Medicine and Health Sciences Commons^™

Poor Pulmonary Function Is Not Associated With Increased Rates Of Toxicity Or Decreased Overall Survival After Stereotactic Body Radiotherapy For Early Stage Non-Small Cell Lung Cancer: Results Of A Multi-Institutional Analysis, M. Guckenberger, J. Belderbos, A. Hope, L. L. Kestin, M. Werner-Wasik, J. J. Sonke, Y. Xiao, D. Yan, J. Wilbert, I. S. Grills

Bodine Journal

Purpose/Objective(s): Stereotactic body radiotherapy (SBRT) is considered as the treatment of choice for stage I non-small cell lung cancer (NSCLC) in medically inoperable patients. It was the purpose of this study to evaluate whether pretreatment pulmonary function is predictive for survival and toxicity after SBRT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

A Multi-National Pooled Analysis Of 434 Cases Of Stage I Non-Small Cell Lung Cancer (Nsclc) Treated With Volumetrically Image-Guided Stereotactic Lung Radiotherapy: Results From The Elekta Collaborative Lung Research Group, I. S. Grills, A. J. Hope, M. Guckenberger, L. L. Kestin, M. Werner-Wasik, D. Yan, J. J. Sonke, J. P. Bissonnette, Y. Xiao, J. Belderbos

Bodine Journal

Background: Published lung SBRT outcomes/dose response data for inoperable NSCLC come from small phase I-II studies or larger datasets not requiring image-guided radiotherapy (IGRT) or volumetric prescriptions. This entire cohort of SBRT patients had daily online cone-beam CT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Toxicity Of Phase I Radiation Oncology Trials: Worldwide Experience, C. Glass, R. B. Den, A. P. Dicker, Y. R. Lawrence

Bodine Journal

Introduction: Informed consent involves understanding the risks and benefits of trial enrollment. This is challenging in the phase I setting since true quantitative information is never known. We therefore performed an analysis of published radiation oncology (RO) phase I trials emphasizing patient outcomes. To our knowledge, no such systemic analysis has previously been published.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Pathologic Correlation Of Pet-Ct Based Auto Contouring For Radiation Planning In Lung Cancer, S. E. Fogh, A. Farach, C. Intenzo, R. Axelrod, P. Mccue, A. Harper, A. Nelson, M Werner-Wasik

Bodine Journal

Purpose/Objective(s): Radiation therapy in lung cancer relies on CT and functional imaging (FDG-PET) to delineate tumor volumes. Semi-automatic contouring tools have been developed for PET to improve on the inter-observer bias of manual contouring and intrinsic differences in imaging equipment. A common method involves using a threshold at a given percentage of the max activity, which may be less accurate with smaller tumors and tumors with low source to background ratio. To overcome this deficiency, a gradient algorithm, which detects changes in image counts at the border of the tumor, has been developed. Few studies have correlated these methods to …

Igrt After Prostatectomy: Evaluation Of Corrective Shifts And Toxicity Using Online Cone Beam Ct Vs. Weekly Port Films For Target Localization, H. B. Eldredge, M. Studenski, S. Keith, E. J. Trabulsi, A. Harvey, C. Lallas, L. Gomella, A. P. Dicker, T. N. Showalter

Bodine Journal

Purpose/Objective(s): Image guidance (IG) may permit higher radiotherapy (RT) doses (>65 Gy) after radical prostatectomy (RP) without increased toxicity, with improved accuracy and smaller margins. Conebeam (CBCT) allows IGRT with volumetric images. This study evaluated CBCT shifts and toxicity after conformal IGRT, compared to RT with port films.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Dosimetric Comparison Of Vmat, Imrt And Proton Therapy For Post- Prostatectomy Radiation Therapy For Prostate Cancer, L. A. Doyle, M. Studenski, A. Harvey, A. P. Dicker, Y. Xiao, Y. Yu, T. N. Showalter, A. Harrison

Bodine Journal

Purpose/Objectives: Radiation therapy (RT) for the treatment of prostate cancer after radical prostatectomy (RP) is widely accepted. With technological advances, radiation treatment technique and dosimetry may vary. The purpose of this study is to quantify dosimetric difference of proton therapy versus VMAT and IMRT focusing on bladder and rectal dose sparing and target coverage.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Should Hypopharynx Cancer Continue To Be Included In “Multi-Head And Neck” Trials Within The Rtog?, R. Den, Q. Zhang, D. Cognetti, M. Machtay, J. S. Cooper, A. S. Garden, C. U. Jones, S. Yom, K. K. Ang

