Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Sheep (139)
- Turkey (139)
- Dog (136)
- Cattle (116)
- COVID-19 (105)
-
- Oxidative stress (96)
- Rat (94)
- Children (90)
- Prevalence (86)
- ELISA (75)
- Growth (72)
- Treatment (72)
- Pregnancy (70)
- Mortality (63)
- Broiler (57)
- Goat (57)
- Immunohistochemistry (57)
- Inflammation (57)
- PCR (57)
- Chicken (52)
- Apoptosis (51)
- Ultrasonography (51)
- Cow (49)
- Prognosis (49)
- Diagnosis (48)
- Lamb (48)
- Liver (47)
- Performance (47)
- Breast cancer (45)
- Magnetic resonance imaging (43)
- Publication Year
Articles 61 - 90 of 7641
Full-Text Articles in Medicine and Health Sciences
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Turkish Journal of Medical Sciences
Laser biostimulation therapy (LBT) is suggested to have positive effects on periodontal healing. This study evaluatedLBT with nonsurgical periodontal therapy (NSPT) in diabetes mellitus (DM) and systemic health (SH) conditions.Materials and methods: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouthdesign, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT – DM: NSPT alonein DM, 2) NSPT + LBT – DM: NSPT + LBT application in DM, 3) NSPT – SH: NSPT alone in SH, and 4) NSPT + …
The Role Of Probiotics For Preventing Dysbiosis In Periodontal Disease: A Randomized Controlled Trial, Tuğba Şahi̇n, Gülçin Akca, Nurdan Özmeri̇ç
The Role Of Probiotics For Preventing Dysbiosis In Periodontal Disease: A Randomized Controlled Trial, Tuğba Şahi̇n, Gülçin Akca, Nurdan Özmeri̇ç
Turkish Journal of Medical Sciences
Scaling and root planing remain inadequate in periodontitis treatment caused by dysbiotic microbial dental plaque. The aim of this clinical trial is to evaluate the effects of probiotics and kefir consumption in initial periodontal therapy (IPT) on oral microbiota composition and treatment outcomes in patients with periodontitis.Materials and methods: The study was carried out in the Gazi University Department of Periodontology, including a sample size of 36 individuals and utilizing a randomized controlled design. Thirty-six patients with periodontitis were randomly allocated to three groups: one receiving probiotic treatment, another receiving kefir, and a third serving as the control group. Obtaining …
Letter To The Editor: Serum Amylase On Postoperative Day One Is A Strong Predictor Of Pancreatic Fistula After Pancreaticoduodenectomy: A Retrospective Cohort, Cengiz Ceylan
Turkish Journal of Medical Sciences
No abstract provided.
Molecular Characterization Of Fecundity-Related Gene Regions In Some Of Türkiye’S Native Sheep Breeds, Ramazan Aymaz, Fulya Özdi̇l, Yalçın Yaman
Molecular Characterization Of Fecundity-Related Gene Regions In Some Of Türkiye’S Native Sheep Breeds, Ramazan Aymaz, Fulya Özdi̇l, Yalçın Yaman
Turkish Journal of Veterinary & Animal Sciences
In this study, the BMP15 and GDF9 gene regions were examined through DNA sequencing in some native sheep breeds of Türkiye (Kıvırcık, Karacabey Merino, Chios, Gökçeada, Çine Çaparı, Awassi, and Karakacan). In the BMP15 exon 2 region, two single nucleotide polymorphisms (SNPs) were identified: one synonymous SNP, P248P (proline/proline), and one nonsynonymous SNP, L251P (leucine/proline), resulting in a missense mutation. In the GDF9 exon 1 region, only a nonsynonymous SNP, R87H (histidine/ arginine), was found. In the GDF9 exon 2 region, four SNPs were identified: two nonsynonymous SNPs, E241K (glutamate/lysine) and V332I (valine/isoleucine), and two synonymous SNPs, L159L (leucine/leucine) and …
Behavioral Activity Budget Of Grower Beetal Kids Offered Total Mixed Ration Under Stall-Fed System, Priya Dhattarwal, Mandeep Singla, Sandeep Kaswan, Ravinder Singh Grewal, Neeraj Kashyap, Dalpat Singh Malik
Behavioral Activity Budget Of Grower Beetal Kids Offered Total Mixed Ration Under Stall-Fed System, Priya Dhattarwal, Mandeep Singla, Sandeep Kaswan, Ravinder Singh Grewal, Neeraj Kashyap, Dalpat Singh Malik
Turkish Journal of Veterinary & Animal Sciences
This study investigates the behavioral activities of grower Beetal kids fed in a conventional method-control group manner orgiven total mixed ration (TMR) (i.e. hay-based - T1 and green fodder-based - T2). Twenty-four weaned Beetal kids were enrolled andrandomly distributed into 3 groups based on their body weight, sex, and age. Behavioral observations were recorded 30 min after givingexperimental ration to the kids using the scan sampling method for 1 h, which inferred time spent eating normally, eating with forelegson the cage, and eating with forelegs on the feeders; standing idle and urination were significantly higher in the control group than …
