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1996

Articles 1 - 17 of 17

Full-Text Articles in Medicine and Health Sciences

Ccnp Position Paper On The Use Of Placebos In Psychiatry, William Friend, Charles Weijer Oct 1996

Ccnp Position Paper On The Use Of Placebos In Psychiatry, William Friend, Charles Weijer

Charles Weijer

No abstract provided.

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Queer Science: The Use And Abuse Of Research Into Homosexuality, Charles Weijer Oct 1996

Queer Science: The Use And Abuse Of Research Into Homosexuality, Charles Weijer

Charles Weijer

No abstract provided.

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Placebo Controls Are Not Good Science, Charles Weijer Aug 1996

Placebo Controls Are Not Good Science, Charles Weijer

Charles Weijer

No abstract provided.

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Selective Absence Of Cone Outer Segment Β3-Transducin Immunoreactivity In Hereditary Cone Degeneration (Cd), Kathryn Gropp, A. Széll, Jun Huang, Gregory Acland, Debora Farber, Gustavo Aguirre Aug 1996

Selective Absence Of Cone Outer Segment Β3-Transducin Immunoreactivity In Hereditary Cone Degeneration (Cd), Kathryn Gropp, A. Széll, Jun Huang, Gregory Acland, Debora Farber, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

We have used immunocytochemistry and in situ hybridization to examine the expression of photoreceptor specific genes in retinas of normal dogs and those affected with hereditary cone degeneration (cd), a rare autosomal recessive disorder that selectively affects cones. In thecdretina, cone disease begins early in life; cones are lost by extrusion of the nucleus into the inner segment, and later, by displacement of the nucleus, surrounded by a thin rim of cytoplasm, into the interphotoreceptor space. Two micrometer sections from the superior and inferior retinal meridians, extending from the optic disk to the ora serrata, were used for in situ …

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Structuring The Review Of Human Genetics Protocols: Gene Localization And Identification Studies, Kathleen Glass, Charles Weijer, Roberta Palmour, Stanley Shapiro, Trudo Lemmens, Karen Lebacqz Jun 1996

Structuring The Review Of Human Genetics Protocols: Gene Localization And Identification Studies, Kathleen Glass, Charles Weijer, Roberta Palmour, Stanley Shapiro, Trudo Lemmens, Karen Lebacqz

Charles Weijer

No abstract provided.

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Evolving Ethical Issues In Selection Of Subjects For Clinical Research, Charles Weijer May 1996

Evolving Ethical Issues In Selection Of Subjects For Clinical Research, Charles Weijer

Charles Weijer

Wittgenstein, in his famous critique of philosophy, noted that the influence of an idea can be such that it alters the way that we see the world. “It is like a pair of glasses on our nose through which we see whatever we look at,” he said. “It never occurs to us to take them off.” This view of the power of an idea suggests that the interpretation of an event, and what response this event calls for, can depend upon the view one has of the world. A person who is naive about medical facts may, for example, interpret …

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What Difference Does It Make To Be Treated In A Clinical Trial? A Pilot Study, Charles Weijer, Benjamin Freedman, Abraham Fuks, James Robbins, Stanley Shapiro, Myriam Skrutkowska May 1996

What Difference Does It Make To Be Treated In A Clinical Trial? A Pilot Study, Charles Weijer, Benjamin Freedman, Abraham Fuks, James Robbins, Stanley Shapiro, Myriam Skrutkowska

Charles Weijer

OBJECTIVE: Pilot study to characterize treatment differences between patients treated in clinical trials and those treated in a clinical setting. Previous studies have shown higher survival rates for participants in trials of cancer therapy. This difference is observed even after rates are adjusted for important covariates such as age and stage of disease.

DESIGN: Retrospective chart review.

SETTING: Oncology outpatient department in a tertiary care hospital.

PATIENTS: Ninety women 18 to 70 years of age with early-stage breast cancer who were diagnosed in 1990. Fifty-one of the women were treated through clinical trials and 39 were treated outside of clinical …

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Ethical Issues In Research, Charles Weijer Mar 1996

Ethical Issues In Research, Charles Weijer

Charles Weijer

No abstract provided.

