Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Engineering

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1 - 30 of 3973

Full-Text Articles in Medicine and Health Sciences

Transplantation Of Umbilical Cord Blood Mononuclear Cells Attenuates The Expression Of Il-1Β Via The Tlr4/Nf-Κb Pathway In Hypoxic-Ischemic Neonatal Rats, Meng-Bei Zhang, Chao-Chao Song, Guang-Zu Li, Lan-Fen Chen, Rui Ma, Xiao-He Yu, Ping Gong, Xiao-Li Wang Nov 2020

Transplantation Of Umbilical Cord Blood Mononuclear Cells Attenuates The Expression Of Il-1Β Via The Tlr4/Nf-Κb Pathway In Hypoxic-Ischemic Neonatal Rats, Meng-Bei Zhang, Chao-Chao Song, Guang-Zu Li, Lan-Fen Chen, Rui Ma, Xiao-He Yu, Ping Gong, Xiao-Li Wang

Journal of Neurorestoratology

Objective:This study aims to observe the effects of transplantation of umbilical cord blood mononuclear cells (UCBMCs) on the expression of interleukin (IL)-1β and explore the mechanism via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway in hypoxic-ischemic neonatal rats.Methods:Seven-day-old Sprague-Dawley neonatal rats were randomly divided into Sham, hypoxic-ischemic brain damage (HIBD), and UCBMC groups. The HIBD model was prepared by Rice-Vannucci method, and UCBMC were transplanted 24 h after HIBD in the UCBMC group. At 7 days after transplantation, changes in neurons and the TLR4 protein were examined by neuronal nuclei (NeuN)/TLR4 immunofluorescence ...


The Cell Repair Research For Parkinson’S Disease: A Systematic Review, Chao Chen, Qingfa Chen, Yan Liu, Chongyang Zhang, Kaixiang Zhu, Xue Li, Haitao Xie, Rui Zhang Nov 2020

The Cell Repair Research For Parkinson’S Disease: A Systematic Review, Chao Chen, Qingfa Chen, Yan Liu, Chongyang Zhang, Kaixiang Zhu, Xue Li, Haitao Xie, Rui Zhang

Journal of Neurorestoratology

Background and Objective:Parkinson’s disease (PD) is a common neurodegenerative disease. Previous studies have demonstrated the effect of cell-based therapies, but their clinical efficacy and safety have not been evaluated. This review protocol aimed to systematically evaluate the effect of stem cell therapy in patients with PD and to develop an evidence base for guiding policy and practice.Methods:PubMed, Embase, MedlinePlus, The Lancet and Brain were searched over the period January 2001 to October 2019. The keywords used for searching were "Parkinson’s disease" and "cell therapy" and "mesenchymal stem cells" and "embryonic stem cells" and "brain-derived neural ...


Preoperative Visualization Of Neurovascular Contact With 3d-Fiesta Combined With 3d-Tof Mra To Guide Microvascular Decompression Surgery Planning, Dezhong Liu, Pengfei Shi, Kai Li, Yazhou Guo, Xiao Liu, Changwei Wang, Yu Liu, Bing He, Xiaoyang Zhang Nov 2020

Preoperative Visualization Of Neurovascular Contact With 3d-Fiesta Combined With 3d-Tof Mra To Guide Microvascular Decompression Surgery Planning, Dezhong Liu, Pengfei Shi, Kai Li, Yazhou Guo, Xiao Liu, Changwei Wang, Yu Liu, Bing He, Xiaoyang Zhang

Journal of Neurorestoratology

Background:Neurovascular compression syndromes including trigeminal neuralgia (TN) and hemifacial spasm (HFS) are caused by neurovascular conflicts at the root entry zone of the corresponding cranial nerves in the posterior fossa. Microvascular decompression (MVD) is the best choice for the treatment of TN and HFS. An accurate delineation of the responsible vessel could decrease the rate of possible operative complications such as nerve paresis.Methods:In this study, three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) and three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) were performed on 113 patients with TN or HFS. The imaging data were compared to the intraoperative ...


