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Articles 1 - 30 of 115
Full-Text Articles in Medicine and Health Sciences
From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe
From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe
Biological, Geological, and Environmental Faculty Publications
No abstract provided.
Analysis Of 3.5 Million Sars-Cov-2 Sequences Reveals Unique Mutational Trends With Consistent Nucleotide And Codon Frequencies, Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael Dicuccio, Anton A. Komar, Chava Kimchi‑Sarfaty
Analysis Of 3.5 Million Sars-Cov-2 Sequences Reveals Unique Mutational Trends With Consistent Nucleotide And Codon Frequencies, Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael Dicuccio, Anton A. Komar, Chava Kimchi‑Sarfaty
Biological, Geological, and Environmental Faculty Publications
Background: Since the onset of the SARS-CoV-2 pandemic, bioinformatic analyses have been performed to understand the nucleotide and synonymous codon usage features and mutational patterns of the virus. However, comparatively few have attempted to perform such analyses on a considerably large cohort of viral genomes while organizing the plethora of available sequence data for a month-by-month analysis to observe changes over time. Here, we aimed to perform sequence composition and mutation analysis of SARS-CoV-2, separating sequences by gene, clade, and timepoints, and contrast the mutational profile of SARS-CoV-2 to other comparable RNA viruses.Methods: Using a cleaned, filtered, and pre-aligned dataset …
Survival Analysis And Prognostic Factors Of The Carcinoma Of Gallbladder, Zainab Feroz, Priyanka Gautam, Sonia Tiwari, Girish C. Shukla, Munish Kuma
Survival Analysis And Prognostic Factors Of The Carcinoma Of Gallbladder, Zainab Feroz, Priyanka Gautam, Sonia Tiwari, Girish C. Shukla, Munish Kuma
Biological, Geological, and Environmental Faculty Publications
Background: The present study aims to evaluate the survival status of patients with gallbladder cancer (GBC) and explore the prognostic factors for the improvement and preventions.
Methods: The study consists of 176 patients with clinically diagnosed gallbladder cancer; the study was conducted between 2019 and 2021 registered at Kamala Nehru Memorial Cancer Hospital, Prayagraj, India. The survival rates were analyzed by the Kaplan-Meier method; survival rate difference was analyzed by log-rank test, prognosis factors; and hazard ratio for mortality outcomes was estimated using Cox regression method.
Results: The overall median survival time of patients was 5 months with the 1-year, …
Transcriptomics-Based Network Medicine Approach Identifies Metformin As A Repurposable Drug For Atrial Fibrillation, Jessica C. Lal, Chengsheng Mao, Yadi Zhou, Shamone R. Gore-Panter, Julie H. Rennison, Beth S. Lovano, Et. Al
Transcriptomics-Based Network Medicine Approach Identifies Metformin As A Repurposable Drug For Atrial Fibrillation, Jessica C. Lal, Chengsheng Mao, Yadi Zhou, Shamone R. Gore-Panter, Julie H. Rennison, Beth S. Lovano, Et. Al
Biological, Geological, and Environmental Faculty Publications
Effective drugs for atrial fibrillation (AF) are lacking, resulting in significant morbidity and mortality. This study demonstrates that network proximity analysis of differentially expressed genes from atrial tissue to drug tar-gets can help prioritize repurposed drugs for AF. Using enrichment analysis of drug-gene signatures and functional testing in human inducible pluripotent stem cell (iPSC)-derived atrial-like cardiomyocytes, we identify metformin as a top repurposed drug candidate for AF. Using the active compactor, a new design analysis of large-scale longitudinal electronic health record (EHR) data, we determine that metformin use is significantly associated with a reduced risk of AF (odds ratio = …
Metabolic Outcomes Of Anaplerotic Dodecanedioic Acid Supplementation In Very Long Chain Acyl-Coa Dehydrogenase (Vlcad) Deficient Fibroblasts, Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana Sandlers
Metabolic Outcomes Of Anaplerotic Dodecanedioic Acid Supplementation In Very Long Chain Acyl-Coa Dehydrogenase (Vlcad) Deficient Fibroblasts, Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana Sandlers
Chemistry Faculty Publications
Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD, OMIM 609575) is associated with energy deficiency and mitochondrial dysfunction and may lead to rhabdomyolysis and cardiomyopathy. Under physiological conditions, there is a fine balance between the utilization of different carbon nutrients to maintain the Krebs cycle. The maintenance of steady pools of Krebs cycle intermediates is critical for mitochondrial energy homeostasis especially in high-energy demanding organs such as muscle and heart. Even-chain dicarboxylic acids are established as alternative energy carbon sources that replenish the Krebs cycle by bypassing a defective β-oxidation pathway. Despite this, even-chain dicarboxylic acids are eliminated in the urine of …
