Animal Experimentation and Research Commons^™

Effect Of Room Arrangement And Blood Sample Collection Sequence On Serum Thyroid Hormone And Cortisol Concentrations In Cynomolgus Macaques (Macacafascicularis), Bryan L. Flow, John T. Jaques

Research Methodology and Laboratory Animals Collection

We evaluated the relationship, in cynomolgus macaques (Macacafascicularis), between rank for order of blood collection with serum concentrations of 3,5,3'-triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), and serum cortisol. These relationships were determined for males and females that were housed in two room arrangements. For both room arrangements, males and females were housed separately. For room arrangement 1, macaques were housed on both sides of the animal holding room. The sides of the animal holding room were designated as side A or side B. Blood was initially collected from animals on side A, then from animals on side B. Animals …

Harry F. Harlow And Animal Research: Reflection On The Ethical Paradox, John P. Gluck

Experimentation Collection

With respect to the ethical debate about the treatment of animals in biomedical and behavioral research, Harry F. Harlow represents a paradox. On the one hand, his work on monkey cognition and social development fostered a view of the animals as having rich subjective lives filled with intention and emotion. On the other, he has been criticized for the conduct of research that seemed to ignore the ethical implications of his own discoveries. The basis of this contradiction is discussed and propositions for current research practice are presented.

Preference And Motivation Testing, David Fraser, Lindsay R. Matthews

Validation of Animal Experimentation Collection

Since the early 1970s, scientists have used preference tests (tests that require animals to choose between two or more different options or environments) as a means of answering questions about animal welfare. Preference tests have been used to establish animals' preferences for common housing options such as ambient temperature, illumination and preferred types of bedding and flooring; to improve the effectiveness of devices such as loading ramps and nest boxes; and to clarify how strongly animals avoid various aspects of confinement and methods of restraint.

To use preference research to answer questions about animal welfare, three issues need to be …

Institutional Animal Care And Use Committees: A Flawed Paradigm Or Work In Progress?, John P. Gluck, F. Barbara Orlans

Animal Welfare Collection

In his challenging article, Steneck (1997) criticized the creation of the Institutional Animal Care and Use Committee (IACUC) system established by the 1985 amendments to the Animal Welfare Act. He saw the IACUC review and approval of biomedical and behavioral research with animals as an unnecessary "reassignment" of duties from existing animal care programs to IACUC committees. He argued that the committees are unable to do the work expected of them for basically three reasons: (a) the membership lacks the expertise in matters relevant to animal research and care, (b) there exists an inherent and disabling conflict of interest, and …