Medicine and Health Sciences Commons^™

Quantifying The Concentration Of 33-Mer In Wheat Flour, Abigail E. Rivas, Kaylee A. Howell, Robert Paris

Scholars Symposium

Celiac Disease is a type IV hypersensitive response to gluten caused by HLA-DQ2 or HLA-DQ8 T-cell presentation, initiating destruction of intestinal epithelial cells. Currently, the only remedy for those suffering from celiac disease is the complete elimination of all gluten from the diet. Studies indicate that an indigestible fragment of the gluten molecule, alpha-gliadin subcomponent 33-mer, rich in proline and glutamine, is responsible for the hypersensitivity response. Determination of 33-mer concentration in wheat lines could be beneficial to the future development of wheat lines with reduced 33-mer concentration. In this study, gliadin protein from wheat flour was extracted and separated …

The Ethics Of Ivf, Breanna Beers

Bioethics in Faith and Practice

In vitro fertilization (IVF) has promised hope to many couples struggling with the pain of infertility. However, as with any new medical technology, the ethical implications of this procedure must be examined, particularly in light of recent events such as the birth of the first genetically modified human beings, made possible by IVF. It is crucial to examine oppositions to IVF based on principle, as well as address concerns related to adjacent issues such as the discard of unused embryos; the selection, payment, privacy, and parental rights of donors and surrogates; the importance of genetic parenthood; new combinations of gametes; …

Does A Vegan Diet Contribute To Prevention Or Maintenance Of Diseases?, Malia K. Burkholder, Danae A. Fields

Exercise Science Senior Research Projects

This literature review deals with the topic of, does a vegan diet contribute to prevention or maintenance of diseases? Our main focus was to look at what a vegan diet entailed, the history of veganism, and why people decide to adhere to this diet type. Multiple research studies were looked over on the topics of how a vegan diet effects the disease processes of cancer, diabetes, gastral intestinal issues, weight loss, and heart disease. The overall arching theme that was found in the research is that a vegan diet is beneficial in helping to lessen the risk or aid in …

The Youngest Victims Of The Opioid Epidemic, Katelyn E. Miller, Abby Reed

The Research and Scholarship Symposium (2013-2019)

When babies are born to opioid-addicted mothers, they often develop Neonatal Abstinence Syndrome (NAS). NAS is characterized by symptoms associated with abrupt opioid withdrawal (“Neonatal Abstinence”, 2015). By preventing NAS in babies before they are born and properly caring for a baby with NAS after birth, we will aim to decrease the incidence of this condition and as its harmful effects in the lives of babies. In Ohio, there are many neonates suffering from NAS. The rates for babies born with NAS have quadrupled since 2011 when 2.2 out of every 1000 babies had NAS to 2015, where 12.3 out …

Mental Illness And The Grace Of God, Laura K. Sjoquist

Bioethics in Faith and Practice

This paper will attempt to address God's grace towards those with mental illnesses. It also attempts to provide direction in response to historical church views towards this population. Through scripture, this paper seeks to emphasize the importance of seeing a person as more than what they physically appear capable of - seeing people through God's eyes.

The Effect Of Photoactivated Tmp On Burkholderia Cepacia Biofilms, Reyna G. Osorio, Chandra N. Swiech, Tracy L. Collins

The Research and Scholarship Symposium (2013-2019)

Burkholderia cepacia is an opportunistic pathogen that causes infections in immunocompromised individuals such as cystic fibrosis patients. B. cepacia infections are typically characterized by the formation of complex communities of cells known as biofilms. Because B. cepacia biofilms are difficult to eradicate using antibiotics, it is important to pursue alternative treatment methods. Photodynamic therapy (PDT) is a type of therapy that uses light, a photosensitizer, and oxygen to elicit cell death through the production of reactive oxygen species. PDT has been shown in previous studies to be successful in killing both Pseudomonas aeruginosa and Staphylococcus aureus. In this study, we …

E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins

The Research and Scholarship Symposium (2013-2019)