Oxyhemoglobin Desaturation As A Function Of Age And Hypercapnia From Ventilatory Pump Failure (Vpf), John R. Bach, Damian Pronello Nov 2020

Oxyhemoglobin Desaturation As A Function Of Age And Hypercapnia From Ventilatory Pump Failure (Vpf), John R. Bach, Damian Pronello

Journal of Neurorestoratology

Background:Supplemental O2 is often administered without knowledge of CO2 levels for patients with ventilatory pump failure (VPF). This can render oximetry ineffective as a gauge of alveolar ventilation, airway secretions, and lung disease. We have noted that diurnal hypoventilation with hypercapnia tends to be symptomatic when O2 saturation levels decrease below 95% and patients extend sleep noninvasive ventilatory support (NVS) into daytime hours. We also noted that with advancing age, less hypercapnia results in desaturation. This study was designed to explore oxyhemoglobin desaturations (O2 desats) as a function of age and hypercapnia for patients with VPF.Methods:A retrospective ...


Clinical Neurorestorative Cell Therapies: Developmental Process, Current State And Future Prospective, Hongyun Huang, Lin Chen, Gengsheng Mao, Hari Shanker Sharma Nov 2020

Clinical Neurorestorative Cell Therapies: Developmental Process, Current State And Future Prospective, Hongyun Huang, Lin Chen, Gengsheng Mao, Hari Shanker Sharma

Journal of Neurorestoratology

Clinical cell therapies (CTs) for neurological diseases and cellular damage have been explored for more than 2 decades. According to the United States Food and Drug Administration, there are 2 types of cell categories for therapy, namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products. However, regardless of the type of CT used, the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials or retrospective clinical studies showed effects on neurological improvement and the ability to either partially or temporarily thwart the deteriorating cellular processes of ...


Chinese Expert Consensus On Diagnosis And Management Of Split Cord Malformation, Bo Xiu, Fuyun Liu, Aijia Shang, Rui Zhang Nov 2020

Chinese Expert Consensus On Diagnosis And Management Of Split Cord Malformation, Bo Xiu, Fuyun Liu, Aijia Shang, Rui Zhang

Journal of Neurorestoratology

Split cord malformation (SCM) is a neural tube defect that the spinal cord is longitudinally separated into two hemicords with individual functions, which causes severe spinal cord impairment and sensorimotor deficit. As a kind of myelodysplasia and a special type of tethered cord syndrome, SCM is not widely understood, and common issues in the diagnosis and treatment of SCM should be clarified. In this paper, the Chinese Split Cord Malformation Working Group made a consensus for SCM on embryopathogenesis and types, clinical presentations, neuroimaging assessment, indications and principle of the surgery, surgical techniques and nuances, and prognosis and follow up.


The 2019 Yearbook Of Neurorestoratology, Hongyun Huang, Lin Chen, Gengsheng Mao, John Bach, Qun Xue, Fabin Han, Xiaoling Guo, Ali Otom, Elena Chernykh, Edgardo Alvarez, Andrey Bryukhovetskiy, Anna Sarnowaska, Xijing He, Milan Dimitrijevic, Ihsan Shanti, Klaus Von Wild, Almudena Ramón-Cueto, Ziad Alzoubi, Gustavo Moviglia, Hamid Mobasheri, Adeeb Alzoubi, Wenchuan Zhang Nov 2020

The 2019 Yearbook Of Neurorestoratology, Hongyun Huang, Lin Chen, Gengsheng Mao, John Bach, Qun Xue, Fabin Han, Xiaoling Guo, Ali Otom, Elena Chernykh, Edgardo Alvarez, Andrey Bryukhovetskiy, Anna Sarnowaska, Xijing He, Milan Dimitrijevic, Ihsan Shanti, Klaus Von Wild, Almudena Ramón-Cueto, Ziad Alzoubi, Gustavo Moviglia, Hamid Mobasheri, Adeeb Alzoubi, Wenchuan Zhang

Journal of Neurorestoratology

Time is infinite movement in constant motion. We are glad to see that Neurorestoratology, a new discipline, has grown into a rich field involving many global researchers in recent years. In this 2019 yearbook of Neurorestoratology, we introduce the most recent advances and achievements in this field, including findings on the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical therapeutic achievements globally. Many patients have benefited from treatments involving cell therapies, neurostimulation/neuromodulation, brain–computer interface, neurorestorative surgery or pharmacy, and many others. Clinical physicians can refer to this yearbook with the latest knowledge and apply it to clinical practice.