Identification Of Dermatophytes And Comparative Efficacy Of Topical Antifungals Fortreating Canine Dermatophytosis, Arun Prakash Vadakkoot, Rathish Ramachandran Latha, Neeraja Eramthottil, Lijo John, Bipin Kuriyedath Chitharalil, Deepa Padinjare Meleppat
Identification Of Dermatophytes And Comparative Efficacy Of Topical Antifungals Fortreating Canine Dermatophytosis, Arun Prakash Vadakkoot, Rathish Ramachandran Latha, Neeraja Eramthottil, Lijo John, Bipin Kuriyedath Chitharalil, Deepa Padinjare Meleppat
Turkish Journal of Veterinary & Animal Sciences
Dermatophytosis is a potentially zoonotic superficial skin infection caused by keratinophilic fungi. Identification ofdermatophytes aids in understanding the epidemiology of infections and finding out better treatment modalities. The study aimed toidentify dermatophytes in dogs and compare the effectiveness of three different topical drugs for treating dermatophytosis. Molecularidentification of dermatophyte isolates obtained on culturing was done by restriction fragment length polymorphism of the ampliconobtained by polymerase chain reaction of the Internal Transcribed Spacer (ITS) region of the recombinant DNA. Thirty of the positivecases were divided into three groups, Group I was treated with shampoo containing 2% each of miconazole chlorhexidine, Group …
The Stereological And Morphometrical Investigation Of Pars Lumbalis Of The Spinal Cord Innew Zealand Rabbit, Berna Duman, İftar Gürbüz
The Stereological And Morphometrical Investigation Of Pars Lumbalis Of The Spinal Cord Innew Zealand Rabbit, Berna Duman, İftar Gürbüz
Turkish Journal of Veterinary & Animal Sciences
In the study, 12 (6 females, 6 males) healthy adult New Zealand rabbits were used to examine the morphometrical andstereological values. White matter, gray matter and total segment volume of the segments in the pars lumbalis were calculated byCavalieri’s principle. The findings were grouped according to sexand statistically evaluated. As a result, 38% of the length of the spinalcord in rabbits belonged to the pars lumbalis. The morphometric parameters were not statistically different between male and femalerabbits (p > 0.05). The segment with the biggest volume was L5. White matter’s greatest volume was the L4 segment. The volume of graymatter was …
Comparison Of Nonlinear Models For Predicting Live Weight Growth Curves In Lambproduction Of Kıvırcık And Karacabey Merino, Vasfi̇ye Kader Esen, Orhan Karadağ, Cengi̇z Elmaci, Seli̇m Esen
Comparison Of Nonlinear Models For Predicting Live Weight Growth Curves In Lambproduction Of Kıvırcık And Karacabey Merino, Vasfi̇ye Kader Esen, Orhan Karadağ, Cengi̇z Elmaci, Seli̇m Esen
Turkish Journal of Veterinary & Animal Sciences
To achieve sustainable lamb production, it is crucial to determine the optimal slaughter age for maximum economic efficiencyand have a comprehensive understanding of breed characteristics. This study focuses on evaluating different nonlinear models todetermine the optimal slaughter age for Karacabey Merino and Kıvırcık lambs, renowned for their early development and superiormeat quality, respectively. The dataset comprised age-related live weight data from 98 lambs, including 36 female and 15 male Kıvırcıklambs, as well as 33 female and 14 male Karacabey Merino lambs. Six models, namely, negative exponential, Brody, Gompertz, logistic,Bertalanffy, and Richards were utilized to analyze the data. The model parameters …
Effect Of Thermo-Insulated Kid Hutch On Location Preference, Growth Performance, And Blood Haemato-Biochemical Indices Of Winter-Born Goat Kids (Capra Hircus), Ajoy Das, Dilip Kumar Mandal, Asish Debbarma, Muthupalani Karunakaran, Anupam Chatterjee, Debajyoti Sarkar
Effect Of Thermo-Insulated Kid Hutch On Location Preference, Growth Performance, And Blood Haemato-Biochemical Indices Of Winter-Born Goat Kids (Capra Hircus), Ajoy Das, Dilip Kumar Mandal, Asish Debbarma, Muthupalani Karunakaran, Anupam Chatterjee, Debajyoti Sarkar
Turkish Journal of Veterinary & Animal Sciences