Burkholderia cepacia and Candida albicans both exhibit cell-to-cell communication through the use of quorum-sensing molecules (QSM) known as autoinducers. E,E-farnesol is a QSM produced by C. albicans which regulates its conversion from yeast to mycelium. Because there is a positive correlation between the presence of B. cepacia and C. albicans in the lungs of individuals with cystic fibrosis (CF), we examined whether E,E-farnesol had an effect on swarming motility in B. cepacia. Swarming motility was inhibited when B. cepacia was exposed to 250 µM of E,E-farnesol. In addition, there was a 26.8% decrease in rhamnolipid production when cells were grown …

2017 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

The Effects Of Square-Stepping Exercise On Risk Of Falling And Balance In Senior Adults, Grace A. Miorelli, Michaela Nelson, Elizabeth A. Sled, Benjamin T. Massa, Mackenzi J. Clemens, Hope E. Mccoll, April D. Crommett

The Research and Scholarship Symposium (2013-2019)

As people age, their body systems gradually deteriorate. Muscle function and the vestibular system slowly deteriorate leading to lower body instability. Older adults who struggle with dizziness and imbalance are more prone to falling. Dizziness and imbalance cause falls, and falls are the leading cause of hospitalization and accidental death in older adults (Shinichi & Tatsuya, 2015). It is possible to prevent and reduce the risk of falls through balance training. It is crucial that older adults take the steps needed to improve their balance and therefore reduce their risk of falling. PURPOSE: To evaluate the effect of a 10-week …

Student Lifestyle Choices And Perceptions Of Stress Based On Majors, Nathan Robinson, Seth Andrews, Benjamin E. Yoder

Exercise Science Senior Research Projects

College students are often experience many stressors. This study was designed to look at perceived-stress and health habits with relation to academic department of undergraduate students at Cedarville University. The results of this study have implications for the Physical Activity and the Christian Life (PACL) class, offered on the Cedarville campus, in assessing its current curriculum and making potential future adjustments to the course. The objective of this study was to answer the question: “Do perceived stress levels within different academic departments affect health habits in Cedarville University undergraduate students?”

The study was conducted with a campus-wide, 27 question survey …

Effects Of Social Support On Compliance In Rehabilitating Athletes, Sarah E. Orr, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

The purpose of the study was to better understand if social support has an effect at all on the athlete’s compliance in coming in to do their rehabilitation during an injury. Those who participated in this study were from the colleges and universities in the state of Ohio. The participants were collegiate athletes who were in a rehabilitation program for six or more weeks and had returned to play. Of the 56 surveys returned, 18 (32.14%) of those were fully completed, and nine (16.07%) of those, consisting of seven (77.78%) females and two (22.22%) males, met the criteria set. Athletes …

Nutritional Knowledge Among Athletic Teams, Hannah F. Gualtieri, Ellen L. Thompson, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

The topic of sports nutrition has often been undermined in the athletic world. Practicing good nutritional habits has the ability to both improve performance and health. Several studies have examined nutritional knowledge among athletic teams; however very few have compared this knowledge among athletic teams. The purpose of this study was to determine the extent of various athletes’ nutritional knowledge and evaluate the differences in this knowledge among NCAA Division II Athletic teams. A secondary purpose was to discover athlete’s confidence level in their nutritional knowledge as well as gain their opinion on how they would improve nutritional knowledge among …

2016 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

Factors Contributing To Professional Self-Efficacy Levels In Recently Graduated Certified Athletic Trainers, Matthew Kuo, Hannah L. Stedge, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Self-efficacy is an important factor for job success, but it has been cited as a missing factor in new athletic training graduates. Therefore, the objective of this study was to find what factors affect the development of self-efficacy in the recently graduated certified athletic trainer. A qualitative survey method was utilized that involved questions aimed to extract as much personal opinion and experiences as possible. Online surveys were sent out electronically to 1,000 prospective participants. A total of 64 survey responses were received but only 52 surveys were qualified for inclusion into the study. Data was collected via the online …

Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

Introduction: Anterior cruciate ligament injuries occur over 200,000 times annually in the United States alone (Brophy, et al. 2009). This injury strains the healthcare system and affects the players, teams, parents, and the organization they are a part of. There have been, however, clinically researched risk factors that predispose athletes to ACL injury (Gignac, et al. 2015; Laible, et al. 2014). As a result, there is a clinical need for an effective screening tool to identify those athletes at risk for ACL injury. The Functional Movement Screen has been shown to be an effective screening tool for detecting athletes who …

2015 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

Evaluating Antioxidant Activity Of Selected Plant Species Native To Cedarville, Ohio, Daniel A. Benson, Alexander P. Treide, David Woodfield, Joshua A. Sitler, Denise S. Simpson, Robert L. Paris

The Research and Scholarship Symposium (2013-2019)

Over the past several decades, there has been an increase in the number of synthetic drug molecules developed and utilized to treat various conditions. Although these synthetic drugs have proven useful, there has been growing public concern regarding the potentially negative long-term effects of synthetic agents on the body. As a result, there has been an increased interest in identifying and utilizing plant extracts and purified compounds since they are perceived to be a more natural alternative to synthetic drugs. The goal of this study was to evaluate the specific antioxidant properties of alsike clover Trifolum hybridum when produced under …

Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Christian A. Carroll, Sara L. Hill, Kelly A. Huston, Tyler Michael, Courtney Noll, Melissa J. Beck, Ginger D. Cameron

The Research and Scholarship Symposium (2013-2019)

Genetically modified organisms (GMOs) refer to organisms whose DNA has been altered to produce a certain characteristic. GMOs account for a significant proportion of the crops produced in the United States. Specifically, GMO corn accounted for approximately 88% of all corn grown for human and animal consumption in the year 2012. Previously conducted studies have not uniformly demonstrated the safe use of GMO corn, and no studies have been conducted to analyze the addictiveness of GMO corn.

The idea of addiction refers to more than just a physical dependence, but to a psychological dependence on something as well. Addiction is …

Burnout Rates In Undergraduate Athletic Training Students Compared To The Burnout Rate Of Certified Athletic Trainers: A Comparative Study, Aaron Wass, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Burnout was first described in 1974. Since then, the condition has been researched and studied numerous times. The healthcare field has experienced this condition at a very high rate and Athletic Training, as a profession, has been affected. Burnout has become prevalent in the healthcare field due to highly stressful situations, heavy workload, and emotionally draining work environments. The profession of Athletic Training has been significantly affected by this condition and many Athletic Trainers (AT) experience burnout over the course of a calendar year. Seemingly every AT has been affected by burnout personally, known a colleague who has struggled with …

Certified Athletic Trainer’S Perceived Comfort Level With Shoulder Reductions, Jessica Pearson, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Joint dislocations are a common injury in the athletic world. The shoulder is the most commonly dislocated joint. It is important for health care professionals to be aware of this injury and be able to treat it. Athletic trainers play a vital role in the immediate care of injured athletes. The purpose of this study was to investigate the perceived comfort level of athletic trainers with reducing a shoulder dislocation. The results showed that there was a significant difference between ATC’s perceived comfort level in the 5-10 and 20+ years of experience groups when reducing posterior dislocations (p=.016). Another significant …

Incidence Of Injuries In Collegiate Cross Country, Haley Merical

The Research and Scholarship Symposium (2013-2019)

Running is becoming increasingly popular not only recreationally, but also competitively. With the increase in the number of people who are running comes an increase in the number of people who are injured. The purpose of this study was to determine if increasing mileage would result in a greater prevalence in injuries among collegiate cross country runners. Participants for this study included cross-country runners in the Great Midwest Athletic Conference. The hypothesis for this study had two parts: the greatest increase in mileage would be seen between the senior year of high school and the freshmen year of college; and …

Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens

Martha McMillan Research Papers

No abstract provided.

California Trip (1904), Michael J. Newman

Martha McMillan Research Papers

No abstract provided.

