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Articles 1 - 30 of 256
Full-Text Articles in Medicine and Health Sciences
Passenger Traits That Predict The Bystander Intervention Model Steps During An Inflight Assault On A Flight Attendant, Michael Pettit
Passenger Traits That Predict The Bystander Intervention Model Steps During An Inflight Assault On A Flight Attendant, Michael Pettit
Doctoral Dissertations and Master's Theses
Every major U.S. airline has experienced a violent inflight assault on one of their flight attendants. The problem is becoming more widespread, but industry leaders have few coping strategies. The first step toward addressing the issue is understanding the various aspects of the event, including the actions of other passengers (bystanders) who may witness the assault. There is ample literature on bystander reactions to similar events such as bullying, medical emergencies, injuries, and violent attacks, but none dedicated to a flight attendant assault or passenger reactions to it.
At the core of bystander action is the bystander effect, which postulates …
Barriers To Mental Health Seeking Among Army Aviation Personnel: A Preliminary Report, Aric J. Raus
Barriers To Mental Health Seeking Among Army Aviation Personnel: A Preliminary Report, Aric J. Raus
National Training Aircraft Symposium (NTAS)
This research explores barriers to mental health seeking, self-reported symptoms, and perspectives on self-help mental-wellness options among U.S. Army Aviation Personnel. Safe aviation operations require constant focus and mental clarity. These requirements expand when considering the implications and added stress of military operations, especially in combat scenarios. Yet, recent studies demonstrate that aviation personnel avoid seeking healthcare due to fears of losing their medical certification. This report provides preliminary results from the first known study on barriers to mental health seeking among U.S. Army aviation personnel. Utilizing an anonymous survey instrument, facilitated primarily through Social Media recruiting of current and …
Understanding Collegiate Aviation Pilot Mental Performance Studies And Future Research Opportunities, Debra Henneberry, Stephanie Brown, Flavio Coimbra, Julius Keller
Understanding Collegiate Aviation Pilot Mental Performance Studies And Future Research Opportunities, Debra Henneberry, Stephanie Brown, Flavio Coimbra, Julius Keller
National Training Aircraft Symposium (NTAS)
According to the Federal Aviation Administration (2022), fatigue is defined as “a condition characterized by increased discomfort with lessened capacity for work, reduced efficiency of accomplishment, loss of power or capacity to respond to stimulation, and is usually accompanied by a feeling of weariness and tiredness” (p. 2). Further outcomes of fatigue include tiredness, weakness, lack of energy, lethargy, depression, and lack of motivation (ICAO, 2016). Stress can release cortisol which can in turn cause sleep issues leading to fatigue (Harvard, 2021). In one study Mendonca, Keller, and Albelo (2023) found 69% (n = 192) percent of collegiate aviation pilots …
A Structured Program For Pilots And Traffic Controllers With Mental Issues., Ian Blair Fries M.D.
A Structured Program For Pilots And Traffic Controllers With Mental Issues., Ian Blair Fries M.D.
National Training Aircraft Symposium (NTAS)
A Structured Program for Pilots and Traffic Controllers with Mental Issues.
by Ian Blair Fries, M.D. Senior HIMS AME, MRO, SAP.
Many pilots and controllers are avoiding appropriate mental care that would have to be reported to the FAA, or omitting required notification of mental care they have received. Either option is detrimental to air safety and personal health.