This study assessed the effect of thermo-insulated kid hutch (TIKH) on location preference, body surface temperature, growth performance, and blood haemato-biochemical indices of winter-born Black Bengal goat kids. Does were maintained in the same shed, born kids (n = 12) were divided into two groups along with mothers to begin experiments from day 1 of birth. The treatment group (TIKH) of kids was given a TIKH to which kids had free access, but not the adults. However, in the control group (CONT) kids were reared without TIKH. The floor surface temperature of TIKH was significantly (p < 0.05) higher at night as compared to goat shed in December (4.28%), January (3.98%), and February (7.72%). The interior roof surface of TIKH had 25.12%, 33.55%, 31.85%, 10.99%, and 4.37% higher (p < 0.01) temperatures at night compared to the roof surface temperature of the goat shed in December, January, February, March, and April, respectively. The presence of kids inside the TIKH at the age of 1–15 days was the greatest in morning (80.5%) and evening (72.2%). Between the ages of 16–-60 days, the preference of kids for the TIKH varied from 69.2% to 54.2% in the morning and from 70.0% to 66.7% in the evening. However, at the age of 61–75 days, kids’ preference for TIKH gradually declined in the morning (11.6%) and evening (19.9%) due to the increased inside temperature. Kids weaning weight was 23.25% higher (p < 0.05) in the TIKH group as compared to that of CONT. The average daily gain (0–30 days) was higher (41.34%; p < 0.05) in kids in the TIKH compared to the CONT shed. The haemato-biochemical profiles of kids were similar in both groups except for blood serum glucose, which was greater (p < 0.05) in kids of the TIKH than that of CONT shed. In conclusion, the provision of TIKH improved the growth and overall performance of winter-born Black Bengal goat kids during pre and postweaning periods.
Investigation Of Three Single-Nucleotide Polymorphisms (1252 G>A, 2534 G>A, And 2569 T>C) Of The Mbl1 Gene In Anatolian Buffaloes, Esma Gamze Aksel, Bi̇lal Akyüz
Investigation Of Three Single-Nucleotide Polymorphisms (1252 G>A, 2534 G>A, And 2569 T>C) Of The Mbl1 Gene In Anatolian Buffaloes, Esma Gamze Aksel, Bi̇lal Akyüz
Turkish Journal of Veterinary & Animal Sciences
It has been reported that since the MBL gene is involved in the first step of infection and inflammation processes, it may be associated with susceptibility to bacterial and viral diseases in living organisms. In this study, it was aimed to determine the genotypic variation of Anatolian buffaloes in terms of three (1252G>A, 2534 G>A, and 2569 T>C) single nucleotide polymorphisms (SNPs) within the MBL-1 gene. For this purpose, 103 Anatolian buffaloes were genotyped for relevant SNPs by PCR-RFLP process. The allele and genotype frequencies of the examined samples were determined, and the population was examined for …
Radiology Versus Rt-Pcr For Detection Of Proventricular Dilatation Disease In Psittacines, Mohammad Bayat, Abolfazl Ghaniei, Majid Jamshidian Mojaver, Ali Mirshahi, Mohammad Azizzadeh
Radiology Versus Rt-Pcr For Detection Of Proventricular Dilatation Disease In Psittacines, Mohammad Bayat, Abolfazl Ghaniei, Majid Jamshidian Mojaver, Ali Mirshahi, Mohammad Azizzadeh
Turkish Journal of Veterinary & Animal Sciences
Proventricular dilatation disease (PDD) is a potentially fatal disease of psittacine birds. Avian bornavirus (ABV), the causative agent of PDD, causes inflammation of the central, peripheral, and autonomic nervous systems. Clinically, birds affected by PDD present with gastrointestinal tract dysfunction, neurological symptoms, or both. In this study, we evaluated the presence of proventriculus dilation and ABV in 40 birds (cockatiel, n = 12; budgerigar, n = 28), submitted to the veterinary clinic, by radiology and RT-PCR. Lateral and ventrodorsal radiographs and feather samples were taken from 36 live birds including the cockatiel and budgerigar, as well as samples of proventriculus …
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Turkish Journal of Veterinary & Animal Sciences
Canine parvovirus-2 (CPV-2), which is common worldwide, is a highly contagious pathogen in domestic dogs and some wild carnivore species. The agent causes a multisystemic infection in affected animals, especially acute hemorrhagic enteritis and fatal myocarditis in puppies. The study aimed to reveal the presence of virus in dogs with clinical symptoms of CPV-2 infection using virological, pathological, and immunohistochemical methods and make molecular characterization based on partial VP-2 gene of strains circulating in the region. As a result of PCR studies, 9 out of 16 rectal swab samples and 17 out of 38 blood samples were positive. A phylogenetic …
