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Full-Text Articles in Physiology
The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson
The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson
Wayne State University Dissertations
Assisted Reproduction Technologies (ART) have been used to treat infertility since 1790. In the centuries following, dramatic advances have been made in the field of infertility research through the employment of a variety of species. Despite these advances, determination of oocyte and embryo quality remains largely subjective. Ascertainment of methods to measure oocyte and embryo quality to improve selection in ART clinics and increase pregnancy success rates is imperative. These methods are only possible with a more comprehensive understanding of the cellular and molecular properties of oocytes and preimplantation embryos. A key component of all cells, including oocytes and embryos, …
Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure
Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure
Wayne State University Dissertations
Previous studies from our laboratory showed that activation of NTS A1 adenosine
receptors yields variable hemodynamic responses with prevailing pressor and iliac
vasoconstrictor responses. These responses are accompanied with differential
activation of regional sympathetic activity (adrenal>>renal≥lumbar) and inhibition of
baroreflex mechanisms at the level of the NTS. The variability of the hemodynamic
responses was a result of simultaneous Β-adrenergic vasodilation counteracted with
sympathetic and unknown humoral vasoconstriction. Among many potential
vasoconstrictors vasopressin, angiotensin II and circulating norepinephrine were
considered. Therefore, blood pressure and iliac vascular responses evoked by
selective stimulation of NTS A1 adenosine receptors (CPA 330 …
Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh
Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh
Wayne State University Theses
Lipodystrophy caused by fat deficiency contributes to metabolic disease for which several treatment modalities have been implemented, with leptin therapy being the most effective to date. In addition to playing a role in energy homeostasis and metabolism, leptin was also shown to play a pro-thrombotic role in mice. This role was not examined in fatless mice, neither was thrombosis measured. The AZIP/F-1 (FVB) lipodystrophic mouse appeared to have a prolonged arterial occlusion time (p〈0.05) in a trial done in our lab, with clotting factors being normal. The present study was designed to observe the thrombotic and metabolic characteristics of fatless …