Medicine and Health Sciences Commons^™

Solid Microneedles For Transdermal Delivery Of Amantadine Hydrochloride And Pramipexole Dihydrochloride, Mylien T. Hoang, Kevin B. Ita, Daniel A. Bair

Faculty Publications & Research of the TUC College of Pharmacy

The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and characterization of the microchannel depth was performed using confocal laser scanning microscopy (CLSM) to demonstrate microchannel formation following microneedle roller application. We also report, for the first time, the use of TA.XT Plus Texture Analyzer to characterize burst force in pig skin for transdermal drug delivery experiments. This is the force required to rupture pig skin. The mean passive flux of amantadine hydrochloride, determined using a …

Involvement Of Sigma-1 Receptors In The Antidepressant-Like Effects Of Dextromethorphan, Linda Nguyen, Matthew J. Robson, Jason R. Healy, Anna L. Scandinaro, Rae Reiko Matsumoto

Faculty Publications & Research of the TUC College of Pharmacy

Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan binds to sigma-1 (s1) receptors, which are believed to be protein targets for a potential new class of antidepressant medications. The purpose of this study was to determine whether dextromethorphan elicits antidepressant-like effects and the involvement of s1 receptors in mediating its antidepressant-like actions. The antidepressant-like effects of dextromethorphan were assessed in male, Swiss Webster mice using the forced swim test. Next, …

Pharmacy Students’ Performance And Perceptions In A Flipped Teaching Pilot On Cardiac Arrhythmias, Terri H. Wong, Eric J. Ip, Ingrid C. Lopes, Vanishree Rajagopalan

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To implement the flipped teaching method in a 3-class pilot on cardiac arrhythmias and to assess the impact of the intervention on academic performance and student perceptions.

Design. An intervention group of 101 first-year pharmacy students, who took the class with the flipped teaching method, were supplied with prerecorded lectures prior to their 3 classes (1 class in each of the following subjects: basic sciences, pharmacology, and therapeutics) on cardiac arrhythmias. Class time was focused on active-learning and case-based exercises. Students then took a final examination that included questions on cardiac arrhythmias. The examination scores of the …

Standardized Field Sobriety Test: False Positive Test Rate Among Sober Subjects, Keith Yoshizuka, Paul J. Perry, Greta Upton, Ingrid C. Lopes, Eric Ip

Faculty Publications & Research of the TUC College of Pharmacy

The Standardized Field Sobriety Test (SFST) is a series of exercises that a law enforcement officer gives to a driver suspected of driving under the influence of alcohol. The original research that demonstrated a high correlation between failure of the SFST and a high blood alcohol concentration did not utilize a standard control group to validate that the failure of the SFST was not a characteristic of the population at large. This study examined a series of drug naive subjects to determine the rate of failure of the SFST to accurately distinguish a suspect with high blood alcohol content from …

Bullying In The Clinical Training Of Pharmacy Students, Katherine K. Knapp, Patricia A. Shane, Debra Sasaki-Hill, Keith Yoshizuka, Paul Chan, Thuy Vo

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To determine whether bullying is a significant factor in the clinical training of pharmacy students.

Methods. The literature as well as the Accreditation Council for Pharmacy Education (ACPE) Standards and American Association of Colleges of Pharmacy (AACP) surveys were reviewed for mention and/or measurement of bullying behaviors in the clinical training of pharmacy students. The authors used a Delphi process to define bullying behavior. The consensus definition was used to analyze 2,087 in-house student evaluations of preceptors for evidence of bullying behaviors. The authors mapped strings of text from in-house student comments to different, established categories of …

Implementation Of An Accelerated Physical Examination Course In A Doctor Of Pharmacy Program, Jackie Ho, Monica K. Bidwal, Ingrid C. Lopes, Bijal M. Shah, Eric J. Ip

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To describe the implementation of a 1-day accelerated physical examination course for a doctor of pharmacy program and to evaluate pharmacy students’ knowledge, attitudes, and confi- dence in performing physical examination.

Design. Using a flipped teaching approach, course coordinators collaborated with a physician faculty member to design and develop the objectives of the course. Knowledge, attitude, and confidence survey questions were administered before and after the practical laboratory.

Assessment. Following the practical laboratory, knowledge improved by 8.3% (p,0.0001). Students’ perceived ability and confidence to perform a physical examination significantly improved (p,0.0001). A majority of students responded …

Nanoparticle Encapsidation Of Flock House Virus By Auto Assembly Of Tobacco Mosaic Virus Coat Protein, Payal D. Maharaj, Jyothi K. Mallajosyula, Gloria Lee, Phillip Thi, Yiyang Zhou, Christopher M. Kearney, Alison A. Mccormick

Faculty Publications & Research of the TUC College of Pharmacy

Tobacco Mosaic virus (TMV) coat protein is well known for its ability to self-assemble into supramolecular nanoparticles, either as protein discs or as rods originating from the ~300 bp genomic RNA origin-of-assembly (OA). We have utilized TMV self-assembly characteristics to create a novel Flock House virus (FHV) RNA nanoparticle. FHV encodes a viral polymerase supporting autonomous replication of the FHV genome, which makes it an attractive candidate for viral transgene expression studies and targeted RNA delivery into host cells. However, FHV viral genome size is strictly limited by native FHV capsid. To determine if this packaging restriction could be eliminated, …

Identifying Psychological Contract Breaches To Guide Improvements In Faculty Recruitment, Retention, And Development, Gretchen L. Peirce, Shane P. Desselle, Jolaine R. Draugalis, Alan R. Spies, Tamra S. Davis, Mark Bolino

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To identify pharmacy faculty members’ perceptions of psychological contract breaches that can be used to guide improvements in faculty recruitment, retention, and development.

Methods. A list of psychological contract breaches was developed using a Delphi procedure involving a panel of experts assembled through purposive sampling. The Delphi consisted of 4 rounds, the first of which elicited examples of psychological contract breaches in an open-ended format. The ensuing 3 rounds consisting of a survey and anonymous feedback on aggregated group responses.

Results. Usable responses were obtained from 11 of 12 faculty members who completed the Delphi procedure. The final list …

Treating Mentoring Programs As A Scholarly Endeavor, Shane P. Desselle

Faculty Publications & Research of the TUC College of Pharmacy

The author discusses mentoring programs for pharmacy school faculty and the research literature around forming these programs.