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Biological, Geological, and Environmental Faculty Publications
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere …
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Biological, Geological, and Environmental Faculty Publications
Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. Many subtelomeric genes are important for responding to environmental cues, and subtelomeric instability can facilitate organismal adaptation to extracellular changes, which is a common theme in a number of microbial pathogens. In this review, I will focus on the delicate and important balance between stability and plasticity at telomeres and subtelomeres of a kinetoplastid parasite, Trypanosoma brucei, which causes human African trypanosomiasis and undergoes antigenic variation to evade the …
Constructing The Panama Canal: A Brief History, Ian E. Phillips
Constructing The Panama Canal: A Brief History, Ian E. Phillips
The Downtown Review
Seeking to commemorate the construction of the Panama Canal, an engineering marvel widely considered a contender for the eighth wonder of the world, this article attempts to retell the story of the Canal's construction by synthesizing a narrative centered on the Canal under French and American leadership, worker segregation, and labor conditions at the Isthmus.
Pharyngeal Constriction As A Cause For Late Acquisition And Speech Sound Disorders Of Rhotic Sounds In English, Spanish, And French, Connor Mahon
The Downtown Review
This paper attempts to explain why rhotic sounds are cross-linguistically late developing among the sound inventory of children. Included is a summary of the current literature regarding classification of rhotic sounds, an examination of the articulatory movement of the tongue root, and an overview of the clinical implications on the field of speech-language pathology. The evidence presented supports the hypothesis that pharyngeal constriction is characteristic of rhotic sounds in many languages, and that it is related to the relative late acquisition and higher rate of speech sound disorders, as seen in English, Spanish, and French.
An Examination Of The Death Penalty, Alexandra N. Kremer
An Examination Of The Death Penalty, Alexandra N. Kremer
The Downtown Review
The death penalty, or capital punishment, is the use of execution through hanging, beheading, drowning, gas chambers, lethal injection, and electrocution among others in response to a crime. This has spurred much debate on whether it should be used for reasons such as ethics, revenge, economics, effectiveness as a deterrent, and constitutionality. Capital punishment has roots that date back to the 18th century B.C., but, as of 2016, has been abolished in law or practice by more than two thirds of the world’s countries and several states within the United States. Here, the arguments for and against the death …
A Comparative Analysis Of Translesion Dna Synthesis Catalyzed By A High-Fidelity Dna Polymerase, Anvesh Dasari, Tejal Deodhar, Anthony J. Berdis
A Comparative Analysis Of Translesion Dna Synthesis Catalyzed By A High-Fidelity Dna Polymerase, Anvesh Dasari, Tejal Deodhar, Anthony J. Berdis
Chemistry Faculty Publications
Translesion DNA synthesis (TLS) is the ability of DNA polymerases to incorporate nucleotides opposite and beyond damaged DNA. TLS activity is an important risk factor for the initiation and progression of genetic diseases such as cancer. In this study, we evaluate the ability of a high-fidelity DNA polymerase to perform TLS with 8-oxo-guanine (8-oxo-G), a highly pro-mutagenic DNA lesion formed by reactive oxygen species. Results of kinetic studies monitoring the incorporation of modified nucleotide analogs demonstrate that the binding affinity of the incoming dNTP is controlled by the overall hydrophobicity of the nucleobase. However, the rate constant for the …
Circling The Drain: Regulating Nutrient Pollution From Agricultural Sources, William Gutermuth
Circling The Drain: Regulating Nutrient Pollution From Agricultural Sources, William Gutermuth
Journal of Law and Health
The 2014 Toledo, Ohio tap water ban has, at least temporarily, put a spotlight on United States water supplies. Consequently, many Americans have begun to take a closer look at the quality of the fresh water bodies being used to supply tap water to their homes. Therefore, this Note analyzes the problems currently threatening the lakes, rivers, and other surface waters that are the source of fresh drinking water for huge populations in the United States. Part II examines the problem of nutrient pollution and explains the harmful effects it has on human health. Part III provides an overview of …
