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Full-Text Articles in Medicine and Health Sciences
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Medical Student Research Poster Symposium
Alcohol (ethanol) abuse is a widely recognized risk factor in the development of several diseases. Previous studies in our lab have shown that ethanol induces reactive oxygen species (ROS) production in osteogenic cells, which results in oxidative damage, skeletal dysfunction, and osteoporosis. Moreover, ethanol inhibits epiphyseal plate proliferation in longitudinal bones and affects chondrocyte function, which results in shorter bones. In osteogenic cells, a major source of ethanol-mediated ROS is derived from NADPH oxidases (NOXs). However, it remains uncertain if ROS produced by NOXs during alcohol metabolism result in impaired chondrocyte function and differentiation. In this study, we investigated if …
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Medical Student Research Poster Symposium
Introduction: Bacterial Vaginosis (BV) is a common disorder associated with the vaginal microbiome characterized by the displacement of lactobacillus with an overgrowth of anaerobes. Symptomatic cases can be associated with Pelvic Inflammatory Disease (PID), complications with pregnancy, and greater susceptibility to sexually transmitted infections. In cases where antibiotics are needed to treat BV, recurrence commonly occurs within 3 months to a year. Despite the prevalence of BV, the specific mechanism associated with the onset is unclear. In this pilot study we utilized shotgun metagenomics to identify the discrete changes occurring in the vaginal microbiome leading up to the onset of …
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Medical Student Research Poster Symposium
Cannabinoids have been suggested as a possible alternative to opioids for pain management and as an adjunct to opioid administration to reduce the many adverse effects associated with their administration (i.e., administered to produce opioid-sparing effects). Although cannabinoids such as delta-9-tetrahydrocannabinol (THC) have been shown to produce antinociceptive effects, these effects have not typically been compared directly with its adverse effects – some of which include the disruption of cognitive and conditioned behaviors. These types of studies are necessary if cannabinoids such as THC can be considered a valid option for pain management. The present experiment was conducted to directly …
Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Medical Student Research Poster Symposium
Background: Chuvash polycythemia is a hematological disorder that is present worldwide but endemic to the Chuvash population, a Turkish ethnic group, in Russia. The disorder is caused by a homozygous germline mutation (R200W) in the von Hippel Lindau gene. This mutation impairs binding of pVHL to hypoxia-inducible factor 1-alpha (HIF-1α); lack of this interaction prevents degradation of HIF-1α. The resultant upregulation of HIF-1α, even in a normal oxygen state, increases the activity of erythropoietin, thereby causing polycythemia. Affected individuals experience increased rates of arterial and venous thrombosis unrelated to the increased concentration of hemoglobin. Aims: To determine whether upregulation of …
Investigating The Role Of Adipor1 In Pro-Homeostatic Fatty Acid Metabolism Pathways, Eric Prestenburg, Alise Aucoin, Marie-Audrey Kautzmann-Guerin, Bokkyoo Jun, William Gordon, Nicolas Bazan
Investigating The Role Of Adipor1 In Pro-Homeostatic Fatty Acid Metabolism Pathways, Eric Prestenburg, Alise Aucoin, Marie-Audrey Kautzmann-Guerin, Bokkyoo Jun, William Gordon, Nicolas Bazan
Medical Student Research Poster Symposium
Docosahexaenoic acid (DHA, 22:6) is a substrate widely accepted as necessary for synthesizing very-long-chain polyunsaturated fatty acids (VLC-PUFAs), a class of lipids found in high concentrations in the retina. VLC-PUFAs are formed from 28:6 derived in the omega-3 fatty acid pathway involving eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) by a series of reactions catalyzed by the elongase ELOVL4 within the inner segments of the photoreceptor cells (PRCs). VLC-PUFAs are precursors to elovanoids (ELVs), which have been indicated to maintain homeostasis in the retina in response to inflammation and uncompensated oxidative stress (UOS). During these conditions, elovanoids are …
Investigating Neuroprotective Efficacy Of Lipid Mediators Neuroprotectin D1 (Npd1)And Resolvin D1 (Rvd1) On Behavioral Outcomes And Ischemic Penumbra, Kierany B. Shelvin, Madigan M. Reid, Larissa Khourtorova, Jeff Ji, William Lewis, Pranab Mukherjee, Ludmila Belayev, Nicolas G. Bazan
Investigating Neuroprotective Efficacy Of Lipid Mediators Neuroprotectin D1 (Npd1)And Resolvin D1 (Rvd1) On Behavioral Outcomes And Ischemic Penumbra, Kierany B. Shelvin, Madigan M. Reid, Larissa Khourtorova, Jeff Ji, William Lewis, Pranab Mukherjee, Ludmila Belayev, Nicolas G. Bazan