I propose a structured aviation program to handle mental issues similar to the HIMS Program for pilots with alcohol and/or drug abuse and dependence. The HIMS Program is extremely successful with about 85 percent of pilots who participate recovering and returning …
Addressing Empty Space Myopia To Enable Deep Space Travel With Extended Reality Auditory Biofeedback, Ethan Waisberg, Joshua Ong, Nasif Zaman, Phani Paladugu, Sharif Amit Kamran, Bruce Markovitz, Andrew G. Lee, Alireza Tavakkoli
Addressing Empty Space Myopia To Enable Deep Space Travel With Extended Reality Auditory Biofeedback, Ethan Waisberg, Joshua Ong, Nasif Zaman, Phani Paladugu, Sharif Amit Kamran, Bruce Markovitz, Andrew G. Lee, Alireza Tavakkoli
International Journal of Aviation, Aeronautics, and Aerospace
Empty space myopia is a phenomenon that has been observed in pilots when flying in the open sky. Previous research has been conducted to develop training biofeedback devices to help pilot visual accommodation in empty skies. During future long-duration spaceflight, astronauts may also experience empty space myopia due to prolonged periods of time in vast space. Extended reality is a relatively novel technology that has emerged as a powerful tool for tracking ocular movements. Extended reality with auditory feedback may serve as a low-cost, easily applicable method to improve ciliary muscle control and vision during long-duration spaceflight to combat empty …
Perception Of Crisis Management, Service Quality, And Loyalty Programs On Airline Travel Intention: What Roles Do Fear Of Covid-19 And Risk Attitude Play?, Sohel M. Imroz, Tamilla Curtis, Scott C. Ambrose
Perception Of Crisis Management, Service Quality, And Loyalty Programs On Airline Travel Intention: What Roles Do Fear Of Covid-19 And Risk Attitude Play?, Sohel M. Imroz, Tamilla Curtis, Scott C. Ambrose
Publications
This research investigates the antecedents of airline travel intention, including the effects of crisis management, service quality perceptions, and loyalty programs, along with the fear of coronavirus disease (COVID-19) and risk attitude among individuals from different parts of the world during the peak of the pandemic. Its main objective is to assess how these variables impact passenger airline travel intention. Partial least squares structural equation modeling was used to assess the measurement model and test the hypothesized relationships on the sample of 944 travelers. Results indicated strong positive associations between fear of COVID-19, risk-averse attitudes, and service quality with respect …
Flying Under The Radar: A Survey Of Collegiate Pilots’ Mental Health To Identify Aeromedical Nondisclosure And Healthcare-Seeking Behaviors, Lauren Pitts, Emily Faulconer
Flying Under The Radar: A Survey Of Collegiate Pilots’ Mental Health To Identify Aeromedical Nondisclosure And Healthcare-Seeking Behaviors, Lauren Pitts, Emily Faulconer
Publications
The disclosure of a new or existing mental health condition in a pilot complicates their medical certification status. It has been proposed that the threat of losing medical certification often discourages pilots from seeking treatment for mental health issues or disclosing such information to aeromedical professionals, contributing to a barrier to seeking healthcare that affects pilots of all certification levels. The current study focused on the nondisclosure and healthcare-seeking behaviors of the collegiate pilot population(N = 2,452)at a large, accredited, private institution that offers flight training in accordance with Pilot Schools (2022). Data collected from our anonymous online survey over …
Flying Under The Radar: A Survey Of Collegiate Pilots’ Mental Health To Identify Aeromedical Nondisclosure And Healthcare-Seeking Behaviors, Emily Faulconer, Lauren Pitts
Flying Under The Radar: A Survey Of Collegiate Pilots’ Mental Health To Identify Aeromedical Nondisclosure And Healthcare-Seeking Behaviors, Emily Faulconer, Lauren Pitts
Publications
The disclosure of a new or existing mental health condition in a pilot complicates their medical certification status. It has been proposed that the threat of losing medical certification often discourages pilots from seeking treatment for mental health issues or disclosing such information to aeromedical professionals, contributing to a barrier to seeking healthcare that affects pilots of all certification levels. The current study focused on the nondisclosure and healthcare-seeking behaviors of the collegiate pilot population(N = 2,452)at a large, accredited, private institution that offers flight training in accordance with Pilot Schools (2022). Data collected from our anonymous online survey over …
Introduction To Bioaerosols Assessment And Control, 2nd Edition, Cheri Marcham, John (Jack) Springston
Introduction To Bioaerosols Assessment And Control, 2nd Edition, Cheri Marcham, John (Jack) Springston
Publications
- Risk Assessment
- Assessment for the Presence of Bioaerosols
- Sampling
- Purpose/ Necessity
- Interpretation Controls
- Ventilation
- Other Controls
Mental Health In Pilots Ages 19-26: What Are The New Pilots Telling Us?, Jason T. Lorenzon, Diana Semilia
Mental Health In Pilots Ages 19-26: What Are The New Pilots Telling Us?, Jason T. Lorenzon, Diana Semilia
National Training Aircraft Symposium (NTAS)
Mental Health is stigma that reaches all professional pilots. After spending a considerable amount of money, a pilot is always afraid of losing his/her medical certification. This leads many pilots to not be honest and forthcoming about his/her own health situation or if he/she is forthcoming with any medical deficiency, the regulatory framework at the Federal Aviation Administration may put a further burden on the pilot to provide additional medical documentation, or the FAA may even amend, revoke, or suspend a pilot's medical certificate.