Organ Donation: A Comparison Of Altruistic And Market-Based Systems, Cameron Caputi
Organ Donation: A Comparison Of Altruistic And Market-Based Systems, Cameron Caputi
The Downtown Review
One of the most heavily regulated aspects of the Health Care industry is the organ donation system (“Legislation and Policy”). Regulations in this area ensure the quality of the organs and morality of the process through which they were procured. This system, however, is failing in at least one sense; the number of patients requiring organ transplants is increasing, but the number of donors remains stagnant (Gordon, Patel, Sohn, Hippen, Sherman , 2014). Due to the lack of available transplant organs, a debate has been sparked on whether the United States government should allow for the purchasing of these organs.
Unreplicable: The Unscientific Nature Of Science Journals, Ernest M. Oleksy
Unreplicable: The Unscientific Nature Of Science Journals, Ernest M. Oleksy
The Downtown Review
Academia shapes the way our species looks at veracity and defines what is deemed as well-founded science. The platform for researchers to make their work known is academic journals. The prerogative of these journals is to disseminate technically sound work so that the public may be informed of up-to-date advances in scientific fields. However, these journals are products on the market whose ultimate purpose is to garner a following that will make the producers money. This results in research that does not have statistically significant findings, or replications of past experiments which are integral to supporting the findings of the …
Determination Of Novel Metabolites Of Therapeutic Agents Used In The Treatment Of Castration-Resistant Prostate Cancer, Mohammad Alyamani
Determination Of Novel Metabolites Of Therapeutic Agents Used In The Treatment Of Castration-Resistant Prostate Cancer, Mohammad Alyamani
ETD Archive
Despite an array of improved treatment options over the past decade, prostate cancer remains the second leading cause of cancer mortality for men in the United States. Abiraterone and galeterone are oral steroidal compounds that are used to treat metastatic castration-resistant prostate cancer (CRPC). Abiraterone blocks 17a-hydroxylase/17,20-lyase (CYP17A1), an enzyme required for androgen synthesis. Galeteron inhibits CYP17A1, blocks the androgen receptor (AR), and decreases AR protein levels. Both drugs share the same structure with endogenous androgens such as dehydroepiandrosterone, which are substrates for the enzyme, 3ß-hydroxysteroid dehydrogenase (3ßHSD). Metabolites of 3ßHSD undergo further metabolism to produce the AR ligand, testosterone …
Myeloperoxidase-Mediated Protein Lysine Oxidation Generates 2- Aminoadipic Acid And Lysine Nitrile In Vivo, Hongqiao Lin, Bruce S. Levison, Jennifer A. Buffa, Ying Huang, Xiaoming Fu, Zeneng Wang, Valentin Gogonea, Joseph A. Didonato, Stanley L. Hazen
Myeloperoxidase-Mediated Protein Lysine Oxidation Generates 2- Aminoadipic Acid And Lysine Nitrile In Vivo, Hongqiao Lin, Bruce S. Levison, Jennifer A. Buffa, Ying Huang, Xiaoming Fu, Zeneng Wang, Valentin Gogonea, Joseph A. Didonato, Stanley L. Hazen
Chemistry Faculty Publications
Recent studies reveal 2-aminoadipic acid (2-AAA) is both elevated in subjects at risk for diabetes and mechanistically linked to glucose homeostasis. Prior studies also suggest enrichment of protein-bound 2-AAA as an oxidative post-translational modification of lysyl residues in tissues associated with degenerative diseases of aging. While in vitro studies suggest redox active transition metals or myeloperoxidase (MPO) generated hypochlorous acid (HOCl) may produce protein-bound 2-AAA, the mechanism(s) responsible for generation of 2- AAA during inflammatory diseases are unknown. In initial studies we observed that traditional acid- or basecatalyzed protein hydrolysis methods previously employed to measure tissue 2-AAA can artificially generate …
The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy
The Chemistry Of The Flint Water Crisis, Ernest M. Oleksy
The Downtown Review
Politics and science do not always go hand-in-hand. Nowhere was this more clear than in the Flint Water Crisis. Negligence towards growing levels of lead poisoning in drinking water led to incredibly deleterious effects on Flint's citizens. The chemistry of equilibrium and the shortcomings of local leaders led to Flint's water becoming a crisis.
