Medicine and Health Sciences Commons^™

Volar V-Y Advancement Flaps In Reconstructing Fingertip Injuries, Sawsan Abiad

BAU Journal - Science and Technology

Fingertip injuries with exposed bones and joints require immediate or early closure for the preservation of function and avoidance of complications. The ideal procedure should maintain the length of the finger and cover the defect with non-tender, well-padded skin with normal sensation. The aim of this study was to evaluate the role of the different types of volar V-Y advancement flaps in reconstructing and resurfacing injuries of the fingertips at different levels and angles. Thirty patients (N=30) sustaining fingertip injuries of variable etiology and lost components, type III & IV according to Allen’s classification were divided into two groups (n=15) …

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …

Foreword From Editor - 14th Edition, Yandi Andri Yatmo

ASEAN Journal of Community Engagement

This edition of AJCE brings together discussions on the various roles and effectiveness of research and community engagement programs in strengthening local identity, developing skills, and enhancing quality of life towards a resilient society. Expanding such roles, this issue consists of four research articles, one review article, and three case-based articles. The authors of this edition emerge from the background of language, engineering, economy, policy, education, and health, providing different outlooks and methods in overseeing the processes of community-related programs.

Combined Risk Based Inspection And Fault Tree Analysis For Repetitive 3-Phase Line Piping Leakage At West Java Offshore Topside Facility, Dona Yuliati, Akhmad Herman Yuwono, Datu Rizal Asral, Donanta Dhaneswara

Journal of Materials Exploration and Findings (JMEF)

Hydrocarbon releases might result in serious consequences in various aspects. In addition to the contribution to environmental pollution, repetitive leakages need high repair costs. This study aim is to minimize potential repetitive leakage for other typical 3-phase piping systems. We conducted the risk assessment by adopting Risk Based Inspection (RBI) API 581 to identify risk level, calculating piping lifetime, recommended inspection plan and mitigations. The most relevant root causes can be obtained through quantitative Fault Tree Analysis (FTA). Observation and investigation was taken from eight 3-phase piping systems that experienced repetitive leakages. It has been found that the risk level …

Nitrogen Gas Quenching Pressure Effect On Bs S155 Alloy Steel In Vacuum Furnace, Agus Mulyadi Hasanudin, Eddy Sumarno Siradj

Journal of Materials Exploration and Findings (JMEF)

The production of metal and alloy products requires the use of heat treatment, when during the heat treatment process, quenching is a crucial step. The quenching medium can be anything from water, a salt bath, oil, air and gas. In a vacuum furnace, pressurized gas, most frequently nitrogen (N₂) gas, serves as one of the quenching mediums. One of the drawbacks of the quenching process is the distortion and dimensional change of the parts. This paper aims to investigate the influence of nitrogen gas quenching pressure on the distortion and dimensional change of aerospace actuator gear planet parts …

Systematic Development Of Ionizable Lipid Nanoparticles For Placental Mrna Delivery Using A Design Of Experiments Approach, Rachel E. Young, Katherine Nelson, Samuel I. Hofbauer, Tara Vijayakumar, Mohamad-Gabriel Alameh, Drew Weissman, Charalampos Papachristou, Jason P Gleghorn, Rachel S. Riley

Henry M. Rowan College of Engineering Faculty Scholarship

Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA stability, circulation time, cellular uptake, and preferential delivery to specific tissues compared to mRNA with no carrier platform. However, LNPs are only in the beginning stages of development for safe and effective mRNA delivery to the placenta to treat placental dysfunction. Here, we develop LNPs that enable high levels of mRNA delivery to trophoblasts in vitro and to the placenta in vivo with no toxicity. We conducted a Design of Experiments to explore how LNP composition, including …

Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen

Purdue Journal of Service-Learning and International Engagement

Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …

A Computational Exploration: Docking Analysis Of Compounds From Foeniculum Vulgare As Potential Aromatase Inhibitors For Endometriosis Candidate Therapy, Dwi Anita Suryandari, Puji Sari, Hadi Sunaryo, Khaerunissa Anbar Istiadi