Medical Student Research Poster Symposium
Background: In the United States, stroke is the sixth leading cause of death, and a major cause of long-term disability. Ischemic stroke elicits a cascade of immune and neuroinflammatory responses that form an ischemic core and surrounding area (penumbra) which can be salvaged upon reperfusion within a limited period of time. Reperfusion signals the release of an essential omega-3 fatty acid, Docosahexaenoic acid (DHA) from injured neuronal cell membranes. DHA is converted into its derivatives, Neuroprotectin D1 (NPD1) via 15- lypoxygenase and Resolvin D1 (RvD1) via 15- and 5-lypoxygenase. These docosanoid lipid mediators have been shown to improve neurologic outcomes …
Novel Biomarkers For Early And Accurate Detection Of A Fatal Gut Inflammatory Diseasein Preemie Babies, Lana Thaljeh, Rebecca Buckley, Anne Tufton, Maya Heath, Brian Barkemeyer, Zhide Fang, Lee Mcdaniel, Andrew Chapple, Kelly Laborde, Beverly Ogden, Misty Good, Duna Penn, Steven Spedale, Sunyoung Kim
Novel Biomarkers For Early And Accurate Detection Of A Fatal Gut Inflammatory Diseasein Preemie Babies, Lana Thaljeh, Rebecca Buckley, Anne Tufton, Maya Heath, Brian Barkemeyer, Zhide Fang, Lee Mcdaniel, Andrew Chapple, Kelly Laborde, Beverly Ogden, Misty Good, Duna Penn, Steven Spedale, Sunyoung Kim
Medical Student Research Poster Symposium
Necrotizing enterocolitis (NEC) is an inflammatory disease that primarily affects the intestinal tract of premature and low birthweight infants. It is one of the most common complications that occur with prematurity, which also results in high morbidity and mortality due to unchecked pathogenic bacterial growth. The median time between death and x-ray diagnosis is 1 day and, currently, there are no reliable molecular methods to predict the onset of NEC in infants. Association of intestinal alkaline phosphatase (iAP) with moderate and severe forms of the disease suggested that iAP can be a diagnostic tool that is accurate and specific for …
Asymptomatic Covid-19 On Lsuhsc’S Campus: Antibodies, Pcr Tests, And Variants, Mallory K. Varnado, San Chu, Caroline Duncan, Ron Horswell, Lucio Miele, Judy Crabtree
Asymptomatic Covid-19 On Lsuhsc’S Campus: Antibodies, Pcr Tests, And Variants, Mallory K. Varnado, San Chu, Caroline Duncan, Ron Horswell, Lucio Miele, Judy Crabtree
Medical Student Research Poster Symposium
Background: Rapid spreading of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic of coronavirus disease 2019 (COVID- 19) which has infected 188,128,952 people and resulted in 4,059,339 deaths worldwide (WHO COVID-19 Dashboard). Despite profound disease prevention measures and recent attempts at widespread vaccination, the virus continues to mutate and infect new people each day. Objective: The goal of this study is to analyze the data collected from the COVID-19 screening and testing program at LSUHSC-New Orleans. This includes antibody testing data, exposure and symptom questionnaires, PCR viral testing, and viral RNA sequencing data from deidentified, …
Sex Differences In The Effects Of Adolescent Alcohol Exposure, Rebecca K. Yoon, S.L. Rein, O.R. Brunke, Eleanor B. Holmgren, T. Henderson, C.R. Kasten, Tiffany Wills
Sex Differences In The Effects Of Adolescent Alcohol Exposure, Rebecca K. Yoon, S.L. Rein, O.R. Brunke, Eleanor B. Holmgren, T. Henderson, C.R. Kasten, Tiffany Wills
Medical Student Research Poster Symposium
Adolescent alcohol exposure is one of the strongest risk factors for the development of alcohol use disorder. Notably, affective disorders tend to emerge during this period of development as well. There is a growing body of evidence that suggests adolescent alcohol use in females is outpacing males, and that there are sex differences in various aspects of alcohol use. Women are more likely to use alcohol to blunt emotions of negative affective disorders such as anxiety and depression, while men are more likely to drink alcohol for the positive reward effects. To understand the underlying mechanism, it is necessary to …
Floppy Eyelid Syndrome And Obesity (Flo) Study, Bethany S. Acosta, Kyle V. Acosta, Stefany D. Primeaux
Floppy Eyelid Syndrome And Obesity (Flo) Study, Bethany S. Acosta, Kyle V. Acosta, Stefany D. Primeaux
Medical Student Research Poster Symposium
Floppy Eyelid Syndrome (FES) was first described in 1981 by Culbertson and Ostler. Often under-diagnosed, the reported incidence ranges from 0.5-31.5% with an average age of 51 years. A patient will typically present with a soft, rubbery tarsus that folds in on itself, a loose upper eyelid that everts easily with manual manipulation, and papillary conjunctivitis. Studies indicate that patients with FES are often diagnosed with obstructive sleep apnea (OSA) and have high rates of obesity (Body Mass Index (BMI) > 30). Patients with FES exhibit a diminished quantity of elastin fibers throughout the pretarsal orbicularis oculi muscle and tarsus. Interestingly, …