The Federal Aviation Administration (FAA) regulations,14 CFR Parts 61 and 67 and internal protocols creates a …
Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Amber M. Paul, Haiyan Sun, Dhiraj Acharya, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen
Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Amber M. Paul, Haiyan Sun, Dhiraj Acharya, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen
Publications
West Nile virus (WNV) causes annual outbreaks globally and is the leading cause of mosquito-borne disease in Unite States. In the absence of licensed therapeutics, there is an urgent need to develop effective and safe human vaccines against WNV. One of the major safety concerns for WNV vaccine development is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of infection (ADE). Herein, we report the development of a plant-based vaccine candidate that provides protective immunity against a lethal WNV challenge mice, while minimizes the risk of ADE for infection by Zika (ZIKV) and dengue …
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
International Journal of Aviation, Aeronautics, and Aerospace
Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, …
Mental Health Needs Among Minority Aviation Students, Jorge L. D. Albelo Ph.D., Stacey Mcintire
Mental Health Needs Among Minority Aviation Students, Jorge L. D. Albelo Ph.D., Stacey Mcintire
Publications
Higher education, including science, technology, engineering, and mathematics (STEM) education, benefit our society and economic growth. However, overcoming gender disparity and increasing the retention of underrepresented minorities within these programs is challenging. Mental health across higher education has shown to be on the rise, and when it comes to the mental health needs of aviation students, research shows that underrepresented minorities experience unique challenges in achieving academic success. This paper focused on identifying aviation minority students' unique challenges in a small STEM university. This mixed-methods action research study collected quantitative data using an adapted version of the Counseling Center Assessment …
Artificial Gravity Partially Protects Space-Induced Neurological Deficits In Drosophila Melanogaster, Amber M. Paul, Siddhita D. Mhatre, Janani Iyer, Juli Petereit, Roberta M. Dolling-Boreham
Artificial Gravity Partially Protects Space-Induced Neurological Deficits In Drosophila Melanogaster, Amber M. Paul, Siddhita D. Mhatre, Janani Iyer, Juli Petereit, Roberta M. Dolling-Boreham
Publications
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFmg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFmg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multiomics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFmg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative …
A Qualitative Descriptive Study On Re-Assessing The Mental Certification By Faa For Future Pilots, Kaung Z. Min
A Qualitative Descriptive Study On Re-Assessing The Mental Certification By Faa For Future Pilots, Kaung Z. Min
Student Works
Mental illness becomes one of the main problems that most pilots do not usually address. It is not because pilots do not have the courage or are open enough to talk with someone, but because the Federal Aviation Administration (FAA) forces them to hide from mental depression. Most of the time, the pilots are not willing to declare such illnesses as they fear losing their job; simultaneously, the Federal Aviation Agencies across the world require pilots to be in peat health, including their mental condition, to operate the aircraft. While it can be said that the passengers’ and crews’ safety …
Combination Of Statistical Shape Modeling And Statistical Parametric Mapping To Quantify Cartilage Contact Mechanics In Hip Dysplasia, Penny R. Atkins Phd, Shireen Y. Elhabian Phd, Jeffrey A. Weiss Phd, Ross T. Whitaker Phd, Christopher L. Peters Md, Andrew E. Anderson Phd
Combination Of Statistical Shape Modeling And Statistical Parametric Mapping To Quantify Cartilage Contact Mechanics In Hip Dysplasia, Penny R. Atkins Phd, Shireen Y. Elhabian Phd, Jeffrey A. Weiss Phd, Ross T. Whitaker Phd, Christopher L. Peters Md, Andrew E. Anderson Phd
PanaSoMM
Finite element models can predict subject-specific chondrolabral stresses and help to elucidate the effect of under-coverage and incongruency of the hip joint in patients with dysplasia. However, complex stress patterns are difficult to generalize and evaluate statistically. With an established correspondence across shapes from statistical shape modeling (SSM), statistical parametric mapping (SPM) allows for evaluation of local variability while preserving model subject-specificity. Herein, we evaluated the combined application of SSM and SPM to compare cartilage contact stress between control subjects and patients with dysplasia.
