Medicine and Health Sciences Commons^™

Topiramate (Topamax): Evolving Role In Weight Reduction Management: A Narrative Review, Irza Wajid, Alexis Vega, Katherine Thornhill, Jack Jenkins, Chandler Merriman, Debbie Chandler, Sahar Shekoohi, Elyse M. Cornett, Alan D. Kaye

School of Medicine Faculty Publications

Obesity has emerged as a widespread disease with epidemic proportions, necessitating effective management to enhance the overall health outcomes of patients. Medical intervention for weight loss becomes necessary when diet and exercise prove ineffective, and topiramate emerges as a potential treatment option for this global problem. Currently approved as an anti-epileptic and migraine prophylaxis medication, topiramate is frequently utilized as adjunctive therapy for patients with mood and eating disorders, as well as for alcohol use disorders. Its multifaceted mechanisms of action contribute to reducing neuronal excitation and enhancing neuronal inhibition. Given its variety of mechanisms, topiramate shows several off-label outcomes, …

Metformin’S Role In The Prevention Of Type 2 Diabetes In Individuals Diagnosed With Prediabetes: A Systematic Literature Review, Jillian Williamson

All Graduate Theses, Dissertations, and Other Capstone Projects

The United States is facing a growing epidemic of unchecked and untreated individuals with prediabetes. While lifestyle interventions have remained the gold standard of treatment, has this been enough? A literature review was carried out to identify metformin’s role in treatment and management of prediabetes as well as perceived barriers to its prescribing. A total of 24 articles met inclusion criteria. Main findings include (a) metformin is effective in reducing the incidence of diabetes, though not as effective as lifestyle interventions; (b) certain populations did benefit more from metformin usage then other populations; (c) there was more treatment compliance with …

Does The Use Of An Oral Lipase Inhibitor (Orlistat) Increase Appetite?, Sandra Boyd

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine whether or not Orlistat ingested prior to a meal causes an increased appetite response.

STUDY DESIGN: A Review of three randomized controlled trials studies from 2003-2008 that were in the English language.

DATA RESOURCES: Randomized controlled trials comparing the effect of Orlistat on satiety were found using PubMed, OVID, and Cochrane databases.

OUTOMES MEASURED: Outcomes measured in the studies were: sensation of appetite, hunger, fullness, nausea, bloating, heartburn, belching, epigastric burning, and prospective food consumption. Each study measured individual patient responses using a VAS (visual analogue scale). Demarchi et al (2004) used a gastric barostat to measure …

Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic review is to determine whether or not white bean extract is a safe and effective treatment for weight loss.

Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not caffeine ingestion prior to exercise effects exercise performance in healthy adults.

Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not liraglutide is safe and effective as a monotherapy for the treatment of obesity in type 2 diabetics and healthy individuals.

Weight Gain And Weight Management Concers For Patients On Beta-Blockers, Linda S. Lamont Ph.D.

Linda S. Lamont Ph.D.

Beta blocking medications are first line therapy for young patients with uncomplicated hypertension. They are also prescribed to 55 to 80% of those discharged from the hospital with a heart attack. These drugs are known to decrease cardiovascular morbidity and mortality, but they also have metabolic side effects. One that is not widely recognized is that these drugs cause a decrease in resting metabolic rate, and taking these medications may result in a small weight gain.