Indonesian Journal of Medical Chemistry and Bioinformatics

Aromatase inhibitors (AI) have controlling symptoms and size of endometriotic implants, making them a promising second-line therapy for endometriosis treatment.pretreatment with letrozole, an AI, combined with leuprolide acetate and resveratrol has been found to improve in vitro fertilization (IVF) outcomes in women mild endometriosis.in this study we screening and analysis of ten phenolic compounds from Foeniculum vulgare using molecular docking with Mcole server.from this results showed that three phenolic trans resveratrol (TR), caempherol coumaril (CC) have low gibbs energy compare with resveratrol (R). The binding modalities of compound TR and compound R were hydrogen-bonding between the hydroxyl and oxygen atom …

Numerical Investigation Of Subglottal Stenosis Effects On Human Voice Production, Dariush Bodaghi

Electronic Theses and Dissertations

This dissertation aimed to advance knowledge of how subglottal stenosis impacts voice production physiology. An in-house fluid-structure-acoustic interaction approach based on the hydrodynamic/acoustic splitting technique was employed. This technique was rigorously verified for simulating phonation by matching the acoustic behavior to a compressible flow solver for phonation-relevant geometries. Simulations of an idealized 2D vocal tract model demonstrated the effects of supraglottal acoustic resonance on vocal fold kinematics and glottal flow waveform. Results showed that the acoustic coupling between higher harmonics and formats generated pressure oscillations, modifying vocal fold dynamics and glottal flow rate.

A major novelty was the incorporation and …

12.04.2023 Orsp Newsletter, Liz Williamson

ORSP Newsletter

Week of December 4, 2023

Glaucoma Neovascular, Una De Las Consecuencias De La Oclusión De La Vena Central De La Retina, Nicol Daniela Jiménez Rojas

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo. Estudiar y describir la relación entre la oclusión de la vena central de la retina y el glaucoma neovascular, su etiología, epidemiología, fisiopatología, factores de riesgo, presentación clínica y tratamientos. Metodología. Revisión de la literatura acerca del glaucoma neovascular secundario a oclusión de la vena central de la retina, tomando artículos comprendidos entre 2014 y 2022, con criterios de exclusión artículos de series de casos. Resultados. El glaucoma neovascular (GNV) es una afectación patológica ocular, secundaria a una afección ocular y/o sistémica hipóxica que conduce a isquemia retiniana, dentro de las etiologías más comunes (33 %) se encuentra la …

Impacto De La Pandemia Por Covid-19 En La Decisión De Los Pacientes Sometidos A Cirugía Refractiva En Una Institución Privada En Bogotá, Colombia, Juliana Palacio Varona, Brian Pérez Riaño, María Paula Castro Mora, María Andrea Estevez Florez, Luis Guillermo Isaza Gómez, Diana V. Rey-Rodríguez

Ciencia y Tecnología para la Salud Visual y Ocular

En el 2020, durante la pandemia por covid-19, disminuyeron los procedimientos en los centros de cirugía refractiva, pero resurgieron para octubre de ese mismo año, ya que aumentaron un 4 % en comparación con el 2019. Existe una información limitada sobre el impacto de la pandemia en la realización de cirugías y la razón que obedece a dicho aumento. Objetivo: identificar el efecto de la pandemia por covid-19 en la cirugía refractiva mediante la delimitación de las principales motivaciones para la realización del procedimiento. Métodos: estudio descriptivo observacional de corte transversal, por medio de la respuesta de un cuestionario sobre …

Prevalencia De Astenopia En Niños Escolares De 6 A 17 Años, Por El Uso De Pantallas Digitales Durante La Pandemia Por Covid-19 (2020-2022): Revisión Sistemática, Jenny Paola Acosta Castellanos, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

Introducción: El uso de dispositivos electrónicos es primordial en la vida cotidiana a nivel mundial y gracias a la emergencia sanitaria por COVID-19 se incrementó, obligando a los estudiantes a tomar clases virtuales, y esto aumento la prevalencia de astenopia. Objetivo General: Determinar la prevalencia de astenopia reportada por la literatura en niños escolares de 6 a 17 años, por el uso de pantallas digitales durante la pandemia por COVID-19. Método de Investigación: Se realizo una revisión sistemática cualitativa mediante la pregunta PECO; la búsqueda bibliográfica de realizo en bases las bases de datos, con ecuaciones construidas con palabras clave …