Metabolomics Reveals New Mechanisms For Pathogenesis In Barth Syndrome And Introduces Novel Roles For Cardiolipin In Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan Mcritchie, Susan Sumner, Hilary J. Vernon
Metabolomics Reveals New Mechanisms For Pathogenesis In Barth Syndrome And Introduces Novel Roles For Cardiolipin In Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan Mcritchie, Susan Sumner, Hilary J. Vernon
Chemistry Faculty Publications
Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and neutropenia. While the primary biochemical defects of reduced mature cardiolipin and increased monolysocardiolipin are well-described, much of the downstream biochemical dysregulation has not been uncovered, and biomarkers are limited. In order to further expand upon the knowledge of the biochemical abnormalities in Barth Syndrome, we analyzed metabolite profiles in plasma from a cohort of individuals with Barth Syndrome compared to age-matched controls via 1H nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry. A clear distinction between metabolite profiles of …
Jainism And Nonviolence: From Mahavira To Modern Times, Lana E. Sims
Jainism And Nonviolence: From Mahavira To Modern Times, Lana E. Sims
The Downtown Review
The research contained in this paper focuses on the religion of Jainism, its main principle of ahimsa, or nonviolence, and how that philosophy has evolved over the years, eventually inspiring today’s nonviolent movements. First, a look will be taken at the origin of Jainism, with a brief explanation of its most important principles and beliefs. Then, ahimsa is explained as it has been traditionally perceived by Jains. The recent evolution of the meaning of ahimsa and its impact on modern nonviolence movements is discussed, with a focus on the influence of second-generation Jains in the United States on the …
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
Undergraduate Research Posters 2016
Introduction Injurious falls have risen significantly in the past decade, raising concerns about the efficacy of fall prevention programs. The purpose of this study was to analyze the correlation between perceived and observed balance measures used in a falls prevention program. Methods Subjects (S) were 70 (F), 59 (F), and 73(M). They were taught the Rate of Perceived Stability (RPS), a perceived measure of balance intensity and completed the Berg Balance Test (Berg), Timed up and Go (TUG), and Activities Specific Balance Confidence Scale (ABC). The Berg and TUG are observed measures and the ABC is a perceived measure. Last, …
Synthesis And Characterization Of Lectin Mimetics (Neo-Lectins), Czharena Kay Rama, Joshua Whited
Synthesis And Characterization Of Lectin Mimetics (Neo-Lectins), Czharena Kay Rama, Joshua Whited
Undergraduate Research Posters 2016
The cell surface expresses a variety of carbohydrates such as glycoproteins, proteoglycans and glycolipids. They play critical roles in pathological and physiological processes, including cell signaling, immune responses, pathogen-host interactions, tumor metastasis, and other cellular events. Due to its function and uses in cell communication, it is a curious subject of observation for scientific research. The molecular mechanism of carbohydrate recognition is still undetermined, and lectins, sugar binding proteins, are used to analyze the particular structures expressed on the cell surface. Lectins are normally found in plants and animals, and the isolation process of lectins is laborious, toxic, immunogenic and …
The Identification Of Anti-Cancer Molecular Targets Of Cox-2 Inhibitor Nimesulide, Yuridia Olivera Ortiz, Nethrie D. Idippily
The Identification Of Anti-Cancer Molecular Targets Of Cox-2 Inhibitor Nimesulide, Yuridia Olivera Ortiz, Nethrie D. Idippily
Undergraduate Research Posters 2016
