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Full-Text Articles in Medicine and Health Sciences
An Improved Tobacco Mosaic Virus (Tmv)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia, Ahd A. Mansour, Sukalyani Banik, Ragavan V. Suresh, Hardeep Kaur, Meenakshi Malik, Alison A. Mccormick, Chandra Bakshi
An Improved Tobacco Mosaic Virus (Tmv)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia, Ahd A. Mansour, Sukalyani Banik, Ragavan V. Suresh, Hardeep Kaur, Meenakshi Malik, Alison A. Mccormick, Chandra Bakshi
Faculty Publications & Research of the TUC College of Pharmacy
Francisella tularensis, the causative agent of the fatal human disease known as tularemia is classified as a Category A Select Agent by the Centers for Disease Control. No licensed vaccine is currently available for prevention of tularemia in the United States. Previously, we published that a tri-antigen tobacco mosaic virus (TMV) vaccine confers 50% protection in immunized mice against respiratory tularemia caused by F. tularensis. In this study, we refined the TMV-vaccine formulation to improve the level of protection in immunized C57BL/6 mice against respiratory tularemia. We developed a tetra-antigen vaccine by conjugating OmpA, DnaK, Tul4, and SucB proteins of …
Intranasal Administration Of A Two-Dose Adjuvanted Multi-Antigen Tmv-Subunit Conjugate Vaccine Fully Protects Mice Against Francisella Tularensis Lvs Challenge, Alison A. Mccormick, Aisha Shakeel, Chris Yi, Hardeep Kaur, Ahd M. Mansour, Chandra Shekhar Bakshi
Intranasal Administration Of A Two-Dose Adjuvanted Multi-Antigen Tmv-Subunit Conjugate Vaccine Fully Protects Mice Against Francisella Tularensis Lvs Challenge, Alison A. Mccormick, Aisha Shakeel, Chris Yi, Hardeep Kaur, Ahd M. Mansour, Chandra Shekhar Bakshi
Faculty Publications & Research of the TUC College of Pharmacy
Tularemia is a fatal human disease caused by Francisella tularensis, a Gram-negative encapsulated coccobacillus bacterium. Due to its low infectious dose, ease of aerosolized transmission, and lethal effects, the CDC lists F. tularensis as a Category A pathogen, the highest level for a potential biothreat agent. Previous vaccine studies have been conducted with live attenuated, inactivated, and subunit vaccines, which have achieved partial or full protection from F. tularensis live vaccine strain (LVS) challenge, but no vaccine has been approved for human use. We demonstrate the improved efficacy of a multi-antigen subunit vaccine by using Tobacco Mosaic virus (TMV) as …