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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
International Journal of Aviation, Aeronautics, and Aerospace
Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, …
Face Mask Effects Of Co2, Heart Rate, Respiration Rate, And Oxygen Saturation On Instructor Pilots, Andrew R. Dattel, Nicola M. O'Toole, Guillermina Lopez, Kenneth P. Byrnes
Face Mask Effects Of Co2, Heart Rate, Respiration Rate, And Oxygen Saturation On Instructor Pilots, Andrew R. Dattel, Nicola M. O'Toole, Guillermina Lopez, Kenneth P. Byrnes
Publications
The COVID-19 pandemic has required people to take new measures to mitigate the spread of the communicable virus. Guidelines from health organizations, government offices, and universities have been disseminated. Adherence to these guidelines cannot be more critical for flight training. This study explored the effects face masks had on CO2, heart rate, respiration rate, and oxygen saturation while wearing a face mask at an oxygen level simulated to 5,000 feet. Thirty-two instructor pilots (IP) volunteered to participate in the study. IPs spent 90 minutes in a normobaric chamber while wearing a cloth face mask or a paper face mask. Participants …
Physiological Effects During Aerobatic Flights On Science Astronaut Candidates, Pedro Llanos, Diego M. Garcia
Physiological Effects During Aerobatic Flights On Science Astronaut Candidates, Pedro Llanos, Diego M. Garcia
Publications
Spaceflight is considered the last frontier in terms of science, technology, and engineering. But it is also the next frontier in terms of human physiology and performance. After more than 200,000 years humans have evolved under earth’s gravity and atmospheric conditions, spaceflight poses environmental stresses for which human physiology is not adapted. Hypoxia, accelerations, and radiation are among such stressors, our research involves suborbital flights aiming to develop effective countermeasures in order to assure sustainable human space presence. The physiologic baseline of spaceflight participants is subject to great variability driven by age, gender, fitness, and metabolic reserve. The objective of …
General Aviation Hypoxia And Reporting Statistics, Timothy B. Holt, Jacqueline Luedtke, Claire Schindler
General Aviation Hypoxia And Reporting Statistics, Timothy B. Holt, Jacqueline Luedtke, Claire Schindler
Publications
“All too often, pilots tell me they don't need physiological training because they don't fly that high. The statement points out the general feelings of a large majority of the aviation population. I suppose then the burning question is ‘why do we still have aircraft accidents?’” (Boshers, 2015). To this day there are no statistics on how often general aviation pilots experience hypoxia during everyday operations. General aviation pilots (i.e. non-commercial operations) were chosen for this study because:
- Little regulation regarding flight physiology training
- General attitude of invulnerability towards hypoxia
- No requirement to report hypoxia or similar events