Medicine and Health Sciences Commons^™

The Effects Of Differing Light Wavelengths And Gravity On, Reese Chesshir

Honors Theses

Physarum is a slime mold in the class of Mycetozoan and the family of Physaraceae. It is a single cellular, multinuclear organism that is not classified as an animal, plant, or fungi. Physarum growth for long-term space travel would be beneficial because it is a decomposer and is able to break down material and waste to recycle. This is important for transferring energy and allowing other organisms to grow. The purpose of this experiment is to study the effect of different light wavelengths and the influence of gravity on Physarum growth patterns.

Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Shelby Lynn Berry, Sydney Ruth Rester

Honors Theses

Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …

Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Sydney Ruth Rester, Shelby Lynn Berry

Honors Theses

Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …

The Effects Of Light Intensity And Cell Structure On The Cultivation Of Arthrospira Platensis, Taylor Barnhart

Honors Theses

As scientists explore further into space, more cost-effective resources are needed for long-term space travel. An interesting solution is Arthrospira platensis, a filamentous cyanobacteria high in proteins and nutrients, and known for its helical structure. In unfavorable conditions, coiled spirulina cells become straight. Spirulina converts carbon dioxide gas into pure oxygen and the different cell structures stimulate different responses in oxygen production and cultivation. In these experiments, 2.3 L containers of pure coiled spirulina and mixed (coiled and straight) spirulina were placed into 3 incubators with different light intensities: 51µmol/m2/s, 25µmol/m2/s, 12µmol/m2/s. Each experiment length was 72 hours and the …

Evaluation Of Selected Computer Software For Concussion Recovery And Diagnosis, J.P. Jensen

Honors Theses

Acquired traumatic brain injuries, such as concussions, impact many athletes participating in sports, particularly at the high school, collegiate, and professional levels. The risks posed by concussions – particularly when an athlete suffers repeated injuries – demands that protocols and tools be developed to maximize athlete health and safety. Computer technology can perform critical roles in the analysis and management of concussions. While specialized devices in the areas of imaging and impact sensing, are most associated with concussion management, researchers within the last two decades have increasingly explored the incorporation of various consumer technologies into the identification and treatment of …

The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway

Honors Theses

The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …

Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price

Honors Theses

ABSTRACT JASON BLAKE PRICE: Surface-Eroding Drug Delivery Films for Sequential and/or

Intermittent Release of Psychoactive Drugs For patients with psychiatric diseases, adherence to medication schedules, medication

errors, and abuse are common issues. Promising new forms of therapy for these patients, such as micro-dosed lysergic acid diethylamide (LSD), where patients receive 10-20% of a full dose every third day, present further drug delivery challenges. Sequential or intermittent release of drugs from an implanted device could ensure long-term drug compliance, automate drug dosing during the life of the implant, and eliminate potential for abuse and medication errors. To this end, we generated …

Sol Retractor: Rapidly Deployable Film-Based C-Section Retractor, Casey Lee, Silas Cleveland, Jose Dolores Valdivieso, Joseph Perks

Honors Theses

Cesarean Sections (C-sections), a surgery conducted for baby delivery, can be divided into four distinct categories; Category 1 and 2 are considered emergency c-sections, and Category 3 and 4 are scheduled c-sections [2]. A comparative study from 2016 analyzed the difference of need for postoperative treatment between the Collins or the Alexis O retractor ( n = 100). The Alexis O C-Section retractor resulted in 19% of women requiring postoperative treatment, including medication, monitoring, and an extended stay at the hospital. The Collins resulted in 43% of the patients requiring postoperative treatment (p = 0.001) [5]. In emergency C-sections, surgical …

Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes

Honors Theses

Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and it is predicted that the number will keep increasing. Parkinson’s disease is difficult to diagnose due to its similarity with other diseases that share the parkinsonian symptoms and the subjectivity of its assessment, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools to improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified into two main …

Designing An Antibiotic Eluting Trauma Screw To Reduce Short Term Infection In Bone Fractures, Dominic Lincoln

