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Quantifying The Concentration Of 33-Mer In Wheat Flour, Abigail E. Rivas, Kaylee A. Howell, Robert Paris

Scholars Symposium

Celiac Disease is a type IV hypersensitive response to gluten caused by HLA-DQ2 or HLA-DQ8 T-cell presentation, initiating destruction of intestinal epithelial cells. Currently, the only remedy for those suffering from celiac disease is the complete elimination of all gluten from the diet. Studies indicate that an indigestible fragment of the gluten molecule, alpha-gliadin subcomponent 33-mer, rich in proline and glutamine, is responsible for the hypersensitivity response. Determination of 33-mer concentration in wheat lines could be beneficial to the future development of wheat lines with reduced 33-mer concentration. In this study, gliadin protein from wheat flour was extracted and separated …