Previously published hip joint contact stresses were mapped onto chondrolabral surface meshes and incorporated into an …
Application Of Statistical Shape Modeling To Predict Clinical Metric Of Femoral Head Coverage In Patients With Developmental Dysplasia, Penny R. Atkins Phd, Praful Agrawal Phd, Joseph D. Mozingo Phd, Keisuke Uemura Md, Phd, Kunihiko Tokunaga Md, Christopher L. Peters Md, Shireen Y. Elhabian Phd, Ross T. Whitaker Phd, Andrew E. Anderson Phd
Application Of Statistical Shape Modeling To Predict Clinical Metric Of Femoral Head Coverage In Patients With Developmental Dysplasia, Penny R. Atkins Phd, Praful Agrawal Phd, Joseph D. Mozingo Phd, Keisuke Uemura Md, Phd, Kunihiko Tokunaga Md, Christopher L. Peters Md, Shireen Y. Elhabian Phd, Ross T. Whitaker Phd, Andrew E. Anderson Phd
PanaSoMM
Developmental dysplasia of the hip (DDH) is described as under-coverage of the femoral head by the acetabulum, resulting in mechanical instability. Though DDH is often diagnosed using plain film radiographs, these images cannot adequately capture 3D joint coverage. Herein, we applied a 3D statistical shape model (SSM) to the femur and hemi-pelvis of patients with DDH to objectively measure shape variation and evaluated whether SSM outputs could predict measurements of joint coverage.
The femur and hemi-pelvis were semi-automatically segmented from CT images (83 hips from 47 females with DDH). Surfaces of each hip were reconstructed from segmentations, aligned, and input …
The Utilization And Validation Of The Human Factors Intervention Matrix And The Companion Assessment Tool Faces In The Development Of Novel Interventions, Victoria Lew
Doctoral Dissertations and Master's Theses
The purpose of the current project was to utilize and validate the Human Factors Intervention Matrix (HFIX) and the companion assessment tool FACES regarding developing and ranking novel interventions. This was completed by 1. Uncovering whether brainstorming with HFIX generated a higher quantity, quality, and broader breadth of ideas compared to traditional brainstorming, and 2. Seeing whether the modality in which HFIX was utilized affected the quantity, quality, and breadth of ideas generated. This research employed a 2x2 between-subjects experimental design (n = 120) where participants were assigned to groups of three in one of the four conditions. Analyses …
Ems To Trauma Care Transitions: An Investigation Of Patient And Handoff Outcomes, Richard Simonson
Ems To Trauma Care Transitions: An Investigation Of Patient And Handoff Outcomes, Richard Simonson
Doctoral Dissertations and Master's Theses
The helicopter as a method of emergency medical service transportation of trauma patients has a long history of effective use-cases dating back to its inception during the Vietnam war. Compared to ground-based emergency medical transit, helicopters have been able to reach severely injured patients in environments with challenging terrain features that ground-based medical services cannot traverse. Additionally, the helicopter offers quicker and more direct-route transit options that result in both quicker response and shorter transportation times compared to their ground-based alternative. Further, research has indicated that helicopter ambulance teams utilize paramedics with more experience than ground ambulance paramedics. Prior research …
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
Doctoral Dissertations and Master's Theses
The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless …
Modelling Air Quality In An Aircraft Passenger Cabin Using Health Care Standards, Bert Silich
Modelling Air Quality In An Aircraft Passenger Cabin Using Health Care Standards, Bert Silich
International Journal of Aviation, Aeronautics, and Aerospace
The interest in aerosol contamination of aircraft passenger cabins has increased since the onset of the COVID-19 pandemic. Mathematical models have been developed to help describe how an aerosol behaves in a closed space. The number of infectious particles inhaled is of scientific interest because it can be related to the risk of getting ill from a pathogen. The data required to calculate these results is often difficult to obtain in real world settings. In fact, particle inhalation details are not obtained in the day-to-day routine of a health care environment and are they not required to maintain safety. Hospital …
Interactions Of International Pilots' Stress, Fatigue, Symptoms Of Depression, Anxiety, Common Mental Disorders And Wellbeing, Marion Venus, Martin Grosse Holtforth
Interactions Of International Pilots' Stress, Fatigue, Symptoms Of Depression, Anxiety, Common Mental Disorders And Wellbeing, Marion Venus, Martin Grosse Holtforth
International Journal of Aviation, Aeronautics, and Aerospace
Objective
This study Investigates more dimensions than previous studies simultaneously: pilots’ duty rosters, stress, sleep difficulties, fatigue levels, wellbeing, symptoms of depression, anxiety, and common mental disorders (CMD), and how they are interrelated.