Honors Theses

Orthopedic infection in the United States is one of the most common and severe health risks faced by trauma patients. The most prevalent infection is orthopedic and trauma device-related infection (ORDI) and often occurs in long bones at the fracture site. The purpose of this paper is to explore this infection, its causes, and solutions currently on the market while providing novel solutions to the problem. The designs proposed will be evaluated for their effectiveness and value, while attempting to keep costs low for all stakeholders. The feasibility of patenting these ideas will also be considered, as will the testing …

Pharmaceutical Manufacturing In The 21st Century: Identification And Analysis Of Key Elements, Robert N. Mills

Honors Theses

The availability of quality pharmaceutical products impacts the lives of the global population on a daily basis. The importance of product availability and quality within pharmaceutical manufacturing requires that quality systems put into place are capable of accurately and robustly capturing the quality compliance, or lack thereof, of the various stages of production. This review intends to analyze current expert-recommended best practices within key elements of a pharmaceutical manufacturing quality control system and provide recommendations throughout. The quality elements discussed include Quality by Design method validation, necessary equipment determination, and equipment qualification, followed by documentation control and data flow.

The Theia Soteria: Alternative Design For Safer Initial Entry During Laparoscopic Procedures, Kayla Dubois, Patrick Ryan, Madelyn Joanis

Honors Theses

Laparoscopic procedures account for 15 million surgeries worldwide [1], with the initial entry into the peritoneal cavity accounting for 33-50% of all major laparoscopic complications [7]. This initial entry is the most dangerous as surgeons must enter the cavity using a sharp object with no visibility and space between the outer surface of the cavity and internal tissues. During the initial entry into the peritoneal cavity, the patients undergoing laparoscopic procedures are at a high risk for damage to internal organs and vasculature, necessitating the development of a device to protect these internal tissues and increase patient safety.

Chitosan Nanoparticle Modifications For Improved Gene Delivery In An Oral Dna Vaccine Application, Austin Helmink

Honors Theses

Vaccines represent one of the most significant medical innovations of the 20^th century, resulting in the eradication or near eradication of a handful of deadly diseases. However, many infectious diseases remain resistant to effective vaccination, largely due to a lack full immune activation by traditional protein-based vaccines. A promising alternative vaccination strategy is the emerging development of DNA vaccines, which rely upon the delivery of exogenous genetic material to host cells encoding for a viral or bacterial antigen in order to induce a robust immune response by closely mimicking live infection. The delivery of genetic material requires a carrier …

Control System For 3d Printable Robotic Hand, Htoo Wai Htet

Honors Theses

Humanoid robotics is a growing area of research due to its potential applications in orthosis and prosthesis for human beings. With the currently available technologies, the most advanced robotic hands used in prosthetics or robotics can cost from $11,000 to $90,000, making it inaccessible to the general population of amputees and robotics hobbyists. Most of the features provided by these expensive technologies are superfluous to many users, creating a great gap in cost and services between users and technology. Using the emerging 3D printing technology, my project is to construct a 3D printed robotic hand that can reproduce as many …

Mobile Application For Biosensor Colorimetric Analysis, Eui Bin You

Honors Theses

Inexpensive paper-based biosensors can be valuable screening tools to test for various illnesses, but it is often challenging to design them to produce a visual change that can easily be identified by untrained users. This research examines one method of compensating for the lack of distinct visual cues by developing and testing a mobile application that uses a machine learning algorithm (k-Nearest Neighbors) to analyze a picture of a sensor and determine whether it shows a positive or negative result. The machine learning algorithm was trained on a set of labeled sensor images and k-fold cross-validation was used to analyze …

Density Functional Theory Calculations On The Doping Sequence Of Mnxfen(1-X)Ge, Jordan C. Ball

Honors Theses

No abstract provided.

