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A Convergent Approach To Aqueous Lead (Pb) Mitigation Of A Supplemental Self-Supply Shallow Groundwater Source Accessed By Handpumps In Madagascar, Adaline Marie Buerck Jun 2022

A Convergent Approach To Aqueous Lead (Pb) Mitigation Of A Supplemental Self-Supply Shallow Groundwater Source Accessed By Handpumps In Madagascar, Adaline Marie Buerck

USF Tampa Graduate Theses and Dissertations

The World Health Organization (WHO) has consistently listed lead (Pb) as one of the ten chemicals of major public health concern. Though the toxic nature of lead has been known since the 20th century it is still utilized in a wide variety of products due to its favorable properties. Exposure to lead still accounts for approximately 900,000 deaths annually and disproportionately impacts those in low- and middle-income countries (LMIC) due to a variety of reasons such as poverty, malnutrition, and lack of knowledge on the toxic nature of lead. Lead exposure routes include air, soil, dust, diet, and water. Though …


Examining The Relationship Between Racial Respect Among Black Early Childhood Professionals And Their Perceptions Of Black Children, Kayla Nembhard Jun 2022

Examining The Relationship Between Racial Respect Among Black Early Childhood Professionals And Their Perceptions Of Black Children, Kayla Nembhard

USF Tampa Graduate Theses and Dissertations

Black children are exposed to the highest rates of negative teacher perceptions and punitive consequences. Healthy People 2020 acknowledges the significance of the first five years of child development and the various factors that promote or hinder health outcomes during this time. Furthermore, it highlights the significance of quality relationships between children and their caregivers, including their ECE teachers. Overall, Black children tend to fare better academically when they are able to engage with Black educators and other ECE professionals. However, there is recent evidence Black educators in ECE settings, specifically, also uphold racialized negative perceptions of Black students that …


Japan’S Covid 19 Infection Rate: A Focus On Tokyo Neighborhoods, Lauren Koerner Jun 2022

Japan’S Covid 19 Infection Rate: A Focus On Tokyo Neighborhoods, Lauren Koerner

USF Tampa Graduate Theses and Dissertations

This thesis asks, are neighborhood demographic and economic variables connected to COVID-19 infection rates in Tokyo, Japan? I hypothesize that variation in urbanization and neighborhood demographics account for Japan’s low, though not uniform COVID-19 infection rates. This thesis applies several anthropological perspectives: The biocultural perspective because I look at epidemiology of COVID 19 considering socio-cultural, economic, and ecological factors as well as biological susceptibilities. The critical biocultural perspective because I look at how structures of power and inequality may impact health and healthcare access. Biomedical/applied anthropology, well placed to study the current epidemiologic situation of COVID 19 in Japan and …


Nonparametric Estimation Of Transition Probabilities In Illness-Death Model Based On Ranked Set Sampling, Ying Ma Jun 2022

Nonparametric Estimation Of Transition Probabilities In Illness-Death Model Based On Ranked Set Sampling, Ying Ma

USF Tampa Graduate Theses and Dissertations

The ranked set sampling (RSS) design is applied widely in agriculture, environmental science, and medical research where the exact measurements of sampling units is costly, but sampling units can be ranked by a correlated concomitant variable. RSS is usually a cost-efficient alternate to simple random sampling (SRS) for selecting more representative samples. This study presents a novel methodology to investigate the nonparametric estimation of transition probabilities in illness-death model using the RSS design. We study the Aalen–Johansen estimator of transition probabilities in illness-death Markov model based on RSS design under random right censoring time and propose nonparametric estimators of the …


Outcomes Of A Periodic Exposure Assessment Of Workers At A University Campus, Logan M. Armagast Jun 2022

Outcomes Of A Periodic Exposure Assessment Of Workers At A University Campus, Logan M. Armagast

USF Tampa Graduate Theses and Dissertations

Standards promulgated by the Occupational Safety and Health Administration (OSHA)are applicable to most businesses in the private sector, however, state and local government entities are not under OSHA’s jurisdiction. Universities that receive public funding fall under the category of state and local government entities and, unless an OSHA-approved State plan explicitly states otherwise, they are not required to demonstrate compliance with OSHA standards and are not subject to OSHA inspections. Without being constrained by federal regulation, those responsible for ensuring the health and safety of employees at publicly funded universities have some leeway in their methods for evaluating the conditions …


