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Full-Text Articles in Physiology
Molecular Machinery For The ‘Kiss And Run’ Mechanism Of Insulin Secretion, Akshata Ramesh Naik
Molecular Machinery For The ‘Kiss And Run’ Mechanism Of Insulin Secretion, Akshata Ramesh Naik
Wayne State University Dissertations
The insulin secreting porosome is a supramolecular lipo-protein complex that
measures roughly 100 – 120 nm in diameter. Porosomes allow transient fusion of insulin
secretory granules to the cell plasma membrane and mediates partial release of secretory
contents. Post secretion, the secretory granule reseals and re-enters to the cell interior.
This is in contrast to the ‘total fusion’ phenomenon, where secretory vesicles completely
fuse at the cell plasma membrane and release all of the contents to the cell exterior. This
study involved a deeper understanding of the transient or ‘kiss-and-run’ mechanism of
cell secretion that involves the insulin secreting porosome …
Peri-Exercise Co-Ingestion Of Branched-Chain Amino Acids And Carbohydrate In Men Does Not Preferentially Augment Resistance Exercise-Induced Increases In Pi3k/Akt-Mtor Pathway Markers Indicative Of Muscle Protein Synthesis, Maria Pontes Ferreira, Rui Li, Matthew Cooke, Richard B. Kreider, Darryn S. Willoughby
Peri-Exercise Co-Ingestion Of Branched-Chain Amino Acids And Carbohydrate In Men Does Not Preferentially Augment Resistance Exercise-Induced Increases In Pi3k/Akt-Mtor Pathway Markers Indicative Of Muscle Protein Synthesis, Maria Pontes Ferreira, Rui Li, Matthew Cooke, Richard B. Kreider, Darryn S. Willoughby
Nutrition and Food Science Faculty Research Publications
The effects of a single bout of resistance exercise (RE) in conjunction with peri-exercise branched chain amino acid (BCAA) and carbohydrate (CHO) ingestion on skeletal muscle signaling markers indicative of muscle protein synthesis (MPS) were determined. It was hypothesized that CHO + BCAA would elicit a more profound effect on these signaling markers compared to CHO. Twenty-seven males were randomly assigned to CHO, CHO + BCAA, or placebo (PLC) groups. Four sets of leg presses and leg extensions were performed at 80% 1RM. Supplements were ingested 30 min and immediately prior to and after RE. Venous blood and muscle biopsy …