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Nonallelism Of Erd And Prcd And Exclusion Of The Canine Rds/Peripherin Gene As A Candidate For Both Retinal Degeneration Loci., K Ray, Gregory M. Acland, Gustavo D. Aguirre Mar 1996

Nonallelism Of Erd And Prcd And Exclusion Of The Canine Rds/Peripherin Gene As A Candidate For Both Retinal Degeneration Loci., K Ray, Gregory M. Acland, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

Purpose:  To determine whether early retinal degeneration (erd) and progressive rod cone degeneration (prcd), two canine hereditary retinal degenerations, are caused by allelic mutations; to determine the cDNA sequence of the canine RDS/peripherin homolog (CFRDSP); and to test whether mutations(s) in CFRDSP cause(s) either erd or prcd.
Methods: Three erd-affected dogs were crossbred to three prcd-affected dogs, and their progeny were tested by electroretinography and retinal morphology for evidence of retinal degeneration. Canine RDS/peripherin cDNA was cloned and sequenced after reverse-transcription-polymerase chain reaction (RT-PCR) of total retinal RNA. A set of overlapping fragments of CFRDSP cDNA amplified from normal and …

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Down With Placebolatry, Charles Weijer, Carl Elliott Mar 1996

Down With Placebolatry, Charles Weijer, Carl Elliott

Charles Weijer

No abstract provided.

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Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass Dec 1995

Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass

Charles Weijer

No abstract provided.

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Empowerment Of Graduate Nursing Students: A Dialogue Toward Change, Genevieve Chandler, S. Roberts Dec 1995

Empowerment Of Graduate Nursing Students: A Dialogue Toward Change, Genevieve Chandler, S. Roberts

Genevieve E. Chandler

This article represents the first phase in exploration of empowerment of graduate advanced practice nursing students. This phase includes a review of the relevant literature on empowerment and discusses the applicability of this literature to current educational practice. The authors suggest that creating an empowering environment for learning necessitates dramatic change in teaching methodology and in faculty-student perspective about their roles. An ongoing dialogue among faculty and between students and faculty is proposed to begin to conceptualize this change. This article also presents a synopsis of a dialogue between the two authors intended to stimulate further discussion.

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Do The Right Thing, Charles Weijer Dec 1995

Do The Right Thing, Charles Weijer

Charles Weijer

McGill ethicists help ensure that medical research conforms to the highest scientific and ethical standards.

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Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer Dec 1995

Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer

Charles Weijer

No abstract provided.

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Adenovirus-Mediated Gene Transfer Of The Tumor Suppressor, P53, Induces Apoptosis In Postmitotic Neurons, R. Slack, Daniel Belliveau, M. Rosenberg, J. Atwal, H. Lochmuller, R. Aloyz, A. Haghighi, B. Lach, P. Seth, E. Cooper, F. Miller Dec 1995

Adenovirus-Mediated Gene Transfer Of The Tumor Suppressor, P53, Induces Apoptosis In Postmitotic Neurons, R. Slack, Daniel Belliveau, M. Rosenberg, J. Atwal, H. Lochmuller, R. Aloyz, A. Haghighi, B. Lach, P. Seth, E. Cooper, F. Miller

Daniel J. Belliveau

Programmed cell death is an ongoing process in both the developing and the mature nervous system. The tumor suppressor gene, p53, can induce apoptosis in a number of different cell types. Recently, the enhanced expression of p53 has been observed during acute neurological disease. To determine whether p53 overexpression could influence neuronal survival, we used a recombinant adenovirus vector carrying wild type p53 to transduce postmitotic neurons. A control consisting of the same adenovirus vector background but carrying the lacZ reporter expression cassette was used to establish working parameters for the effective genetic manipulation of sympathetic neurons. We have found …

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An Improved Diagnostic Test For Rod Cone Dysplasia 1 (Rcdl) Using Allele-Specific Polymerase Chain Reaction, Kunal Ray, Maria Lara Tejero, Victoria Baldwin, Gustavo Aguirre Dec 1995

An Improved Diagnostic Test For Rod Cone Dysplasia 1 (Rcdl) Using Allele-Specific Polymerase Chain Reaction, Kunal Ray, Maria Lara Tejero, Victoria Baldwin, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Purpose. To develop an improved diagnostic test for rod-cone dysplasia type 1 (rcdl). The rcdl phenotype is an early onset, autosomal recessive disease caused by a mutation in the canine rod cyclic GMP phosphodiesterase (β-subunit (PDE6B) gene. A G to A transition in codon 807 at nucleotide position 2420 results in a stop codon. This is the only disease causing mutation detected so far in the canine PDE6B gene.
Methods. Allele specific primers were designed in which the 3' end had the nucleotide corresponding to either the wild type or the mutant rcdl allele. PCR was …

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Suffering, Ethics, And The Body Of Christ: Anointing As A Strategic Alternative Practice, M. Therese Lysaught Dec 1995

Suffering, Ethics, And The Body Of Christ: Anointing As A Strategic Alternative Practice, M. Therese Lysaught

M. Therese Lysaught

No abstract provided.

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