12.11.2023 Orsp Newsletter, Liz Williamson

ORSP Newsletter

December 11, 2023 Newsletter

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Biomedical Engineering: Graduate Reports and Projects

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …

Docai, Riley Badnin, Justin Brunings

Computer Science and Software Engineering

DocAI presents a user-friendly platform for recording, transcribing, summarizing, and classifying doctor-patient consultations. The application utilizes AssemblyAI for conversational transcription, and the user interface allows users to either live-record consultations or upload an existing MP3 file. The classification process, powered by 'ml-classify-text,' organizes the consultation transcription into SOAP (Subjective, Objective, Assessment, and Plan) format – a widely used method of documentation for healthcare providers. The result of this development is a simple yet effective interface that effectively plays the role of a medical scribe. However, the application is still facing challenges of inconsistent summarization from the AssemblyAI backend. Future work …

An Investigation Of Match For Lossless Video Compression, Brittany Sullivan-Reicks

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

A new lossless video compression technique, Match, is investigated. Match uses the similarity between the frames of a video or the slices of medical images to find a prediction for the current pixel. A portion of the previous frame is searched to find a matching context, which is the pixels surrounding the current pixel, within some distance centered on the current location. The best distance to use for each dataset is found experimentally. The matching context refers to the neighborhood of w, nw, n, and ne, where the pixel in the previous frame with the closest matching context becomes the …

Combining Adhesive And Nonadhesive Injectable Hydrogels For Intervertebral Disc Repair In An Ovine Discectomy Model., Christopher J Panebianco, Caroline Constant, Andrea J. Vernengo, Dirk Nehrbass, Dominic Gehweiler, Tyler J Distefano, Jesse Martin, David J Alpert, Saad B Chaudhary, Andrew C Hecht, Alan C Seifert, Steven B Nicoll, Sibylle Grad, Stephan Zeiter, James C Iatridis

Henry M. Rowan College of Engineering Faculty Scholarship

BACKGROUND: Intervertebral disc (IVD) disorders (e.g., herniation) directly contribute to back pain, which is a leading cause of global disability. Next-generation treatments for IVD herniation need advanced preclinical testing to evaluate their ability to repair large defects, prevent reherniation, and limit progressive degeneration. This study tested whether experimental, injectable, and nonbioactive biomaterials could slow IVD degeneration in an ovine discectomy model.

METHODS: Ten skeletally mature sheep (4-5.5 years) experienced partial discectomy injury with cruciate-style annulus fibrosus (AF) defects and 0.1 g nucleus pulposus (NP) removal in the L1-L2, L2-L3, and L3-L4 lumbar IVDs. L4-L5 IVDs were Intact controls. IVD injury …

Fatigue Behaviour Of Load-Bearing Polymeric Bone Scaffolds: A Review, Hamed Bakhtiari, Alireza Nouri, Mehrdad Khakbiz, Majid Tolouei-Rad

Research outputs 2022 to 2026

Bone scaffolds play a crucial role in bone tissue engineering by providing mechanical support for the growth of new tissue while enduring static and fatigue loads. Although polymers possess favourable characteristics such as adjustable degradation rate, tissue-compatible stiffness, ease of fabrication, and low toxicity, their relatively low mechanical strength has limited their use in load-bearing applications. While numerous studies have focused on assessing the static strength of polymeric scaffolds, little research has been conducted on their fatigue properties. The current review presents a comprehensive study on the fatigue behaviour of polymeric bone scaffolds. The fatigue failure in polymeric scaffolds is …

Bioactivity And Structural Properties Of Hydroxyapatite On Ti6a|4v And Si(100) Surfaces By Pulsed Laser Deposition, Salizhan Kylchbekov

Masters Theses & Specialist Projects

Although biomedical implant technology is very advanced, there are still caveats in terms of biocompatibility properties because metals are inert to biological processes such as osseointegration, cell growth, and cell adhesion. This results in statistically significant complications and opens rooms for improvements. Among many techniques to improve this problem, coating the metal surface with biologically functional materials has resulted in the best performances. Hydroxyapatite (HAP), Ca_₁₀(PO_₄)_₆(OH)_₂, is the most stable form of calcium phosphates in human body environment and is functional in key processes such as ion exchange, osteoblast (bone cells) formation, …