"Are We Done?": The Minimization Of Covid-19 And The Individualization Of Health In The United States, Cassidy R. Boe Jun 2022

"Are We Done?": The Minimization Of Covid-19 And The Individualization Of Health In The United States, Cassidy R. Boe

USF Tampa Graduate Theses and Dissertations

As the death toll from Covid-19 in the United States exceeds 1 million in just over two years, more variants continue to emerge, threatening more waves of Covid-19 and ultimately, more deaths. Despite this, mask use continues to decline, and one third of Americans say that the pandemic is over. The Centers for Disease Control and Prevention (CDC) has been central in publicly disseminating biomedical knowledge using Twitter. The CDC’s Twitter account (@CDCgov) shares information related to the spread of Covid-19, including mitigation measures such as mask recommendations and vaccine information. I have conducted a narrative analysis of the replies …


A Macro Social Examination Of The Relationship Between Disabilities And Crime Using Neighborhood And County Level Data, Natasha A. Baloch Mar 2022

A Macro Social Examination Of The Relationship Between Disabilities And Crime Using Neighborhood And County Level Data, Natasha A. Baloch

USF Tampa Graduate Theses and Dissertations

Over the last few decades, there has been a consistent increase in mental illnesses in the US population. This has also lead to increased interactions of those with mental illnesses and/or disabilities with law enforcement and the criminal justice system. Despite these instances, there is limited research on the relationship between disabilities, mental health issues and crime in the large body of criminological research. Further, the current extant research is a) outside the field of Criminology, b) primarily focuses on those with only intellectual or developmental disabilities and/or c) does not examine this relationship at the macro level, despite evidence …


A Study Of Noise Exposures For Amusement Park Employees By Positions And Ride Categories, Danielle M. Dao Jan 2022

A Study Of Noise Exposures For Amusement Park Employees By Positions And Ride Categories, Danielle M. Dao

USF Tampa Graduate Theses and Dissertations

Millions of workers in the United States encounter daily noise exposures in their workplace, associated with millions of dollars in workers compensation annually. Many industries have been well studied for the presence of hazardous noise, but little exposure data exists for the amusement park industry.Major attractions found at amusement parks fall within one of three categories and in each of those categories, five employee positions are common. This thesis sought to identify if there are differences in potential employee noise exposure among the ride types and if there are differences in noise exposure among the employee positions. The analysis of …


The Debate On Physician-Assisted Death In The United States: A Narrative Analysis Of Formula Stories, Rebecca Blackwell Nov 2021

The Debate On Physician-Assisted Death In The United States: A Narrative Analysis Of Formula Stories, Rebecca Blackwell

USF Tampa Graduate Theses and Dissertations

Public policy discussions can be viewed as empirical windows into broadly shared culturalvalues and emotions of the social contexts in which the policy discussions take place. This project is a narrative analysis of the public debate on physician-assisted death (PAD), drawing from three data sources: newspaper articles, the websites of social movement organizations, and testimonies from a state legislative hearing. This analysis explores ways in which social actors deploy personal stories that contribute to shape the policy-making process by appealing to cultural beliefs and broadly shared emotions. The findings of this project constitute a contribution to the study of emotions …


Community Assessment Of Water Perceptions And Household Point-Of-Use Treatment Methods In Madagascar, Isabella Rose Silverman Oct 2021

Community Assessment Of Water Perceptions And Household Point-Of-Use Treatment Methods In Madagascar, Isabella Rose Silverman

USF Tampa Graduate Theses and Dissertations

One in four people around the world do not have access to safe drinking water, which means that two billion people globally lack access. In high-income countries, 0.02% of yearly deaths are attributed to unsafe water sources; however, an alarming 10.6% of deaths occur in Madagascar, for the same reason.

To achieve Sustainable Development Goal 6: Ensure access to water and sanitation for all, a collaboration between public health and engineering is critical. Within the public health sector, social marketing is commonly utilized to address a problem by using commercial marketing principles to change behavior for the good of society. …


Seasonality In Competence To Transmit West Nile Virus For A Widespread Reservoir, Kyle L. Koller Oct 2021

Seasonality In Competence To Transmit West Nile Virus For A Widespread Reservoir, Kyle L. Koller