Functional Training Promotes Benefits In The Physical Condition Of Horses, Paula Gomes Rodrigues, Camila Fernanda Fidêncio, Katia De Oliveira, Camilla Mendonça Silva, Clistenes Gomes Oliveira, José Miradelson Oliveira Carvalho, Anselmo Domingos Ferreira Santos, Gregorio Murilo De Oliveira Junior, José Camisão De Souza
Functional Training Promotes Benefits In The Physical Condition Of Horses, Paula Gomes Rodrigues, Camila Fernanda Fidêncio, Katia De Oliveira, Camilla Mendonça Silva, Clistenes Gomes Oliveira, José Miradelson Oliveira Carvalho, Anselmo Domingos Ferreira Santos, Gregorio Murilo De Oliveira Junior, José Camisão De Souza
Turkish Journal of Veterinary & Animal Sciences
Horses that perform constant physical activity related to sport or work are subject to musculoskeletal disorders. Thus, the objective was to evaluate the effectiveness of a functional training program to promote physical conditions (epaxial musculature biometry and linear kinematics) and behavior traits in patrol horses. Sixteen crossbred horses were randomly distributed in two experimental treatments: not submitted (control group) and submitted (test group) to a functional exercise program. The training program exercises were performed three times per week for 90 days and consisted of dynamic mobilization techniques, reflexive mobilization, dynamic imbalance, and passive stretching. The studied variables were Longissimus dorsi …
Determining The Quality Of Sugar Beet Pulp, Lenox, And Ryegrass Silages Used In Feeding Dairy Cattle, In Comparison To Corn Silage, Fatma Özkan, Suphi̇ Deni̇z
Determining The Quality Of Sugar Beet Pulp, Lenox, And Ryegrass Silages Used In Feeding Dairy Cattle, In Comparison To Corn Silage, Fatma Özkan, Suphi̇ Deni̇z
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to determine the quality of sugar beet pulp (Beta vulgaris L.), lenox (Brassica rapa L.), and ryegrass (Lolium multiflorium cv. caramba) silages used in feeding dairy cattle, in comparison to corn silage. Whole corn was harvested at the dough stage, lenox was harvested at the end of flowering, and ryegrass was harvested at the beginning of spike. No additives were added to the corn silage, but 5% molasses was added to the sugar beet pulp, ryegrass, and lenox silages that have low levels of easily degradable sugar. Additionally, 5% sainfoin was added to the sugar …
Water Buffalo Social Networks During Their Activities On Pasture Under The Rain, Eleni Tsiobani, Maria Yiakoulaki, Nikolaos Hasanagas, Ioannis Antoniou
Water Buffalo Social Networks During Their Activities On Pasture Under The Rain, Eleni Tsiobani, Maria Yiakoulaki, Nikolaos Hasanagas, Ioannis Antoniou
Turkish Journal of Veterinary & Animal Sciences
Water buffaloes exhibit various social structures during their activities on pasture, but the impact of abiotic factors (i.e. rainfall) on these structures remains unknown. While existing research has provided evidence concerning the effect of weather conditions on grazing animals’ behavior, they have not examined how animals differentiate their social organization within the herd during their activities on pasture under the rainfall. This study utilized social network analysis to construct, depict, and analyze the proximity networks among buffaloes in each activity they perform on pasture before, during, and after the rainfall. By applying various network indices, we have shown that water …
Prevalence Of Carriers Of Cholesterol Deficiency–Associated Apob Mutation In Some Native, Holstein And Simmental Cattle Breeds In Türkiye, Hasan Meydan, Kübra Bedi̇r Di̇bi̇ç, Onur Vural, Mehmet Ali̇ Yildiz, Jørgen S. Agerholm
Prevalence Of Carriers Of Cholesterol Deficiency–Associated Apob Mutation In Some Native, Holstein And Simmental Cattle Breeds In Türkiye, Hasan Meydan, Kübra Bedi̇r Di̇bi̇ç, Onur Vural, Mehmet Ali̇ Yildiz, Jørgen S. Agerholm
Turkish Journal of Veterinary & Animal Sciences