Transportation Needs Of Older Adults In Suburban And Rural Areas, Dahai Han

Theses and Dissertations

The fact that the average age of the world's population is increasing, which is more pronounced in developed countries, necessitates the understanding of the challenges faced by older adults in accessing transportation services. With advancing age, individuals may experience age-related changes that can notably affect their driving capabilities, emphasizing the importance of alternative transportation alternatives. This challenge is more evident in suburban and rural settings, where transportation choices are limited, and older adults often find themselves without access to suitable transportation alternatives. Given that mobility plays an essential role in maintaining social connections, accessing healthcare services, and fulfilling daily needs, …

11.27.2023 Orsp Newsletter, Liz Williamson

ORSP Newsletter

November 27, 2023 edition of the ORSP newsletter

Occlusive Membranes For Guided Regeneration Of Inflamed Tissue Defects., Woojin Choi, Utkarsh Mangal, Jin-Young Park, Ji-Yeong Kim, Taesuk Jun, Ju Won Jung, Moonhyun Choi, Sungwon Jung, Milae Lee, Ji-Yeong Na, Du Yeol Ryu, Jin Man Kim, Jae-Sung Kwon, Won-Gun Koh, Sangmin Lee, Patrick T J Hwang, Kee-Joon Lee, Ui-Won Jung, Jae-Kook Cha, Sung-Hwan Choi, Jinkee Hong

Henry M. Rowan College of Engineering Faculty Scholarship

Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration …

11.20.2023 Orsp Newsletter, Liz Williamson

ORSP Newsletter

ORSP Newsletter for the week of November 20, 2023.

Screensafefuture: A Parent-Empathetic And Practical Mhealth Application For Toddlers' Brain Development Addressing Screen-Addiction Challenges, Nafisa Anjum

Master of Science in Information Technology Theses

The surging incidents of infants and toddlers screen addiction in the United States are becoming a pressing concern due to its detrimental and compound impact on cognitive development, mental health, and physical growth. To address this era's critical child health and human development problem, we propose an innovative mHealth application-- ScreenSafeFuture-- in this paper. ScreenSafeFuture provides practical and parent-friendly solutions that seamlessly fit into parents' busy lifestyles, also acknowledging the effectiveness and convenience of smartphones as a healthcare tool. Our offering includes essential features designed to enhance the experience between parents and their children under 3 years old. With an …

Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov

Doctoral Dissertations

Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …

Mining High Impact Combinations Of Conditions From The Medical Expenditure Panel Survey, Arjun Mohan

Masters Theses

The condition of multimorbidity — the presence of two or more medical conditions in an individual — is a growing phenomenon worldwide. In the United States, multimorbid patients represent more than a third of the population and the trend is steadily increasing in an already aging population. There is thus a pressing need to understand the patterns in which multimorbidity occurs, and to better understand the nature of the care that is required to be provided to such patients.

In this thesis, we use data from the Medical Expenditure Panel Survey (MEPS) from the years 2011 to 2015 to identify …

11.13.2023, Liz Williamson

ORSP Newsletter

No abstract provided.

Transport Barriers Influence The Activation Of Anti-Tumor Immunity: A Systems Biology Analysis, Mohammad R. Nikmaneshi, James W. Baish, Hengbo Zhou, Lance L. Munn

Faculty Journal Articles

Effective anti-cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Here, mathematical modeling is used to explore the possibility that immune activation in lymph nodes is a rate-limiting step in anti-cancer immunity and can affect response rates to immune checkpoint therapy. The model provides a mechanistic framework for optimizing cancer immunotherapy and developing testable solutions to unleash anti-tumor immune responses for more patients with cancer. The results show that antigen production rate and …

Large Language Model Use Cases For Instruction, Plus A Primer On Prompt Engineering, Roy Haggerty, Justin Cochran

LSU Health New Orleans Symposium Series on Artificial Intelligence

AMA Credit Designation Statement: The Louisiana State University School of Medicine, New Orleans designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NCPD Credit Designation Statement: Nursing participants may earn 1.0 NCPD contact hours. Each nursing participant must be present for the entire session for which NCPD contact hours are requested and must complete an evaluation of the session to receive credit.