Animal Experimentation and Research Commons^™

An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …

Examining The Regulatory Value Of Multi-Route Mammalian Acute Systemic Toxicity Studies, Troy Seidle, Pilar Prieto, Anna Bulgheroni

Experimentation Collection

Regulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products. Similar multi-route testing is required in the European Union and elsewhere for industrial chemicals. To determine the value of acute toxicity testing by more than one route, oral-dermal and oralinhalation concordances among regulatory classifications were examined for large data sets of chemicals and pesticide active ingredients. Across all sectors examined, oral acute toxicity classifications for pure active substances were more severe than those derived from dermal data in more than …

‘Concentration Camps For Lost And Stolen Pets’: Stan Wayman’S Life Photo Essay And The Animal Welfare Act, Bernard Unti

Laws and Legislation Collection

In the 1960s, LIFE was America's single most important general weekly magazine, its photo-essay formula catering to a middle class constituency of millions. By the halfway point of that tumultuous decade, readers were accustomed to seeing searing and unpleasant images of a changing nation, one racked by civil unrest and entangled in a bloody war in Southeast Asia. But when LIFE's February 4, 1966 issue landed on newsstands and in mailboxes across the United States, with the cover's warning "YOUR DOG IS IN CRUEL DANGER," tens of millions of readers became acquainted for the first time with another kind of …

The Class B Dealer: Down And Out?, Bernard Unti

Laboratory Experiments Collection

The supply of dogs and cats to laboratories by Class B animal dealers has been a contentious matter for decades. The subject engenders heated debate whenever it surfaces, most recently in September 2005 when Senator Daniel Akaka (D-HI) proposed an amendment to the FY 2006 agriculture funding bill to withhold federal monies to research institutions that purchase animals from Class B dealers.

An Evaluation Of The Us High Production Volume (Hpv) Chemical-Testing Programme: A Study In (Ir)Relevance, Redundancy And Retro Thinking, Andrew Nicholson, Jessica Sandler, Troy Seidle

Experimentation Collection

Under the US Environmental Protection Agency (EPA) High Production Volume (HPV) Challenge Programme, chemical companies have volunteered to conduct screening-level toxicity tests on approximately 2800 widely-used industrial chemicals. Participating companies are committed to providing available toxicity information to the EPA and presenting testing proposals for review by the EPA and posting on the EPA Web site as public information. People for the Ethical Treatment of Animals (PETA) and a coalition of animal protection organisations have reviewed all the test plans submitted by the participating chemical companies for compliance with the original HPV framework, as well as with animal welfare guidelines …

Meeting Offers Hope For Fewer Animal Tests, Iver Peterson

News Reports

No abstract provided.

The Animal Slave Trade: Brutality On The Road To Research

Close Up Reports

The HSUS is working on several fronts to stop the exploitation of our nation's pets. In January, we were instrumental in establishing a coalition to abolish pound seizure-the practice of relinquishing pound and shelter animals for research purposes. Consisting of 11 of the country's leading animal welfare organizations, The National Coalition to Protect Our Pets will be working with local groups to outlaw pound seizure on a state-by-state basis. HSUS investigators will continue to trace the road to research, and we'll be taking legal action against both dealers and research centers whenever necessary. In our effort tore- r duce the …

Cruel Cosmetic Testing Could Be Stopped Today If Consumers Demanded It!

Close Up Reports

The HSUS is launching an all-out offensive to bring an end to the terror and torture endured by millions of animals used in product-safety tests for cosmetics. In recent years, pressure from the animal-welfare community has prompted cosmetic companies to begin developing more humane methods of testing their products. Despite what appears to be progress, findings of a new HSUS study indicate that non-animal alternatives for testing cosmetics may never be implemented on an industry-wide basis unless consumers take action now.

Is Your Pet Safe From Laboratory Experimentation?

Close Up Reports

In the U.S., the path from public or private shelters to laboratories is treat too often by dogs and cats. In a few states, so-called "pound seizure" laws require shelters to turn over unclaimed or unwanted dogs and cats to researchers. In other states, shelters may voluntarily sell dogs and cats to "bunchers" who travel around a state or states, bunching animals together to resell to research facilities. Even in the handful of states that prohibit release of animals for research purposes, unscrupulous profit seekers can find animals and sell them for research across state lines.

Many scientists claim these …

Sewer Science & Pound Seizure, Kenneth P. Stoller

Laboratory Experiments Collection

Significant decisions are being made in the City and County of Los Angeles over a seemingly insignificant issue- pound seizure. Outwardly, the issue is a triflepotentially inconvenienced animal research professionals vs. irate citizens who don't want lost pets sold for research. However, on another level, this conflict has imp I ications that reach to the very depths of irrationality- for far from fighting to promote the practice of pound seizure, scientists should be fighting to end it.

Definition Of The Concept Of ''Humane Treatment" In Relation To Food And Laboratory Animals, Bernard E. Rollin

International Journal for the Study of Animal Problems

The very title of this talk makes a suggestion which must be forestalled, namely the idea that laboratory and food animals enjoy some exceptional moral status by virtue of the fact that we use them. In fact, it is extremely difficult to find any morally relevant grounds for distinguishing between food and laboratory animals and other animals and, far more dramatically, between animals and humans. The same conditions which require that we apply moral categories to humans rationally require that we apply them to animals as well. While it is obviously pragmatically impossible in our current sociocultural setting to expect …

Animals Are Suffering: Hsus Seeks To End Rabbit Blinding Tests

Close Up Reports

The research industry has long held that the use of animals is the only "reliable" way we have of determining the safety of a cosmetic, drug, or household product. Over the years this belief has served to support scientists as they subjected animals to many tests. The American public has seen little of the massive animal suffering that has taken place in the research labs.

Today, a new debate is taking place. People from all walks of life are asking if all the suffering and death is worth it. Many research scientists have joined the ranks of those who are …