USF Tampa Graduate Theses and Dissertations

All organisms face a central conflict; a limited supply of resources must beoptimally allocated to competing biological functions. Utilizing robust immune defenses can be energetically costly;, thus, immune function is often diminished when other processes, such as reproduction, molt, or migration demand energy. As wild animals residing in temporally dynamic environments face seasonal patterns in resource availability, infectious disease risk, and environmental suitability, many species have evolved endogenous biological rhythms so that the performance of reproduction, molt, or migration and the associated trade-off with immune function be completed when doing so best promotes fitness. In turn, this demand to optimize …


Synthesis Of A Multimodal Ecological Model For Scalable, High-Resolution Arboviral Risk Prediction In Florida, Sean P. Beeman Oct 2021

Synthesis Of A Multimodal Ecological Model For Scalable, High-Resolution Arboviral Risk Prediction In Florida, Sean P. Beeman

USF Tampa Graduate Theses and Dissertations

West Nile virus (WNV) and Eastern Equine Encephalitis virus (EEEV) represent the two greatest endemic arboviral risks to the state of Florida. Currently, no approved human vaccine exists for the prevention of either virus. In the absence of a vaccine, effective disease surveillance is paramount for public health. In Florida, WNV and EEEV sentinel chicken surveillance is conducted by mosquito control programs operated at the county, municipality, or special taxing district level. This program was implemented in 1978 following human outbreaks of St. Louis Encephalitis virus (SLEV) that occurred between 1959 and 1977, with initial sentinel coops placed in proximity …


Who To Choose? Rating Broker Best Practices In The Medicare Advantage Industry, Darwin R. Hale Oct 2021

Who To Choose? Rating Broker Best Practices In The Medicare Advantage Industry, Darwin R. Hale

USF Tampa Graduate Theses and Dissertations

The purpose of this study is to help navigate the U.S. Healthcare system in a way that maximizes value and minimizes risk to Medicare Beneficiaries. We do this through the creation of a tool that will aid in the selection of an independent health broker. Brokers are the trusted resource who have the responsibility and expertise to optimize client value through needs analysis, education, and expectations setting. Beneficiaries need help with life impacting health and wellness decisions and ongoing support across the continuum of care. The qualitative research included interviews of industry experts with combined Medicare experience of more than …


Multidimensional Well-Being Across Time Scales In Caregivers And Non-Caregivers, Victoria R. Marino Jul 2021

Multidimensional Well-Being Across Time Scales In Caregivers And Non-Caregivers, Victoria R. Marino

USF Tampa Graduate Theses and Dissertations

Contemporary research on informal caregiving recognizes that, though stressful, providing care for a disabled family member or friend can bring psychological benefits, such as increased meaning or purpose in life, growing closer to the care recipient, and learning new skills. Scales of eudaimonic well-being (EWB – e.g., meaning in life, personal growth, and positive relations with others) developed in positive psychology literature offer an innovative solution to incorporating caregiving benefits into between-groups comparisons of caregiver and non-caregiver well-being, which have typically focused on cross-sectional assessment of hedonic well-being (HWB – i.e., negative/positive affect and life satisfaction). Moreover, using daily using …


Predictors Of Goal Attainment Among High School Students In Accelerated Academic Curricula Receiving School-Based Motivational Interviewing Intervention, Camille E. Hanks Jul 2021

Predictors Of Goal Attainment Among High School Students In Accelerated Academic Curricula Receiving School-Based Motivational Interviewing Intervention, Camille E. Hanks

USF Tampa Graduate Theses and Dissertations

Students enrolled in Advanced Placement (AP) courses and International Baccalaureate (IB) programs represent a unique group of adolescents given the high demands of their rigorous coursework and the elevated stress they experience compared to peers in the general education (Suldo & Shaunessy-Dedrick, 2013). These students are often missed in traditional screening procedures that tend to identify students struggling academically or exhibiting disruptive behaviors. Fortunately, Shaunessy-Dedrick and colleagues (2021) developed a comprehensive school-based intervention program, including universal (Tier 1) and selective (Tier 2) components, which aims to support the well-being of AP/IB students. The Tier 2 component of this program (i.e., …


Exploring Adult Attachment In Intimate Relationships Among Women Who Were Exposed To Intimate Partner Violence In Childhood: A Convergent Mixed Methods Approach, Ngozichukwuka C. Agu Jul 2021

Exploring Adult Attachment In Intimate Relationships Among Women Who Were Exposed To Intimate Partner Violence In Childhood: A Convergent Mixed Methods Approach, Ngozichukwuka C. Agu