Steady-State Visual Evoked Potential (Ssvep)-Based Brain–Computer Interface (Bci) Of Chinese Speller For A Patient With Amyotrophic Lateral Sclerosis: A Case Report, Nanlin Shi, Liping Wang, Yonghao Chen, Xinyi Yan, Chen Yang, Yijun Wang, Xiaorong Gao Nov 2020

Steady-State Visual Evoked Potential (Ssvep)-Based Brain–Computer Interface (Bci) Of Chinese Speller For A Patient With Amyotrophic Lateral Sclerosis: A Case Report, Nanlin Shi, Liping Wang, Yonghao Chen, Xinyi Yan, Chen Yang, Yijun Wang, Xiaorong Gao

Journal of Neurorestoratology

This study applied a steady-state visual evoked potential (SSVEP) based brain–computer interface (BCI) to a patient in lock-in state with amyotrophic lateral sclerosis (ALS) and validated its feasibility for communication. The developed calibration-free and asynchronous spelling system provided a natural and efficient communication experience for the patient, achieving a maximum free-spelling accuracy above 90% and an information transfer rate of over 22.203 bits/min. A set of standard frequency scanning and task spelling data were also acquired to evaluate the patient’s SSVEP response and to facilitate further personalized BCI design. The results demonstrated that the proposed SSVEP-based ...


State-Of-The-Art Non-Invasive Brain–Computer Interface For Neural Rehabilitation: A Review, Miaomiao Zhuang, Qingheng Wu, Feng Wan, Yong Hu Nov 2020

State-Of-The-Art Non-Invasive Brain–Computer Interface For Neural Rehabilitation: A Review, Miaomiao Zhuang, Qingheng Wu, Feng Wan, Yong Hu

Journal of Neurorestoratology

Brain–computer interface (BCI) is a novel communication method between brain and machine. It enables signals from the human brain to influence or control external devices. Currently, much research interest is focused on the BCI-based neural rehabilitation of patients with motor and cognitive diseases. Over the decades, BCI has become an alternative treatment for motor and cognitive rehabilitation. Previous studies demonstrated the usefulness of BCI intervention in restoring motor function and recovery of the damaged brain. Electroencephalogram (EEG)-based BCI intervention could cast light on the mechanisms underlying neuroplasticity during upper limb recovery by providing feedback to the damaged brain ...


Neurorestoration: Advances In Human Brain–Computer Interface Using Microelectrode Arrays, Jiawei Han, Hongjie Jiang, Junming Zhu Nov 2020

Neurorestoration: Advances In Human Brain–Computer Interface Using Microelectrode Arrays, Jiawei Han, Hongjie Jiang, Junming Zhu

Journal of Neurorestoratology

Neural damage has been a great challenge to the medical field for a very long time. The emergence of brain–computer interfaces (BCIs) offered a new possibility to enhance the activity of daily living and provide a new formation of entertainment for those with disabilities. Intracortical BCIs, which require the implantation of microelectrodes, can receive neuronal signals with a high spatial and temporal resolution from the individual’s cortex. When BCI decoded cortical signals and mapped them to external devices, it displayed the ability not only to replace part of the human motor function but also to help individuals restore ...


Correlation Between Programmed Stimulation Parameters And Their Efficacy After Deep Brain Electrode Implantation For Parkinson’S Disease, Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao Nov 2020

Correlation Between Programmed Stimulation Parameters And Their Efficacy After Deep Brain Electrode Implantation For Parkinson’S Disease, Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao

Journal of Neurorestoratology

Purpose:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an indispensable and effective surgery for patients with primary Parkinson’s disease (PD). Nonetheless, its postoperative effects can be decided by many factors including the optimal programmed stimulation parameters. In this study, we analyzed the correlation between different postoperative programmed stimulation parameters and their efficacy after STN–DBS electrode implantation in patients with PD.Methods:A total of 87 patients underwent electrode implantation and completed at least one year follow-up. Then, various combinations of stimulation parameters, including stimulus intensity, frequency, and pulse width, were examined for their effects on ...