Background
Several scientific studies have confirmed that fatigue can pose a significant risk to flight safety. Other studies reported positive depression screening results for more pilots, compared with the general population.
Method
A cross-sectional online survey was completed by 406 international pilots, who reported their duty rosters of the last two months. Pilots also self-assessed their stress-levels, sleep problems, fatigue, wellbeing, and mental health.
Results
Although pilots …
Comparison Of Schedules, Stress, Sleep Problems, Fatigue, Mental Health And Well-Being Of Low Cost And Network Carrier Pilots, Marion Venus
Comparison Of Schedules, Stress, Sleep Problems, Fatigue, Mental Health And Well-Being Of Low Cost And Network Carrier Pilots, Marion Venus
International Journal of Aviation, Aeronautics, and Aerospace
Objective
This research investigates and compares working-conditions, duty rosters, stress, sleep problems, fatigue levels, mental health, and well-being of pilots working for network (NWCs), and low-cost carriers (LCCs). This study extends previous research by investigating working conditions, pilots’ actual rosters, fatigue and mental health of two groups of pilots flying for LCC or NWC.
Method
A comprehensive cross-sectional online survey was completed by N=338 pilots (185 NWC, 153 LCC pilots). All pilots reported their roster data of the last 2 months during peak flight season, psychosocial and work-related stress (e.g., high job insecurity, less total flight-experience, lower income, more time …
Stroboscopic Augmented Reality As An Approach To Mitigate Gravitational Transition Effects During Interplanetary Spaceflight, Ethan Waisberg, Joshua Ong, Nasif Zaman, Sharif Amit Kamran, Andrew G. Lee, Alireza Tavakkoli
Stroboscopic Augmented Reality As An Approach To Mitigate Gravitational Transition Effects During Interplanetary Spaceflight, Ethan Waisberg, Joshua Ong, Nasif Zaman, Sharif Amit Kamran, Andrew G. Lee, Alireza Tavakkoli
International Journal of Aviation, Aeronautics, and Aerospace
During interplanetary spaceflight, periods of extreme gravitational transitions will occur such as transitions between hypergravity, hypogravity, and microgravity. Following gravitational transitions, rapid sensorimotor adaptation or maladaptation may occur which can affect gaze control and weaken dynamic visual acuity in astronauts. A reduction in dynamic visual acuity during spaceflight could possibly impact or impair mission critical activities (e.g., control of extraterrestrial machinery/vehicles and other important tasks). Stroboscopic visual training is an emerging visual tool that has been terrestrially observed to enhance visual performance and perception by performing tasks under conditions of intermittent vision. This technique has also been seen to increase …
Fatigue In Aircraft Maintenance Technician Schools, Natalie Zimmermann, Peng Hao Wang, Keegan Pullen
Fatigue In Aircraft Maintenance Technician Schools, Natalie Zimmermann, Peng Hao Wang, Keegan Pullen
International Journal of Aviation, Aeronautics, and Aerospace
Fatigue has long been identified as a human factor in aviation. Subsequently, a series of studies have highlighted fatigue-related elements within the context of the aviation industry, focusing on the flight deck – with some extension to flight students – and aviation maintenance activities. However, the latter has not been as deeply examined as its flight crew-centered counterpart. Similarly – if not more significantly – fatigue experienced by aircraft maintenance technician (AMT) students is scarcely explored, especially in comparison to the research conducted to understand fatigue in flight schools. AMT students are subject to comparable, but not the same, experiences …
Assessment Of Scientific Payload Carrying Spirulina Onboard Blue Origin’S New Shepard Vehicle, Pedro J. Llanos, Morgan Shilling, Kristina Andrijauskaite, Kody Kidder, Vijay V. Duraisamy