USF Tampa Graduate Theses and Dissertations

Background: Trauma in childhood including exposure to intimate partner violence is associated with a myriad of negative outcomes in physical health, mental health, academic performance, and relationship domains. Adult attachment in intimate relationships is a key factor that determines several health outcomes as well as healthy relationships. This study explored: 1) the perceptions of childhood exposures to intimate partner violence and how these exposures could have impacted adult attachment; 2) the perceptions of relationship factors that play a role in the development of adult attachment in intimate relationships; and 3) the behavioral and socioenvironmental influences that frame perceptions of adult …


Feasibility Of A Virtual Group Nutrition Intervention For Adolescents With Autism Spectrum Disorder, Acadia W. Buro Jun 2021

Feasibility Of A Virtual Group Nutrition Intervention For Adolescents With Autism Spectrum Disorder, Acadia W. Buro

USF Tampa Graduate Theses and Dissertations

Background: Youth with autism spectrum disorder (ASD) have an increased likelihood of being overweight or developing obesity. As children and adolescents with ASD exhibit problematic eating behaviors and may consume more energy-dense foods and fewer fruits and vegetables than typically developing youth, nutrition represents a modifiable obesity risk factor for adolescents with ASD, yet there is a lack of interventions to improve healthy eating and reduce the risk of obesity in this population.

Purpose: The purpose of this study was to examine the feasibility, acceptability, and preliminary efficacy of a virtual implementation of BALANCE (Bringing Adolescent Learners with Autism Nutrition …


Chorine Conversion: Biological And Water Quality Impact On Activated Carbon Block Point Of Use Filters, Horace S. Jakpa Jun 2021

Chorine Conversion: Biological And Water Quality Impact On Activated Carbon Block Point Of Use Filters, Horace S. Jakpa

USF Tampa Graduate Theses and Dissertations

Point-of-use (POU) activated carbon (AC) filters are ubiquitous in many U.S. households. AC can reduce concentrations of lead, other heavy metals, and mitigate taste and odor issues. However, AC filters also remove residual disinfectants, thus allowing for the proliferation of microbes in the filter. In chloraminated systems, this can lead to localized, filter-induced nitrification. Most notably, high nitrite and nitrate in drinking water can cause methemoglobinemia (blue baby syndrome) in children under the age of three, raising public health concerns.

As a control measure for nitrification within distribution systems, utilities practice periodic, short-term secondary disinfectant switches from chloramine to free …


An Examination Of Covid-19 Health Behaviors And Public Health Messaging Using The Health Belief Model And Organization-Public Relationship Quality, Aaron L. Nichols Jun 2021

An Examination Of Covid-19 Health Behaviors And Public Health Messaging Using The Health Belief Model And Organization-Public Relationship Quality, Aaron L. Nichols

USF Tampa Graduate Theses and Dissertations

In the context of the most severe pandemic in over 100 years, this study examined public health behavior and public health messaging using the health belief model (HBM) and organization-public relationships (OPR) as frameworks. The study employed a cross-sectional survey of students (N = 288) and employees (N = 203) at a large public university in the southeastern United States. First, the study empirically tested the components of the HBM as determinants of engaging in public health behaviors meant to slow or prevent the spread of COVID-19 and found all components of the model to be significantly related to engaging …


Development And Validation Of An Isothermal Amplification Assay For Eastern Equine Encephalitis Virus, Mikayla D. Maddison Jun 2021

Development And Validation Of An Isothermal Amplification Assay For Eastern Equine Encephalitis Virus, Mikayla D. Maddison

USF Tampa Graduate Theses and Dissertations

Eastern Equine Encephalitis virus (EEEV) is a neurotrophic alphavirus for which there is no effective treatment or vaccine for humans. Periodic outbreaks in the Eastern United States represent an ongoing public health problem; Florida serves as the reservoir for EEEV for the rest of the country. Reverse transcription-polymerase chain reaction (RT-PCR) is the current gold standard for molecular diagnostic testing of the presence of EEEV in vectors. However, RT-PCR is technically complex and can be difficult for mosquito control districts to utilize. In order to provide a simple, cost-effective alternative for mosquito surveillance and control, a novel one step reverse …


Serious Mental Illness In Nursing Homes: Quality Concerns, Dylan J. Jester Jun 2021

Serious Mental Illness In Nursing Homes: Quality Concerns, Dylan J. Jester

USF Tampa Graduate Theses and Dissertations

Objective: This dissertation is made of two academic papers followed by a chapter discussing policy implications of the findings. The objective of this dissertation is to better understand if high-serious mental illness (SMI) nursing homes (NHs) provide poorer quality of care (e.g., operationalized as staffing levels, NH Compare quality star ratings, and health deficiencies) and whether quality in high-SMI NHs is confounded by payer mix (e.g., the proportion of residents who are Medicaid-reimbursed). A modified Donabedian Structure, Process, Outcome (SPO) Model was used as the main theoretical framework.