Brain Gamma Rhythm And Potential Treatment Of Neurodegenerative Disease, Jianhua Zhao, Ailin Du, Chengbiao Lu Nov 2020

Brain Gamma Rhythm And Potential Treatment Of Neurodegenerative Disease, Jianhua Zhao, Ailin Du, Chengbiao Lu

Journal of Neurorestoratology

In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz), and their induction and modulation by physical stimulation, such as light and sound, and pharmacological stimulation with agents such as agonists of the kainite subunit ionotropic glutamate receptor, metabotropic glutamate receptor, metabotropic cholinergic receptor, and nicotinic cholinergic receptor. Recent findings demonstrate that boosting gamma oscillations in specific brain areas appears to be able to restore cognitive function and reduce relative ...


Traditional Chinese Medicine-Based Neurorestorative Therapy For Alzheimer’S And Parkinson’S Disease, Zhu Zhang, Shiqing Zhang, Cathy Nga-Ping Lui, Peili Zhu, Zhang Zhang, Kaili Lin, Yiwu Dai, Ken Kin-Lam Yung Nov 2020

Traditional Chinese Medicine-Based Neurorestorative Therapy For Alzheimer’S And Parkinson’S Disease, Zhu Zhang, Shiqing Zhang, Cathy Nga-Ping Lui, Peili Zhu, Zhang Zhang, Kaili Lin, Yiwu Dai, Ken Kin-Lam Yung

Journal of Neurorestoratology

The prevalence of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), has been dramatically increasing, particularly in the aging population. However, the currently available therapies merely alleviate the symptoms of these diseases and are unable to retard disease progression significantly. Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years for ameliorating symptoms or interfering with the pathogenesis of aging- associated diseases. Modern pharmacological studies have proved that TCM imparts disease-modifying therapeutic effects against these diseases, such as protection of neurons, clearance of protein aggregates, and regulation of neuroinflammation. This ...


Small Ruptured And Unruptured Complex Cerebral Aneurysms: Single Center Experience Of Low-Profile Visualized Intraluminal Support Stent, Xianli Lv, Chuhan Jiang, Shikai Liang Nov 2020

Small Ruptured And Unruptured Complex Cerebral Aneurysms: Single Center Experience Of Low-Profile Visualized Intraluminal Support Stent, Xianli Lv, Chuhan Jiang, Shikai Liang

Journal of Neurorestoratology

Objectives:Even though low-profile visualized intraluminal support (LVIS) device is used extensively currently and provide intraluminal support in complex cerebral aneurysm embolization, only few studies have reported its clinical results. This study presents the results of patients treated with LVIS.Patients and methods:Cerebral aneurysms with an undefined neck, fusiform shape, and blood blister-like aneurysms that were treated with LVIS between May 2017 and May 2019 were reviewed retrospectively.Results:Overall, 112 aneurysms in 104 patients were treated using LVIS, and 105 LVISs were placed. Of these, 101 aneurysms (90%) were small (< 10 mm) in size, 17 were fusiform aneurysms, and 3 were blood blister-like aneurysms. Overall, 39 patients suffered a subarachnoid hemorrhage and 65 had no bleeding history. 2 patients died of internal carotid artery (ICA) thrombosis, resulting in 1.9% mortality rate. Follow-up angiography was obtained in 68 patients (65%), and the complete obliteration rate was 98.5% in 6–12 months.Conclusion:The LVIS is a safe and effective treatment for small ruptured or unruptured complex intracranial aneurysms.


Research And Application Progress On Dural Substitutes, Weizuo Wang, Qiang Ao Nov 2020

Research And Application Progress On Dural Substitutes, Weizuo Wang, Qiang Ao

Journal of Neurorestoratology

Dural defects are a common problem in clinical practice, and various types of dural substitutes have been used to deal with dural defects. These play an important role in dural repair. Dural substitutes have gradually reached researchers, neurosurgeons, and patients for approval. This article summarizes the structural characteristics of the dura mater and its regeneration after injury, and reviews the state of progress in research and application. It will provide a reference for the development and application of dural substitutes.


