes Promote Myeloid-Derived Suppressor Cell Expansion Via Inhibiting Mir-124 To Regulate T Follicular Cell Differentiation And Function, Ling Wang, Dechao Cao, Ling Wang, Juan Zhao, Lam Nhat Nguyen, Xindi Dang, Yingjie Ji, Xiao Y. Wu, Zheng D. Morrison, Qian Xie, Mohamed El Gazzar, Shunbin Ning, Jonathon P. Moorman, Zhi Q. Yao Sep 2018

Hcv-Associated Exosomes Promote Myeloid-Derived Suppressor Cell Expansion Via Inhibiting Mir-124 To Regulate T Follicular Cell Differentiation And Function, Ling Wang, Dechao Cao, Ling Wang, Juan Zhao, Lam Nhat Nguyen, Xindi Dang, Yingjie Ji, Xiao Y. Wu, Zheng D. Morrison, Qian Xie, Mohamed El Gazzar, Shunbin Ning, Jonathon P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Virus-infected cells can regulate non-permissive bystander cells, but the precise mechanisms remain incompletely understood. Here we report that this process can be mediated by transfer of viral RNA-loaded exosomes shed from infected cells to myeloid-derived suppressor cells (MDSCs), which in turn regulate the differentiation and function of T cells during viral infection. Specifically, we demonstrated that patients with chronic hepatitis C virus (HCV) infection exhibited significant increases in T follicular regulatory (TFR) cells and decreases in T follicular helper (TFH) cells. These MDSC-mediated T-cell dysregulations resulted in an increased ratio of TFR/TFH and IL-10 production in peripheral blood. Specifically, co-culture …