Methods: Data came from the Certification and Survey Provider Enhanced Reports (CASPER) …


Mealtimes In Early Childhood Education Centers During Covid-19: A Mixed-Methods Assessment Of Responsibilities, Interactions, And Best Practices, Joanna Mackie Jun 2021

Mealtimes In Early Childhood Education Centers During Covid-19: A Mixed-Methods Assessment Of Responsibilities, Interactions, And Best Practices, Joanna Mackie

USF Tampa Graduate Theses and Dissertations

Background: Childhood obesity is a public health problem associated with many co-morbidities. The majority of young children in the United States (U.S.) attend formal early childhood education (ECE) programs, often consuming the majority of daily calories and engaging with teachers during mealtimes. Mealtime best practices support children’s development of healthy eating habits. This dissertation aimed to understand how COVID-19 has influenced mealtimes in ECE centers, including (1) the division of responsibility between adults and children during mealtimes, (2) the child feeding dynamic, and (3) how mealtime best practices have been included during COVID-19.

Methods: This dissertation used a concurrent mixed-methods …


How Race Is Made In Everyday Life: Food, Eating, And Dietary Acculturation Among Black And White Migrants In Florida, U.S., Laura Kihlstrom Apr 2021

How Race Is Made In Everyday Life: Food, Eating, And Dietary Acculturation Among Black And White Migrants In Florida, U.S., Laura Kihlstrom

USF Tampa Graduate Theses and Dissertations

This dissertation explores how race impacts everyday food decisions and experiences among Black and White migrants in Florida, United States. The study is rooted in scholarship on food and immigration, which asserts that dietary acculturation or the “Americanization” of diets adversely affects the overall health status of migrant populations in the U.S. To date, the majority of this literature has focused on the experiences of Latinx migrants and has not centered race in its analysis. Building on participant observation and semi-structured interviews (n=49) completed over a period of 13 months in the Tampa and Miami Metropolitan areas among Ethiopian and …


Mechanisms And Mitigation: Effects Of Light Pollution On West Nile Virus Dynamics, Meredith E. Kernbach Mar 2021

Mechanisms And Mitigation: Effects Of Light Pollution On West Nile Virus Dynamics, Meredith E. Kernbach

USF Tampa Graduate Theses and Dissertations

Light pollution, or the presence of unnatural light at night, is a pervasive and growing problem across the globe. While often pictured in urban centers, light pollution is far reaching and can affect seemingly safe and minimally developed environments. For example, agricultural communities with artificial lighting near facilities can generate such light pollution in rural areas. Further, streetlights and illuminated billboards along roads and highways can generate light pollution far from cities. Given how pervasive this anthropogenic stressor is, it is surprising that not much is known about how artificial light at night, or ALAN, affects humans or wildlife, especially …


Screening Of Pregnant Women With Opioid Use Disorder: Identifying Factors Impacting Implementation Of Screening Recommendations Using The Theoretical Domains Framework, Tara R. Foti Mar 2021

Screening Of Pregnant Women With Opioid Use Disorder: Identifying Factors Impacting Implementation Of Screening Recommendations Using The Theoretical Domains Framework, Tara R. Foti

USF Tampa Graduate Theses and Dissertations

Background: Prenatal opioid exposure is a growing problem in the United States with high and increasing rates of opioid use and opioid use disorder during pregnancy. Almost 23% of pregnant women enrolled in Medicaid programs filled an opioid prescription during pregnancy in 2007, marking a 21.1% increase since 2000. Maternal opioid use during pregnancy is associated with a variety of poor maternal, pregnancy and infant outcomes, including overdose, pregnancy-associated death, prematurity, low birth weight and Neonatal Opioid Withdrawal Syndrome. To optimize prenatal care and pregnancy-associated outcomes, the Alliance for Innovation in Maternal Health, in collaboration with The American College of …