Progress In Research Into Spinal Cord Injury Repair: Tissue Engineering Scaffolds And Cell Transdifferentiation, Changke Ma, Peng Zhang, Yixin Shen Nov 2020

Progress In Research Into Spinal Cord Injury Repair: Tissue Engineering Scaffolds And Cell Transdifferentiation, Changke Ma, Peng Zhang, Yixin Shen

Journal of Neurorestoratology

As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting the repair of central nervous system injuries. For example, transplantation of neural stem cells (NSCs), olfactory ensheathing cells (OECs), and gene- mediated transdifferentiation to repair central nervous system ...


Lateralized Spontaneous Exploratory Behavior In Maturing Rats Induced By New Geometrically Differentiated Environments After Administration With Trace Elements, Silvia G. Ratti, Osvaldo J. Sacchi, Edgardo O. Alvarez Nov 2020

Lateralized Spontaneous Exploratory Behavior In Maturing Rats Induced By New Geometrically Differentiated Environments After Administration With Trace Elements, Silvia G. Ratti, Osvaldo J. Sacchi, Edgardo O. Alvarez

Journal of Neurorestoratology

Functional laterality is known as an intrinsic property of the brain. Since several studies have shown the presence of laterality in many species other than humans, it has been suggested that this is an adaptive mechanism to aid survival. Previous studies have shown that lateralized behavior observed during exposure to different environmental stimuli is not constant in normal animals, depending on the geometrical form of the exploratory field. In these exploratory fields, animals showed right- or left-biased exploratory behavior, according to the nature of the geometrical properties of the environment. Previously, it was found that tellurium (Te) was able to ...


Cerebral Small Vessel Disease And Cognitive Impairment, Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li Nov 2020

Cerebral Small Vessel Disease And Cognitive Impairment, Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li

Journal of Neurorestoratology

Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets. Imaging features vary; they are mainly composed of recent subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensities (WMHs) of presumed vascular origin, cerebral microbleeds, enlarged perivascular spaces, and global and regional brain atrophy. CSVD is a common cause of vascular cognitive dysfunction, and in its end stage, dementia often develops. CSVD has been a major research hotspot; however, its causes are poorly understood. Neuroimaging markers of CSVD can be used as the basis for etiological analysis. This review ...


The Treatment Of Neurotrophic Foot And Ankle Deformity Of Spinal Bifida: 248 Cases In Single Center, Jiancheng Zang, Sihe Qin, Vigneshwaran P, Lei Shi, Xulei Qin Nov 2020

The Treatment Of Neurotrophic Foot And Ankle Deformity Of Spinal Bifida: 248 Cases In Single Center, Jiancheng Zang, Sihe Qin, Vigneshwaran P, Lei Shi, Xulei Qin

Journal of Neurorestoratology

Objective:To evaluate the functional outcome of foot and ankle deformity secondary to spinal bifida treated by various methods.Methods:A retrospective analysis of 248 patients with foot and ankle deformity secondary to spina bifida with an average age of 25.5 years and underwent surgical treatment in our hospital from March 2012 to April 2016. The deformity correction was achieved by various methods like soft tissue procedure, bony procedure combined with external fixator application. All the patients were followed up at regular interval. Post operative rehabilitation and protective splints were provided after fixator removal. The final outcome was evaluated ...


The Significance Of Occipitocervical Dura Angulation In Selection Of Surgery Procedures For Chiari Malformation Type I, Bo Xiu, Rui Zhang Nov 2020

The Significance Of Occipitocervical Dura Angulation In Selection Of Surgery Procedures For Chiari Malformation Type I, Bo Xiu, Rui Zhang

Journal of Neurorestoratology

At present, the common surgical procedures for the Chiari malformation type I are comprised of posterior fossa decompression, duraplasty and tonsillectomy. Some neurosurgeons prefer these so called minimally invasive surgeries. However, there are still some failures for patients undergoing the above surgeries in clinical practice. Analyzing causes of many surgical failures, the author put forward the anatomical concept of occipitocervical dura angulation (ODA). The ODA is defined as the included angle between the cerebral dura mater and spinal dura mater at the posterior foramen magnum on the median sagittal plane. For Chiari malformation type I without atlantoaxial instability, the selection ...