Electrical Characterization Of Nanomaterials, Chase Martin

Honors Theses

Our dependence on energy sources and depleting fossil fuel reserves are forcing the world to look for efficient and renewable sources of energy. Current renewable technology lacks the efficiency and storage capability necessary to continue our heavy reliance on energy. This project focuses on understanding the physical and electrical properties of nanomaterials for their use as super capacitors and as photovoltaic cells. Using multiple microscopy techniques on the Cascade Probe Station and Veeco Dimension V Atomic Force Microscope, local and bulk conductivity measurements were performed on Laponite RD infused polyaniline (PANI) samples synthesized by Union College Chemistry Department Students. Four …

Design Of A Double-Dose Epinephrine Auto-Injector Using 3d-Printing, Timothy Calvin Sheehan

Honors Theses

This project involved the design and prototyping of an epinephrine auto-injector capable of administering two separate doses. Epinephrine auto-injectors are used in the treatment of patients undergoing anaphylaxis, an allergic reaction causing the restriction of airways and a drop in blood pressure. The timely administration of epinephrine counteracts these symptoms and can be lifesaving. Currently the only devices available to consumers administer one unit dose of epinephrine and are then no longer usable. In 30% of cases where patients undergo these symptoms a second dose of epinephrine is required. My design was based partially off the concept behind currently available …

The Optimization Of Porosity And Pore Patterning For Patient-Specific Ti-6 Al-4v Femur Implants, Stephen Paolicelli

Honors Theses

Metastatic bone cancer often arises in the long bones of the body. Taking a patient specific approach by utilizing a customized implant is a superior method of treatment compared to today’s solutions, which often includes amputation. A titanium-alloy femur implant has been optimized by varying pore size, pore pattern, and porosity in order to maximize osseointegration. By maximizing osseointegration, the implant will remain firmly in place for a longer period of time because bone will grow throughout the implant, securing it. In addition, it is important for the bone to behave mechanically like bone. This requires the global elastic modulus …

Effects Of Playing Surface And Shoe Type Of Acl Tears In Soccer Players, Melissa Mansfield

Honors Theses

Anterior Cruciate Ligament injuries have become more common in athletes over the past decade which is believed to result from playing on more artificial turf surfaces. This study tested the playing surface theory by building upon a previous study conducted with Albany Medical Center which tested surface samples using an axial-torsion load frame located at Union College. The motion that causes most ACL noncontact injuries is replicated by the load frame which pushes and rotates a shoe against the playing surface and measures the torque it experiences. The foot position, normal load, degree of rotation and rate of rotation were …

History Of Concussion Research In American Football, Timothy Hersey

Honors Theses

Concussions have been the topic of discussion in the news and media in recent years for their profound impact on today’s sport industry. Athletes have become bigger, faster, and stronger then in the past, increasing the chance of injury. This can been seen in all sports. Contact sports specifically have seen a rise in mild traumatic brain injuries (MTBIs) over the years. Extensive research has been done to determine the causes of concussion, the short and long term effects of brain injury, and better ways to reduce the risk in sports. Concussion research in athletics has mainly focused on American …

Analysis Of Degenerative Cervical Spondylolisthesis And Corrective Orthopaedic Implants, Tyler Heck

Honors Theses

Back pain is often due to the degeneration of intervertebral discs, which can lead to a condition known as spondylolisthesis, whereby a vertebra slips out of position in the anteroposterior direction. There are numerous orthopaedic implants which are used by surgeons to correct this condition; however, there has been no conclusive research conducted in comparing the efficacies of these implants. In the cervical spine, this condition most commonly occurs over two levels. For the purposes of this study, an implant’s efficacy depends on its ability to return the slipped vertebra back into natural position immediately after surgery. To test these …

Studying The Material Properties Of The Embryonic Chicken Heart, Kyra Burnett

Honors Theses

Congenital heart disease is the number one cause of birth defects in the United States, affecting approximately 40,000 newborns each year. Research has shown that serious structural defects of the heart can occur due to abnormal looping. Looping refers to the positional and morphological changes of the early embryo heart and is divided into different phases. Although progress has been made in identifying the genetic processes behind heart looping, the forces involved with the developmental process are still not fully understood. In this research, the chicken embryo heart was used as the experimental model and certain material properties were characterized. …