Sleep Diagnoses And Low Back Pain In U.S. Military Veterans, Kenneth A. Taylor Mar 2021

Sleep Diagnoses And Low Back Pain In U.S. Military Veterans, Kenneth A. Taylor

USF Tampa Graduate Theses and Dissertations

Low back pain (LBP) is a common problem that is the primary contributor to years lived with disability worldwide. In the U.S. LBP is disproportionately experienced by military veterans. In recent years interest has grown in the impact of sleep and sleep-related diagnoses on musculoskeletal pain complaints (including LBP) and despite growth in the scientific literature investigating this, gaps in our understanding of how sleep diagnoses impact LBP remain. To that end, this dissertation uses administrative electronic health record data from veterans seeking care through the Veterans Health Administration in three manuscripts to address the following specific aims: (1) investigate …


Making Change In The Nickel City: Food Banking And Food Insecurity In Buffalo, Ny During The Covid-19 Pandemic, Sarah E. Bradley Mar 2021

Making Change In The Nickel City: Food Banking And Food Insecurity In Buffalo, Ny During The Covid-19 Pandemic, Sarah E. Bradley

USF Tampa Graduate Theses and Dissertations

In March 2020, the coronavirus 2019 (COVID-19) pandemic began to spread across the United States. The pandemic disrupted the food system in an unprecedented fashion, exacerbating existing inequalities and contributing to increased rates of food insecurity and charitable food use. This research project considers the food system of Buffalo, New York and seeks to capture the way in which both food insecure households and the food pantries that serve them adapted to the pandemic. Using data from 75 client surveys, 52 qualitative semi-structured interviews with food pantry staff and clients, and 15 participatory GIS mapping interviews, this mixed-methods project describes …


Defining Codes Based On The Consolidated Framework For Implementation Research In The Context Of The Implementing Universal Lynch Syndrome Screening, Jasmine A. Burton-Akright Mar 2021

Defining Codes Based On The Consolidated Framework For Implementation Research In The Context Of The Implementing Universal Lynch Syndrome Screening, Jasmine A. Burton-Akright

USF Tampa Graduate Theses and Dissertations

Lynch syndrome (LS) is the most common hereditary cause of both colorectal cancer (CRC) and endometrial cancer (EC). Universal tumor screening (UTS) of newly diagnosed EC and CRC patients has been shown to be both an effective and economical approach to identify patients with LS and subsequently reduce future cancer s for patients and their family members. Despite its efficacy, LS UTS has not been consistently adopted across hospital systems and existing programs vary widely in their structure and execution. The Implementing Universal Lynch Syndrome Screening (IMPULSS) study aims to determine the critical factors necessary for successful implementation of LS …


Evaluating The Development And Implementation Of Campus-Based Sexual And Interpersonal Violence Prevention Programming, Robyn Manning-Samuels Mar 2021

Evaluating The Development And Implementation Of Campus-Based Sexual And Interpersonal Violence Prevention Programming, Robyn Manning-Samuels

USF Tampa Graduate Theses and Dissertations

1 in 5 women in institutions of higher education experience an attempted or completed sexual assault every year. Sexual and interpersonal violence prevention programming is one of the main ways colleges and universities attempt to address this issue. The purpose of this exploratory qualitative pilot study is to evaluate the development and implementation of campus-based sexual and interpersonal violence prevention programming, looking specifically at facilitators and barriers for prevention staff, what they experience as preventionists, and how COVID-19 has impacted these essential programs. Ten preventionists were recruited from the Campus Advocacy and Prevention Professionals Association for 90-minute interviews. Results of …


Bait-And-Kill: Targeting A Novel Heme Biochemical Pathway In Hundreds Of Cancers, Christopher G. Marinescu Mar 2021

Bait-And-Kill: Targeting A Novel Heme Biochemical Pathway In Hundreds Of Cancers, Christopher G. Marinescu

USF Tampa Graduate Theses and Dissertations

Cancer cells are characterized by their ability to grow and proliferate in rates that far exceed normal cells by modifying their iron/heme metabolisms to levels higher than normal. This imbalance of heme biosynthesis can lead to cancer cells having a flux of heme intermediates to the point where they enter a state called heme-overdrive. Heme-overdrive is a process unique to a variety of cancers but absent in normal tissues. With this enhanced production, heme can act as an epigenic regulator for signaling proliferation (18). Through the novel strategy called ‘bait-and-kill,’ cancer cells will be coerced into a state of heme …