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Articles 1 - 10 of 10
Full-Text Articles in Research Methods in Life Sciences
Animal Organs In Humans: Uncalculated Risks And Unanswered Questions, Gillian R. Langley, Joyce D'Silva
Animal Organs In Humans: Uncalculated Risks And Unanswered Questions, Gillian R. Langley, Joyce D'Silva
Biomedicine and Animal Models in Research Collection
This report, produced jointly by the British Union for the Abolition of Vivisection and Compassion in World Farming, fills a number of significant gaps in the current debate about xenotransplantation.
In this report we also summarise the ethical and welfare issues concerning experiments on animals for xenotransplant research and their possible use as source animals for organs. Both these aspects are responsible for much pain and distress caused to many animals. We prefer the term “source animals” to “donor animals”, because animals do not choose to donate their organs for xenotransplantation.
Assessment Of Side Effects Induced By Injection Of Different Adjuvant/Antigen Combinations In Rabbits And Mice, P.P.A.M. Leenaars, M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, C. F.M. Hendriksen
Assessment Of Side Effects Induced By Injection Of Different Adjuvant/Antigen Combinations In Rabbits And Mice, P.P.A.M. Leenaars, M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, C. F.M. Hendriksen
Biomedicine and Animal Models in Research Collection
We evaluated the side effects induced by injection of Freund's adjuvant (FA)and alternative adjuvants combined with different antigens. Rabbits and mice were injected subcutaneously, intramuscularly (rabbits) and intraperitoneally (mice)with different adjuvants (FA, Specol, RIBI,TiterMax, Montanide ISA50)in combination with several types of antigens (synthetic peptides, autoantigen, glycolipid, protein, mycoplasma or viruses). The effects of treatment on the animals' well-being were assessed by clinical and behavioural changes (POTand LABORASassays) and gross and histopathological changes. In rabbits, treatment did not appear to induce acute or prolonged pain and distress. Mice showed behavioural changes immediately after (predominantly secondary) immunization. Injection of several adjuvant/antigen mixtures …
Localization Of Sodium, Potassium-Adenosine Triphosphatase In The Cerebral Cortex Of Developing Rats, Maki Ujiie
Localization Of Sodium, Potassium-Adenosine Triphosphatase In The Cerebral Cortex Of Developing Rats, Maki Ujiie
Loma Linda University Electronic Theses, Dissertations & Projects
Active transport via Na+, K+-ATPase plays an important role in establishing and maintaining proper ionic gradient across all mammalian cell membranes. A strict regulation of Na+, and K+ ion levels is especially important in excitable cells such as neurons and myocytes. Inhibition of the enzyme is associated with several pathological conditions and has serious detrimental effects on cerebral cortical cells. Yet the enzyme appears to be limited in amount and distribution in newborn rats. In this study, Na+, K+- ATPase expression and distribution in early postnatal rats were studied …
The Effect Of Exercise Training On Cardiovascular Dynamics In The Diabetic Rat, Nicole Marie Griffith
The Effect Of Exercise Training On Cardiovascular Dynamics In The Diabetic Rat, Nicole Marie Griffith
Morehead State Theses and Dissertations
A thesis presented to the faculty of the College of Science and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Biology by Nicole Marie Griffith on July 24, 1998.