Genetic diseases play an increasingly important role in cattle breeding as breeding technologies such as artificial insemination has an inborn risk of disseminating deleterious genes, especially from high merit breeding sires. Cholesterol deficiency (CD) is a metabolic disorder first recognized in Holstein cattle in 2015. The condition is characterized by chronic diarrhea and unthriftiness in calves being homozygous for the defective allele. The prevalence of carriers of CD in Turkish cattle is at present unknown and therefore 700 heifers and cows of different breeds, including 300 Holsteins were genotyped. Of the tested Holsteins, 2.0% turned out to be carriers of …
Validation Of A Chimeric Proteins-Based Elisa For The Diagnosis Of Brucellosis In Kazakhstan, Aitbay Bulashev, Saule Eskendirova, Bakytkali Ingirbay, Alfiya Syzdykova, Fariza Zhagipar
Validation Of A Chimeric Proteins-Based Elisa For The Diagnosis Of Brucellosis In Kazakhstan, Aitbay Bulashev, Saule Eskendirova, Bakytkali Ingirbay, Alfiya Syzdykova, Fariza Zhagipar
Turkish Journal of Veterinary & Animal Sciences
This study aimed to compare the suitability of three chimeric recombinant outer membrane proteins of Brucella (rOmps 19 + 25, 19 + 31, and 25 + 31) for the diagnosis of bovine and sheep brucellosis using an indirect ELISA (i-ELISA). The diagnostic properties of these proteins in an i-ELISA were studied using blood serum samples from cattle and sheep with known positive and negative results for brucellosis based on the rose Bengal plate test (RBT), complement fixation test (CFT), and a commercial ELISA (c-ELISA) kit, as well as using animal sera from fresh foci of infection with unknown reactivity. rOmps19 …
Noninvasive Pregnancy Detection In Wild Felids Using Enzyme Immunoassay Of Fecal 13, 14–Dihydro–15–Keto–Pgf2Α Metabolite (Pgfm), Nikitha Prakash, Suchitra Bhadravathi Raju, Sahadev Annayappa, Leena Gowda, Veena Malavalli Prabhushankar
Noninvasive Pregnancy Detection In Wild Felids Using Enzyme Immunoassay Of Fecal 13, 14–Dihydro–15–Keto–Pgf2Α Metabolite (Pgfm), Nikitha Prakash, Suchitra Bhadravathi Raju, Sahadev Annayappa, Leena Gowda, Veena Malavalli Prabhushankar
Turkish Journal of Veterinary & Animal Sciences
The study was carried out on Panthera species (4 lions and 5 tigers) housed in Bannerghatta Biological Park, Bengaluru, and Sri Chamarajendra Zoological Gardens, Mysuru. Estrus behavior such as rolling, licking, nudging, chuffing, frequent urination, whitish discharge, vocalisation, lordosis and copulatory behavior such as vocalisation, allowed to be mounted, aggression towards male, mounting, and biting of the nape of female were exhibited both in lions and tigers which helped to identify the time of fecal sample collection. The study’s main aim was to carry out noninvasive and noncontact pregnancy detection in these wild felids. Feces samples collected from the female …
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Turkish Journal of Medical Sciences
Ulcerative colitis is a chronic, immune-mediated disease characterized by recurring episodes of mucosal inflammation in the colon and rectum. The primary pathogenic mechanism of ulcerative colitis is the dysregulation of the mucosal immune response. The disease follows a relapsing-remitting course, and the goal of management is to successfully induce and then maintain remission. Effectively managing this chronic disease requires addressing all aspects of it. Currently, we have various antitumor necrosis factor agents and novel biologics available for treating ulcerative colitis patients with moderate-to-severe disease. However, none of the existing treatments are considered entirely satisfactory or ideal in these cases. After …
Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin
Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin
Turkish Journal of Medical Sciences
Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in …
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Turkish Journal of Medical Sciences
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Turkish Journal of Medical Sciences
Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …
Protective Effects Of Safranal On Kidney Tissue In A Rat Model Of Distant Ischemiareperfusion Injury With Infrarenal Aortic Occlusion, Mehmet Tort, Hülya Sevi̇l, Fehi̇m Can Sevi̇l, Neci̇p Beci̇t, Uğur Aksu, Zülfükar Kadi̇r Saritaş, Hasan Hüseyi̇n Demi̇rel, Azi̇z Bülbül, Zehra Yaşar, Merve Beci̇t Kizilkaya, Hazen Saritaş
Protective Effects Of Safranal On Kidney Tissue In A Rat Model Of Distant Ischemiareperfusion Injury With Infrarenal Aortic Occlusion, Mehmet Tort, Hülya Sevi̇l, Fehi̇m Can Sevi̇l, Neci̇p Beci̇t, Uğur Aksu, Zülfükar Kadi̇r Saritaş, Hasan Hüseyi̇n Demi̇rel, Azi̇z Bülbül, Zehra Yaşar, Merve Beci̇t Kizilkaya, Hazen Saritaş