Bodine Journal

Purpose/Objective(s): It is becoming increasingly evident that the behavior of cancers from different subsites of the head and neck varies greatly despite similar histologic appearance. As current head and neck trials are focusing more on a risk-based approach, it is unclear into which trials patients with hypopharyngeal primaries (HP) should be included. Thus, we undertook to examine whether patients with HP perform as well as oropharyngeal primaries (OP) in the definitive setting and whether HP perform as well as larynx primaries (LX) in the post-operative setting in the multi-institutional setting. American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting …

Uncertainty And Margin Study For Imrt, Vmat, And Proton Beam Therapy For Treatment After Radical Prostatectomy, Y. Cui, A. S. Harrison, M T. Studenski, T. N. Showalter, J. O. Deasy, Y. Yu, J. M. Galvin, Y. Xiao

Bodine Journal

Purpose/Objective(s): To compare the uncertainties of 3D dose distributions, caused by the geometrical uncertainty of patient setup, in IMRT, VMAT, and proton plans for post-prostatectomy treatment. To test the effectiveness of a common margin recipe in these three types of treatment plans.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Dosimetric Evaluation Of Tumor Tracking In 4d Radiotherapy, I. Buzurovic, M. Werner-Wasik, T. Biswas, J. Galvin, A. Dicker, Y. Yu, T. Podder

Bodine Journal

Purpose: In some patients the tumors in lung, pancreas, liver, breast, and other organs move significantly during cardiac and breathing cycles. In this study we have investigated the dosimetric benefits of real-time tumor tracking for patients who were diagnosed with lung cancer.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Decrease Of Morbidity And Cost Of Care With Prophylactic Cranial Irradiation For Non-Small Cell Lung Cancer, C. E. Champ, N. Ohri, M. Werner-Wasik

Bodine Journal

Purpose: While several studies analyze the incidence of brain metastases in patients with non-small cell lung cancer (NSCLC) treated with prophylactic cranial irradiation (PCI), there is little data available on how this treatment can affect medical cost and morbidity. Our goal was to analyze those issues patients encounter secondary to brain metastases, often in the final months of their lives, and to support the hypothesis of economic benefit and cost effectiveness resulting from the use of PCI in this population.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Time Interval Between Staging Fdg Positron Emission Tomography (Pet) And Initiation Of Stereotactic Lung Radiotherapy (Sbrt) Impacts The Risk Of Recurrence And Metastasis In Non-Small Cell Lung Cancer (Nsclc), B. Belderbos, A. Hope, L. L. Kestin, M. Guckenberger, M. Werner-Wasik, J. J. Sonke, J. P. Bissonnette, Y. Xiao, D. Yan, I. S. Grills

Bodine Journal

Background: To study influence of time interval from staging PET scanning to RT start time on recurrence and survival in patients with NSCLC undergoing lung SBRT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Results Of A Phase I Trial Of Induction Cisplatin, Docetaxel, 5-Fu And Erlotinib Followed By Cisplatin, Bevacizumab And Erlotinib With Radiotherapy For Advanced Head And Neck Cancer, P. H. Ahn, M. Machtay, P. R. Anné, E. Wuthrick, W. M. Keane, D. Cognetti, A. P. Dicker, R. S. Axelrod

Bodine Journal

Background: A phase I trial of induction cisplatin, docetaxel, 5-FU and erlotinib (TPF-E) followed by cisplatin, bevacizumab and erlotinib (PA-E) with radiotherapy (XRT) for advanced head and neck cancer (HNC) was conducted.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Effect Of Cediranib, Temozolamide And Radiotherapy In U87 Gbm Wtegfr And Egfrviii-Expressing Xenografts, P. Wachsberger, R. Y, Lawrence, Y. Liu, B. Andersen, A. P. Dicker

Bodine Journal

Introduction: Glioblastomas (GBM) frequently overexpress the epidermal growth factor receptor (wtEGFR) or its mutant, EGFRvIII contributing to radioresistance. New treatment strategies for GBM include blockade of EGFR signaling and angiogenesis. Cediranib (CD) is a highly potent VEGFR-2 RTKI that inhibits all three VEGF receptors. This study investigated the radiosensitizing potential of CD in combination with temozolamide (TMZ) in U87 GBM xenografts expressing wtEGFR or EGFRvIII.