Non-steroidal anti inflammatory drugs which were primarily used for the treatment inflammation and pain have also shown anti-cancer activity in many studies. The mechanism of action of NSAIDs in cancer may involve cyclooxygenase (COX) dependent or independent pathways. According to studies, COX-2 is overexpressed in several cancers such as prostate, breast, nonsmall-cell lung, colon, and pancreas. Nimesulide is an NSAID with COX-2 inhibitory activity and investigations show that it could induce apoptosis in cancer. Previously, a library of compounds was synthesized using Nimesulide as a lead compound. However, they displayed different molecular targets: tubulin and heat shock protein 27 (HSP27). …
The Use Of Ipad Pros As An Assistive Device In Occupational Therapy, Osorio Lana
The Use Of Ipad Pros As An Assistive Device In Occupational Therapy, Osorio Lana
Undergraduate Research Posters 2016
RESEARCH QUESTION: How can IPADS be used as an assistive devices for children and adults with disabilities? A literature review was conducted using the keywords, in order to find articles about using iPads as a therapeutic device. As a result it was concluded that iPads due to its versatility and popularity has made great progress as a therapeutic tool. Apps recommended as having a therapeutic purpose were also purchased and installed. The iPads will be used as a learning device amongst the Health Science Programs at Cleveland State University. KEYWORDS: iPad, assistive technology, occupational therapy, tablet, allied health, assistive therapeutic …
Variation Of Bone Microarchitecture Within And Among Contemporaneous Species Of Fossil Horses: Feasibility, Emily A. Edwards
Variation Of Bone Microarchitecture Within And Among Contemporaneous Species Of Fossil Horses: Feasibility, Emily A. Edwards
Undergraduate Research Posters 2016
Mesohippus, Miohippus, and Merychippus are extinct horse species that date back fifteen to thirty million years ago, which spanned over three time periods in North America. Each of the horses habituated different terrains from wet to dry. The third metacarpal became the prominent one-toe of horse evolution and is the specimen of this study. The aim is to determine if reorientation, segmentation, correcting size differences, and isolation are feasible. Horse fossils are extensive, documented, and are used as an analogous fossil lineage to humans for this study. Imaging of the third metacarpal was accomplished by micro-CT scanning with a focus …
The Effects Of Superior Laryngeal Nerve Lesion On Swallowing Kinematics And Airway Protection, Saja Abid, Rebecca Z. German
The Effects Of Superior Laryngeal Nerve Lesion On Swallowing Kinematics And Airway Protection, Saja Abid, Rebecca Z. German
Undergraduate Research Posters 2016
The superior laryngeal nerve (SLN) carries sensory information from the mucosal tissues of the pharynx superior to the vocal folds, and carries motor signals to the cricothyroid muscles. It also provides partial innervation to the thyroarytenoid and posterior cricoarytenoid muscles. Finally, the SLN initiates the swallow. When a food or liquid bolus is swallowed, the epiglottis and the false and true vocal folds work together to seal off the airway and allow the bolus to pass through the esophagus. If the SLN is damaged, it usually leads to dysphasia in which food or liquid enters the airway. We hypothesized that …
Dialects Accents And Intelligence: A Study On Dialectal Perceptions, Taylor Moore
Dialects Accents And Intelligence: A Study On Dialectal Perceptions, Taylor Moore
Undergraduate Research Posters 2016
Speech language pathologists are given the tools to help clients with a wide range of pathologies. Issues relating to speech, hearing, swallowing, etc can all benefit from a Speech language pathologist's insight. One area that can be difficult is dialect. People across America speak with many different dialects and speech language pathologists are taught to recognize these differences but not correct them. Dialect showcases culture but does not define intelligence. Dialects like African American Venacular English are rule governed systems of communication (Carter, 2012). The research done on AAVE is seemingly endless (Baugh, 1983; Pearson,2013; Robinson,2011; Carter 2010; Bronstein,1970......) and …