The Golgi Apparatus In Neurorestoration, Jianyang Liu, Jialin He, Yan Huang, Han Xiao, Zheng Jiang, Zhiping Hu Nov 2020

The Golgi Apparatus In Neurorestoration, Jianyang Liu, Jialin He, Yan Huang, Han Xiao, Zheng Jiang, Zhiping Hu

Journal of Neurorestoratology

The central role of the Golgi apparatus in critical cellular processes such as the transport, processing, and sorting of proteins and lipids has placed it at the forefront of cell science. Golgi apparatus dysfunction caused by primary defects within the Golgi or pharmacological and oxidative stress has been implicated in a wide range of neurodegenerative diseases. In addition to participating in disease progression, the Golgi apparatus plays pivotal roles in angiogenesis, neurogenesis, and synaptogenesis, thereby promoting neurological recovery. In this review, we focus on the functions of the Golgi apparatus and its mediated events during neurorestoration.


Impact Of Preoperative Karnofsky Performance Scale (Kps) And American Society Of Anesthesiologists (Asa) Scores On Perioperative Complications In Patients With Recurrent Glioma Undergoing Repeated Operation, Zhong Deng, Hai Yu, Ning Wang, Wahap Alafate, Jia Wang, Tuo Wang, Changwang Du, Maode Wang Nov 2020

Impact Of Preoperative Karnofsky Performance Scale (Kps) And American Society Of Anesthesiologists (Asa) Scores On Perioperative Complications In Patients With Recurrent Glioma Undergoing Repeated Operation, Zhong Deng, Hai Yu, Ning Wang, Wahap Alafate, Jia Wang, Tuo Wang, Changwang Du, Maode Wang

Journal of Neurorestoratology

Objective:The objective of this study was to document the impact of the preoperative Karnofsky Performance Scale (KPS) and American Society of Anesthesiologists (ASA) scores on perioperative complications in patients with recurrent glioma who underwent tumor resection via craniotomy.Methods:A total of 96 patients were retrospectively reviewed. Based on KPS and ASA scores, patients were categorized into high KPS (> 70) or low KPS (≤ 70) and high ASA (3~4) or low ASA (1~2) groups. Differences in intraoperative risk factors and perioperative complications among the groups were analyzed. Multivariate analysis was performed to identify risk factors for perioperative complications ...


Hand Function Recovery Using Nerve Segment Insert Grafting In Patients With Chronic Incomplete Lower Cervical Spinal Cord Injury: A Preliminary Clinical Report, Wenbin Ding, Shaocheng Zhang, Dajiang Wu, Yanpeng Zhang, Hualong Ye Nov 2020

Hand Function Recovery Using Nerve Segment Insert Grafting In Patients With Chronic Incomplete Lower Cervical Spinal Cord Injury: A Preliminary Clinical Report, Wenbin Ding, Shaocheng Zhang, Dajiang Wu, Yanpeng Zhang, Hualong Ye

Journal of Neurorestoratology

Objective:The objective of this study was to show that hand functions could be recovered using nerve segment insert grafting in quadriplegic patients with chronic incomplete lower cervical spinal cord injury (CSCI) (C5/6/7/8).Methods:A retrospective analysis was performed in 18 quadriplegic patients (12 male and 6 female patients; mean age, 27 years; age range, 17–55 years) with chronic incomplete lower CSCI who had undergone nerve segment insert grafting from January 2001 to June 2015. Among the 18 patients, the right upper limb was involved in 7, left upper limb in 4, and bilateral upper limbs ...


Clinical Observation Of Effects Of Ultrashort Wave Therapy Combined With Acupuncture And Rehabilitation Training In The Treatment Of Patients With Dysphagia After Stroke, Weiwei Zhao, Chuanguang Ju, Daozhen Wang, Huifen Shen Nov 2020

Clinical Observation Of Effects Of Ultrashort Wave Therapy Combined With Acupuncture And Rehabilitation Training In The Treatment Of Patients With Dysphagia After Stroke, Weiwei Zhao, Chuanguang Ju, Daozhen Wang, Huifen Shen

Journal of Neurorestoratology

Aim:The present study aimed to assess the clinical effects of ultrashort wave therapy combined with acupuncture and rehabilitation training on patients with dysphagia after stroke.Method:A total of 126 patients with stroke with dysphagia were randomly divided into an acupuncture group (control group: 63 patients) and a comprehensive rehabilitation training group (treatment group: 63 patients). The control group received rehabilitation training and acupuncture, whereas the treatment group received ultrashort wave therapy in addition to rehabilitation training and acupuncture (comprehensive rehabilitation training). The curative effect was evaluated using water-drinking test scores and swallowing quality of life scale (SWAL-QOL) scores ...


