Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physiology
Molecular Machinery For The ‘Kiss And Run’ Mechanism Of Insulin Secretion, Akshata Ramesh Naik
Molecular Machinery For The ‘Kiss And Run’ Mechanism Of Insulin Secretion, Akshata Ramesh Naik
Wayne State University Dissertations
The insulin secreting porosome is a supramolecular lipo-protein complex that
measures roughly 100 – 120 nm in diameter. Porosomes allow transient fusion of insulin
secretory granules to the cell plasma membrane and mediates partial release of secretory
contents. Post secretion, the secretory granule reseals and re-enters to the cell interior.
This is in contrast to the ‘total fusion’ phenomenon, where secretory vesicles completely
fuse at the cell plasma membrane and release all of the contents to the cell exterior. This
study involved a deeper understanding of the transient or ‘kiss-and-run’ mechanism of
cell secretion that involves the insulin secreting porosome …