Regeneration In Periodontal Defects With Rhbmp-2 : A Dosage Study, Paola Guglielmoni
Regeneration In Periodontal Defects With Rhbmp-2 : A Dosage Study, Paola Guglielmoni
Loma Linda University Electronic Theses, Dissertations & Projects
Bone morphogenetic proteins (BMPs) have been shown to induce bone formation in ectopic and orthotopic sites. This inductive capability has led to their evaluation as possible adjuncts in periodontal reconstructive therapy. Indeed, studies have reported periodontal regeneration following surgical implantation of recombinant human BMP-2. This study evaluated regeneration of alveolar bone and cementum following periodontal reconstructive surgery including implantation of a construct consisting of sterile lyophilized rhBMP-2 in buffer adsorbed onto an absorbable collagen sponge. Critical size mandibular supra-alveolar periodontal defects were surgically created, and an incomplete block design was used to evaluate the regenerative potential of rhBMP-2 at 0.05, …
A Model Using Radiation And Pws4-Htnf-Α Gene Therapy For Treatment Of Glioblastomas, Angelo G. Baher
A Model Using Radiation And Pws4-Htnf-Α Gene Therapy For Treatment Of Glioblastomas, Angelo G. Baher
Loma Linda University Electronic Theses, Dissertations & Projects
The efficacy of radiotherapy for cancer is limited by the dose that can be safely delivered to the tumor without causing debilitating side effects. In addition, successful treatment of highly malignant tumors such as glioblastomas is likely to require adjunctive therapies to enhance tumor response to radiation. Previous studies have shown immunomodulation and a synergestic reduction in tumor volume of malignant tumors when tumor necrosis factor-α (TNF-α) protein is administered prior to radiation. The major goal of the present investigation was to evaluate the efficacy of pWS4-human TNF-α (pWS4-hTNF-α), a new plasmid construct that expresses human TNF-α protein, together with …
The Biology Of Xenopus By R. C. Tinsley And H. C. Kobel, Rafael O. De Sá
The Biology Of Xenopus By R. C. Tinsley And H. C. Kobel, Rafael O. De Sá
Biology Faculty Publications
The Biology of Xenopus presents a summary of current knowledge about a single genus resulting from a symposium held at the Zoological Society of London in September 1992. This approach to summarizing available information has also been taken for other taxa, such as Atelopus (Lotters, 1996). However, the task of compiling data for Xenopus is enormous relative to any other amphibian group, because Xenopus laevis has become a model system for molecular and development research (Cannatella and de Sa, 1993). Unfortunately, most of our knowledge of Xenopus is biased toward this single species. There are about 20 recognized species of …
The Mechanics And Regulation Of Rat Aortic Smooth Muscle Contraction: Implications Of Cytoskeletal Remodeling, Protein Phosphorylations, And Microtubule-Based Kinase Transport, Alison Summers Battistella-Patterson
The Mechanics And Regulation Of Rat Aortic Smooth Muscle Contraction: Implications Of Cytoskeletal Remodeling, Protein Phosphorylations, And Microtubule-Based Kinase Transport, Alison Summers Battistella-Patterson
Theses, Dissertations and Capstones
The exact nature of the mechanisms and the regulation of vascular smooth muscle contraction is not well understood. To better understand these processes, we examined two systems involved in smooth muscle contraction, the cytoskeleton and the protein kinases. In order to study the role of the cytoskeleton in smooth muscle contraction, we examined the contractile and mechanical effects of cytoskeleton disruption. We found that the relationship between passive tension applied to aortic rings and the resulting increase in tissue length was nearly linear over the range of 1 g to 15 g. However, even with increasing tissue length, within the …
Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton
Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton
Experimentation Collection
Pain and distress are core issues in the field of animal experimentation and in the controversy that surrounds it. We sought to add to the empirical base of the literature on pain and distress by examining government data on experimental procedures that caused unrelieved pain and distress (UPAD) in animals. Of the species regulated by the U.S. Department of Agriculture (USDA), most of the approximately 100,000 animals subjected to UP AD during the year analyzed (1992) were guinea pigs and hamsters. Most of these animals were used in industry laboratories for various testing procedures, primarily vaccine potency testing. We discuss …
Psychology's Use Of Animals: Current Practices And Attitudes, Kenneth J. Shapiro
Psychology's Use Of Animals: Current Practices And Attitudes, Kenneth J. Shapiro
Experimentation Collection
In this chapter, I present a psychology primer for the uninitiated, with special emphasis on psychology's uses of animals. After sketching the scope of the field generally, I review available data on present numbers and species of animals used in psychological research, level of suffering induced and current trends. I also provide several concrete examples of psychological research involving animals. Finally, the chapter concludes with a presentation of attitudes of psychologists toward animals and these practices.