Munch A Bunch, Ginger D. Cameron

Pharmacy Practice Faculty Presentations

No abstract provided.

2014 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

Concussion Return To Play Protocols Effect On Athletes' Reporting Of Symptoms, Timothy S. Waller, Amanda R. Meade, Elizabeth A. Sled, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

When an athlete suffers a concussion, the standard return to play (RTP) guidelines are that they must sit out a minimum of a week as they go through a slow progression of exertional and neurocognitive tests once they are asymptomatic. This is a great improvement to concussion treatment in the past where athletes were often dangerously returned. However, because of this “blanket” 7-day minimum return policy, we believe the current RTP guidelines are potentially leading athletes to hide their symptoms more so they do not have to sit out. Fifty-three athletes were surveyed from soccer, basketball, lacrosse, and football teams …

Rnai Therapeutics In Autoimmune Disease, Kaleb M. Pauley, Seunghee Cha

Science and Mathematics Faculty Publications

Since the discovery of RNA interference (RNAi), excitement has grown over its potential therapeutic uses. Targeting RNAi pathways provides a powerful tool to change biological processes post-transcriptionally in various health conditions such as cancer or autoimmune diseases. Optimum design of shRNA, siRNA, and miRNA enhances stability and specificity of RNAi-based approaches whereas it has to reduce or prevent undesirable immune responses or off-target effects. Recent advances in understanding pathogenesis of autoimmune diseases have allowed application of these tools in vitro as well as in vivo with some degree of success. Further research on the design and delivery of effectors of …

Autoantibodies Against Muscarinic Type 3 Receptor In Sjögren's Syndrome Inhibit Aquaporin 5 Trafficking, B. Lee, A. E. Gauna, G. Perez, Y. Park, Kaleb M. Pauley, Toshihisa Kawai, Seunghee Cha

Science and Mathematics Faculty Publications

Sjo¨gren’s syndrome (SjS) is a chronic autoimmune disease that mainly targets the salivary and lacrimal glands. It has been controversial whether anti-muscarinic type 3 receptor (a-M3R) autoantibodies in patients with SjS inhibit intracellular trafficking of aquaporin-5 (AQP5), water transport protein, leading to secretory dysfunction. To address this issue, GFPtagged human AQP5 was overexpressed in human salivary gland cells (HSG-hAQP5) and monitored AQP5 trafficking to the plasma membrane following carbachol (CCh, M3R agonist) stimulation. AQP5 trafficking was indeed mediated by M3R stimulation, shown in partial blockage of trafficking by M3R-antagonist 4-DAMP. HSG-hAQP5 pre-incubated with SjS plasma for 24 hours significantly reduced …

Presence Of Porphyromonas Gingivalis In Gingival Squamous Cell Carcinoma, J. Katz, M. Onate, Kaleb M. Pauley, I Bhattacharyya, S. Cha

Science and Mathematics Faculty Publications

Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardiovascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal disease, Porphyromonas gingivalis (P. gingivalis) has not yet been studied in the malignant gingival tissues. The objective of this study was to investigate the presence of P. gingivalis in specimens from squamous cell carcinoma patients. We have performed immunohistochemical staining to investigate the presence of P. gingivalis and Streptococcus gordonii (S. gordonii), a non invasive oral bacteria, in paraffin embedded samples of gingival squamous cell carcinoma (n=10) and …

Microrna In Autoimmunity And Autoimmune Diseases, Kaleb M. Pauley, S. Cha, E. K. Chan

Science and Mathematics Faculty Publications

MicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3′ untranslated region (UTR) of specific messenger RNAs (mRNAs) for degradation or translational repression. miRNA-mediated gene regulation is critical for normal cellular functions such as the cell cycle, differentiation, and apoptosis, and as much as one-third of human mRNAs may be miRNA targets. Emerging evidence has demonstrated that miRNAs play a vital role in the regulation of immunological functions and the prevention of autoimmunity. Here we review the many newly discovered roles of miRNA regulation in immune functions and in the development of autoimmunity …