The Cell Repair Research Of Spinal Cord Injury: A Review Of Cell Transplantation To Treat Spinal Cord Injury, Zhenrong Zhang, Fangyong Wang, Mingjie Song Nov 2020

The Cell Repair Research Of Spinal Cord Injury: A Review Of Cell Transplantation To Treat Spinal Cord Injury, Zhenrong Zhang, Fangyong Wang, Mingjie Song

Journal of Neurorestoratology

Through retrospective analysis of the literature on the cell repair of spinal cord injury worldwide, it is found that the mechanism of cell transplantation repairing spinal cord injury is mainly to replace damaged neurons, protect host neurons, prevent apoptosis, promote axonal regeneration and synapse formation, promote myelination, and secrete trophic factors or growth factors to improve microenvironment. A variety of cells are used to repair spinal cord injury. Stem cells include multipotent stem cells, embryonic stem cells, and induced pluripotent stem cells. The multipotent stem cells are mainly various types of mesenchymal stem cells and neural stem cells. Non-stem cells ...


Olfactory Ensheathing Cell Transplantation Improving Cerebral Infarction Sequela: A Case Report And Literature Review, Xiaoling Guo, Xin Wang, Yan Li, Bo Zhou, Weidong Chen, Lihua Ren Nov 2020

Olfactory Ensheathing Cell Transplantation Improving Cerebral Infarction Sequela: A Case Report And Literature Review, Xiaoling Guo, Xin Wang, Yan Li, Bo Zhou, Weidong Chen, Lihua Ren

Journal of Neurorestoratology

Stroke is the second leading cause of death and the main cause of long-term disability in the world. Therefore, treatment of the sequelae of stroke is one of the most important challenges in clinical neurotherapy. A 63-year-old Chinese woman with inarticulateness and right limb physical activity disorder for more than 4 months received olfactory ensheathing cells (OECs)-based neurorestorative therapy during the stay in hospital. Her neurological functions improved during 1-year follow-up. This case report showed that OECs therapy could be a treatment option for cerebral infarction sequela.


Intranasal Delivery Of M2 Macrophage-Derived Soluble Products Reduces Neuropsychological Deficit In Patients With Cerebrovascular Disease: A Pilot Study, Ekaterina Shevela, Marina Davydova, Natalia Starostina, Alexandra Yankovskaya, Alexandr Ostanin, Elena Chernykh Nov 2020

Intranasal Delivery Of M2 Macrophage-Derived Soluble Products Reduces Neuropsychological Deficit In Patients With Cerebrovascular Disease: A Pilot Study, Ekaterina Shevela, Marina Davydova, Natalia Starostina, Alexandra Yankovskaya, Alexandr Ostanin, Elena Chernykh

Journal of Neurorestoratology

Objective:We assessed the safety and clinical effectiveness of intranasal therapy with M2 macrophage-derived soluble products (M2-SPs) for treating patients with cerebrovascular disease (CVD).Materials and methods:The protocol of the study was registered at www.ClinicalTrails.gov (NCT02957123). The study group comprised 30 patients with chronic CVD. Neurological status was examined before therapy and at 1- and 6-month follow–up. Concentrations of 32 cytokines in the blood serum were evaluated before and 1 month after therapy onset. Neurological assessment was conducted with the following scales: Subjective Assessment of Clinical (neurological) Symptoms (SACS), Hospital Anxiety and Depression Scale (HADS), Functional ...