Turkish Journal of Medical Sciences
Background/aim: Ischemia-reperfusion (IR) injury to a part of the body can cause damage to distant organs such as the kidney and heart. This study investigated the protective effects of safranal against IR-induced renal injury. Materials and methods: Used in this study were 24 Wistar Albino male rats, which were divided into 3 equal and randomised groups. The sham group underwent laparotomy only. In the IR group, the infrarenal aorta was clamped for 1 h, and then reperfused for 2 h. In the IR-safranal group, safranal was administered 30 min before the procedure and IR injury was induced in the same …
Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal
Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal
Turkish Journal of Medical Sciences
Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Neuropathic pain (NP) is a type of chronic pain usually caused by damage to the somatosensory system. Bioactive antioxidant compounds, such as curcumin and ginger, are widely preferred in the treatment of NP. However, the ingredient-based mechanism that underlies their pain-relieving activity remains unknown. The aim of this study was to investigate the therapeutic effects of trans-[6]-Shogaol and [6]-Gingerol active ingredients of the Zingiber officinale Roscoe extract on the spinal cord and cortex in the neuroinflammatory pathway in rats with experimental sciatic nerve injury. Materials and methods: Forty-six volatile phenolic components were identified in ginger samples using gas chromatography-mass …
Effects Of Acetylsalicylic Acid And Ultrasound Elastography On Testicular Torsion In Rats, Ezgi̇ Gün Soytürk, Ünal Biçakci, Serdar Aslan, Tolga Güvenç, Meltem Neci̇be Ceyhan Bi̇lgi̇ci̇
Effects Of Acetylsalicylic Acid And Ultrasound Elastography On Testicular Torsion In Rats, Ezgi̇ Gün Soytürk, Ünal Biçakci, Serdar Aslan, Tolga Güvenç, Meltem Neci̇be Ceyhan Bi̇lgi̇ci̇
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of acetylsalicylic acid (ASA) and the use of ultrasound elastography on testicular torsion. Materials and methods: Herein, 6 equal groups of rats were formed (n: 48): control group, sham group, torsion/detorsion (T/D)-1 h group, T/D-1 h + ASA group, T/D-8 h group, and T/D-8 h + ASA group. Testicular torsion was created by rotating the left testis 720° clockwise. At 30 min before torsion, 100 mg/kg of ASA was injected intraperitoneally. Elastography was performed at 8 and 24 h. After orchiectomy, specimens were collected for histopathological evaluation. Results: When comparing the left testicular volume (LV) …
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Turkish Journal of Medical Sciences
Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …
Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang
Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang
Turkish Journal of Medical Sciences
Background/aim: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is of great significance in the radioprotection of normal tissues. In this study, the radioprotective effect of ß-D-glucan (BG) derived from Saccharomyces cerevisiae on human umbilical vein endothelial cell (EA.hy926) cytotoxicity produced by carbon-ion irradiation was examined and the probable mechanism was established. Materials and methods: EA.hy926 cells were divided into seven groups: a control group; 1, 2, or 4 Gy radiation; and 10 µg/mL BG pretreatment for 24 …
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Turkish Journal of Medical Sciences
Background/aim: The common disease gastric adenocarcinoma (GAC) has a high morbidity and mortality, so there is an urgent need for research to explore new diagnostic markers and therapeutic targets. This investigation was carried out to investigate the expression of sphingomyelin phosphodiesterase acid-like 3b (SMPDL3B) in GAC and its effects on tumor progression. Materials and methods: Samples were collected from patients who underwent radical gastrectomy from January 2021 to December 2022. Along with the normal gastric epithelial cell lines GES-1 and SGC-7901, the AGS, MGC-803, and MSN-45 human gastric cancer cell lines were used to confirm SMPDL3B expression. RT-qPCR, Western blot, …
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Turkish Journal of Medical Sciences
Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.