Radiation Research Society (RRS) 8th Annual Meeting September 25-29, Maui, HI

Control Of Glycolytic Flux By Ampk And P53-Mediated Signaling Pathways In Tumor Cells Grown At Low Ph, D. B. Leeper, E. E. Mendoza, J. Caro, R. Burd

Bodine Journal

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays upregulated Hif-1α anaerobic glycolysis, chronic acidification, reduced rate of overall protein synthesis, lower rate of cell proliferation and aggressive invasive characteristics. Most transplantable tumors exhibit a pHe of 6.7- 7.0; the DB-1 melanoma xenografts used here have a pHe=6.7. Understanding tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to radiotherapy. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6- Biphosphatase Isoform-3 (PFKFB3), is a bifunctional …

A Procedure For Standardizing Mlc Quality Assurance For Elekta Linac, K. Yan, M. Studenski, H. Liu, I. Buzurovic, Y. Cui, L. Shabason, A. Harrison, Y. Yu, M. Hossain, Y. Xiao

Bodine Journal

Purpose: As specified in TG142, MLC position accuracy needs to be tested on weekly/monthly basis, with 1mm tolerance. This study focuses on developing techniques, hardware and software tools for implementation of MLC QA tests for Elekta Linacs.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Measuring Pacemaker Dose: A Clinical Perspective, M. Studenski, Y. Xiao, A. Harrison

Bodine Journal

Purpose: The number of patients presenting with pacemakers in our clinic has increased recently. Following AAPM recommendations, a treatment plan is developed that minimizes the dose to the pacemaker. The most efficient way to measure in vivo dose during treatment is to use MOSFETs or diodes which offer a simple but inaccurate (up to 25% error) method of recording. In this abstract, we analyze the dose measured by these different devices in an attempt to assess pacemaker dose.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Imrt For Craniospinal Irradiation: A Dosimetric Comparison, M. Studenski, T. Biswas, Y. Xiao, A. Harrison

Bodine Journal

Purpose: This work tests the possibility of using IMRT to promote organ sparing for the treatment of CSI. The traditional CSI technique uses opposed lateral fields to treat the brain and posterior fields to treat the spine. Published manuscripts focusing on the possibility of IMRT for CSI have only looked at pediatric cases. Here, we will plan IMRT for CSI on adult patients to quantify the dosimetric gains when compared to traditional techniques.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Comparison Of A Novel Curvilinear Approach To Conventional Rectilinear Approach For Prostate Seed Implant, T. K. Podder, A. P. Dicker, Y. Yu

Bodine Journal

Purpose: To evaluate dosimetric benefit of curvilinear distribution of seeds for low-dose-rate (LDR) prostate brachytherapy with I-125 isotopes.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Predictors Of Survival For Patients With Non-Small Cell Lung Cancer And Synchronous Brain Metastases With Fdg-Pet/Ct Staging, N. Ohri, Y. Xiao, M. Werner-Wasik

Bodine Journal

Purpose: The clinical course of patients diagnosed with non-small cell lung cancer (NSCLC) with brain metastases (BM) at presentation is variable. Here we seek to identify predictors of survival in patients staged with FDG-PET/CT.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Feasibility Of Improving Cone Beam Ct Number Consistency With A Scatter-Correction Algorithm, J. Li, W. Yao, Y. Xiao, Y. Yu

Bodine Journal

Purpose: To explore the feasibility of improving Elekta cone beam CT (CBCT) number consistency using a scatter-correction algorithm, with the aim of using CBCT images for treatment planning with heterogeneity correction.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Quantitative Analysis Of Dose Enhancement Contributed By Different Photon Interactions In X-Ray Irradiation With The Presence Of Hz Materials With Geant4 Monte Carlo Simulation, K. Huang, Y. Yu

Bodine Journal

Purpose: To study the overall dose enhancements and those contributed by different processes quantitatively in the presence of HZ materials and X-ray with different energies with Monte Carlo method.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Performance Study Of Novel Accelerationenhanced Filters In The Prediction Of Normal And Irregular Respiration Motion, K. Huang, I. Buzurovic, M. Werner-Wasik, T. Biswas, A. Dicker, J. Galvin, Y. Yu, T. Podder

Bodine Journal

Purpose: To study the performance of the novel acceleration-enhanced (AE) filters in the prediction of normal and irregular respiration motion and compare them with those of traditional adaptive normalized least mean squares (nLMS) and adaptive neuron network (ANN) filters. This facilitates the real-time tumor tracking and dynamic delivery of radiation dose to the tumor.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Optical Guidance System Vs. Cbct For Phantom And Patient Setup, L. Fu, H. Perera, H. Liu, Y. Xiao, Y. Yu

Bodine Journal

Purpose: To quantify the discrepancy between Varian optical guidance (OG) frameless localization system and Varian Trilogy on board imaging (OBI) system for setting up phantom and SRS patient.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Motion Control Consistency With Abdominal Compression Device From Daily 4d Cbct, Y. Cui, A. S. Harrison, Y. Xiao

