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Full-Text Articles in Medicine and Health Sciences
Evolving Role Of Vorinostat Combined With Radiation Therapy In The Treatment Of Brain Tumors, From The Lab To The Clinic, Y. R. Lawrence, P. Wachsberger, Y. Liu, B. Andersen, A. P. Dicker
Evolving Role Of Vorinostat Combined With Radiation Therapy In The Treatment Of Brain Tumors, From The Lab To The Clinic, Y. R. Lawrence, P. Wachsberger, Y. Liu, B. Andersen, A. P. Dicker
Bodine Journal
Purpose/Objective(s): Radiation therapy (RT) is a critical element in the treatment of both brain metastases and glioblastoma (GBM). Temozolomide (TMZ) has an established role in the upfront treatment of GBM. Down-regulated mismatch repair (MMR) is a known mechanism of resistance to TMZ. Vorinostat (SAHA), an HDAC inhibitor, has successfully been combined with a number of cytotoxic agents, including ionizing radiation (IR). We performed a series of preclinical and clinical studies to examine the role of SAHA in the treatment of brain tumors.
American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA
Dosimetric Comparison Of Vmat, Imrt And Proton Therapy For Post- Prostatectomy Radiation Therapy For Prostate Cancer, L. A. Doyle, M. Studenski, A. Harvey, A. P. Dicker, Y. Xiao, Y. Yu, T. N. Showalter, A. Harrison
Dosimetric Comparison Of Vmat, Imrt And Proton Therapy For Post- Prostatectomy Radiation Therapy For Prostate Cancer, L. A. Doyle, M. Studenski, A. Harvey, A. P. Dicker, Y. Xiao, Y. Yu, T. N. Showalter, A. Harrison
Bodine Journal
Purpose/Objectives: Radiation therapy (RT) for the treatment of prostate cancer after radical prostatectomy (RP) is widely accepted. With technological advances, radiation treatment technique and dosimetry may vary. The purpose of this study is to quantify dosimetric difference of proton therapy versus VMAT and IMRT focusing on bladder and rectal dose sparing and target coverage.
American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA