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Effect Of Somatostatin On Voltage-Gated Calcium Influx In Isolated Neonatal Rat Carotid Body Type I Cells, Eric J. Dunn
Effect Of Somatostatin On Voltage-Gated Calcium Influx In Isolated Neonatal Rat Carotid Body Type I Cells, Eric J. Dunn
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Somatostatin (SST) is a neuropeptide hormone that regulates the release of secondary hormones. Evidence suggests SST plays a neuromodulatory role due to its distribution throughout the central nervous system. Interestingly, SST has been suggested to affect the carotid body, the small peripheral chemoreceptors that regulate breathing. It has been shown that the peripheral chemoreflex sensitivity to CO2 and hypoxia is reduced by SST in humans (Pedersen et al., 1999; Pandit et al., 2014). SST has also been found to inhibit whole cell Ca2+ currents recorded from adult rat carotid body type I cells (e Silva & Lewis, 1995), but the …