Decreased Npas4 Expression In Patients With Post-Stroke Depression, Shina Gu, Xiaodan Li, Lin Zhao, Huicong Ren, Chendi Pei, Wenqiang Li, Junlin Mu, Jinggui Song, Zhaohui Zhang Nov 2020

Decreased Npas4 Expression In Patients With Post-Stroke Depression, Shina Gu, Xiaodan Li, Lin Zhao, Huicong Ren, Chendi Pei, Wenqiang Li, Junlin Mu, Jinggui Song, Zhaohui Zhang

Journal of Neurorestoratology

Purpose:Post-stroke depression (PSD) is a frequent neuropsychiatric disorder following stroke which is associated with poor outcome. Neuronal Per-Arnt-Sim (PAS) domain protein 4 (Npas4) is associated with cognitive function. Npas4 expression in peripheral blood mononuclear cells (PBMCs) from patients with PSD was measured to find new therapeutic strategy.Patients and methods:Ischemic stroke patients (n = 152) within 1 week of stroke onset were recruited. At 3 months follow-up, the patients were divided into a PSD group (n = 77) and a stroke group (n = 75) using the Hamilton Rating Scale. Healthy subjects (n = 75) were also recruited in the study. The ...


Associated Factors Of Early Neurological Deterioration In Isolated Acute Lacunar Infarction In Basal Ganglia, Honghao Man, Yuhua Bi, Yongpeng Yu, Shengwu Wang, Zhenming Zhao, Xiaohong Qiao, Weiping Ju Nov 2020

Associated Factors Of Early Neurological Deterioration In Isolated Acute Lacunar Infarction In Basal Ganglia, Honghao Man, Yuhua Bi, Yongpeng Yu, Shengwu Wang, Zhenming Zhao, Xiaohong Qiao, Weiping Ju

Journal of Neurorestoratology

Objective:To investigate, in basal ganglia, the factors associated with early neurological deterioration (END) of isolated acute lacunar infarction.Methods:167 patients, in the retrospective group, with isolated acute lacunar infarction in basal ganglia, were defined by magnetic resonance imaging (MRI). The National Institutes of Health Stroke Scale (NIHSS) defined early neurological deterioration as increases of ≥ 2 within 72 hours following admission. Baseline variables predicting END were investigated with multivariate logistic regression analysis.Results:In the study, END occurred in 42 (25.15%) patients. Lesions located in posterior limb of internal capsule were independent risk factors for END (P < 0.01). Associated with END were the age of onset, history of cerebral infarction, history of diabetes, systolic blood pressure at admission and lesions of cerebral white matter. This presented significant differences (P < 0.05). With or without diabetes and different lesion location at varying layers and inter-layers, single-factor and multi-factor analysis revealed no effect on the association between positive ENT and age, history of stroke, white matter. Previous history of stroke, pathological changes of white matter, and age of onset, correlates with END which showed significant difference (P < 0.05).Conclusions:There is a close relationship between the lesion location and other related factors, such as lesions of cerebral white matter, history of cerebral infarction, history of diabetes and age, etc. and END in patients with isolated acute lacunar infarction in basal ganglia. Protective factors of END included age ≥ 65, high systolic pressure, stroke history, cerebral white matter lesions in our study.


Application Of Olfactory Ensheathing Cells In Clinical Treatment Of Spinal Cord Injury: Meta-Analysis And Prospect, Huijing Chen, Qijia Tan, Caijun Xie, Cong Li, Yun Chen, Yuer Deng, Yanling Gan, Wengang Zhan, Zhiqiang Zhang, Aruna Sharma, Hari Sharma Nov 2020

Application Of Olfactory Ensheathing Cells In Clinical Treatment Of Spinal Cord Injury: Meta-Analysis And Prospect, Huijing Chen, Qijia Tan, Caijun Xie, Cong Li, Yun Chen, Yuer Deng, Yanling Gan, Wengang Zhan, Zhiqiang Zhang, Aruna Sharma, Hari Sharma

Journal of Neurorestoratology

Background:A number of clinical trials of olfactory ensheathing cells (OECs) for the treatment of chronic spinal cord injury (SCI) have been carried out all over the world. However, their safety and efficacy have not been basically evaluated. Moreover, there are no uniform standards laid out for the use of optimal source, transplantation method and the dosage of OECs.Objective:This study evaluated the source, dose, and route of transplantation of OECs for the treatment of chronic SCI.Methods:PubMed, Cochrane Library, EMBASE, CNKI, and Wanfang Data were searched for the clinical studies of OECs in the treatment of chronic ...