Sequential And Dynamic Rna:Rna Base-Pairing Interactions Between U6atac And U12 Snrnas Predicted To Form Helix 1a And Helix 1b, Maitri Patel, Jagjit Singh
Sequential And Dynamic Rna:Rna Base-Pairing Interactions Between U6atac And U12 Snrnas Predicted To Form Helix 1a And Helix 1b, Maitri Patel, Jagjit Singh
Undergraduate Research Posters 2016
In eukaryotes, pre-mRNA splicing is important step for gene expression. Splicing is a two-step process which is carried out by a multi-megadalton molecular weight ribonucleoprotein (RNP) machinery called spliceosome. Spliceosome converts pre- mRNA to mRNA by removing non-coding sequence (introns) and splice together coding sequence (exons). Mammalian pre-mRNA are spliced by two different class of spliceosomes which are known as U2- and U12- dependent spliceosomes. U12 dependent spliceosome is composed of five small nuclear RNAs (snRNA). As compared to U2-dependent spliceosome, there is very less known about the catalytic process of U12-dependent splicing. U6atac and U12 snRNA are central to …
Defining An Enriched Environment For Pre-Ambulation Training Using A Multi-Directional, Over-Ground Harness System For Young Children With Down Syndrome, Lauren Schuck, Lisa Haecker
Defining An Enriched Environment For Pre-Ambulation Training Using A Multi-Directional, Over-Ground Harness System For Young Children With Down Syndrome, Lauren Schuck, Lisa Haecker
Undergraduate Research Posters 2016
This theoretical literature review aims to define the components of an enriched environment (EE) while using a multi-directional, over-ground harness system (MOH), for pre-ambulatory children with Down syndrome (DS). While using an EE has not been clearly defined within humans, children with DS may benefit from this combination of interventions to optimize developmental outcomes. Of the 15 articles critiqued, 6 were found to be most relevant to help define an EE with specific activities when using a MOH for pre-ambulation training. As a part of defining an EE within a MOH, activities will be suggested that stimulate the four components …
Effect Of Calorie Restriction On Circadian Rhythms Of Glycolytic Enzymes In Mice, Enas A. Muhammad, Artem Astafev, Kuldeep Makwana
Effect Of Calorie Restriction On Circadian Rhythms Of Glycolytic Enzymes In Mice, Enas A. Muhammad, Artem Astafev, Kuldeep Makwana
Undergraduate Research Posters 2016
Multicellular and unicellular organisms have all proven to exhibit circadian rhythms which persist over approximately 24 hours. This internal time keeping system is responsible for regulating the body's biological functions. It has been known that calorie restriction effects circadian rhythms by causing a response in clock gene expression. These clock genes react to food intake and become either upregulated or downregulated accordingly. With glycolysis being a biological pathway that occurs in most organisms, measuring glycolytic gene expression in the liver tissue of young male mice becomes of interest. More specifically, hexokinase, PFK-1, and pyruvate kinase are the enzymes of interest. …
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Undergraduate Research Posters 2016
Skeletal muscle regeneration relies on myoblast stem cell differentiation and is a crucial response to muscle injury caused by trauma and numerous diseases. In skeletal myoblasts, cell death and differentiation are mutually exclusive biological endpoints that are both induced by culture in differentiation media. MyoD, the master muscle- specific transcription factor, is well-known to regulate the expression of muscle specific genes such as myogenin and the ensuing differentiation. However, we have previously reported that MyoD also plays a critical role in the expression of PUMA and apoptosis, rather than myogenin and differentiation, in a subset of myoblasts, thus diminishing the …