Assessment Of Scientific Payload Carrying Spirulina Onboard Blue Origin’S New Shepard Vehicle, Pedro J. Llanos, Morgan Shilling, Kristina Andrijauskaite, Kody Kidder, Vijay V. Duraisamy
Publications
The research team at ERAU and UTHSCSA analyzed the effects of suborbital flight stressors and various light conditions (red, white, no light) on the Arthrospira platensis (Spirulina), onboard Blue Origin’s New Shepard vehicle. Commercially available cyanobacterium species were cultivated and closely monitored in mother colonies several months before the suborbital flight mission. The aim of this study was to estimate the biomass production and growth as a potential dietary alternative for prospective human spaceflight's life support system. Spirulina samples were flown in a NanoLab with adjacent avionics supporting the light conditions and sensors to monitor the temperature, relative humidity, and …
Viability And Application Of Mounting Personal Pid Voc Sensors To Small Unmanned Aircraft Systems, Cheri Marcham
Viability And Application Of Mounting Personal Pid Voc Sensors To Small Unmanned Aircraft Systems, Cheri Marcham
Publications
Small Unmanned Aerial Systems in Emergency Response
Current sUAS Uses
- Search and rescue
- Thermal imaging
- Evaluating structural stability
- Spread of wildfires
- Storm damage
What Factors Predict An Anesthesiologist’S Willingness To Proceed With An Anesthetic?, Nadine K. Ragbir
What Factors Predict An Anesthesiologist’S Willingness To Proceed With An Anesthetic?, Nadine K. Ragbir
Doctoral Dissertations and Master's Theses
Anesthesiologists are exposed to higher stress levels than many other physician specialties. They are also at an increased risk for developing mental disorders, alcohol and drug dependencies, sleep disturbances, and suicidal ideations. Therefore, the purpose of this dissertation was to explore the factors that predict an anesthesiologist’s willingness to proceed with an anesthetic. The current study consisted of two stages. The first stage was developing a regression equation that was used to predict anesthesiologists’ willingness to proceed with an anesthetic. During the second stage, additional data was collected to test the model that was developed in the first stage. Six …
Mammalian And Invertebrate Models As Complementary Tools For Gaining Mechanistic Insight On Muscle Responses To Spaceflight, Amber M. Paul, Thomas Cahill, Henry Cope, Joseph J. Bass, Eliah G. Overbey, Rachel Gilbert
Mammalian And Invertebrate Models As Complementary Tools For Gaining Mechanistic Insight On Muscle Responses To Spaceflight, Amber M. Paul, Thomas Cahill, Henry Cope, Joseph J. Bass, Eliah G. Overbey, Rachel Gilbert
Publications
Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruit fly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals …
Immunological And Hematological Outcomes Following Protracted Low Dose/Low Dose Rate Ionizing Radiation And Simulated Microgravity, Amber M. Paul, Eliah G. Overbey, Willian A. Da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao
Immunological And Hematological Outcomes Following Protracted Low Dose/Low Dose Rate Ionizing Radiation And Simulated Microgravity, Amber M. Paul, Eliah G. Overbey, Willian A. Da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao
Publications
Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mice at 7-days post-exposure was performed. Collected blood was profiled with a hematology analyzer and spleens were analyzed by whole transcriptome shotgun sequencing (RNA-sequencing). The results revealed negligible differences in immune differentials. However, hematological system analyses of whole blood indicated large disparities in red blood cell differentials and morphology, suggestive of anemia. Murine Reactome networks indicated majority of spleen cells displayed differentially expressed genes (DEG) …