Bodine Journal

Purpose: To investigate the effectiveness of abdominal compression in tumor motion control for lung cancer radiotherapy. To study the motion control consistency during radiation treatment course through 4D reconstruction of daily cone beam computed tomography (CBCT) images.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Dosimetric Advantages Of Active Tracking And Dynamic Dose Delivery, I. Buzurovic, K. Huang, M. Werner-Wasik, T. Biswas, J. M. Galvin, A. Dicker, Y. Yu, T. Podder

Bodine Journal

Purpose: To investigate dosimetric effect of tumor tracking. To evaluate changes of treatment volumes when tracking is applied.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA.

Combination Of Vorinostat With Whole-Brain Radiotherapy In The Treatment Of Brain Metastases, Y. R. Lawrence, R. M. Pfeffer, M. Werner-Wasik, H. Choy, A. Dicker

Bodine Journal

Background: A third of patients with solid malignancies develop brain metastases. Expected overall survival is 4-7 months depending on age, performance status, and extracranial disease. Standard treatment is controversial; however, the majority of patients receive wholebrain radiation therapy at some point. Vorinostat (suberoylanilide hydroxamic acid, SAHA), an FDA-approved HDAC inhibitor, has been demonstrated to radiosensitize tumor cells in vitro, as assessed by both radiation-induced DNA damage and clonogenic cell survival (Munshi et al. Molecular Cancer Therapeutics 5, 1967-1974, 2006). We have shown that vorinostat downregulates key genes involved in double-strand DNA repair (Rad50, Rad51, XRCC2, XRCC3, XRCC6), as assessed by …

Accuracy Of Cancer Information On The Internet: A Comparison Of A Wiki With A Professionally Maintained Database, M. S. Rajagopalan, V. Khanna, M. Stott, Y. Leiter, T. N. Showalter, A. Dicker, Y. L. Lawrence

Bodine Journal

Background: A Wiki is a website which can be directly, openly edited; Wikipedia, a collaborative encyclopedia, is a well-known example. Due to Wiki’s lack of editorial control and formal structure, we hypothesized that the content would be less complete and less accurate than that presented on a formal, peer-reviewed web site. Our goal was to compare the coverage, accuracy, and readability of cancer information from a Wiki (Wikipedia) with a peer-reviewed web site, the patientoriented National Cancer Institute’s Physician Data Query (PDQ) comprehensive cancer database.

American Society of Clinical Oncology (ASCO) 46th Annual Meeting June 4-8, Chicago, IL.

Acute Neurological Toxicity (Nt) And Long-Term Outcomes In High-Grade Glioma Rtog Trials, Y. R. Lawrence, M. Wang, A. P. Dicker, D. W. Andrews, W. J. Curran, J. M. Michalski, L. Souhami, W. A. Yung, M. Mehta

Bodine Journal

Background: Treatment of high-grade glioma consists of fractionated radiation therapy (RT) ± chemotherapy. The incidence/significance of neurological toxicity (NT) in this disease is not known. We evaluated the relationship between acute and chronic NT, and ultimate outcome, as well as risk factors for NT from the RTOG database.

American Society of Clinical Oncology (ASCO) 46th Annual Meeting June 4-8, Chicago, IL.

Potential For Thermal Enhancement By Quercetin Mediated Mechanisms Targeting P53 Antagonists In Human Melanoma Cells, T. Thangasamy, K. Limesand, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Recently Temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents. Although the response rates achieved by TMZ alone are less than satisfactory, there is great interest in identifying compounds that could be used in combination therapy. We have previously demonstrated that the bioflavonoid quercetin (Qct) promotes a p53-mediated response in melanoma and sensitizes melanoma to DTIC. Here we demonstrate that Qct also sensitizes cells to TMZ by a mechanism that involves the modulation of a truncated p53 family member, ΔNp73.

Society for Thermal Medicine Annual Meeting April 23-26, Clearwater Beach, FL.

Control Of Glycolytic Flux By Ampk And P53-Mediated Signaling Pathways In Tumor Cells Adapted To Grow At Low Ph, E. E. Mendoza, J. Caro, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays anaerobic glycolysis, chronic acidification and aggressive tumor characteristics. Understanding the tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to hyperthermia. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase Isoform-3 (PFKFB3), is a bifunctional enzyme central to glycolytic flux and downstream of the metabolic stress sensor AMP-activated protein kinase (AMPK), which has been shown to activate an isoform of Phosphofructokinase (PFK-2).

Society for Thermal Medicine …